The preparation of 3H-labeled acyclic nucleoside phosphonates and study of their stability

Collection of Czechoslovak Chemical Communications

Volumn 75, Issue 7, 2010, Pages 757-766

  Elbert, Tomáš ^a   Brehová, Petra ^a   Holý, Antonín ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

3H NMR; 3H label stability; Acyclic nucleotide analogues; Adefovir; Radioactive labelling; Tenofovir; Tritium

Indexed keywords

EID: 77957087824     PISSN: 00100765     EISSN: None     Source Type: Journal    
DOI: 10.1135/cccc2010020     Document Type: Article

References (12)

1. De Clercq E., Holý A.: Nat. Rev. Drug Discov. 2005, 4, 928.
2. De Clercq E.: Future Virol. 2006, 1, 709.
3. Delaney IV W. E., Borroto-Esoda K.: Curr. Opin. Pharmacol. 2008, 8, 532.
4. De Clercq E.: Antiviral Res. 2007, 75, 1.
5. Reiser H., Wang J. Y., Chong L., Watkins W. J., Ray A. S., Shibata R., Birkus G., Cihlar T., Wu S., Li B., Liu X. H., Henne I. N., Wolfgang G. H. I., Desai M., Rhodes G. R., Fridland A., Lee W. A., Plunkett W., Vail D., Thamm D. H., Jeraj R., Tumas D. B.: Clin. Cancer Res. 2008, 14, 2824.
6. Holý A.: Curr. Pharm. Design 2003, 9, 2567.
7. Tomasz M., Olson J., Mercado C. M.: Biochemistry 1972, 11, 1235;
8. Maslova R. N., Lesnik E. A., Varshavsky Y. M.: FEBS Lett. 1974, 49, 181;
9. Filip J., Boháček L.: Radioisotopy 1971, 12, 949;
10. Chem. Abstr. 1972, 76, 113481.
11. Holý A., Guenter J., Dvořáková H., Masojídková M., Andrei G., Snoeck R., Balzarini J., De Clercq E.: J. Med. Chem. 1999, 42, 2064.
12. Holý A., Dvořáková H., Masojí dková M.: Collect. Czech. Chem. Commun. 1995, 60, 1390.