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Volumn 165, Issue 1, 2011, Pages 121-129

Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary osteoporosis

Author keywords

BMD; CAIA; CIA; Luciferase ERE; Oestradiol; Ovariectomy; Raloxifene

Indexed keywords

6 HYDROXY 2 (4 HYDROXYPHENYL) 3 [4 [2 (1 PYRROLIDINYL)ETHOXY]BENZOYL]BENZO[B]THIOPHENE; BIOLOGICAL MARKER; CARTILAGE OLIGOMERIC MATRIX PROTEIN; COLLAGEN ANTIBODY; COLLAGEN TYPE 2; ESTRADIOL BENZOATE; INTERLEUKIN 6; LUCIFERASE; OSTEOCALCIN;

EID: 79958170434     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04397.x     Document Type: Article
Times cited : (12)

References (43)
  • 1
    • 0036191292 scopus 로고    scopus 로고
    • Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period
    • Doran MF, Pond GR, Crowson CS, O'Fallon WM, Gabriel SE. Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. Arthritis Rheum 2002; 46:625-31.
    • (2002) Arthritis Rheum , vol.46 , pp. 625-631
    • Doran, M.F.1    Pond, G.R.2    Crowson, C.S.3    O'Fallon, W.M.4    Gabriel, S.E.5
  • 2
    • 0038208285 scopus 로고    scopus 로고
    • Radiographic joint destruction in postmenopausal rheumatoid arthritis is strongly associated with generalised osteoporosis
    • Forsblad D'Elia H, Larsen A, Waltbrand E etal. Radiographic joint destruction in postmenopausal rheumatoid arthritis is strongly associated with generalised osteoporosis. Ann Rheum Dis 2003; 62:617-23.
    • (2003) Ann Rheum Dis , vol.62 , pp. 617-623
    • Forsblad D'Elia, H.1    Larsen, A.2    Waltbrand, E.3
  • 3
    • 0033748422 scopus 로고    scopus 로고
    • A multicenter cross sectional study on bone mineral density in rheumatoid arthritis. Italian Study Group on Bone Mass in Rheumatoid Arthritis
    • Sinigaglia L, Nervetti A, Mela Q etal. A multicenter cross sectional study on bone mineral density in rheumatoid arthritis. Italian Study Group on Bone Mass in Rheumatoid Arthritis. J Rheumatol 2000; 27:2582-9.
    • (2000) J Rheumatol , vol.27 , pp. 2582-2589
    • Sinigaglia, L.1    Nervetti, A.2    Mela, Q.3
  • 4
    • 0038166889 scopus 로고    scopus 로고
    • Influence of hormone replacement therapy on disease progression and bone mineral density in rheumatoid arthritis
    • Forsblad D'Elia H, Larsen A, Mattsson LA etal. Influence of hormone replacement therapy on disease progression and bone mineral density in rheumatoid arthritis. J Rheumatol 2003; 30:1456-63.
    • (2003) J Rheumatol , vol.30 , pp. 1456-1463
    • Forsblad D'Elia, H.1    Larsen, A.2    Mattsson, L.A.3
  • 5
    • 30544443806 scopus 로고    scopus 로고
    • Estrogens and progestins: background and history, trends in use, and guidelines and regimens approved by the US Food and Drug Administration
    • Stefanick ML. Estrogens and progestins: background and history, trends in use, and guidelines and regimens approved by the US Food and Drug Administration. Am J Med 2005; 118:64-73.
    • (2005) Am J Med , vol.118 , pp. 64-73
    • Stefanick, M.L.1
  • 6
    • 35348922481 scopus 로고    scopus 로고
    • Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis
    • Jochems C, Islander U, Kallkopf A, Lagerquist M, Ohlsson C, Carlsten H. Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis. Arthritis Rheum 2007; 56:3261-70.
    • (2007) Arthritis Rheum , vol.56 , pp. 3261-3270
    • Jochems, C.1    Islander, U.2    Kallkopf, A.3    Lagerquist, M.4    Ohlsson, C.5    Carlsten, H.6
  • 7
    • 43349097778 scopus 로고    scopus 로고
    • Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis
    • Jochems C, Lagerquist M, Hakansson C, Ohlsson C, Carlsten H. Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis. Clin Exp Immunol 2008; 152:593-7.
    • (2008) Clin Exp Immunol , vol.152 , pp. 593-597
    • Jochems, C.1    Lagerquist, M.2    Hakansson, C.3    Ohlsson, C.4    Carlsten, H.5
  • 8
    • 0344585474 scopus 로고    scopus 로고
    • Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis
    • Latham KA, Zamora A, Drought H etal. Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis. J Immunol 2003; 171:5820-7.
    • (2003) J Immunol , vol.171 , pp. 5820-5827
    • Latham, K.A.1    Zamora, A.2    Drought, H.3
  • 9
    • 28544452323 scopus 로고    scopus 로고
    • Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation
    • Jochems C, Islander U, Erlandsson M, Verdrengh M, Ohlsson C, Carlsten H. Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation. Arthritis Res Ther 2005; 7:R837-43.
    • (2005) Arthritis Res Ther , vol.7
    • Jochems, C.1    Islander, U.2    Erlandsson, M.3    Verdrengh, M.4    Ohlsson, C.5    Carlsten, H.6
  • 10
    • 24344440857 scopus 로고    scopus 로고
    • Efficient promotion of collagen antibody induced arthritis (CAIA) using four monoclonal antibodies specific for the major epitopes recognized in both collagen induced arthritis and rheumatoid arthritis
    • Nandakumar KS, Holmdahl R. Efficient promotion of collagen antibody induced arthritis (CAIA) using four monoclonal antibodies specific for the major epitopes recognized in both collagen induced arthritis and rheumatoid arthritis. J Immunol Methods 2005; 304:126-36.
    • (2005) J Immunol Methods , vol.304 , pp. 126-136
    • Nandakumar, K.S.1    Holmdahl, R.2
  • 11
    • 0036745063 scopus 로고    scopus 로고
    • Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen-induced arthritis in the mouse
    • Burkhardt H, Koller T, Engstrom A etal. Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen-induced arthritis in the mouse. Arthritis Rheum 2002; 46:2339-48.
    • (2002) Arthritis Rheum , vol.46 , pp. 2339-2348
    • Burkhardt, H.1    Koller, T.2    Engstrom, A.3
  • 12
    • 0142213223 scopus 로고    scopus 로고
    • Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes
    • Nandakumar KS, Svensson L, Holmdahl R. Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol 2003; 163:1827-37.
    • (2003) Am J Pathol , vol.163 , pp. 1827-1837
    • Nandakumar, K.S.1    Svensson, L.2    Holmdahl, R.3
  • 14
    • 78650043912 scopus 로고    scopus 로고
    • The selective estrogen receptor alpha agonist Org 37663 induces estrogenic effects but lacks antirheumatic activity: a phase IIa trial investigating efficacy and safety of Org 37663 in postmenopausal female rheumatoid arthritis patients receiving stable background methotrexate or sulfasalazine
    • van Vollenhoven RF, Houbiers JG, Buttgereit F etal. The selective estrogen receptor alpha agonist Org 37663 induces estrogenic effects but lacks antirheumatic activity: a phase IIa trial investigating efficacy and safety of Org 37663 in postmenopausal female rheumatoid arthritis patients receiving stable background methotrexate or sulfasalazine. Arthritis Rheum 2010; 62:3832-3.
    • (2010) Arthritis Rheum , vol.62 , pp. 3832-3833
    • van Vollenhoven, R.F.1    Houbiers, J.G.2    Buttgereit, F.3
  • 15
    • 78649804890 scopus 로고    scopus 로고
    • Efficacy and safety of a selective estrogen receptor-beta agonist, ERB-041, in patients with rheumatoid arthritis
    • Roman-Blas JA, Castaneda S, Cutolo M, Herrero-Beaumont G. Efficacy and safety of a selective estrogen receptor-beta agonist, ERB-041, in patients with rheumatoid arthritis. Arthritis Care Res 2010; 62:1588-93.
    • (2010) Arthritis Care Res , vol.62 , pp. 1588-1593
    • Roman-Blas, J.A.1    Castaneda, S.2    Cutolo, M.3    Herrero-Beaumont, G.4
  • 16
    • 77952497806 scopus 로고    scopus 로고
    • Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta
    • Dulos J, Vijn P, van Doorn C etal. Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta. Arthritis Res Ther 2010; 12:R101.
    • (2010) Arthritis Res Ther , vol.12
    • Dulos, J.1    Vijn, P.2    van Doorn, C.3
  • 17
    • 0141525429 scopus 로고    scopus 로고
    • Evaluation of an estrogen receptor-beta agonist in animal models of human disease
    • Harris HA, Albert LM, Leathurby Y etal. Evaluation of an estrogen receptor-beta agonist in animal models of human disease. Endocrinology 2003; 144:4241-9.
    • (2003) Endocrinology , vol.144 , pp. 4241-4249
    • Harris, H.A.1    Albert, L.M.2    Leathurby, Y.3
  • 18
    • 75749106248 scopus 로고    scopus 로고
    • Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor 30
    • Engdahl C, Jochems C, Windahl SH etal. Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor 30. Arthritis Rheum 2010; 62:524-33.
    • (2010) Arthritis Rheum , vol.62 , pp. 524-533
    • Engdahl, C.1    Jochems, C.2    Windahl, S.H.3
  • 19
    • 0034319148 scopus 로고    scopus 로고
    • Effects of raloxifene, a selective estrogen receptor modulator, on thymus, T cell reactivity, and inflammation in mice
    • Erlandsson MC, Gomori E, Taube M, Carlsten H. Effects of raloxifene, a selective estrogen receptor modulator, on thymus, T cell reactivity, and inflammation in mice. Cell Immunol 2000; 205:103-9.
    • (2000) Cell Immunol , vol.205 , pp. 103-109
    • Erlandsson, M.C.1    Gomori, E.2    Taube, M.3    Carlsten, H.4
  • 20
  • 21
    • 0034088850 scopus 로고    scopus 로고
    • Comparative effects of estrogen and raloxifene on B lymphopoiesis and bone loss induced by sex steroid deficiency in mice
    • Onoe Y, Miyaura C, Ito M, Ohta H, Nozawa S, Suda T. Comparative effects of estrogen and raloxifene on B lymphopoiesis and bone loss induced by sex steroid deficiency in mice. J Bone Miner Res 2000; 15:541-9.
    • (2000) J Bone Miner Res , vol.15 , pp. 541-549
    • Onoe, Y.1    Miyaura, C.2    Ito, M.3    Ohta, H.4    Nozawa, S.5    Suda, T.6
  • 22
    • 0022869847 scopus 로고
    • Homologous type II collagen induces chronic and progressive arthritis in mice
    • Holmdahl R, Jansson L, Larsson E, Rubin K, Klareskog L. Homologous type II collagen induces chronic and progressive arthritis in mice. Arthritis Rheum 1986; 29:106-13.
    • (1986) Arthritis Rheum , vol.29 , pp. 106-113
    • Holmdahl, R.1    Jansson, L.2    Larsson, E.3    Rubin, K.4    Klareskog, L.5
  • 23
    • 0032748023 scopus 로고    scopus 로고
    • Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice
    • Windahl SH, Vidal O, Andersson G, Gustafsson JA, Ohlsson C. Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice. J Clin Invest 1999; 104:895-901.
    • (1999) J Clin Invest , vol.104 , pp. 895-901
    • Windahl, S.H.1    Vidal, O.2    Andersson, G.3    Gustafsson, J.A.4    Ohlsson, C.5
  • 25
    • 0026764017 scopus 로고
    • Histopathological and serological progression of experimental Staphylococcus aureus arthritis
    • Bremell T, Abdelnour A, Tarkowski A. Histopathological and serological progression of experimental Staphylococcus aureus arthritis. Infect Immun 1992; 60:2976-85.
    • (1992) Infect Immun , vol.60 , pp. 2976-2985
    • Bremell, T.1    Abdelnour, A.2    Tarkowski, A.3
  • 26
    • 0023739278 scopus 로고
    • Functional discrimination between interleukin 6 and interleukin 1
    • Helle M, Boeije L, Aarden LA. Functional discrimination between interleukin 6 and interleukin 1. Eur J Immunol 1988; 18:1535-40.
    • (1988) Eur J Immunol , vol.18 , pp. 1535-1540
    • Helle, M.1    Boeije, L.2    Aarden, L.A.3
  • 27
    • 0026660250 scopus 로고
    • Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood
    • Saxne T, Heinegard D. Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood. Br J Rheumatol 1992; 31:583-91.
    • (1992) Br J Rheumatol , vol.31 , pp. 583-591
    • Saxne, T.1    Heinegard, D.2
  • 28
    • 0028934327 scopus 로고
    • Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism
    • Mansson B, Carey D, Alini M etal. Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. J Clin Invest 1995; 95:1071-7.
    • (1995) J Clin Invest , vol.95 , pp. 1071-1077
    • Mansson, B.1    Carey, D.2    Alini, M.3
  • 29
    • 0033281490 scopus 로고    scopus 로고
    • Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
    • Joosten LA, Lubberts E, Helsen MM etal. Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis. Arthritis Res 1999; 1:81-91.
    • (1999) Arthritis Res , vol.1 , pp. 81-91
    • Joosten, L.A.1    Lubberts, E.2    Helsen, M.M.3
  • 30
    • 0022871108 scopus 로고
    • Female sex hormones suppress development of collagen-induced arthritis in mice
    • Holmdahl R, Jansson L, Andersson M. Female sex hormones suppress development of collagen-induced arthritis in mice. Arthritis Rheum 1986; 29:1501-9.
    • (1986) Arthritis Rheum , vol.29 , pp. 1501-1509
    • Holmdahl, R.1    Jansson, L.2    Andersson, M.3
  • 31
    • 0024378258 scopus 로고
    • Oestrogen induced suppression of collagen arthritis. IV: progesterone alone does not affect the course of arthritis but enhances the oestrogen-mediated therapeutic effect
    • Jansson L, Holmdahl R. Oestrogen induced suppression of collagen arthritis. IV: progesterone alone does not affect the course of arthritis but enhances the oestrogen-mediated therapeutic effect. J Reprod Immunol 1989; 15:141-50.
    • (1989) J Reprod Immunol , vol.15 , pp. 141-150
    • Jansson, L.1    Holmdahl, R.2
  • 32
    • 0034972673 scopus 로고    scopus 로고
    • Effects of ovariectomy and estrogen replacement therapy on arthritis and bone mineral density in rats with collagen-induced arthritis
    • Yamasaki D, Enokida M, Okano T, Hagino H, Teshima R. Effects of ovariectomy and estrogen replacement therapy on arthritis and bone mineral density in rats with collagen-induced arthritis. Bone 2001; 28:634-40.
    • (2001) Bone , vol.28 , pp. 634-640
    • Yamasaki, D.1    Enokida, M.2    Okano, T.3    Hagino, H.4    Teshima, R.5
  • 33
    • 0025049718 scopus 로고
    • Estrogen induced suppression of collagen arthritis. V: physiological level of estrogen in DBA/1 mice is therapeutic on established arthritis, suppresses anti-type II collagen T-cell dependent immunity and stimulates polyclonal B-cell activity
    • Jansson L, Mattsson A, Mattsson R, Holmdahl R. Estrogen induced suppression of collagen arthritis. V: physiological level of estrogen in DBA/1 mice is therapeutic on established arthritis, suppresses anti-type II collagen T-cell dependent immunity and stimulates polyclonal B-cell activity. J Autoimmun 1990; 3:257-70.
    • (1990) J Autoimmun , vol.3 , pp. 257-270
    • Jansson, L.1    Mattsson, A.2    Mattsson, R.3    Holmdahl, R.4
  • 34
    • 0033745370 scopus 로고    scopus 로고
    • The selective oestrogen receptor modulators idoxifene and raloxifene have fundamentally different cell-specific oestrogen-response element (ERE)-dependent/independent mechanisms in vitro
    • Nuttall ME, Fisher PW, Suva LJ, Gowen M. The selective oestrogen receptor modulators idoxifene and raloxifene have fundamentally different cell-specific oestrogen-response element (ERE)-dependent/independent mechanisms in vitro. Eur J Cancer 2000; 36 (Suppl. 4):S63-4.
    • (2000) Eur J Cancer , vol.36 , Issue.4 SUPPL.
    • Nuttall, M.E.1    Fisher, P.W.2    Suva, L.J.3    Gowen, M.4
  • 35
    • 0029841146 scopus 로고    scopus 로고
    • Identification of an estrogen response element activated by metabolites of 17beta-estradiol and raloxifene
    • Yang NN, Venugopalan M, Hardikar S, Glasebrook A. Identification of an estrogen response element activated by metabolites of 17beta-estradiol and raloxifene. Science 1996; 273:1222-5.
    • (1996) Science , vol.273 , pp. 1222-1225
    • Yang, N.N.1    Venugopalan, M.2    Hardikar, S.3    Glasebrook, A.4
  • 36
    • 0030801841 scopus 로고    scopus 로고
    • Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
    • Paech K, Webb P, Kuiper GG etal. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 1997; 277:1508-10.
    • (1997) Science , vol.277 , pp. 1508-1510
    • Paech, K.1    Webb, P.2    Kuiper, G.G.3
  • 37
    • 0025047078 scopus 로고
    • Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor
    • Weisz A, Rosales R. Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor. Nucleic Acids Res 1990; 18:5097-106.
    • (1990) Nucleic Acids Res , vol.18 , pp. 5097-5106
    • Weisz, A.1    Rosales, R.2
  • 38
    • 0031986230 scopus 로고    scopus 로고
    • Increases in osteocalcin after ovariectomy are amplified by LPS injection: strain differences in bone remodelling
    • Blanque R, Cottereaux C, Gardner CR. Increases in osteocalcin after ovariectomy are amplified by LPS injection: strain differences in bone remodelling. Gen Pharmacol 1998; 30:51-6.
    • (1998) Gen Pharmacol , vol.30 , pp. 51-56
    • Blanque, R.1    Cottereaux, C.2    Gardner, C.R.3
  • 39
    • 33845981069 scopus 로고    scopus 로고
    • IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation
    • Gao Y, Grassi F, Ryan MR etal. IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest 2007; 117:122-32.
    • (2007) J Clin Invest , vol.117 , pp. 122-132
    • Gao, Y.1    Grassi, F.2    Ryan, M.R.3
  • 40
    • 4344584784 scopus 로고    scopus 로고
    • An arthritogenic monoclonal antibody to type II collagen, CII-C1, impairs cartilage formation by cultured chondrocytes
    • Amirahmadi SF, Pho MH, Gray RE etal. An arthritogenic monoclonal antibody to type II collagen, CII-C1, impairs cartilage formation by cultured chondrocytes. Immunol Cell Biol 2004; 82:427-34.
    • (2004) Immunol Cell Biol , vol.82 , pp. 427-434
    • Amirahmadi, S.F.1    Pho, M.H.2    Gray, R.E.3
  • 41
    • 33645735642 scopus 로고    scopus 로고
    • Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro
    • Crombie DE, Turer M, Zuasti BB etal. Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro. Arthritis Res Ther 2005; 7:R927-37.
    • (2005) Arthritis Res Ther , vol.7
    • Crombie, D.E.1    Turer, M.2    Zuasti, B.B.3
  • 42
    • 20744447757 scopus 로고    scopus 로고
    • Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells
    • Amirahmadi SF, Whittingham S, Crombie DE etal. Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells. Arthritis Rheum 2005; 52:1897-906.
    • (2005) Arthritis Rheum , vol.52 , pp. 1897-1906
    • Amirahmadi, S.F.1    Whittingham, S.2    Crombie, D.E.3
  • 43
    • 38149006291 scopus 로고    scopus 로고
    • Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation
    • Nandakumar KS, Bajtner E, Hill L etal. Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation. Arthritis Rheum 2008; 58:184-96.
    • (2008) Arthritis Rheum , vol.58 , pp. 184-196
    • Nandakumar, K.S.1    Bajtner, E.2    Hill, L.3


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