Aqueous extract of Tribulus terrestris Linn induces cell growth arrest and apoptosis by down-regulating NF-κB signaling in liver cancer cells

Journal of Ethnopharmacology

Volumn 136, Issue 1, 2011, Pages 197-203

  Kim, Hye Jin ^a   Kim, Jin Chul ^a   Min, Jung Sun ^a   Kim, Mi Jee ^a   Kim, Ji Ae ^a   Kor, Myung Ho ^a   Yoo, Hwa Seung ^b   Ahn, Jeong Keun ^a  

^a Chungnam National University   (South Korea)

^b Daejeon University   (South Korea)

Author keywords

Apoptosis; I B ; IKK; Liver cancer cell; NF B; Tribulus terrestris L.

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN SUBUNIT; TRIBULUS TERRESTRIS EXTRACT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INVASION; CANCER PATIENT; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HEPG2; CLONOGENESIS; CYTOTOXICITY; DOSE RESPONSE; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION; GENES, REPORTER; HEP G2 CELLS; HEPATOBLASTOMA; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; LIVER NEOPLASMS; NEOPLASM INVASIVENESS; NF-KAPPA B; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; SIGNAL TRANSDUCTION; TRIBULUS; TUMOR STEM CELL ASSAY;

TRIBULUS TERRESTRIS;

EID: 79958162133     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.04.060     Document Type: Article

References (22)

1. Abdel-Hameed el, S.S., El-Nahas, H.A., El-Wakil, E.A., Ahmed, W.S., 2007. Cytotoxic cholestane and pregnane glycosides from Tribulus macropterus. Zeitschrift für Naturforschung C 62, 319-325.
2. Adams, J.M., Cory, S., 2001. Life-or-death decisions by the Bcl-2 protein family. Trends in Biochemical Sciences 26, 61-66. (Pubitemid 32124712)
3. Adimoelja, A., 2000. Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. International Journal of Andrology 23 (Suppl. 2), 82-84. (Pubitemid 30330244)
4. Aggarwal, B.B., 2004. Nuclear factor-kappaB: the enemy within. Cancer Cell 6, 203-208.
5. Amin, A., Lotfy, M., Shafiullah, M., Adeghate, E., 2006. The protective effect of Tribulus terrestris in diabetes. Annals of the New York Academy of Sciences 1084, 391-401. (Pubitemid 47091940)
6. Chu, S., Qu, W., Pang, X., Sun, B., Huang, X., 2003. Effect of saponin from Tribulus terrestris on hyperlipidemia. Journal of Chinese Medicinal Materials 26, 341-344.
7. Egeblad, M., Werb, Z., 2002. New functions for the matrix metalloproteinases in cancer progression. Nature Reviews Cancer 2, 161-174. (Pubitemid 37328786)
8. Feng, B., Cheng, S., Hsia, C.Y., King, L.B., Monroe, J.G., Liou, H.C., 2004. NF-kappaB inducible genes BCL-X and cyclin E promote immature B-cell proliferation and survival. Cellular Immunology 232, 9-20. (Pubitemid 40732716)
9. Franken, N.A., Rodermond, H.M., Stap, J., Haveman, J., van Bree, C., 2006. Clonogenic assay of cells in vitro. Nature Protocols 1, 2315-2319.
10. Henry, S.H., Bosch, F.X., Bowers, J.C., 2002. Aflatoxin, hepatitis and worldwide liver cancer risks. Advances in Experimental Medicine and Biology 504, 229-233. (Pubitemid 34457495)
11. Hsieh, T.C., Wijeratne, E.K., Liang, J.Y., Gunatilaka, A.L., Wu, J.M., 2005. Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens. Biochemical and Biophysical Research Communications 337, 224-231. (Pubitemid 41393783)
12. Joyce, D., Albanese, C., Steer, J., Fu, M., Bouzahzah, B., Pestell, R.G., 2001. NF-kappaB and cell-cycle regulation: the cyclin connection. Cytokine & Growth Factor Reviews 12, 73-90. (Pubitemid 32294588)
13. Karin, M., 2008. The IkappaB kinase-a bridge between inflammation and cancer. Cell Research 18, 334-342. (Pubitemid 351333897)
14. Kim, H.J., Yoo, H.S., Kim, J.C., Park, C.S., Choi, M.S., Kim, M., Choi, H., Min, J.S., Kim, Y.S., Yoon, S.W., Ahn, J.K., 2009. Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. Journal of Ethnopharmacology 124, 189-196.
15. Kim, S.Y., Kim, J.K., Kim, H.J., Ahn, J.K., 2005. Hepatitis B virus X protein sensitizes UV-induced apoptosis by transcriptional transactivation of Fas ligand gene expression. Journal of the International Union of Biochemistry and Molecular Biology Life 57, 651-658. (Pubitemid 41530554)
16. Kukreja, A., Hutchinson, A., Dhodapkar, K., Mazumder, A., Vesole, D., Angitapalli, R., Jagannath, S., Dhodapkar, M.V., 2006. Enhancement of clonogenicity of human multiple myeloma by dendritic cells. Journal of Experimental Medicine 203, 1859-1865. (Pubitemid 44188460)
17. Li, Z.W., Chu, W., Hu, Y., Delhase, M., Deerinck, T., Ellisman, M., Johnson, R., Karin, M., 1999. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. Journal of Experimental Medicine 189, 1839-1845. (Pubitemid 29272700)
18. Nabel, G.J., Verma, I.M., 1993. Proposed NF-kappa B/I kappa B family nomenclature. Genes & Development 7, 2063. (Pubitemid 23336133)
19. Okamoto, T., Sanda, T., Asamitsu, K., 2007. NF-kappa B signaling and carcinogenesis. Current Pharmaceutical Design 13, 447-462.
20. Okudaira, T., Hirashima, M., Ishikawa, C., Makishi, S., Tomita, M., Matsuda, T., Kawakami, H., Taira, N., Ohshiro, K., Masuda, M., Takasu, N., Mori, N., 2007. A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines. International Journal of Cancer 120, 2251-2261. (Pubitemid 46555866)
21. Phillips, O.A., Mathew, K.T., Oriowo, M.A., 2006. Antihypertensive and vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats. Journal of Ethnopharmacology 104, 351-355. (Pubitemid 43356647)
22. Zhang, J.D., Cao, Y.B., Xu, Z., Sun, H.H., An, M.M., Yan, L., Chen, H.S., Gao, P.H., Wang, Y., Jia, X.M., Jiang, Y.Y., 2005. In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L. with potent activity against fluconazole-resistant fungal. Biological & Pharmaceutical Bulletin 28, 2211-2215.