Immunomodulatory properties of a lemon-quince preparation (Gencydo®) as an indicator of anti-allergic potency

Phytomedicine

Volumn 18, Issue 8-9, 2011, Pages 760-768

  Gründemann, Carsten ^a   Papagiannopoulos, Menelaos ^b   Lamy, Evelyn ^a   Mersch Sundermann, Volker ^a   Huber, Roman ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b WELEDA AG   (Germany)

Author keywords

Allergy; Anthroposophic medicine; Citrus limon; Cydonia oblonga; Flavonoids; Phytotherapy

Indexed keywords

ANTIALLERGIC AGENT; AZELASTINE; DEXAMETHASONE; EOTAXIN; GENCYDO; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN E; INTERLEUKIN 8; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC REACTION; ARTICLE; BASOPHIL; BASOPHIL DEGRANULATION; CELL ACTIVATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; EOSINOPHIL; HISTAMINE RELEASE; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM; MAST CELL; PRIORITY JOURNAL;

ANIMALS; ANTI-ALLERGIC AGENTS; BRONCHI; CELL DEGRANULATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRUS; CYTOKINES; EPITHELIAL CELLS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GRANULOCYTES; HISTAMINE RELEASE; HUMANS; HYPERSENSITIVITY; IMMUNOLOGIC FACTORS; MALE; MAST CELLS; MICE; MICE, INBRED C57BL; PHYTOTHERAPY; PLANT EXTRACTS; ROSACEAE; TANDEM MASS SPECTROMETRY;

CITRUS LIMON; CYDONIA OBLONGA;

EID: 79958155981     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.11.016     Document Type: Article

References (26)

1. Aketani, S., Teshima, R., Umezawa, Y., Sawada, J., 2001. Correlation between cytosolic calcium concentration and degranulation in RBL-2H3 cells in the presence of various concentrations of antigen-specific IgEs. Immunology Letters 75, 185-189. (Pubitemid 32166773)
2. Baars, E.W., De Bruin, A., 2005. The effect of Gencydo (R) injections on hayfever symptoms: a therapeutic causality report. Journal of Alternative and Complementary Medicine 11, 863-869. (Pubitemid 41739358)
3. Baars, E.W., Savelkoul, H.F.J., 2008. Citrus/Cydonia comp. can restore the immunological balance in seasonal allergic rhinitis-related immunological parameters in vitro. Mediators of Inflammation, 1-5.
4. Broide, D.H., Lotz, M., Cuomo, A.J., Coburn, D.A., Federman, E.C., Wasserman, S.I., 1992. Cytokines in symptomatic asthma airways. Journal of Allergy and Clinical Immunology 89, 958-967.
5. De Bruin, A., Baars, E., 2001. Citrus/Cydonia Comp. Use in Gerneral Practice. A Survey Among Anthroposophic Physicians. Louis Bolk Instituut, Driebergen, The Netherlands.
6. Gimborn, K., Lessmann, E., Kuppig, S., Krystal, G., Huber, M., 2005. SHIP down-regulates Fc epsilon R1-induced degranulation at supraoptimal IgE or antigen levels. Journal of Immunology 174, 507-516. (Pubitemid 40007441)
7. Gould, H.J., Sutton, B.J., 2008. IgE in allergy and asthma today. Nature Reviews Immunology 8, 205-217. (Pubitemid 351323292)
8. Granberg, M., Fowler, C.J., Jacobsson, S.O.P., 2001. Effects of the cannabimimetic fatty acid derivatives 2-arachidonoylglycerol, anandamide, palmitoylethanolamide and methanandamide upon IgE-dependent antigen-induced beta-hexosaminidase, serotonin and TNF alpha release from rat RBL-2H3 basophilic leukaemia cells. Naunyn-Schmiedebergs Archives of Pharmacology 364, 66-73. (Pubitemid 32646343)
9. Greiner, A.N., Meltzer, E.O., 2006. Pharmacologic rationale for treating allergic and nonallergic rhinitis. Journal of Allergy and Clinical Immunology 118, 985-996. (Pubitemid 44666975)
10. Hide, I., Toriu, N., Nuibe, T., Inoue, A., Hide, M., Yamamoto, S., Nakata, Y., 1997. Suppression of TNF-alpha secretion by azelastine in a rat mast (RBL-2H3) cell line - evidence for differential regulation of TNF-alpha release, transcription, and degranulation. Journal of Immunology 159, 2932-2940. (Pubitemid 127681316)
11. Holgate, S.T., Polosao, R., 2008. Treatment strategies for allergy and asthma. Nature Reviews Immunology 8, 218-230. (Pubitemid 351323290)
12. Horie, S., Okubo, Y., Hossain, M., Sato, E., Nomura, H., Koyama, S., Suzuki, J., Isobe, M., Sekiguchi, M., 1997. Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis. Internal Medicine 36, 179-185. (Pubitemid 27249724)
13. Juniper, E.F., Stahl, E., Doty, R.L., Simons, F.E., Allen, D.B., Howarth, P.H., 2005. Clinical outcomes and adverse effect monitoring in allergic rhinitis. The Journal of Allergy and Clinical Immunology 115, S390-S413. (Pubitemid 40326191)
14. Kawai, M., Hirano, T., Higa, S., Arimitsu, J., Maruta, M., Kuwahara, Y., Ohkawara, T., Hagihara, K., Yamadori, T., Shima, Y., Ogata, A., Kawase, I., Tanaka, T., 2007. Flavonoids and related compounds as anti-allergic substances. Allergology International 56, 113-123. (Pubitemid 46984239)
15. Kempuraj, D., Madhappan, B., Christodoulou, S., Boucher, W., Cao, J., Papadopoulou, N., Cetrulo, C.L., Theoharides, T.C., 2005. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. British Journal of Pharmacology 145, 934-944. (Pubitemid 41129015)
16. Macfarlane, A.J., Kon, O.M., Smith, S.J., Zeibecoglou, K., Khan, L.N., Barata, L.T., Mceuen, A.R., Buckley, M.G., Walls, A.F., Meng, Q., Humbert, M., Barnes, N.C., Robinson, D.S., Ying, S., Kay, A.B., 2000. Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in late-phase allergic reactions in the lung and skin. Journal of Allergy and Clinical Immunology 105, 99-107. (Pubitemid 30059109)
17. Mainardi, T., Kapoor, S., Bielory, L., 2009. Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. Journal of Allergy and Clinical Immunology 123, 283-294.
18. Nishikawa, K., Morii, T., Ako, H., Hamada, K., Saito, S., Narita, N., 1992. Invivo expression of Cd69 on lung eosinophils in eosinophilic pneumonia - Cd69 as a possible activation marker for eosinophils. Journal of Allergy and Clinical Immunology 90, 169-174.
19. Ortega Soto, E., Pecht, I., 1988. A monoclonal antibody that inhibits secretion from rat basophilic leukemia cells and binds to a novel membrane component. Journal of Immunology 141, 4324-4332. (Pubitemid 19018224)
20. Park, H.H., Lee, S., Son, H.Y., Park, S.B., Kim, M.S., Choi, E.J., Singh, T.S.K., Ha, J.H., Lee, M.G., Kim, J.E., Hynn, M.C., Kwon, T.K., Kim, Y.H., Kim, S.H., 2008. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Archives of Pharmacal Research 31, 1303-1311.
21. Pearlman, D.S., 1999. Pathophysiology of the inflammatory response. Journal of Allergy and Clinical Immunology 104, S132-S137. (Pubitemid 30249318)
22. Rother, C., Eexle, J., 2008. Untersuchung zur Ermittlung des Anwendungsnutzens von Weleda Heuschnupfenspray unter besonderer Berücksichtigung der Wirkungsdynamik. Ergebnisse einer prospektiven Beobachtungsstudie. Der Merkurstab 61, 167-171.
23. Saltoun, C., Avila, P.C., 2008. Advances in upper airway diseases and allergen immunotherapy in 2007. Journal of Allergy and Clinical Immunology 122, 481-487.
24. Scholz, S., Williamson, G., 2007. Interactions affecting the bioavailability of dietary polyphenols in vivo. International Journal for Vitamin and Nutrition Research 77, 224-235. (Pubitemid 47607432)
25. Strober, W., 2001. Trypan blue exclusion test of cell viability. Current Protocols in Immunology, A.3B.1-A.3B.2.
26. Zimmermann, N., Hershey, G.K., Foster, P.S., Rothenberg, M.E., 2003. Chemokines in asthma: cooperative interaction between chemokines and IL-13. Journal of Allergy and Clinical Immunology 111, 227-242.