Inhibition of nitric oxide synthase augments myocardial contractile responses to β-adrenergic stimulation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 6 40-6, 1996, Pages

  Keaney Jr , John F ^a   Hare, Joshua M ^b   Balligand, Jean Luc ^b   Loscalzo, Joseph ^b   Smith, Thomas W ^b   Colucci, Wilson S ^a  

^a BOSTON MEDICAL CENTER   (United States)

^b Boston Medical Center ^*

Author keywords

dobutamine; guanosine 3',5' cyclic monophosphate; isoproterenol; N(G) nitro L arginine methyl ester

Indexed keywords

CYCLIC GMP; DOBUTAMINE; ISOPRENALINE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BETA ADRENERGIC STIMULATION; CHRONOTROPISM; DOG; DOSE RESPONSE; ENZYME INHIBITION; FEMALE; HEART INNERVATION; HEART MUSCLE CONTRACTILITY; MALE; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER;

EID: 0030470660     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.6.h2646     Document Type: Article

References (40)

1. Arnold, W. P., C. K. Mittal, S. Katsuki, and F. Murad. Nitric oxide activates guanylate cyclase and increases guanosine 3′,5′-cyclic monophosphate levels in various tissue preparations. Proc. Natl. Acad. Sci. USA 74: 3203-3207, 1977.
2. Balligand, J. L., R. A. Kelly, P. A. Marsden, T. W. Smith, and T. Michel. Control of cardiac muscle cell function by an endogenous nitric oxide signalling system. Proc. Natl. Acad. Sci. USA 90:347-351, 1993.
3. Balligand, J. L., L. Kobzik, X. Han, D. M. Kaye, L. Belhassen, D. S. Ohara, R. A. Kelly, T. W. Smith, and T. Michel. Nitric oxide dependent parasympathetic signalling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J. Biol. Chem. 270: 14582-14586, 1995.
4. Balligand, J. L., D. Ungureanu, R. A. Kelly, L. Kobzik, D. Pimental, T. Michel, and T. W. Smith. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J. Clin. Invest. 91: 2314-2319, 1993.
5. Balligand, J. L., D. Ungureanu-Longrois, W. W. Simmons, D. Pimental, T. A. Malinski, M. Kapturczak, Z. Taha, C. J. Lowenstein, A. J. Davidoff, R. A. Kelly, T. W. Smith, and T. Michel. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes: characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J. Biol. Chem. 269: 27580-27588, 1994.
6. Bradford, M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
7. Brady, A. J., P. A. Poole-Wilson, S. E. Harding, and J. B. Warren. Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia. Am J. Physiol. 263 (Heart Circ. Physiol. 32): H1963-H1966, 1992.
8. Brady, A. J. B., J. B. Warren, P. A. Poole-Wilson, T. J. Williams, and S. E. Harding. Nitric oxide attenuates cardiac myocyte contraction. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H176-H182, 1993.
9. De Belder, A. J., M. W. Radomski, H. J. F. Why, P. J. Richardson, C. A. Bucknall, E. Salas, J. F. Martin, and S. Moncada. Nitric oxide synthase activities in human myocardium. Lancet 341: 84-85, 1993.
10. Elvan, A., J. J. Rohleder, and D. P. Zipes. Role of nitric oxide in the autonomic modulation of sinus rate in dogs (Abstract). Circulation 90:1-247, 1994.
11. Fischmeister, R., and H. C. Hartzell. Cyclic guanosine 3′,5′-monophosphate regulates the calcium current in single cells from frog ventricle. J. Physiol. Lond. 387: 453-472, 1987.
12. George, W. J., R. D. Wilkerson, and P. J. Kadowitz. Influence of acetylcholine on contractile force and cyclic nucleotide levels in the isolated perfused rat heart. J. Pharmacol. Exp. Ther. 184: 228-235, 1973.
13. Gleason, W. L., and E. Braunwald. Studies on the first derivative of the ventricular pressure pulse in man. J. Clin. Invest. 41: 80-91, 1962.
14. Goto, Y., B. K. Slinker, and M. M. LeWinter. Effect of coronary hyperemia on Emax and oxygen consumption in blood-perfused rabbit hearts: energetic consequences of Gregg's phenomenon. Circ. Res. 68: 482-492, 1991.
15. Grossman, W. Evaluation of systolic and diastolic function of the myocardium. In: Cardiac Catheterization, Angiography, and Intervention (4th ed.), edited by W. Grossman and D. S. Baim. Malvern, PA: Lea and Febiger, 1991, p. 319-339.
16. Gulick, T., S. J. Pieper, M. A. Murphy, L. G. Lange, and G. F. Schreiner. A new method for assessment of cultured cardiac myocyte contractility detects immune factor-mediated inhibition of β-adrenergic responses. Circulation 84: 313-321, 1991.
17. Han, X., Y. Shimoni, and W. R. Giles. An obligatory role for nitric oxide in autonomic control of mammalian heart rate. J. Physiol. Lond. 476.2: 309-314, 1994.
18. Hare, J. M., J. F. Keaney, Jr., J. L. Balligand, J. Loscalzo, T. W. Smith, and W. S. Colucci. Role of nitric oxide in parasypathetic modulation of Beta-adrenergic myocardial contractility in normal dogs. J. Clin. Invest. 95: 360-366, 1995.
19. Hare, J. M., E. Loh, M. A. Creager, and W. S. Colucci. Nitric oxide inhibits the contractile response to Beta adrenergic stimulation in humans with left ventricular dysfunction. Circulation 92: 2198-2203, 1995.
20. 2+ current in single heart cells. Nature Lond. 323: 273-275, 1986.
21. Henning, R. J., I. R. Khalil, and M. N. Levy. Vagal stimulation attenuates sympathetic enhancement of left ventricular function. Am. J. Physiol. 258 (Heart Circ Physiol. 27): H1470-H1475, 1990.
22. Hoffman, B. B., and R. J. Lefkowitz. Catecholamines and sympathomimetic drugs. In: The Pharmacological Basis of Therapeutics (8th ed. ), edited by A. Gilman, T. W. Rall, A. S. Nies, and P. Taylor. New York: Pergamon, 1990, p. 187-220.
23. Kelm, M., and J. Schrader. Nitric oxide release from the isolated guinea pig heart. Eur. J. Pharmacol. 155: 317-321, 1988.
24. G-methyl-L-arginine decreases contractility, cGMP and cAMP in isoproterenol-stimulated rat hearts in vitro. Eur. J. Pharmacol. 223:1-7, 1992.
25. Klimaschewski, L., W. Kummer, B. Mayer, J. Y. Couraud, U. Preissler, B. Philippin, and C. Heym. Nitric oxide synthase in cardiac nerve fibers and neurons of rat and guinea pig heart. Circ. Res. 71:1533-1537, 1992.
26. Krause, E. G., W. Halle, and A. Wellenbergen Effect of dibutyryl cyclic GMP on cultured beating rat heart cells. Adv. Cyclic Nucleotide Res. 1: 301-305, 1972.
27. Lander, H. M., P. K. Sehajpal, and A. Novogrodsky. Nitric oxide signalling: a possible role for G proteins. J. Immunol. 151: 7182-7187, 1993.
28. Landzberg, J. S., J. D. Parker, D. F. Gauthier, and W. S. Colucci. Effects of myocardial alpha 1-adrenergic receptor stimulation and blockade on contractility in humans. Circulation 84: 1608-1614, 1991.
29. Ca by carbachol and sodium nitroprusside. Pfluegers Arch. 426: 419-426, 1995.
30. Levy, M. N., M. Ng, P. Martin, and H. Zeiske. Sympathetic and parasympathetic interactions upon the left ventricle of the dog. Circ. Res. 19: 6-10, 1966.
31. 2+ current is regulated by cGMP-dependent protein kinase in mammalian cardiac myocytes. Proc. Natl. Acad. Sci. USA 88. 1197-1201, 1991.
32. 2+ current. Involvement of eGMP-inhibited and cGMP-stimulated posphodiesterases through guanylyl cyclase activation. J. Biol. Chem. 268: 26286-26295, 1993.
33. Parent, R., M. Al-Obaidi, and M. Lavallee. Nitric oxide formation contributes to β-adrenergic dilation of resistance coronary vessels in conscious dogs. Circ. Res. 73: 241-251, 1993.
34. Robison, G. A., R. W. Butcher, I. Oye, H. E. Morgan, and E. W. Sutherland. Effect of epinephrine on adenosine 3′,5′-monophosphate levels in the isolated perfused rat heart. Mol Pharmacol 1: 168-177, 1965.
35. Shah, A. M., M. J. Lewis, and A. H. Henderson. Effects of 8-bromo-cyclic GMP on contraction and on inotropic response of ferret cardiac muscle J. Mol. Cell. Cardiol. 23: 55-64, 1991.
36. 2+-independent nitric oxide synthase in the myocardium. Br. J. Pharmacol. 105: 575-580, 1992.
37. Stamler, J. S. Redox signalling: nitrosylation and related target interactions of nitric oxide. Cell 78: 931-936, 1994.
38. ω-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-argmine. J. Biol. Chem. 266: 6259-6263, 1991.
39. Ungureanu-Longrois, D., J. L. Balligand, I. Okada, W. W. Simmons, L. Kobzik, C. J. Lowenstein, S. L. Kunkel, T. Michel, R. A. Kelly, and T. W. Smith. Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Circ. Res. 77: 486-493, 1995.
40. Vatner, S. F., J. D. Rutherford, and H. R. Ochs. Baroreflex and vagal mechanisms modulating ventricular contractile responses to sympathomimetic amines. Circ. Res. 44: 195-207, 1979.