Preparation and characterization of pH-sensitive hydrogel microparticles as a biological on-off switch

Polymer Bulletin

Volumn 67, Issue 1, 2011, Pages 67-76

  Lee, Eunmi ^a   Kim, Bumsang ^a  

^a Hong Ik University   (South Korea)

Author keywords

Anionic hydrogels; Biological on off switch; Hydrogel microparticles; Intelligent drug delivery system; pH responsive

Indexed keywords

ANIONIC HYDROGELS; AVERAGE DIAMETER; BIOLOGICAL ON-OFF SWITCH; CHARGED GROUPS; DRUG DELIVERY SYSTEM; ELECTROSTATIC REPULSION; EQUILIBRIUM WEIGHTS; HIGH PH; INTELLIGENT DRUG DELIVERY SYSTEM; MICRO-PARTICLES; PH CHANGE; PH-RESPONSIVE; PH-SENSITIVE HYDROGEL; RELEASE BEHAVIORS; SWELLING PROPERTIES; SWELLING RATIO; WELL-DISPERSED;

DRUG DELIVERY; RHODIUM; SWELLING;

HYDROGELS;

EID: 79958149948     PISSN: 01700839     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00289-010-0403-x     Document Type: Article

References (17)

1. NA Peppas P Bures W Leobandung H Ichikawa 2000 Hydrogels in pharmaceutical formulations Eur J Pharm Biopharm 50 27 46 10.1016/S0939-6411(00) 00090-4 1:CAS:528:DC%2BD3cXjslyju7Y%3D (Pubitemid 30326687)
2. CL Bell NA Peppas 1996 Water, solute and protein diffusion in physiologically responsive hydrogels of poly (methacrylic acid-g-ethylene glycol) J Control Release 39 1203 1218 10.1016/0168-3659(95)00154-9 (Pubitemid 26194219)
3. KS Soppirnath TM Aminabhavi 2002 Water transport and drug release study from cross-linked polyacrylamide grafted guar hydrogel microspheres for the controlled release application Eur J Pharm Biopharm 53 87 98 10.1016/S0939-6411(01)00205-3 1:CAS:528:DC%2BD38XltFCq (Pubitemid 34040993)
4. D Tada T Tanabe A Tachobana K Yamauchi 2005 Drug release from hydrogel containing albumin as crosslinker J Biosci Bioeng 100 551 555 10.1263/jbb.100.551 1:CAS:528:DC%2BD28XosFehtA%3D%3D (Pubitemid 43181257)
5. RA Scott NA Peppas 1999 Highly crosslinked PEG-containing copolymers for sustained solute delivery Biomaterials 20 1371 1380 10.1016/S0142-9612(99)00040- X 1:CAS:528:DyaK1MXkvVGjsLw%3D (Pubitemid 29326807)
6. C Kim S Lim 2002 Recent progress in drug delivery systems for anticancer agents Arch Pharm Res 25 229 239 10.1007/BF02976620 1:CAS:528: DC%2BD38Xlt1egs70%3D (Pubitemid 43093299)
7. B Kim KL Flamme NA Peppas 2003 Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery J Appl Polym Sci 89 1606 1613 10.1002/app.12337 1:CAS:528:DC%2BD3sXks1Ghtr4%3D (Pubitemid 36864234)
8. NA Peppas 2004 Devices based on intelligent biopolymers for oral protein delivery Int J Pharm 277 11 17 10.1016/j.ijpharm.2003.03.001 1:CAS:528:DC%2BD2cXktFOis7Y%3D (Pubitemid 38670416)
9. B Kim NA Peppas 2003 In vitro release behavior and stability of insulin in complexation hydrogels as oral drug delivery carriers Int J Pharm 266 29 37 10.1016/S0378-5173(03)00378-8 1:CAS:528:DC%2BD3sXotVSjur8%3D (Pubitemid 37258337)
10. M Morishita T Goto NA Peppas JI Joseph MC Torjman C Munsick K Nakamura T Yamagata K Takayama AM Lowman 2004 Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption J Control Release 97 115 124 10.1016/j.jconrel.2004.03.008 1:CAS:528:DC%2BD2cXjvFOnt7c%3D (Pubitemid 38624514)
11. AC Foss T Goto M Morishita NA Peppas 2004 Development of acrylic-based copolymers for oral insulin delivery Eur J Pharm Biopharm 57 163 169 10.1016/S0939-6411(03)00145-0 1:CAS:528:DC%2BD2cXhslWltLc%3D (Pubitemid 38283691)
12. KC Kim SJ Lee 1989 pH-dependent swelling properties of methacrylic acid copolymer hydrogels J Pharm Soc Kor 33 372 376 1:CAS:528:DyaK3cXktFajsL4%3D
13. C Donini DN Robinson P Colombo F Giordano NA Peppas 2002 Preparation of poly(methacrylic acid-g-poly(ethylene glycol)) nanospheres from methacrylic monomers for pharmaceutical applications Int J Pharm 245 83 91 10.1016/S0378-5173(02)00335-6 1:CAS:528:DC%2BD38XntFygsrw%3D (Pubitemid 35299894)
14. H He L Li LJ Lee 2006 Photopolymerization and structure formation of methacrylic acid based hydrogels in water/ethanol mixture Polymer 47 1612 1619 10.1016/j.polymer.2006.01.014 1:CAS:528:DC%2BD28Xhs12itrY%3D (Pubitemid 43238203)
15. B Kim NA Peppas 2003 Analysis of molecular interactions in poly(methacrylic acid-g-ethylene glycol) hydrogels Polymer 44 3701 3707 10.1016/S0032-3861(03)00307-0 1:CAS:528:DC%2BD3sXkt1Wmu7o%3D (Pubitemid 36648643)
16. DN Robinson NA Peppas 2002 Preparation and characterization of pH-responsive poly(methacrylic acid-g-ethylene glycol) nanospheres Macromolecules 35 3668 3674 10.1021/ma011525u 1:CAS:528:DC%2BD38Xit12ku7Y%3D (Pubitemid 34590342)
17. NO Mchedlov-Petrossyan NA Vodolazkaya AO Doroshenko 2003 Ionic equilibria of fluorophores in organized solutions: the influence of micellar microenvironment on protolytic and photophysical properties of rhodamine B J Fluoresc 13 235 248 10.1023/A:1025089916356 1:CAS:528:DC%2BD3sXlvV2isrk%3D