Impact of vitamin D in the treatment of tuberculosis

American Journal of the Medical Sciences

Volumn 341, Issue 6, 2011, Pages 493-498

  Luong, Khanh Vinh Quoc ^a   Nguyen, Lan Thi Hoang ^a  

^a Vietnamese American Medical Research Foundation   (United States)

Author keywords

Calcitriol; Tuberculosis; Vitamin D

Indexed keywords

CALCITRIOL; CATHELICIDIN; CHLOROQUINE; DNA; INTERLEUKIN 1BETA; KETOCONAZOLE; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; PYRAZINAMIDE; TOLL LIKE RECEPTOR 2; TUBERCULOSTATIC AGENT; VITAMIN D; VITAMIN D BINDING PROTEIN; VITAMIN D RECEPTOR;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC THERAPY; BACTERICIDAL ACTIVITY; DNA POLYMORPHISM; DRUG MEGADOSE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; HYPERCALCEMIA; INFECTION RISK; INFECTION SENSITIVITY; INNATE IMMUNITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN TUBERCULOSIS; TUBERCULOSIS; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

EID: 79958147813     PISSN: 00029629     EISSN: 15382990     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e3182070f47     Document Type: Review

References (114)

1. 3 prevents the in vivo induction of murine experimental autoimmune encephalomyeli-tis. J Clin Invest 1991;87:1103-7.
2. Hayes CE, Cantorna MT, DeLuca HF. Vitamin D and multiple sclerosis. Proc Soc Exp Biol Med 1997;216:21-7.
3. Cantorna MT, Hayes CE, DeLuca HF. 1,25-Dihydroxycholecalcif-erol inhibits the progression of arthritis in murine models of human arthritis. J Nutr 1998;128:68-72. (Pubitemid 28087178)
4. Luong K, Nguyen LT, Nguyen DN. The role of vitamin in protecting type 1 diabetes mellitus. Diabetes Metab Res Rev 2005;21:338-46. (Pubitemid 40945955)
5. Luong KV, Nguyen LT. Vitamin D and cardiovascular disease. Curr Med Chem 2006;13:2443-7. (Pubitemid 44184646)
6. Luong K, Nguyen LT. The beneficial role of vitamin D and its analogs in cancer treatment and prevention. Crit Rev Oncol Hematol 2010;73:192-201.
7. 3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lym-phocytes following activation. J Clin Endocrinol Metab 1983;57: 1308-10. (Pubitemid 14209439)
8. 3 receptors in human leukocytes. Science 1983;221:1181-3.
9. Overbergh L, Decallonne B, Valckx D, et al. Identification and immune regulation of 25-hydroxyvitamin D-1-α-hydroxylase in mu-rine macrophages. Clin Exp Immunol 2000;120:139-46. (Pubitemid 30176911)
10. Laaksi I, Ruohola JP, Tuohimaa P, et al. An association of serum vitamin D concentrations 40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr 2007;86:714-7 (Pubitemid 47435839)
11. Rook GA. Role of activated macrophages in the immunopathology of tuberculosis. Br Med Bull 1988;44:611-23.
12. Lowrie DB, Andrew PW. Macrophage antimycobacterial mecha-nisms. Br Med Bull 1988;44:624-34.
13. Good RA. Nutrition and immunity. J Clin Immunol 1981;1:3-11. (Pubitemid 12064714)
14. Davies PD. A possible link between vitamin D deficiency and im-paired host defence to Mycobacterium tuberculosis. Tubercle 1985; 66:301-6. (Pubitemid 16203099)
15. Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 2007;167:1730-7. (Pubitemid 47403059)
16. Bellamy R, Ruwende C, Corrah T, et al. Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the Vitamin D receptor gene. J Infect Dis 1999;179:721-4. (Pubitemid 30016163)
17. Wilbur AK, Kubatko LS, Hurtado AM, et al. Vitamin D receptor gene polymorphisms and susceptibility M. tuberculosis in native Paraguayans. Tuberculosis 2007;13:396-7.
18. Chen XR, Feng YL, Ma Y, et al. Study on the association of two polymorphisms of the vitamin D receptor (VDR) gene with the susceptibility to pulmonary tuberculosis (PTB) in Chinese Tibetans. [Article in Chinese.] Sichuan Da Xue Xue Bao Yi Xue Ban 2006;37: 847-51. (Pubitemid 44862252)
19. Roth DE, Soto G, Arenas F, et al. Association between vitamin D receptor gene polymorphisms and response to treatment ofpulmonary tuberculosis. J Infect Dis 2004;190:920-7. (Pubitemid 39120969)
20. Friedland JS, Shaw TC, Price NM, et al. Differential regulation of MMP-1/9 and TIMP-1 secretion in human monocytic cells in response to Mycobacterium tuberculosis. Matrix Biol 2002;21:103-10. (Pubitemid 34100827)
21. Timms PM, Mannan N, Hitman GA, et al. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? QJM 2002;95:787-96. (Pubitemid 36032948)
22. Dean DD, Schwartz Z, Schmitz J, et al. Vitamin D regulation of metalloproteinase activity in matrix vesicles. Connect Tissue Res 1996;35:331-6. (Pubitemid 27118865)
23. Wilkinson RJ, Llewelyn M, Toossi Z, et al. Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet 2000;355:618-21. (Pubitemid 30099469)
24. Selvaraj P, Chandra G, Kurian SM, et al. Association of vitamin D receptor gene variants of BsmI, ApaI and Fok1 polymorphisms with susceptibility or resistance to pulmonary tuberculosis. Curr Sci 2003; 84:1564-8. (Pubitemid 39160624)
25. Selvaraj P, Narayanan PR, Reetha AM. Association of vitamin D receptor genotype with susceptibility to pulmonary tuberculosis in female patients & resistance in female contacts. Indian J Med Res 2000;111:172-9. (Pubitemid 30495297)
26. Babb C, van der Merwe L, Beyers N, et al. Vitamin D receptor gene polymorphisms and sputum conversion time in pulmonary tuberculo-sis patients. Tuberculosis (Edinb) 2007;87:295-302. (Pubitemid 46951033)
27. Liu W, Cao WC, Zhang CY, et al. VDR and NRAMP1 gene polymorphisms in susceptibility to pulmonary tuberculosis among the Chinese Han population: a case-control study. Int J Tuberc Lung Dis 2004;8:428-34. (Pubitemid 38624850)
28. Merza M, Farnia P, Anoosheh S, et al. The NRAMPI, VDR and TNF-alpha gene polymorphisms in Iranian tuberculosis patients: the study on host susceptibility. Braz J Infect Dis 2009;13:252-6.
29. Forbes JR, Gros P. Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions. Trends Microbiol 2001; 9: 397-403. (Pubitemid 32763067)
30. Delgado JC, Baena A, Thim S, et al. Ethnic-specific genetic asso-ciations with pulmonary tuberculosis. J Infect Dis 2002;186:1463-8. (Pubitemid 35286114)
31. Søborg C, Andersen AB, Madsen HO, et al. Natural resistance-associated macrophage protein 1 polymorphisms are associated with microscopy-positive tuberculosis. J Infect Dis 2002;186:517-21. (Pubitemid 34876261)
32. Liaw YS, Tsai-Wu JJ, Wu CH, et al. Variations in the NRAMP1 gene and susceptibility of tuberculosis in Taiwanese. Int J Tuberc Lung Dis 2002;6:454-60.
33. El Baghdadi J, Remus N, Benslimane A, et al. Variants of the human NRAMP1 gene and susceptibility to tuberculosis in Morocco. Int J Tuberc Lung Dis 2003;7:599-602. (Pubitemid 36713260)
34. Ben-Ali M, Barbouche MR, Bousnina S, et al. Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuber-culosis in Tunisian patients. Clin Diagn Lab Immunol 2004;11:625-6. (Pubitemid 38661434)
35. Motsinger-Reif AA, Antas PR, Oki NO, et al. Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis. BMC Med Genet 2010; 11:37.
36. Lewis SJ, Baker G, Davey Smith G. Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk. Int J Tuberc Lung Dis 2005;9:1174-7. (Pubitemid 41433810)
37. Bornman L, Campbell SJ, Fielding K, et al. Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. J Infect Dis 2004;190:1631-41. (Pubitemid 39411013)
38. Gao L, Tao Y, Zhang L, et al. Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analy-sis. Int J Tuberc Lung Dis 2010;14:15-23.
39. 3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis. Exp Mol Pathol 2009;86:69-73.
40. Lauridsen AL, Vestergaard P, Hermann AP, et al. Plasma concen-trations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women Calcif Tissue Int 2005;77:15-22. (Pubitemid 41504168)
41. Abbas S, Linseisen J, Slanger T, et al. The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status. Cancer Epidemiol Biomarkers Prev 2008;17:1339-43.
42. Charpy J, Dowling GB. Vitamin D in cutaneous tuberculosis. Lancet 1947;13:2:398.
43. Pattison CE. Vitamin D and the calcification ofbone in tuberculosis. British Med J 1929:419-20.
44. Williams CJB. Cod liver oil in phthisis. London J Med 1949;1:1-18.
45. Warren P. The evolution of the sanatorium: the first half-century, 1854-1904. Can Bull Med Hist 2006;23:457-76.
46. Yesudian PD, Berry JL, Wiles S, et al. The effect of ultraviolet B-induced vitamin D levels on host resistance to Mycobacterium tuberculosis: a pilot study in immigrant Asian adults living in the United Kingdom. Photodermatol Photoimmunol Photomed 2008;24: 97-8. (Pubitemid 351436832)
47. Strachan DP, Powell KJ, Thaker A, et al. Vegetarian diet as a risk factor for tuberculosis in immigrant south London Asians. Thorax 1995;50:175-80.
48. Davies PDO, Brown RC, Woodhead JS. Serum concentrations of vitamin D metabolites in untreated tuberculosis. Thorax 1985;40: 187-90. (Pubitemid 15108303)
49. Sita-Lumsden, Lapthorn G, Swaminathan R, et al. Reactivation of tuberculosis and vitamin D deficiency: the contribution of diet and exposure to sunlight. Thorax 2009;62:1003-7. (Pubitemid 350084502)
50. Gibney KB, MacGregor L, Leder K, et al. Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immi-grants from sub-Saharan Africa. Clin Infect Dis 2008;46:443-6. (Pubitemid 351263529)
51. Talat N, Perry S, Parsonnet J, et al. Vitamin d deficiency and tuberculosis progression. Emerg Infect Dis 2010;16:853-5.
52. Cuss FM, Carmichael DJ, Linington A, et al. Tuberculosis in renal failure: a high incidence in patients born in the Third World. Clin Nephrol 1986;25:129-33. (Pubitemid 16164548)
53. Hsu CH, Patel SR. Uremic toxins and vitamin D metabolism. Kidney Int Suppl 1997;62:S65-8. (Pubitemid 27489407)
54. Nnoaham KE, Clarke A. Low serum vitamin D levels and tubercu-losis: a systematic review and meta-analysis. Int J Epidemiol 2008; 37:113-9. (Pubitemid 351228619)
55. 3 induces nitric oxide synthase and suppresses growth of Mycobacte-rium tuberculosis in a human macrophage-like cell line. Infect Immun 1998;66:5314-21. (Pubitemid 29044625)
56. 3 of the multiplication of virulent tubercle bacilli in cultured human macrophages. Infect Immun 1987;55:2945-50. (Pubitemid 18008262)
57. Brincourt J. Liquefying effect on suppurations of an oral dose of calciferol. [Article in French.] Presse Med 1969;77:467-70.
58. Range N, Changalucha J, Krarup H, et al. The effect of multi-vitamin/mineral supplementation on mortality during treatment of pulmonary tuberculosis: a randomised two-by-two factorial trial in Mwanza, Tanzania. Br J Nutr 2006;95:762-70.
59. Morcos MM, Gabr AA, Samuel S, et al. Vitamin D administra-tion to tuberculous children and its value. Boll Chim Farm 1998; 137:157-64. (Pubitemid 29135376)
60. Nursyam EW, Amin Z, Rumende CM. The effect of vitamin D as supplementary treatment in patients with moderately advanced pul-monary tuberculous lesion. Acta Med Indones 2006;38:3-5.
61. Yamshchikov AV, Oladele A, Leonard MK Jr, et al. Vitamin D as adjunctive therapy in refractory pulmonary tuberculosis: a case report. South Med J 2009;102:649-52.
62. Wejse C, Gomes VF, Rabna P, et al. Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-con-trolled trial. Am J Respir Crit Care Med 2009;179:843-50.
63. Ferrari G, Langen H, Naito M, et al. A Coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell 199;97: 435-47.
64. 3-dependent pathway regulates TACO gene transcription. Biochem Biophys Res Commun 2003;310:876-7. (Pubitemid 37188703)
65. Anand PK, Kaul D, Sharma M. Synergistic action of vitamin D and retinoic acid restricts invasion of macrophages by pathogenic myco-bacteria. J Microbiol Immunol Infect 2008;41:17-25. (Pubitemid 351792117)
66. 3-phosphoinositide 3-kinase pathway. J Cell Sci 200;117:2131-40.
67. Thoma-Uszynski S, Stenger S, Takeuchi O, et al. Induction ofdirect antimicrobial activity through mammalian toll-like receptors. Science 2001;291:1544-7. (Pubitemid 32179220)
68. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006;311: 1770-3.
69. 3. J Cyst Fibros 2007;6:403-10. (Pubitemid 350028703)
70. Rivas-Santiago B, Hernandez-Pando R, Carranza C, et al. Expres-sion of cathelicidin LL-37 during Mycobacterium tuberculosis infec-tion in human alveolar macrophages, monocytes, neutrophils, and epithelial cells. Infect Immun 2008;76:935-41. (Pubitemid 351428052)
71. Liu PT, Stenger S, Tang DH, et al. Cutting edge: vitamin D-medi-ated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction ofcathelicidin. J Immunol 2007;179: 2060-3.
72. 3 is a direct inducer ofantimicrobial peptide gene expression. J Immunol 2004;173:2909-12. (Pubitemid 39141992)
73. Liu PT, Schenk M, Walker VP, et al. Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One 2009;4:e5810.
74. 3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe 2009;6:231-43.
75. O'Donnell MR, Chamblee S, von Reyn CF, et al. Racial disparities in primary and reactivation tuberculosis in a rural community in the southeastern United States. Int J Tuberc Lung Dis 2010;14:733-40.
76. Crowle AJ, Elkins N. Relative permissiveness ofmacrophages from black and white people for virulent tubercle bacilli. Infect Immun 1990;58:632-8. (Pubitemid 20072624)
77. Harris SS. Vitamin D and African Americans. J Nutr 2006;136: 1129-9.
78. Dawson-Hughes B, Harris S, Kramich C, et al. Calcium retention and hormone levels in black and white women on high-and low-calcium diets. J Bone Miner Res 1993;8:779-87. (Pubitemid 23191630)
79. Dawson-Hughes B, Harris S, Finneran S, et al. Calcium absorption responses to calcitriol in black and white premenopausal women. J Clin Endocrinol Metab 1995;80:3068-72.
80. Elkington PT, Nuttall RK, Boyle JJ, et al. Mycobacterium tubercu-losis, but not vaccine BCG, specifically upregulates matrix metallo-proteinase-1. Am J Respir Crit Care Med 2005;172:1596-604. (Pubitemid 43076552)
81. Chang JC, Wysocki A, Tchou-Wong KM, et al. Effect of Myco-bacterium tuberculosis and its components on macrophages and the release ofmatrix metalloproteinases. Thorax 1996;51:306-11. (Pubitemid 26086477)
82. Elkington PT, Emerson JE, Lopez-Pascua LD, et al. Mycobacte-rium tuberculosis up-regulates matrix metalloproteinase-1 secretion from human airway epithelial cells via a p38 MAPK switch. J Immunol 2005;175:5333-40. (Pubitemid 41456419)
83. 3 inhibits matrix metalloproteinases induced by Mycobacte-rium tuberculosis infection. Immunology2009;127:539-48.
84. 3 on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1in pul-monary tuberculosis. Clin Immunol 2009;133:126-31.
85. Sly LM, Lopez M, Nauseef WM, et al. 1α,25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phos-phatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase. J Biol Chem 2001;276:35482-93.
86. Fry MJ. Structure, regulation and function ofphosphoinositide 3-ki-nases. Biochim Biophys Acta 1994;1226:237-68. (Pubitemid 24260129)
87. 3 and the regulation ofmacrophage function. Cacif Tissue Int 1981;33: 673-6.
88. 3 and their relation in alveolar mac-rophages. Proc Natl Acad Sci USA 1984;81:7112-6. (Pubitemid 15216707)
89. 3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine, mononuclear cell factor. J Clin Invest 1984;73:731-9. (Pubitemid 14156855)
90. 3 activates secretion of hydrogen peroxide by human monocytes. J Im-munol 1986;136:1049-53. (Pubitemid 16146396)
91. 3 and mono-nuclear phagocytes: enhancement ofmouse macrophage and human monocyte hydrogen peroxide production without alteration of tumor cytolysis. J Leukoc Biol 1987;42:498-503.
92. 3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 1986;57:159-63. (Pubitemid 16232232)
93. Crowle AJ, Ross EJ. Inhibition by retinoic acid of multiplication of virulent tubercle bacilli in cultured human macrophages. Infect Immun 1989;57:840-4. (Pubitemid 19064547)
94. Waters WR, Palmer MV, Nonnecke BJ, et al. Mycobacterium bovis infection of vitamin D-deficient NOS2-/-mice. Microb Pathog 2004; 36:11-7. (Pubitemid 37476185)
95. 3. Clin Diagn Lab Immunol 2001;8:1204-12. (Pubitemid 33035756)
96. Martineau AR, Wilkinson KA, Newton SM, et al. IFN-gamma-and TNF-independent vitamin D-inducible human suppression of myco-bacteria: the role of cathelicidin LL-37. J Immunol 2007;178:7190-8. (Pubitemid 46847445)
97. Murray HW, Spitalny GL, Nathan CF. Activation ofmouse peri-toneal macrophages in vitro and in vivo by interferon-gamma. J Im-munol 1985;134:1619-22. (Pubitemid 15130280)
98. 3 stimulates phagocy-tosis but suppresses HLA-DR and CD13 antigen expression in human mononuclear phagocytes. Proc Soc Exp Biol Med 1996;211:244-50.
99. Chacón-Salinas R, Serafín-López J, Ramos-Payán R, et al. Differ-ential pattern ofcytokine expression by macrophages infected in vitro with different Mycobacterium tuberculosis genotypes. Clin Exp Im-munol 2005;140:443-9. (Pubitemid 40813954)
100. 3 modulated cytokine response in pulmonary tuberculosis. Cytokine 2007;40:128-34. (Pubitemid 350180529)
101. O'Garra A. Cytokines induce the development of functionally heter-ogeneous T helper cell subsets. Immunity 1998;8:275-83. (Pubitemid 28188888)
102. Lin Y, Zhang M, Hofman FM, et al. Absence of a prominent Th2 cytokine response in human tuberculosis. Infect Immun 1996;64: 1351-6. (Pubitemid 26102400)
103. Wade MM, Zhang Y. Effects ofweak acids, UV and proton motive force inhibitors on pyrazinamide activity against Mycobacterium tu-berculosis in vitro. J Antimicrob Chemother 2006;58:936-41.
104. 3 syner-gizes with pyrazinamide to kill tubercle bacilli in cultured human macrophages. Am Rev Respir Dis 1989;139:549-52. (Pubitemid 19057439)
105. Sharma OP. Hypercalcemia in granulomatous disorders: a clinical review. Curr Opin Pulm Med 2000;6:442-7. (Pubitemid 30637660)
106. 3 pro-duction by T lymphocytes and alveolar macrophages recovered by lavage from normocalcemic patients with tuberculosis. J Clin Invest 1990;85:1588-93. (Pubitemid 20176456)
107. 3 in patients with pulmonary tuberculosis and normal calcium metabolism. Calcif Tissue Int 1984;36:541-4. (Pubitemid 15157106)
108. 3 level and expression of vitamin d receptor and cathelicidin in pulmonary tuberculosis. J Clin Immunol 2009;29: 470-8.
109. Adams JS, Chen H, Chun R, et al. Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response. J Bone Miner Res 2007; 22(suppl 2):V20-4. (Pubitemid 351304643)
110. Ren S, Nguyen L, Wu S, et al. Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation ofextrarenal 1,25-dihydroxyvitamin D synthesis. J Biol Chem 2005;280:20604-11. (Pubitemid 40776763)
111. 3 and calcium metabolism in sarcoid-osis. N Engl J Med 1986;315:727-30. (Pubitemid 16054987)
112. 3. Antimicrob Agents Chemother 1990;34:2217-22. (Pubitemid 20373859)
113. Saggese G, Bertelloni S, Baroncelli GI, et al. Ketoconazole de-creases the serum ionized calcium and 1,25-dihydroxyvitamin D levels in tuberculosis-associated hypercalcemia. Am J Dis Child 1993;147:270-3. (Pubitemid 23077282)
114. Byrne ST, Denkin SM, Gu P, et al. Activity of ketoconazole against Mycobacterium tuberculosis in vitro and in the mouse model. J Med Microbiol 2007;56(Pt 8):1047-51. (Pubitemid 47262666)