Hippocampal gene expression analysis highlights ly6a/Sca-1 as candidate gene for previously mapped novelty induced behaviors in mice

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  de Jong, Simone ^a   Kas, Martien J H ^b   Kiernan, Jeffrey ^c   de Mooij van Malsen, Annetrude G ^d   Oppelaar, Hugo ^b   Janson, Esther ^a   Vukobradovic, Igor ^e   Farber, Charles R ^f   Stanford, William L ^c   Ophoff, Roel A ^a,b,g  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF TORONTO   (Canada)

^d RADBOUD UNIVERSITY   (Netherlands)

^e MOUNT SINAI HOSPITAL   (Canada)

^f UNIVERSITY OF VIRGINIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; LY ANTIGEN; LY6A PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME 15; COGNITION; CONTROLLED STUDY; COVARIANCE; FEMALE; GENE EXPRESSION PROFILING; GENETIC REGULATION; GENETIC VARIABILITY; GENOME ANALYSIS; HIPPOCAMPUS; KNOCKOUT MOUSE; MOTOR ACTIVITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN FIELD TEST; PROTEIN FUNCTION; QUANTITATIVE TRAIT LOCUS MAPPING; SCA 1 GENE; WILD TYPE; ANIMAL; CYTOLOGY; DNA MICROARRAY; EXPLORATORY BEHAVIOR; GENETICS; GENOMICS; METABOLISM; QUANTITATIVE TRAIT LOCUS;

MURINAE; MUS;

ANIMALS; ANTIGENS, LY; BEHAVIOR, ANIMAL; EXPLORATORY BEHAVIOR; FEMALE; GENE EXPRESSION PROFILING; GENOMICS; HIPPOCAMPUS; MEMBRANE PROTEINS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; QUANTITATIVE TRAIT LOCI;

EID: 79958137528     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020716     Document Type: Article

References (38)

1. Ormel J, Petukhova M, Chatterji S, Aguilar-Gaxiola S, Alonso J, et al. (2008) Disability and treatment of specific mental and physical disorders across the world. Br J Psychiatry 192: 368-375.
2. Bienvenu OJ, Davydow DS, Kendler KS, (2011) Psychiatric 'diseases' versus behavioral disorders and degree of genetic influence. Psychol Med 41: 33-40.
3. Kas MJ, de Mooij-van Malsen AJ, Olivier B, Spruijt BM, van Ree JM, (2008) Differential genetic regulation of motor activity and anxiety-related behaviors in mice using an automated home cage task. Behav Neurosci 122: 769-776.
4. de Mooij-van Malsen AJ, Olivier B, Kas MJ, (2008) Behavioural genetics in mood and anxiety: a next step in finding novel pharmacological targets. Eur J Pharmacol 585: 436-440.
5. Cryan JF, Holmes A, (2005) The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov 4: 775-790.
6. Crawley JN, (1985) Exploratory behavior models of anxiety in mice. Neurosci Biobehav Rev 9: 37-44.
7. Mathis C, Paul SM, Crawley JN, (1994) Characterization of benzodiazepine-sensitive behaviors in the A/J and C57BL/6J inbred strains of mice. Behav Genet 24: 171-180.
8. Miller BH, Schultz LE, Gulati A, Su AI, Pletcher MT, (2010) Phenotypic characterization of a genetically diverse panel of mice for behavioral despair and anxiety. PLoS One 5: e14458.
9. Nadeau JH, Singer JB, Matin A, Lander ES, (2000) Analysing complex genetic traits with chromosome substitution strains. Nat Genet 24: 221-225.
10. Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, et al. (2004) Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304: 445-448.
11. de Mooij-van Malsen AJ, van Lith HA, Oppelaar H, Hendriks J, de Wit M, et al. (2009) Interspecies Trait Genetics Reveals Association of Adcy8 with Mouse Avoidance Behavior and a Human Mood Disorder. Biol Psychiatry.
12. Turri MG, Talbot CJ, Radcliffe RA, Wehner JM, Flint J, (1999) High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice. Mamm Genome 10: 1098-1101.
13. Henderson ND, Turri MG, DeFries JC, Flint J, (2004) QTL analysis of multiple behavioral measures of anxiety in mice. Behav Genet 34: 267-293.
14. Barkus C, McHugh SB, Sprengel R, Seeburg PH, Rawlins JN, et al. (2010) Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion. Eur J Pharmacol 626: 49-56.
15. Crusio WE, (2001) Genetic dissection of mouse exploratory behaviour. Behav Brain Res 125: 127-132.
16. Kobayashi K, Ikeda Y, Suzuki H, (2006) Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission. Eur J Neurosci 24: 1867-1873.
17. Fuller TF, Ghazalpour A, Aten JE, Drake TA, Lusis AJ, et al. (2007) Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome 18: 463-472.
18. Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, et al. (2006) Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet 2: e130.
19. Oldham MC, Horvath S, Geschwind DH, (2006) Conservation and evolution of gene coexpression networks in human and chimpanzee brains. Proc Natl Acad Sci U S A 103: 17973-17978.
20. Zhang B, Horvath S, (2005) A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol 4: Article17.
21. Langfelder P, Horvath S, (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9: 559.
22. Du P, Kibbe WA, Lin SM, (2008) lumi: a pipeline for processing Illumina microarray. Bioinformatics 24: 1547-1548.
23. Lynch M, Welsh B, (1998) Genetics and Analysis of Quantitative Traits Sunderland, Massachusetts Sinauer.
24. de Jong S, Fuller TF, Janson E, Strengman E, Horvath S, et al. (2010) Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background. BMC Genomics 11: 20.
25. Yip AM, Horvath S, (2007) Gene network interconnectedness and the generalized topological overlap measure. BMC Bioinformatics 8: 22.
26. Horvath S, Zhang B, Carlson M, Lu KV, Zhu S, et al. (2006) Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A 103: 17402-17407.
27. Abramow-Newerly W, Lipina T, Abramow-Newerly M, Kim D, Bechard AR, et al. (2006) Methods to rapidly and accurately screen a large number of ENU mutagenized mice for abnormal motor phenotypes. Amyotroph Lateral Scler 7: 112-118.
28. Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I, (2009) Replication and narrowing of gene expression quantitative trait loci using inbred mice. Mamm Genome 20: 437-446.
29. Ghazalpour A, Doss S, Kang H, Farber C, Wen PZ, et al. (2008) High-resolution mapping of gene expression using association in an outbred mouse stock. PLoS Genet 4: e1000149.
30. Holmes C, Stanford WL, (2007) Concise review: stem cell antigen-1: expression, function, and enigma. Stem Cells 25: 1339-1347.
31. Stanford WL, Haque S, Alexander R, Liu X, Latour AM, et al. (1997) Altered proliferative response by T lymphocytes of Ly-6A (Sca-1) null mice. J Exp Med 186: 705-717.
32. Williams TM, Lisanti MP, (2004) The caveolin proteins. Genome Biol 5: 214.
33. Holmes C, Khan TS, Owen C, Ciliberti N, Grynpas MD, et al. (2007) Longitudinal analysis of mesenchymal progenitors and bone quality in the stem cell antigen-1-null osteoporotic mouse. J Bone Miner Res 22: 1373-1386.
34. Kas MJ, de Mooij-van Malsen JG, de Krom M, van Gassen KL, van Lith HA, et al. (2009) High-resolution genetic mapping of mammalian motor activity levels in mice. Genes Brain Behav 8: 13-22.
35. Lin SM, Du P, Huber W, Kibbe WA, (2008) Model-based variance-stabilizing transformation for Illumina microarray data. Nucleic Acids Res 36: e11.
36. Broman KW, Wu H, Sen S, Churchill GA, (2003) R/qtl: QTL mapping in experimental crosses. Bioinformatics 19: 889-890.
37. Langfelder P, Zhang B, Horvath S, (2008) Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R. Bioinformatics 24: 719-720.
38. Ito CY, Li CY, Bernstein A, Dick JE, Stanford WL, (2003) Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice. Blood 101: 517-523.