Endothelial cell migration was impaired by irradiation-induced inhibition of SHP-2 in radiotherapy: An in vitro study

Journal of Radiation Research

Volumn 52, Issue 3, 2011, Pages 320-328

  Zheng, Xiangpeng ^a,b   Mohan, Sumathy ^c   Otto, Randal A ^b   Natarajan, Mohan ^b  

^a HUADONG HOSPITAL AFFILIATED TO FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Cell migration; Endothelial cell; Focal adhesion kinase; Integrin signaling pathways

Indexed keywords

ADHESION; CELL SIGNALING; CYTOLOGY; ENERGY TRANSFER; GLYCOPROTEINS; IRRADIATION; PHOSPHATASES; PHOSPHORYLATION;

CELL MIGRATION; ENDOTHELIAL-CELLS; FOCAL ADHESION KINASE; IN-VITRO; INTEGRIN SIGNALING PATHWAY; INTEGRINS; VITRO STUDIES; WOUND CLOSURE; WOUND HEALING; WOUND HEALING PROCESS;

ENDOTHELIAL CELLS;

EID: 79958134684     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.10071     Document Type: Article

References (32)

1. Braunhut SJ, et al (1996) Tempol prevents impairment of the endothelial cell wound healing response caused by ionising radiation. Br J Cancer Suppl 27: S157-160.
2. Schaffer M, et al (2002) Differential expression of inflammatory mediators in radiation-impaired wound healing. J Surg Res 107: 93-100.
3. Sonveaux P, et al (2003) Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy. Cancer Res 63: 1012-1019.
4. Ogata T, et al (2005) Particle irradiation suppresses metastatic potential of cancer cells. Cancer Res 65: 113-120.
5. Adair JC, et al (1999) Radiation-induced blood-brain barrier damage in astrocytoma: relation to elevated gelatinase B and urokinase. J Neurooncol 44: 283-289.
6. Baker DG and Krochak RJ (1989) The response of the microvascular system to radiation: a review. Cancer Invest 7: 287-294.
7. Rhee JG, Lee I and Song CW (1986) The clonogenic response of bovine aortic endothelial cells in culture to radiation. Radiat Res 106: 182-189.
8. Waters CM, et al (1996) Dose-response effects of radiation on the permeability of endothelial cells in culture. Radiat Res 146: 321-328.
9. 3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy. Clin Cancer Res 11: 6270-6279.
10. Hallahan D, et al (2003) Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. Cancer Cell 3: 63-74.
11. Ballestrem C, et al (2001) Marching at the front and dragging behind: differential αVβ3-integrin turnover regulates focal adhesion behavior. J Cell Biol 155: 1319-1332.
12. Cance WG, et al (2000) Immunhistochemical analysis of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 6: 2417-2423.
13. Kantak SS, Diglio CA and Onoda JM (1993) Low dose radiation-induced endothelial cell retraction. Int J Radiat Biol 64: 319-328.
14. Rodriguez LG, Wu XY and Guan JL (2005) Wound-Healing Assay. In: Guan JL ed. Cell Migration: Developmental Methods and Protocols. pp. 23-30, Humana Press, Totowa; New Jersy.
15. Yo K, et al (2009) SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration. Biochem Biophys Res Commun 382(1): 210-214.
16. Mañes S, et al (1999) Concerted Activity of Tyrosine Phosphatase SHP-2 and Focal Adhesion Kinase in Regulation of Cell Motility. Mol Cell Biol 19: 3125-3135.
17. Onoda JM, Piechocki MP and Honn KV (1992) Radiation-induced increase in expression of the alpha IIb beta 3 integrin in melanoma cells: effects on metastatic potential. Radiat Res 130: 281-288.
18. Drake DB and Oishi SN (1995) Wound healing considerations in chemotherapy and radiation therapy. Clin Plast Surg 22: 31-37.
19. Sheetz MP, et al (1999) Cell migration as a five-step cycle. Biochem Soc Symp 65: 233-243.
20. Geiger B and Bershadsky A (2002) Exploring the neighborhood: adhesion-coupled cell mechanosensors. Cell 110: 139-142.
21. Plasswilm L, et al (1999) Investigation of microvessel density after irradiation. Radiat Res 151: 454-460.
22. Kaur P and Potten CS (1986) Cell migration velocities in the crypts of the small intestine after cytotoxic insult are not dependent on mitotic activity. Cell Tissue Kinet 19: 601-610.
23. Lisiak E and Cordes N (2004) Integrins and the cellular radiation response. Cancer Therapy 2: 271-278.
24. Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110:673-687.
25. Mitra SK, Hanson DA and Schlaepfer DD (2005) Focal adhesion kinase: in commond and control of cell motility. Nat Rev Mol Cell Biol 6: 56-68.
26. Tsuruta D, et al (2002) Microfilament-dependent movement of the β3 integrin subunit within focal contacts of endothelial cells. FASEB J 16: 866-888.
27. Izaguirre G, et al (2001) The cytoskeletal/non-muscle isoform of α-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase. J Biol Chem 276: 28676-28685.
28. Xu J, Wirtz D and Pollard TD (1998) Dynamic cross-linking by α-actinin determines the mechanical properties of actin filament networks. J Biol Chem 273: 9570-9576.
29. Fishkind DJ and Wang YL (1993) Orientation and three-dimensional organization of actin filaments in dividing cultured cells. J Cell Biol 123: 837-848.
30. von Wichert G, et al (2003) Force-dependent integrincytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. EMBO J 22: 5023-5035.
31. Ilic D, et al (1995) Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377: 539-544.
32. Taylor JM, et al (2001) Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells. Mol Cell Biol 21: 1565-1572.