Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues

Journal of Virology

Volumn 85, Issue 12, 2011, Pages 6091-6095

  Farrell, Helen E ^a   Abraham, Alexander M ^a   Cardin, Rhonda D ^b   Sparre Ulrich, Alexander H ^c   Rosenkilde, Mette M ^c   Spiess, Katja ^d   Jensen, Tine H ^d   Kledal, Thomas N ^d   Davis Poynter, Nicholas ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d INAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; PROTEIN UL33; PROTEIN US28; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DRUG TARGETING; EXPLANT; FEMALE; GENETIC COMPLEMENTATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SALIVARY GLAND; STRAIN DIFFERENCE; VIRUS LATENCY; VIRUS MUTANT; VIRUS REACTIVATION; VIRUS REPLICATION;

ANIMALS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DISEASE MODELS, ANIMAL; FEMALE; HERPESVIRIDAE INFECTIONS; HUMANS; MICE; MICE, INBRED BALB C; MUROMEGALOVIRUS; ORGAN SPECIFICITY; RECEPTORS, CHEMOKINE; SALIVARY GLANDS; VIRAL PROTEINS; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS REPLICATION;

ANIMALIA; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 79958114662     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02113-10     Document Type: Article

References (18)

1. Beisser, P. S., et al. 1998. The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an essential role in the pathogenesis of viral infection. J. Virol. 72:2352-2363.
2. Cardin, R. D., G. C. Schaefer, J. R. Allen, N. J. Davis-Poynter, and H. E. Farrell. 2009. The M33 chemokine receptor homolog of murine cytomegalovirus exhibits a differential tissue-specific role during in vivo replication and latency. J. Virol. 83:7590-7601.
3. Casarosa, P., et al. 2001. Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28. J. Biol. Chem. 276:1133-1137.
4. Case, R., et al. 2008. Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo. J. Virol. 82:1884-1898.
5. Davis-Poynter, N. J., et al. 1997. Identification and characterization of a G protein-coupled receptor homolog encoded by murine cytomegalovirus. J. Virol. 71:1521-1529.
6. Hughes, A. L., and M. Yeager. 1999. Coevolution of the mammalian chemokines and their receptors. Immunogenetics 49:115-124.
7. Hulshof, J. W., et al. 2006. Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28. Bioorg. Med. Chem. 14:7213-7230.
8. Kledal, T. N., M. M. Rosenkilde, and T. W. Schwartz. 1998. Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broad-spectrum receptor US28. FEBS Lett. 441:209-214.
9. Luttichau, H. R., and T. W. Schwartz. 2000. Validation of chemokine receptors as drug targets. Curr. Opin. Drug Discov. Dev. 3:610-623.
10. McLean, K. A., P. J. Holst, L. Martini, T. W. Schwartz, and M. M. Rosenkilde. 2004. Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74. Virology 325:241- 251.
11. Miller, W. E., D. A. Houtz, C. D. Nelson, P. E. Kolattukudy, and R. J. Lefkowitz. 2003. G protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. J. Biol. Chem. 278:21663-21671.
12. Morrison, T. B., Y. Ma, J. H. Weis, and J. J. Weis. 1999. Rapid and sensitive quantification of Borrelia burgdorferi-infected mouse tissues by continuous fluorescent monitoring of PCR. J. Clin. Microbiol. 37:987-992.
13. Osborn, J. E., and D. L. Walker. 1968. Enhancement of infectivity of murine cytomegalovirus in vitro by centrifugal inoculation. J. Virol. 2:853-858.
14. Rosenkilde, M. M., and T. N. Kledal. 2006. Targeting herpesvirus reliance of the chemokine system. Curr. Drug Targets 7:103-118.
15. Sherrill, J. D., et al. 2009. Activation of intracellular signaling pathways by the murine cytomegalovirus G protein-coupled receptor M33 occurs via PLC-/PKC-dependent and -independent mechanisms. J. Virol. 83:8141- 8152.
16. Smit, M. J., et al. 2003. Virally encoded G protein-coupled receptors: targets for potentially innovative anti-viral drug development. Curr. Drug Targets 4:431-441.
17. Stoddart, C. A., et al. 1994. Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus. J. Virol. 68:6243-6253.
18. Waldhoer, M., T. N. Kledal, H. Farrell, and T. W. Schwartz. 2002. Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities. J. Virol. 76:8161-8168.