Drug quantification in turbid media by fluorescence imaging combined with light-absorption correction using white Monte Carlo simulations

Journal of Biomedical Optics

Volumn 16, Issue 6, 2011, Pages

  Xie, Haiyan ^a   Liu, Haichun ^a   Svenmarker, Pontus ^a   Axelsson, Johan ^a   Xu, Can T ^a   Gräfe, Susanna ^b   Lundeman, Jesper Holm ^c   Cheng, Haynes Pak Hay ^c   Svanberg, Sune ^a   Bendsoe, Niels ^d   Andersen, Peter E ^c   Svanberg, Katarina ^d   Andersson Engels, Stefan ^a  

^a LUND UNIVERSITY   (Sweden)

^b Biolitec AG   (Germany)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

absorption; biomedical optics; fluorescence; imaging; Monte Carlo; optical properties; photon migration; tissues

Indexed keywords

BEER LAMBERT LAW; BIOLOGICAL TISSUES; BIOMEDICAL OPTICS; CRITICAL ISSUES; DRUG QUANTIFICATION; FLUORESCENCE IMAGE; FLUORESCENCE IMAGING; FLUORESCENCE INTENSITIES; FLUORESCENCE SIGNALS; FLUOROPHORE CONCENTRATION; GOOD CORRELATIONS; IN-VIVO; MONTE CARLO; MONTE CARLO SIMULATION; PHOTON MIGRATION; PRE-CLINICAL; TIME-RESOLVED FLUORESCENCE; TISSUE PHANTOM; TURBID MEDIA;

ABSORPTION; COMPUTER SIMULATION; DRUG THERAPY; FLUORESCENCE; HISTOLOGY; IMAGING TECHNIQUES; LIGHT; LIGHT ABSORPTION; MONTE CARLO METHODS; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS; TISSUE; TURBIDITY;

FLUOROPHORES;

MURINAE;

FLUORESCENT DYE; PHOTOSENSITIZING AGENT; RHODAMINE; RHODAMINE 6G;

ABSORPTION; ALGORITHM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DRUG MONITORING; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGE QUALITY; METHODOLOGY; MONTE CARLO METHOD; MOUSE; NUDE MOUSE; PHOTOCHEMOTHERAPY; SIGNAL PROCESSING; SPECTROFLUOROMETRY; TISSUE DISTRIBUTION;

ABSORPTION; ALGORITHMS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER SIMULATION; DRUG MONITORING; FEMALE; FLUORESCENT DYES; MICE; MICE, NUDE; MODELS, BIOLOGICAL; MONTE CARLO METHOD; PHANTOMS, IMAGING; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; RHODAMINES; SIGNAL PROCESSING, COMPUTER-ASSISTED; SPECTROMETRY, FLUORESCENCE; TISSUE DISTRIBUTION;

EID: 79958108697     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3585675     Document Type: Article

References (36)

1. A. Johansson and S. Andersson-Engels, Chapter in Laser Imaging and Manipulation in Cell Biology, pp. 167-199, Wiley-VCH, Verlag (2010).
2. K. Svanberg, N. Bendsoe, J. Axelsson, S. Andersson-Engels, and S. Svanberg, Photodynamic therapy: superficial and interstitial illumination., J. Biomed. Opt. 15 (4), 041502 (2010). 10.1117/1.3466579
3. H.-P. Lassalle, D. Dumas, S. Grfe, M.-A. D'Hallewin, F. Guillemin, and L. Bezdetnaya, Correlation between in vivo pharmacokinetics, intratumoral distribution and photodynamic efficiency of liposomal mTHPC., J. Controlled Release 134 (2), 118-124 (2009). 10.1016/j.jconrel.2008.11.016
4. A. Johansson, J. Svensson, N. Bendsoe, K. Svanberg, E. Alexandratou, M. Kyriazi, D. Yova, S. Grfe, T. Trebst, and S. Andersson-Engels, Fluorescence and absorption assessment of a lipid mTHPC formulation following topical application in a non-melanotic skin tumor model., J. Biomed. Opt. 12 (3), 034026 (2007). 10.1117/1.2743080 (Pubitemid 47249788)
5. J. R. Mourant, I. J. Bigio, D. A. Jack, T. M. Johnson, and H. D. Miller, Measuring absorption coefficients in small volumes of highly scattering media: source-detector separations for which path lengths do not depend on scattering properties., Appl. Opt. 36 (22), 5655-5661 (1997). 10.1364/AO.36.005655 (Pubitemid 127638525)
6. J. R. Mourant, T. M. Johnson, G. Los, and I. J. Bigio, Non-invasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements., Phys. Med. Biol. 44 (5), 1397-1417 (1999). 10.1088/0031-9155/44/5/322 (Pubitemid 29225668)
7. L. Lilge, C. O'Carroll, and B. Wilson, A solubilization technique for photosensitizer quantification in ex vivo tissue samples., J. Photochem. Photobiol. B: Biol. 39 (3), 229-235 (1997). 10.1016/S1011-1344(97)00010-9 (Pubitemid 27356834)
8. D. Jocham, H. Stepp, and R. Waidelich, Photodynamic diagnosis in urology: state-of-the-art., Eur. Urol. 53 (6), 1138-1150 (2008). 10.1016/j.eururo.2007. 11.048
9. Q. T. Nguyen, E. S. Olson, T. A. Aguilera, T. Jiang, M. Scadeng, L. G. Ellies, and R. Y. Tsien, Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival., Proc. Nat. Acad. Sci. USA 107 (9), 4317-4322 (2010). 10.1073/pnas.0910261107
10. M. S. Eljamel, Fluorescence image-guided surgery of brain tumors: Explained step-by-step., Photodiagn. Photodyn. Ther. 5 (4), 260-263 (2008). 10.1016/j.pdpdt.2008.11.003
11. N. Haj-Hosseini, J. Richter, S. Andersson-Engels, and K. Wrdell, Optical touch pointer for fluorescence guided glioblastoma resection using 5-aminolevulinic acid., Lasers Surg. Med. 42, 9-14 (2010). 10.1002/lsm.20868
12. A. Bogaards, H. Sterenborg, and B. Wilson, In vivo quantification of fluorescent molecular markers in real-time: A review to evaluate the performance of five existing methods., Photodiagn. Photodyn. Ther. 4 (3), 170-178 (2007). 10.1016/j.pdpdt.2007.02.003 (Pubitemid 47239501)
13. A. Bogaards, H. Sterenborg, J. Trachtenberg, B. Wilson, and L. Lilge, In vivo quantification of fluorescent molecular markers in real-time by ratio imaging for diagnostic screening and image-guided surgery., Lasers Surg. Med. 39 (7), 605-613 (2007). 10.1002/lsm.20525 (Pubitemid 47502869)
14. H. Stepp, T. Beck, W. Beyer, C. Pfaller, M. Schuppler, R. Sroka, and R. Baumgartner, Measurement of fluorophore concentration in turbid media by a single optical fiber., Med. Laser Appl. 22 (1), 23-34 (2007). 10.1016/j.mla.2006.08.005 (Pubitemid 46901052)
15. M. M. Korol', A. S. Slesar', M. V. Parkhots, A. Y. Khairullina, and T. V. Olshanskaya, Determination of photosensitizer concentration in biological tissues from diffuse reflectance and fluorescence., J. Appl. Spectrosc. 76 (2), 260-267 (2009). 10.1007/s10812-009-9155-5
16. C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Chen, H. Liang, H. Liu, Z. Zhang, and S. Andersson-Engels, Autofluorescence insensitive imaging using upconverting nanocrystals in scattering media., Appl. Phys. Lett. 93 (17), 171103 (2008). 10.1063/1.3005588
17. V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, Looking and listening to light: the evolution of whole-body photonic imaging., Nat. Biotech. 23, 313-320 (2005). 10.1038/nbt1074 (Pubitemid 41094419)
18. V. Ntziachristos, Fluorescence molecular imaging., Annu. Rev. Biomed. Eng. 8 (1), 1-33 (2006). 10.1146/annurev.bioeng.8.061505.095831 (Pubitemid 44314811)
19. L. Sampath, W. Wang, and E. M. Sevick-Muraca, Near infrared fluorescent optical imaging for nodal staging., J. Biomed. Opt. 13 (4), 041312 (2008). 10.1117/1.2953498
20. C. T. Xu, J. Axelsson, and S. Andersson-Engels, Fluorescence diffuse optical tomography using upconverting nanoparticles., Appl. Phys. Lett. 94 (25), 251107 (2009). 10.1063/1.3156857
21. J. Svensson, A. Johansson, S. Grfe, B. Gitter, T. Trebst, N. Bendsoe, S. Andersson-Engels, and K. Svanberg, Tumor selectivity at short times following systemic administration of a liposomal temoporfin formulation in a murine tumor model., Photochem. Photobiol. 83 (5), 1211-1219 (2007). 10.1111/j.1751-1097. 2007.00146.x (Pubitemid 47438520)
22. G. Themelis, J. S. Yoo, K.-S. Soh, R. Schulz, and V. Ntziachristos, Real-time intraoperative fluorescence imaging system using light-absorption correction., J. Biomed. Opt. 14 (6), 064012 (2009). 10.1117/1.3259362
23. G. Alexandrakis, F. R. Rannou, and A. F. Chatziioannou, Tomographic bioluminescence imaging by use of a combined optical-PET (OPET) system: a computer simulation feasibility study., Phys. Med. Biol. 50 (17), 4225-4241 (2005). 10.1088/0031-9155/50/17/021 (Pubitemid 41225267)
24. E. Alerstam, S. Andersson-Engels, and T. Svensson, White Monte Carlo for time-resolved photon migration., J. Biomed. Opt. 13 (4), 041304 (2008). 10.1117/1.2950319 (Pubitemid 351987909)
25. H. J. van Staveren, C. J. M. Moes, J. van Marie, S. A. Prahl, and M. J. C. van Gemert, Light scattering in Intralipid-10 in the wavelength range of 400-1100 nm., Appl. Opt. 30, 4507-4514 (1991). 10.1364/AO.30.004507
26. V. Engelhardt, B. Krammer, and K. Plaetzer, Antibacterial photodynamic therapy using water-soluble formulations of hypericin or mTHPC is effective in inactivation of Staphylococcus aureus., Photochem. Photobiol. Sci. 9 (1), 365-369 (2010). 10.1039/b9pp00144a
27. J. Buchholz, B. Kaser-Hotz, T. Khan, C. Rohrer Bley, K. Melzer, R. A. Schwendener, M. Roos, and H. Walt, Optimizing photodynamic therapy: in vivo pharmacokinetics of liposomal meta-(tetrahydroxyphenyl)chlorin in feline squamous cell carcinoma., Clin. Cancer Res. 11 (20), 7538-7544 (2005). 10.1158/1078-0432.CCR-05-0490 (Pubitemid 41507716)
28. R. L. P. van Veen, W. Verkruysse, and H. J. C. M. Sterenborg, Diffuse-reflectance spectroscopy from 500 to 1060 nm by correction for inhomogeneously distributed absorbers., Opt. Lett. 27 (4), 246-248 (2002). 10.1364/OL.27.000246 (Pubitemid 34618015)
29. L. O. Svaasand, E. J. Fiskerstrand, G. Kopstad, L. T. Norvang, E. K. Svaasand, J. S. Nelson, and M. W. Berns, Therapeutic response during pulsed laser treatment of port-wine stains: Dependence on vessel diameter and depth in dermis., Lasers Med. Sci. 10, 235-243 (1995). 10.1007/BF02133615 (Pubitemid 26245480)
30. Z. Xu, J. Liu, and Y. L. Kim, Diffuse light suppression of back-directional gating imaging in high anisotropic media., J. Biomed. Opt. 14 (3), 030510 (2009). 10.1117/1.3156801
31. H. Xie, P. Svenmarker, S. Andersson-Engels, Pharmacokinetic and biodistribution study following systemic administration of Fospeg-a pegylated liposomal temoporfin formulation in a murine model., in preparation.
32. J. H. Lundeman, O. B. Jensen, P. E. Andersen, S. Andersson-Engels, B. Sumpf, G. Erbert, and P. M. Petersen, High power 404 nm source based on second harmonic generation in PPKTP of a tapered external feedback diode laser., Opt. Express 16 (4), 2486-2493 (2008). 10.1364/OE.16.002486 (Pubitemid 351293468)
33. J. Swartling, A. Pifferi, A. M.K. Enejder, and S. Andersson-Engels, Accelerated Monte Carlo models to simulate fluorescence spectra from layered tissues., J. Opt. Soc. Am. A 20 (4), 714-727 (2003). 10.1364/JOSAA.20.000714
34. E. Alerstam, S. Andersson-Engels, and T. Svensson, Improved accuracy in time-resolved diffuse reflectance spectroscopy., Opt. Express 16, 10440-10454 (2008). 10.1364/OE.16.010440
35. B. Kruijt, S. Kascakova, H. S. de Bruijn, A. van der Ploeg-van den Heuvel, H. J. C. M. Sterenborg, and D. J. Robinson, In vivo quantification of chromophore concentration using fluorescence differential path length spectroscopy., J. Biomed. Opt. 14 (3), 034022 (2009). 10.1117/1.3149862
36. N. Bendsoe, L. Persson, A. Johansson, J. Axelsson, J. Svensson, S. Grfe, S. Svanberg, and K. Svanberg, Fluorescence monitoring of a topically applied liposomal temoporfin formulation and photodynamic therapy of nonpigmented skin malignancies., J. Environ. Pathol. Toxicol. Oncol. 26 (2), 117-126 (2007). (Pubitemid 47298899)