Angiogenic response of placental villi to heparin

Obstetrics and Gynecology

Volumn 117, Issue 6, 2011, Pages 1375-1383

  Sobel, Mara L ^a   Kingdom, John ^a   Drewlo, Sascha ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; LOW MOLECULAR WEIGHT HEPARIN;

ADULT; ANGIOGENESIS; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; EXPLANT; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MEDICAL PHOTOGRAPHY; PLACENTA VILLUS; PREECLAMPSIA; PREMATURE LABOR; PRIORITY JOURNAL; SECOND TRIMESTER PREGNANCY; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTICOAGULANTS; CELLS, CULTURED; CHORIONIC VILLI; DRUG EVALUATION, PRECLINICAL; ENDOTHELIAL CELLS; FEMALE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; PRE-ECLAMPSIA; PREGNANCY; UMBILICAL VEINS;

EID: 79958099789     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/AOG.0b013e31821b5384     Document Type: Article

References (29)

1. Hirsh J, Guyatt G, Albers GW, Harrington R, Schunemann HJ; American College of Chest Physician. Antithrombotic and thrombolytic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008;133(suppl):110S-2S. Erratum in Chest 2008;134: 473. (Pubitemid 351892962)
2. Casu B, Vlodavsky I, Sanderson RD. Non-anticoagulant heparins and inhibition of cancer. Pathophysiol Haemost Thromb 2008;36:195-203.
3. Kaandorp SP, Goddijn M, van der Post JA, Hutten BA, Verhoeve HR, Hamulyák K, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 2010;362:1586-96.
4. Clark P, Walker ID, Langhorne P, Crichton L, Thomson A, Greaves M, et al. SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of lowmolecular-weight heparin and low-dose aspirin in women with recurrent miscarriage. Blood 2010;115:4162-7.
5. Drewlo S, Walker M, McLeod A, Dodd J, Kingdom J. Heparin in human placental development and the prevention of placental complications of pregnancy. Fetal Maternal Medicine Review. 2010;21:1-19.
6. Rodger MA, Paidas M, McLintock C, Middeldorp S, Kahn S, Martinelli I, et al. Inherited thrombophilia and pregnancy complications revisited. Obstet Gynecol 2008;112:320-4.
7. Toal M, Keating S, Machin G, Dodd J, Adamson SL, Windrim RC, et al. Determinants of adverse perinatal outcome in high-risk women with abnormal uterine artery Doppler images. Am J Obstet Gynecol 2008;198:330.e1-7.
8. Lim JH, Kim SY, Park SY, Yang JH, Kim MY, Ryu HM. Effective prediction of preeclampsia by a combined ratio of angiogenesis-related factors. Obstet Gynecol 2008;111: 1403-9.
9. Ahmad S, Ahmed A. Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circ Res 2004;95:884-91. (Pubitemid 39435003)
10. Rey E, Garneau P, David M, Gauthier R, Leduc L, Michon N, et al. Dalteparin for the prevention of recurrence of placentalmediated complications of pregnancy in women without thrombophilia: a pilot randomized controlled trial. J Thromb Haemost 2009;7:58-64.
11. Falanga A, Piccioli A. Effect of anticoagulant drugs in cancer. Curr Opin Pulm Med 2005;11:403-7. (Pubitemid 41291083)
12. Marchetti M, Vignoli A, Russo L, Balducci D, Pagnoncelli M, Barbui T, et al. Endothelial capillary tube formation and cell proliferation induced by tumor cells are affected by low molecular weight heparins and unfractionated heparin. Thromb Res 2008;121:637-45. (Pubitemid 351305285)
13. ACOG Committee on Obstetric Practice. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 2002; 77:67-75.
14. Baczyk D, Dunk C, Huppertz B, Maxwell C, Reister F, Giannoulias D, Kingdom JC. Bi-potential behaviour of cytotrophoblasts in first trimester chorionic villi. Placenta 2006;27: 367-74.
15. Vignoli A, Marchetti M, Balducci D, Barbui T, Falanga A. Differential effect of the low-molecular-weight heparin, dalteparin, and unfractionated heparin on microvascular endothelial cell hemostatic properties. Haematologica 2006;91:207-14. Erratum in Haematologica 2006;91:620.
16. Folkman J, Shing Y. Control of angiogenesis by heparin and other sulfated polysaccharides. Adv Exp Med Biol 1992;313: 355-64.
17. Collen A, Smorenburg SM, Peters E, Lupu F, Koolwijk P, Van Noorden C, et al. Unfractionated and low molecular weight heparin affect fibrin structure and angiogenesis in vitro. Cancer Res 2000;60:6196-200.
18. Khorana AA, Sahni A, Altland OD, Francis CW. Heparin inhibition of endothelial cell proliferation and organization is dependent on molecular weight. Arterioscler Thromb Vasc Biol 2003;23:2110-5. (Pubitemid 37433208)
19. Norrby K. 2.5 kDa and 5.0 kDa heparin fragments specifically inhibit microvessel sprouting and network formation in VEGF165-mediated mammalian angiogenesis. Int J Exp Pathol 2000;81:191-8. (Pubitemid 30485818)
20. Lepri A, Benelli U, Bernardini N, Bianchi F, Lupetti M, Danesi R, et al. Effect of low molecular weight heparan sulphate on angiogenesis in the rat cornea after chemical cauterization. J Ocul Pharmacol 1994;10:273-80. (Pubitemid 24119448)
21. Green D, Hull RD, Brant R, Pineo GF. Lower mortality in cancer patients treated with low-molecular-weight versus standard heparin. Lancet 1992;339:1476.
22. Robson SC, Hunter S. Boys RJ, Dunlop W. Serial study of factors influencing changes in cardiac output during human pregnancy. Am J Physiol 1989;256:H1060-5.
23. Dunk C, Smith S, Hazan A, Whittle W, Jones RL. Promotion of angiogenesis by human endometrial lymphocytes. Immunol Invest 2008;37:583-610.
24. Jauniaux E, Hempstock J, Greenwold N, Burton GJ. Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol 2003;162:115-25. (Pubitemid 36041994)
25. Thilaganathan B, Wormald B, Zanardini C, Sheldon J, Ralph E, Papageorghou AT. Early-pregnancy multiple serum markers and second-trimester uterine artery Doppler in predicting preeclampsia. Obstet Gynecol 2010;115:1233-8.
26. Tanaka S, Kunath T, Hadjantonakis AK, Nagy A, Rossant J. Promotion of trophoblast stem cell proliferation by FGF4. Science 1998;282:2072-5. (Pubitemid 29001261)
27. Bose P, Black S, Kadyrov M, Weissenborn U, Neulen J, Regan L, et al. Heparin and aspirin attenuate placental apoptosis in vitro: implications for early pregnancy failure. Am J Obstet Gynecol 2005;192:23-30. (Pubitemid 40164214)
28. Ahmad S, Ahmed A. Antiangiogenic effect of soluble vascular endothelial growth factor receptor-1 in placental angiogenesis. Endothelium 2005;12:89-95. (Pubitemid 40861891)
29. Fitzgerald B, Levytska K, Kingdom J, Walker M, Baczyk D, Keating S. Villous trophoblast abnormalities in extremely preterm deliveries with elevated second trimester maternal serum hCG or inhibin-A. Placenta 2011;32:339-45.