Antiangiogenic effect of soluble vascular endothelial growth factor receptor-1 in placental angiogenesis

Endothelium: Journal of Endothelial Cell Research

Volumn 12, Issue 1-2, 2005, Pages 89-95

  Ahmad, Shakil ^a   Ahmed, Asif ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Angiogenesis; Hypoxia; Preeclampsia; Soluble vascular endothelial growth factor receptor; Vascular endothelial growth factor

Indexed keywords

ANGIOGENESIS INHIBITOR; MESSENGER RNA; RECOMBINANT VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

ANGIOGENESIS; ARTICLE; ATTENUATION; BINDING AFFINITY; CELL HYPOXIA; CELL MIGRATION; CELL STIMULATION; CHORION VILLUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; EXPLANT; GESTATION PERIOD; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOLOCALIZATION; MODULATION; PLACENTA CIRCULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; RNA SPLICING; SIGNAL TRANSDUCTION; TROPHOBLAST; UMBILICAL VEIN; UPREGULATION;

ALTERNATIVE SPLICING; FEMALE; GENE EXPRESSION REGULATION; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; ORGAN CULTURE TECHNIQUES; PLACENTA; PREGNANCY; PROTEINS; TROPHOBLASTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 20844451913     PISSN: 10623329     EISSN: None     Source Type: Journal    
DOI: 10.1080/10623320590933888     Document Type: Article

References (40)

1. Ahmad S., and Ahmed A. (2001) Regulation of soluble vegfr-1 by vegf and oxygen and its elevation in pre-eclampsia and fetal growth restriction. Placenta, 22, A.7.
2. Ahmad S., and Ahmed A. (2004) Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circulation Research, 95, 884-891.
3. Ahmed A., Dunk C., Ahmad S., and Khaliq A. (2000) Regulation of placental vascular endothelial growth factor (vegf) and placenta growth factor (pigf) and soluble flt-1 by oxygen - a review. Placenta, 21 (Suppl. A), S16-S24.
4. Ahmed A., Li X.F., Dunk C., Whittle M.J., Rushton D.I., and Rollason T. (1995) Colocalisation of vascular endothelial growth factor and its flt-1 receptor in human placenta. Growth Factors, 12, 235-243.
5. Baker P.N., Krasnow J., Roberts J.M., and Yeo K.T. (1995) Elevated serum levels of vascular endothelial growth factor in patients with preeclampsia. Obstetrics and Gynecology, 86, 815-821.
6. Benirschke and Kaufmann (1995) Pathology of the Human Placenta, 3rd ed. Springer-Verlag, Berlin.
7. Brogi E., Schatteman G., Wu T., Kim E.A., Varticovski L., Keyt B., and Isner J.M. (1996) Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. Journal of Clinical Investigation, 97, 469-476.
8. Bussolati B., Dunk C., Grohman M., Kontos C.D., Mason J., and Ahmed A. (2001) Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. American Journal of Pathology, 159, 993-1008.
9. Castellucci M., Scheper M., Scheffen I., Celona A., and Kaufmann P. (1990) The development of the human placental villous tree. Anatomy, and Embryology (Berlin), 181, 117-128.
10. Chappell L.C., Seed P.T., Briley A., Kelly F.J., Hunt B.J., Charnock-Jones D.S., Mallet A.I., and Poston L. (2002) A longitudinal study of biochemical variables in women at risk of preeclampsia. American Journal of Obstetrics and Gynecology, 187, 127-136.
11. Clark D.E., Smith S.K., He Y., Day K.A., Licence D.R., Corps A.N., Lammoglia R., and Charnock-Jones D.S. (1998) A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation. Biology of Reproduction, 59, 1540-1548.
12. Friedman S.A., Taylor R.N., and Roberts J.M. (1991) Pathophysiology of preeclampsia. Clinical Perinatology, 18, 661-682.
13. Frusca T., Morassi L., Pecorelli S., Grigolato P., and Gastaldi A. (1989) Histological features of uteroplacental vessels in normal and hypertensive patients in relation to birthweight. British Journal of Obstetrics and Gynaecology, 96, 835-839.
14. Fujikura T., and Yoshida J. (1996) Blood gas analysis of placental and uterine blood during cesarean delivery. Obstetrics and Gynecology, 87, 133-136.
15. Hornig C., Barleon B., Ahmad S., Vuorela P., Ahmed A., and Weich H.A. (2000) Release and complex formation of soluble vegfr-1 from endothelial cells and biological fluids. Laboratory Investigation, 80, 443-454.
16. Hubel C.A. (1999) Oxidative stress in the pathogenesis of preeclampsia. Proceedings of the Society for Experimental Biology and Medicine, 222, 222-235.
17. Hunter A., Aitkenhead M., Caldwell C., McCracken G., Wilson D., and McClure N. (2000) Serum levels of vascular endothelial growth factor in preeclamptic and normotensive pregnancy. Hypertension, 36, 965-969.
18. Inoue T., Kibata K., Suzuki M., Nakamura S., Motoda R., and Orita K. (2000) Identification of a vascular endothelial growth factor (vegf) antagonist, sflt-1, from a human hematopoietic cell line nalm-16. FEBS Letters, 469, 14-18.
19. Jones C.J., and Fox H. (1980) An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia. Placenta, 1, 61-76.
20. Kendall R.L., and Thomas K.A. (1993) Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proceedings of the National Academy of Sciences of the United States of America, 90, 10705-10709.
21. Kendall R.L., Wang G., and Thomas K.A. (1996) Identification of a natural soluble form of the vascular endothelial growth factor receptor, flt-1, and its heterodimerization with kdr. Biochemical Biophysical Research Communications, 226, 324-328.
22. Khaliq A., Dunk C., Jiang J., Shams M., Li X.F., Acevedo C., Weich H., Whittle M., and Ahmed A. (1999) Hypoxia down-regulates placenta growth factor, whereas fetal growth restriction up-regulates placenta growth factor expression: molecular evidence for "placental hyperoxia" in intrauterine growth restriction. Laboratory Investigation, 79, 151-170.
23. Kupferminc M.J., Daniel Y., Englender T., Baram A., Many A., Jaffa A.J., Gull I., and Lessing J.B. (1997) Vascular endothelial growth factor is increased in patients with preeclampsia. American Journal of Reproductive Immunology, 38, 302-306.
24. Levine R.J., Maynard S.E., Qian C., Lim K.H., England L.J., Yu K.F., Schisterman E.F., Thadhani R., Sachs B.P., Epstein F.H., Sibai B.M., Sukhatme V.P., and Karumanchi S.A. (2004) Circulating angiogenic factors and the risk of preeclampsia. New England Journal of Medicine, 350, 672-683.
25. Li X., Shams M., Zhu J., Khalig A., Wilkes M., Whittle M., Barnes N., and Ahmed A. (1998) Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxants. Journal of Clinical Investigation, 101, 442-454.
26. Lunell N.O., Nylund L.E., Lewander R., and Sarby B. (1982) Uteroplacental blood flow in pre-eclampsia measurements with indium-113m and a computer-linked gamma camera. Clinical and Experimental Hypertension, B, 1, 105-117.
27. Maynard S.E., Min J.Y., Merchan J., Lim K.H., Li J., Mondal S., Libermann T.A., Morgan J.P., Sellke F.W., Stillman I.E., Epstein F.H., Sukhatme V.P., and Karumanchi S.A. (2003) Excess placental soluble fms-like tyrosine kinase 1 (sflt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. Journal of Clinical Investigation, 111, 649-658.
28. Mellembakken J.R., Aukrust P., Olafsen M.K., Ueland T., Hestdal K., and Videm V. (2002) Activation of leukocytes during the uteroplacental passage in preeclampsia. Hypertension, 39, 155-160.
29. Nagamatsu T., Fujii T., Kusumi M., Zou L., Yamashita T., Osuga Y., Momoeda M., Kozuma S., and Taketani Y. (2004) Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: An implication for the placental vascular development and the pathophysiology of preeclampsia. Endocrinology, 145, 4838-4845.
30. Perkins J., St John J., and Ahmed A. (2002) Modulation of trophoblast cell death by oxygen and egf. Molecular Medicine, 8, 847-856.
31. Redman C.W. (1990) Platelets and the beginnings of preeclampsia. New England Journal of Medicine, 323, 478-480.
32. Sharkey A.M., Cooper J.C., Balmforth J.R., McLaren J., Clark D.E., Charnock-Jones D.S., Morris N.H., and Smith S.K. (1996) Maternal plasma levels of vascular endothelial growth factor in normotensive pregnancies and in pregnancies complicated by pre-eclampsia. European Journal of Clinical Investigation, 26, 1182-1185.
33. Shore V.H., Wang T.H., Wang C.L., Torry R.J., Caudle M.R., and Torry D.S. (1997) Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast. Placenta, 18, 657-665.
34. Soothill P.W., Nicolaides K.H., Rodeck C.H., and Campbell S. (1986) Effect of gestational age on fetal and intervillous blood gas and acid-base values in human pregnancy. Fetal Therapy, 1, 168-175.
35. Su Y.N., Lee C.N., Cheng W.F., Shau W.Y., Chow S.N., and Hsieh F.J. (2001) Decreased maternal serum placenta growth factor in early second trimester and preeclampsia. Obstetrics and Gynecology, 97, 898-904.
36. Sugimoto H., Hamano Y., Charytan D., Cosgrove D., Kieran M., Sudhakar A., and Kalluri R. (2003) Neutralization of circulating vascular endothelial growth factor (vegf) by anti-vegf antibodies and soluble vegf receptor 1 (sflt-1) induces proteinuria. Journal of Biological Chemistry, 278, 12605-12608.
37. Taylor C.M., Stevens H., Anthony F.W., and Wheeler T. (1997) Influence of hypoxia on vascular endothelial growth factor and chorionic gonadotrophin production in the trophoblast-derived cell lines: JEG, JAr and BeWo. Placenta, 18, 451-458.
38. Tidwell S.C., Ho H.N., Chiu W.H., Torry R.I., and Torry D.S. (2001) Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia. American Journal of Obstetrics and Gynecology, 184, 1267-1272.
39. Tuder R.M., Flook B.E., and Voelkel N.F. (1995) Increased gene expression for vegf and the vegf receptors kdr/flk and flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. Journal of Clinical Investigation, 95, 1798-1807.
40. Vuorela P., Helske S., Hornig C., Alitalo K., Weich H., and Halmesmaki E. (2000) Amniotic fluid - soluble vascular endothelial growth factor receptor-1 in preeclampsia. Obstetrics and Gynecology, 95, 353-357.