Stromal cells do not share KRAS mutations that the epithelial component harbors in colorectal carcinomas

Cancer Letters

Volumn 308, Issue 1, 2011, Pages 118-121

  Baloglu, Huseyin ^a   Yigit, Nuri ^a  

^a GATA HAYDARPASA TRAINING HOSPITAL   (Turkey)

Author keywords

Cancer stroma; Colorectal cancer; KRAS

Indexed keywords

K RAS PROTEIN;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CELL INTERACTION; CELLS AND CELL COMPONENTS; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA EXTRACTION; EPITHELIUM CELL; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; MUTATIONAL ANALYSIS; PRIMARY TUMOR; PRIORITY JOURNAL; RECTUM BIOPSY; STROMA CELL; TARGET CELL; TUMOR GROWTH;

AGED; COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; STROMAL CELLS;

EID: 79958083829     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.04.021     Document Type: Article

References (19)

1. Kurose K., Hoshaw-Woodard S., Adeyinka A., Lemeshow S., Watson P.H., Eng C. Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions. Hum. Mol. Genet. 2001, 10:1907-1913.
2. Moinfar F., Man Y.G., Arnould L., Bratthauer G.L., Ratschek M., Tavassoli F.A. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res. 2000, 60:2562-2566.
3. Kopantzev E.P., Vayshlya N.A., Kopantseva M.R., Egorov V.I., Pikunov M., Zinovyeva M.V., Vinogradova T.V., Zborovskaya I.B., Sverdlov E.D. Cellular and molecular phenotypes of proliferating stromal cells from human carcinomas. Br. J. Cancer 2010, 102:1533-1540.
4. Fukino K., Shen L., Matsumoto S., Morrison C.D., Mutter G.L., Eng C. Combined total genome loss-of-heterozygosity scan of breast cancer stroma and epithelium reveals multiplicity of stromal targets. Cancer Res. 2004, 64:7231-7236.
5. Pelham R.J., Rodgers L., Hall I., Lucito R., Nguyen K.C., Navin N., Hicks J., Mu D., Powers S., Wigler M., Botstein D. Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc. Natl. Acad. Sci. USA 2006, 103:19848-19853.
6. Kurose K., Gilley K., Matsumoto S., Watson P.H., Zhou X.P., Eng C. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat. Genet. 2002, 32:355-357.
7. Ishiguro K., Yoshida T., Yagishita H., Numata Y., Okayasu T. Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas. Gut 2006, 55:695-702.
8. Nakagawa H., Liyanarachchi S., Davuluri R.V., Auer H., Martin E.W., de la Chapelle A., Frankel W.L. Role of cancer-associated stromal fibroblasts in metastatic colon cancer to the liver and their expression profiles. Oncogene 2004, 23(44):7366-7377.
9. Matsumoto N., Yoshida T., Yamashita K., Numata Y., Okayasu I. Possible alternative carcinogenesis pathway featuring microsatellite instability in colorectal cancer stroma. Br. J. Cancer 2003, 89:707-712.
10. Heinemann V., Stintzing S., Kirchner T., Boeck S., Jung A. Clinical relevance of EGFR- and KRAS-status in colorectal cancer patients treated with monoclonal antibodies directed against the EGFR. Cancer Treatm. Rev. 2009, 35:262-271.
11. Tanwar P.S., Zhang L., Roberts D.J., Teixeira J.M. Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer. Cancer Res. 2011, 71(5):1584-1596.
12. Y. Su, K. Shankar, O. Rahal, R.C. Simmen, Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer-preventive actions of dietary factors. J. Nutr. Biochem. 2011. <> (accessed 17.03.11). http://www.ncbi.nlm.nih.gov.
13. Ishiguro K., Yoshida T., Yagishita H., Numata Y., Okayasu T. Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas. Gut 2006, 55(5):695-702.
14. Umeto H., Yoshida T., Araki K., Yagishita H., Mikami T., Okayasu I. Appearance of epithelial and stromal genomic instability in background colorectal mucosa of sporadic colorectal cancer patients: relation to age and gender. J. Gastroenterol. 2009, 44(10):1036-1045.
15. Liao C.P., Adisetiyo H., Liang M., Roy-Burman P. Cancer-associated fibroblasts enhance the gland-forming capability of prostate cancer stem cells. Cancer Res. 2010, 70(18):7294-7303.
16. Kopantzev E.P., Vayshlya N.A., Kopantseva M.R., Egorov V.I., Pikunov M., Zinovyeva M.V., Vinogradova T.V., Zborovskaya I.B., Sverdlov E.D. Cellular and molecular phenotypes of proliferating stromal cells from human carcinomas. Br. J. Cancer 2010, 102(10):1533-1540.
17. Macheda M.L., Stacker S.A. Importance of Wnt signaling in the tumor stroma microenvironment. Curr. Cancer Drug Targets 2008, 8(6):454-465.
18. Mahadevan D., Von Hoff D.D. Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol. Cancer Ther. 2007, 6(4):1186-1197.
19. Anton K., Glod J. Targeting the tumor stroma in cancer therapy. Curr. Pharm. Biotechnol. 2009, 10(2):185-191.