Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by using urinary metabonomics based on liquid chromatography-mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 56, Issue 1, 2011, Pages 86-92

  Dai, Weidong ^a   Wei, Cong ^b   Kong, Hongwei ^a   Jia, Zhenhua ^b   Han, Jianke ^b   Zhang, Fengxia ^a   Wu, Zeming ^a   Gu, Yan ^a   Chen, Shili ^a   Gu, Qun ^a   Lu, Xin ^a   Wu, Yiling ^b   Xu, Guowang ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b The Integration of Traditional and Western Medical Research Academy of Hebei Province   (China)

Author keywords

Endothelial dysfunction; LC MS; Metabonomics; Simvastatin; Tongxinluo; Urine

Indexed keywords

1 METHYLADENOSINE; 4 CRESOL GLUCURONIDE; ADENINE; COPROPORPHYRIN; ENDOTHELIN 1; GLUCURONIDE; HERBACEOUS AGENT; HIPPURIC ACID; INDICAN; NITRIC OXIDE; PHENYLALANINE; PORPHYRIN; RIBOFLAVIN; SIMVASTATIN; TONGXINLUO; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; HISTOPATHOLOGY; ION TRAP TIME OF FLIGHT MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RAT; ULTRA FAST LIQUID CHROMATOGRAPHY; URINALYSIS;

ANIMALS; AORTA, THORACIC; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; MALE; MASS SPECTROMETRY; METABOLOMICS; NITRIC OXIDE; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, WISTAR; SIMVASTATIN;

EID: 79958075132     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.04.020     Document Type: Article

References (30)

1. Endemann D., Schiffrin E. Endothelial dysfunction. J. Am. Soc. Nephrol. 2004, 15:1983-1992.
2. Cai H., Harrison D. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. 2000, 87:840-844.
3. Bonetti P.O. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler. Thromb. Vasc. Biol. 2002, 23:168-175.
4. Davignon J., Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004, 109. III-27-III-32.
5. Shinozaki K., Hirayama A., Nishio Y., Yoshida Y., Ohtani T., Okamura T., Masada M., Kikkawa R., Kodama K., Kashiwagi A. Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress. J. Am. Coll. Cardiol. 2001, 38:1821-1828.
6. Esper R.J., Vilarino J.O., Machado R.A., Paragano A. Endothelial dysfunction in normal and abnormal glucose metabolism. Cardiovascular Diabetology: Clinical, Metabolic and Inflammatory Facets 2008, 17-43. Karger, Basel. E. Fisman (Ed.).
7. Nicholson J., Lindon J., Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29:1181-1189.
8. Yang J., Zhao X.J., Liu X.L., Wang C., Gao P., Wang J.S., Li L.J., Gu J.R., Yang S.L., Xu G.W. High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis B. J. Proteome Res. 2006, 5:554-561.
9. Lehmann R., Zhao X., Weigert C., Simon P., Fehrenbach E., Fritsche J., Machann J., Schick F., Wang J., Hoene M., Schleicher E.D., Haring H.-U., Xu G., Niess A.M. Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation. PLoS One 2010, 5:e11519.
10. Wang M., Lamers R.-J.A.N., Korthout H.A.A.J., van Nesselrooij J.H.J., Witkamp R.F., van der Heijden R., Voshol P.J., Havekes L.M., Verpoorte R., van der Greef J. Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology. Phytother. Res. 2005, 19:173-182.
11. Gu Y., Zhang Y.F., Shi X.Z., Li X.Y., Hong J., Chen J., Gu W.G., Lu X., Xu G.W., Ning G. Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta 2010, 81:766-772.
12. Wang P., Sun H., Lv H., Sun W., Yuan Y., Han Y., Wang D., Zhang A., Wang X. Thyroxine and reserpine-induced changes in metabolic profiles of rat urine and the therapeutic effect of Liu Wei Di Huang Wan detected by UPLC-HDMS. J. Pharm. Biomed. Anal. 2010, 53:631-645.
13. Yan S., Wu B., Lin Z., Jin H., Huang J., Yang Y., Zhang X., Shen Z., Zhang W. Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium. Mol. BioSyst. 2009, 5:1204-1213.
14. Zhang F., Jia Z., Dai W., Gao P., Lu X., Wu Y., Xu G. Plasma metabonomics study of depression-atherosclerosis rats treated with the traditional Chinese medicine Tongxinluo. Sci. China Chem. 2010, 40:725-732.
15. Zhang F., Jia Z., Gao P., Kong H., Li X., Chen J., Yang Q., Yin P., Wang J., Lu X. Metabonomics study of atherosclerosis rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry. Talanta 2009, 79:836-844.
16. Sangster T., Major H., Plumb R., Wilson A.J., Wilson I.D. A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis. Analyst 2006, 131:1075-1078.
17. Gika H.G., Theodoridis G.A., Wingate J.E., Wilson I.D. Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine. J. Proteome Res. 2007, 6:3291-3303.
18. Feletou M., Vanhoutte P. Endothelial dysfunction: a multifaceted disorder. Am. J. Physiol. Heart Circ. Physiol. 2006, 291:H985-H1002.
19. Bijlsma S., Bobeldijk L., Verheij E.R., Ramaker R., Kochhar S., Macdonald I.A., van Ommen B., Smilde A.K. Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation. Anal. Chem. 2006, 78:567-574.
20. Chen J., Wang W., Lv S., Yin P., Zhao X., Lu X., Zhang F., Xu G. Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations. Anal. Chim. Acta 2009, 650:3-9.
21. Niwa T., Ise M. Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. J. Lab. Clin. Med. 1994, 124:96-104.
22. Dou L., Bertrand E., Cerini C., Faure V., Sampol J., Vanholder R., Berland Y., Brunet P. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney Int. 2004, 65:442-451.
23. Dou L., Jourde-Chiche N., Faure V., Cerini C., Berland Y., Dignat-George F., Brunet P. The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells. J. Thromb. Haemost. 2007, 5:1302-1308.
24. Tumur Z., Niwa T. Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells. Am. J. Nephrol. 2009, 29:551-557.
25. Dou L., Cerini C., Brunet P., Guilianelli C., Moal V., Grau G., De Smet R., Vanholder R., Sampol J., Berland Y. P-cresol, a uremic toxin, decreases endothelial cell response to inflammatory cytokines. Kidney Int. 2002, 62:1999-2009.
26. Vanholder R., Glorieux G., Lameire N. New insights in uremic toxicity, Cardiovascular disorders in hemodialysis 2005, 315-324. Karger, Basel. C. Ronco, A. Brendolan, N. Levin (Eds.).
27. Jaffe E., Minick C., Adelman B., Becker C., Nachman R. Synthesis of basement membrane collagen by cultured human endothelial cells. J. Exp. Med. 1976, 144:209-225.
28. Zhou H., Wang X., Wang A., Liu M., Shen F., Lv C., Lv D., Zhou H. Protection of hemin against oxidative-stress damage in human umbilicus vein endothelial cells. Chin. J. Biochem. Mol. Biol. 2003, 19:528-532.
29. Teran F., Johnson R., Stevenson B., Peyton K., Jackson K., Appleton S., Durante W., Johnson F. Heme oxygenase-derived carbon monoxide promotes arteriolar endothelial dysfunction and contributes to salt-induced hypertension in Dahl salt-sensitive rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288:R615-R622.
30. O'Driscoll G., Green D., Taylor R. Simvastatin, an HMG Ccoenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation 1997, 95:1126-1131.