Mycoplasma genitalium: An Emerging Cause of Sexually Transmitted Disease in Women

PLoS Pathogens

Volumn 7, Issue 5, 2011, Pages

  McGowin, Chris L ^a   Anderson Smits, Colin ^b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TULANE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLAMYDIA TRACHOMATIS; FEMALE; FEMALE INFERTILITY; HIGH RISK POPULATION; HUMAN; MYCOPLASMA GENITALIUM; MYCOPLASMA GENITALIUM INFECTION; MYCOPLASMOSIS; NEISSERIA GONORRHOEAE; NONHUMAN; PELVIC INFLAMMATORY DISEASE; REVIEW; SEXUALLY TRANSMITTED DISEASE; URETHRITIS; UTERINE CERVICITIS; VAGINA DISCHARGE; ISOLATION AND PURIFICATION; MICROBIOLOGY; PATHOGENICITY; PREVALENCE;

CHLAMYDIA TRACHOMATIS; MYCOPLASMA GENITALIUM; NEISSERIA GONORRHOEAE;

FEMALE; HUMANS; INFERTILITY, FEMALE; MYCOPLASMA GENITALIUM; MYCOPLASMA INFECTIONS; PELVIC INFLAMMATORY DISEASE; PREVALENCE; SEXUALLY TRANSMITTED DISEASES, BACTERIAL;

EID: 79958067825     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001324     Document Type: Review

References (78)

1. World Health Organization (2007) Sexually transmitted infections fact sheet. Available: http://www.who.int/mediacentre/factsheets/fs110/en/. Accessed 22 April 2011.
2. Manhart LE, Holmes KK, Hughes JP, Houston LS, Totten PA, (2007) Mycoplasma genitalium among young adults in the United States: an emerging sexually transmitted infection. Am J Public Health 97: 1118-1125.
3. Tully JG, Taylor-Robinson D, Cole RM, Rose DL, (1981) A newly discovered mycoplasma in the human urogenital tract. Lancet 1: 1288-1291.
4. Jensen JS, (2004) Mycoplasma genitalium: the aetiological agent of urethritis and other sexually transmitted diseases. J Eur Acad Dermatol Venereol 18: 1-11.
5. Martin DH, (2008) Nongonococcal urethritis: new views through the prism of modern molecular microbiology. Curr Infect Dis Rep 10: 128-132.
6. Jensen JS, Uldum SA, Sondergard-Andersen J, Vuust J, Lind K, (1991) Polymerase chain reaction for detection of Mycoplasma genitalium in clinical samples. J Clin Microbiol 29: 46-50.
7. Palmer HM, Gilroy CB, Claydon EJ, Taylor-Robinson D, (1991) Detection of Mycoplasma genitalium in the genitourinary tract of women by the polymerase chain reaction. Int J STD AIDS 2: 261-263.
8. Anagrius C, Lore B, Jensen JS, (2005) Mycoplasma genitalium: prevalence, clinical significance, and transmission. Sex Transm Infect 81: 458-462.
9. Falk L, Fredlund H, Jensen JS, (2004) Symptomatic urethritis is more prevalent in men infected with Mycoplasma genitalium than with Chlamydia trachomatis. Sex Transm Infect 80: 289-293.
10. Falk L, Fredlund H, Jensen JS, (2005) Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection. Sex Transm Infect 81: 73-78.
11. Hjorth SV, Bjornelius E, Lidbrink P, Falk L, Dohn B, et al. (2006) Sequence-based typing of Mycoplasma genitalium reveals sexual transmission. J Clin Microbiol 44: 2078-2083.
12. Keane FE, Thomas BJ, Gilroy CB, Renton A, Taylor-Robinson D, (2000) The association of Chlamydia trachomatis and Mycoplasma genitalium with non-gonococcal urethritis: observations on heterosexual men and their female partners. Int J STD AIDS 11: 435-439.
13. Thurman AR, Musatovova O, Perdue S, Shain RN, Baseman JG, et al. (2010) Mycoplasma genitalium symptoms, concordance and treatment in high-risk sexual dyads. Int J STD AIDS 21: 177-183.
14. Tosh AK, Van Der Pol B, Fortenberry JD, Williams JA, Katz BP, et al. (2007) Mycoplasma genitalium among adolescent women and their partners. J Adolesc Health 40: 412-417.
15. Ma L, Taylor S, Jensen JS, Myers L, Lillis R, et al. (2008) Short tandem repeat sequences in the Mycoplasma genitalium genome and their use in a multilocus genotyping system. BMC Microbiol 8: 130.
16. Andersen B, Sokolowski I, Ostergaard L, Kjolseth Moller J, Olesen F, et al. (2007) Mycoplasma genitalium: prevalence and behavioural risk factors in the general population. Sex Transm Infect 83: 237-241.
17. Clausen HF, Fedder J, Drasbek M, Nielsen PK, Toft B, et al. (2001) Serological investigation of Mycoplasma genitalium in infertile women. Hum Reprod 16: 1866-1874.
18. Edwards RK, Ferguson RJ, Reyes L, Brown M, Theriaque DW, et al. (2006) Assessing the relationship between preterm delivery and various microorganisms recovered from the lower genital tract. J Matern Fetal Neonatal Med 19: 357-363.
19. Ghebremichael M, Paintsil E, Larsen U, (2009) Alcohol abuse, sexual risk behaviors, and sexually transmitted infections in women in Moshi urban district, northern Tanzania. Sex Transm Dis 36: 102-107.
20. Hitti J, Garcia P, Totten P, Paul K, Astete S, et al. (2010) Correlates of cervical Mycoplasma genitalium and risk of preterm birth among Peruvian women. Sex Transm Dis 37: 81-85.
21. Oakeshott P, Hay P, Taylor-Robinson D, Hay S, Dohn B, et al. (2004) Prevalence of Mycoplasma genitalium in early pregnancy and relationship between its presence and pregnancy outcome. BJOG 111: 1464-1467.
22. Olsen B, Lan PT, Stalsby Lundborg C, Khang TH, Unemo M, (2009) Population-based assessment of Mycoplasma genitalium in Vietnam-low prevalence among married women of reproductive age in a rural area. J Eur Acad Dermatol Venereol 23: 533-537.
23. Rahman S, Garland S, Currie M, Tabrizi SN, Rahman M, et al. (2008) Prevalence of Mycoplasma genitalium in health clinic attendees complaining of vaginal discharge in Bangladesh. Int J STD AIDS 19: 772-774.
24. Svenstrup HF, Fedder J, Kristoffersen SE, Trolle B, Birkelund S, et al. (2008) Mycoplasma genitalium, Chlamydia trachomatis, and tubal factor infertility-a prospective study. Fertil Steril 90: 513-520.
25. Arraiz RN, Colina Ch S, Marcucci JR, Rondon GN, Reyes SF, et al. (2008) Mycoplasma genitalium detection and correlation with clinical manifestations in population of the Zulia State, Venezuela. Rev Chilena Infectol 25: 256-261.
26. Baczynska A, Hvid M, Lamy P, Birkelund S, Christiansen G, et al. (2008) Prevalence of Mycoplasma genitalium, Mycoplasma hominis and Chlamydia trachomatis among Danish patients requesting abortion. Syst Biol Reprod Med 54: 127-134.
27. Bjartling C, Osser S, Persson K, (2010) The association between Mycoplasma genitalium and pelvic inflammatory disease after termination of pregnancy. BJOG 117: 361-364.
28. Blanchard A, Hamrick W, Duffy L, Baldus K, Cassell GH, (1993) Use of the polymerase chain reaction for detection of Mycoplasma fermentans and Mycoplasma genitalium in the urogenital tract and amniotic fluid. Clin Infect Dis 17 (Suppl 1): S272-279.
29. Bradshaw CS, Chen MY, Fairley CK, (2008) Persistence of Mycoplasma genitalium following azithromycin therapy. PLoS ONE 3: e3618 doi:10.1371/journal.pone.0003618.
30. Casin I, Vexiau-Robert D, De La Salmoniere P, Eche A, Grandry B, et al. (2002) High prevalence of Mycoplasma genitalium in the lower genitourinary tract of women attending a sexually transmitted disease clinic in Paris, France. Sex Transm Dis 29: 353-359.
31. Cohen CR, Manhart LE, Bukusi EA, Astete S, Brunham RC, et al. (2002) Association between Mycoplasma genitalium and acute endometritis. Lancet 359: 765-766.
32. Cohen CR, Mugo NR, Astete SG, Odondo R, Manhart LE, et al. (2005) Detection of Mycoplasma genitalium in women with laparoscopically diagnosed acute salpingitis. Sex Transm Infect 81: 463-466.
33. Cohen CR, Nosek M, Meier A, Astete SG, Iverson-Cabral S, et al. (2007) Mycoplasma genitalium infection and persistence in a cohort of female sex workers in Nairobi, Kenya. Sex Transm Dis 34: 274-279.
34. de Barbeyrac B, Bernet-Poggi C, Febrer F, Renaudin H, Dupon M, et al. (1993) Detection of Mycoplasma pneumoniae and Mycoplasma genitalium in clinical samples by polymerase chain reaction. Clin Infect Dis 17 (Suppl 1): S83-S89.
35. Edberg A, Jurstrand M, Johansson E, Wikander E, Hoog A, et al. (2008) A comparative study of three different PCR assays for detection of Mycoplasma genitalium in urogenital specimens from men and women. J Med Microbiol 57: 304-309.
36. Gaydos C, Maldeis NE, Hardick A, Hardick J, Quinn TC, (2009) Mycoplasma genitalium as a contributor to the multiple etiologies of cervicitis in women attending sexually transmitted disease clinics. Sex Transm Dis 36: 598-606.
37. Grzesko J, Elias M, Maczynska B, Kasprzykowska U, Tlaczala M, et al. (2009) Occurrence of Mycoplasma genitalium in fertile and infertile women. Fertil Steril 91: 2376-2380.
38. Haggerty CL, Totten PA, Astete SG, Ness RB, (2006) Mycoplasma genitalium among women with nongonococcal, nonchlamydial pelvic inflammatory disease. Infect Dis Obstet Gynecol 2006: 30184.
39. Haggerty CL, Totten PA, Astete SG, Lee S, Hoferka SL, et al. (2008) Failure of cefoxitin and doxycycline to eradicate endometrial Mycoplasma genitalium and the consequence for clinical cure of pelvic inflammatory disease. Sex Transm Infect 84: 338-342.
40. Hogdahl M, Kihlstrom E, (2007) Leucocyte esterase testing of first-voided urine and urethral and cervical smears to identify Mycoplasma genitalium-infected men and women. Int J STD AIDS 18: 835-838.
41. Huppert JS, Mortensen JE, Reed JL, Kahn JA, Rich KD, et al. (2008) Mycoplasma genitalium detected by transcription-mediated amplification is associated with Chlamydia trachomatis in adolescent women. Sex Transm Dis 35: 250-254.
42. Jurstrand M, Jensen JS, Magnuson A, Kamwendo F, Fredlund H, (2007) A serological study of the role of Mycoplasma genitalium in pelvic inflammatory disease and ectopic pregnancy. Sex Transm Infect 83: 319-323.
43. Korte JE, Baseman JB, Cagle MP, Herrera C, Piper JM, et al. (2006) Cervicitis and genitourinary symptoms in women culture positive for Mycoplasma genitalium. Am J Reprod Immunol 55: 265-275.
44. Labbe AC, Frost E, Deslandes S, Mendonca AP, Alves AC, et al. (2002) Mycoplasma genitalium is not associated with adverse outcomes of pregnancy in Guinea-Bissau. Sex Transm Infect 78: 289-291.
45. Lawton BA, Rose SB, Bromhead C, Gaitanos LA, MacDonald EJ, et al. (2008) High prevalence of Mycoplasma genitalium in women presenting for termination of pregnancy. Contraception 77: 294-298.
46. Manhart LE, Critchlow CW, Holmes KK, Dutro SM, Eschenbach DA, et al. (2003) Mucopurulent cervicitis and Mycoplasma genitalium. J Infect Dis 187: 650-657.
47. Manhart LE, Mostad SB, Baeten JM, Astete SG, Mandaliya K, et al. (2008) High Mycoplasma genitalium organism burden is associated with shedding of HIV-1 DNA from the cervix. J Infect Dis 197: 733-736.
48. Mellenius H, Boman J, Lundqvist EN, Jensen JS, (2005) Mycoplasma genitalium should be suspected in unspecific urethritis and cervicitis. A study from Vasterbotten confirms the high prevalence of the bacteria. Lakartidningen 102: 3538 3540-3531.
49. Moi H, Reinton N, Moghaddam A, (2009) Mycoplasma genitalium in women with lower genital tract inflammation. Sex Transm Infect 85: 10-14.
50. Musatovova O, Baseman JB, (2009) Analysis identifying common and distinct sequences among Texas clinical strains of Mycoplasma genitalium. J Clin Microbiol 47: 1469-1475.
51. Pepin J, Labbe AC, Khonde N, Deslandes S, Alary M, et al. (2005) Mycoplasma genitalium: an organism commonly associated with cervicitis among west African sex workers. Sex Transm Infect 81: 67-72.
52. Ross JD, Brown L, Saunders P, Alexander S, (2009) Mycoplasma genitalium in asymptomatic patients: implications for screening. Sex Transm Infect 85: 436-437.
53. Short VL, Jensen JS, Nelson DB, Murray PJ, Ness RB, et al. (2010) Mycoplasma genitalium among young, urban pregnant women. Infect Dis Obstet Gynecol 2010: 984760.
54. Simms I, Eastick K, Mallinson H, Thomas K, Gokhale R, et al. (2003) Associations between Mycoplasma genitalium, Chlamydia trachomatis and pelvic inflammatory disease. J Clin Pathol 56: 616-618.
55. Tsunoe H, Tanaka M, Nakayama H, Sano M, Nakamura G, et al. (2000) High prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium in female commercial sex workers in Japan. Int J STD AIDS 11: 790-794.
56. Uno M, Deguchi T, Komeda H, Hayasaki M, Iida M, et al. (1997) Mycoplasma genitalium in the cervices of Japanese women. Sex Transm Dis 24: 284-286.
57. Spence D, Melville C, (2007) Vaginal discharge. BMJ 335: 1147-1151.
58. Marrazzo JM, Martin DH, (2007) Management of women with cervicitis. Clin Infect Dis 44 (Suppl 3): S102-S110.
59. Moller BR, Taylor-Robinson D, Furr PM, (1984) Serological evidence implicating Mycoplasma genitalium in pelvic inflammatory disease. Lancet 1: 1102-1103.
60. Westrom L, (1975) Effect of acute pelvic inflammatory disease on fertility. Am J Obstet Gynecol 121: 707-713.
61. McGowin CL, Spagnuolo RA, Pyles RB, (2010) Mycoplasma genitalium rapidly disseminates to the upper reproductive tracts and knees of female mice following vaginal inoculation. Infect Immun 78: 726-736.
62. Moller BR, Taylor-Robinson D, Furr PM, Freundt EA, (1985) Acute upper genital-tract disease in female monkeys provoked experimentally by Mycoplasma genitalium. Br J Exp Pathol 66: 417-426.
63. Taylor-Robinson D, Furr PM, Tully JG, Barile MF, Moller BR, (1987) Animal models of Mycoplasma genitalium urogenital infection. Isr J Med Sci 23: 561-564.
64. Mena LA, Mroczkowski TF, Nsuami M, Martin DH, (2009) A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men. Clin Infect Dis 48: 1649-1654.
65. Workowski KA, Berman S, (2010) Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 59: 1-110.
66. Ness RB, Soper DE, Holley RL, Peipert J, Randall H, et al. (2002) Effectiveness of inpatient and outpatient treatment strategies for women with pelvic inflammatory disease: results from the Pelvic Inflammatory Disease Evaluation and Clinical Health (PEACH) Randomized Trial. Am J Obstet Gynecol 186: 929-937.
67. Bjornelius E, Anagrius C, Bojs G, Carlberg H, Johannisson G, et al. (2008) Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial. Sex Transm Infect 84: 72-76.
68. Deguchi T, Yoshida T, Yokoi S, Ito M, Tamaki M, et al. (2002) Longitudinal quantitative detection by real-time PCR of Mycoplasma genitalium in first-pass urine of men with recurrent nongonococcal urethritis. J Clin Microbiol 40: 3854-3856.
69. Falk L, Fredlund H, Jensen JS, (2003) Tetracycline treatment does not eradicate Mycoplasma genitalium. Sex Transm Infect 79: 318-319.
70. Horner PJ, Gilroy CB, Thomas BJ, Naidoo RO, Taylor-Robinson D, (1993) Association of Mycoplasma genitalium with acute non-gonococcal urethritis. Lancet 342: 582-585.
71. Wikstrom A, Jensen JS, (2006) Mycoplasma genitalium: a common cause of persistent urethritis among men treated with doxycycline. Sex Transm Infect 82: 276-279.
72. Maeda SI, Tamaki M, Kojima K, Yoshida T, Ishiko H, et al. (2001) Association of Mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis. Sex Transm Dis 28: 472-476.
73. Jernberg E, Moghaddam A, Moi H, (2008) Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: an open study. Int J STD AIDS 19: 676-679.
74. Quayle AJ, (2002) The innate and early immune response to pathogen challenge in the female genital tract and the pivotal role of epithelial cells. J Reprod Immunol 57: 61-79.
75. McGowin CL, Popov VL, Pyles RB, (2009) Intracellular Mycoplasma genitalium infection of human vaginal and cervical epithelial cells elicits distinct patterns of inflammatory cytokine secretion and provides a possible survival niche against macrophage-mediated killing. BMC Microbiol 9: 139.
76. Ueno PM, Timenetsky J, Centonze VE, Wewer JJ, Cagle M, et al. (2008) Interaction of Mycoplasma genitalium with host cells: evidence for nuclear localization. Microbiology 154: 3033-3041.
77. McGowin CL, Ma L, Martin DH, Pyles RB, (2009) Mycoplasma genitalium-encoded MG309 activates NF-kappaB via Toll-like receptors 2 and 6 to elicit proinflammatory cytokine secretion from human genital epithelial cells. Infect Immun 77: 1175-1181.
78. Napierala Mavedzenge S, Weiss HA, (2009) Association of Mycoplasma genitalium and HIV infection: a systematic review and meta-analysis. AIDS 23: 611-620.