Mycoplasma genitalium among young adults in the United States: An emerging sexually transmitted infection

American Journal of Public Health

Volumn 97, Issue 6, 2007, Pages 1118-1125

  Manhart, Lisa E ^a,b   Holmes, King K ^b   Hughes, James P ^b   Houston, Laura S ^b   Totten, Patricia A ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHLAMYDIASIS; CONDOM; CONTRACEPTION; CONTROLLED STUDY; FEMALE; GONORRHEA; HUMAN; MAJOR CLINICAL STUDY; MALE; MYCOPLASMA GENITALIUM; PREVALENCE; RISK FACTOR; SEXUAL BEHAVIOR; SEXUAL INTERCOURSE; SEXUALLY TRANSMITTED DISEASE; TRICHOMONIASIS; UNITED STATES; URINALYSIS; BACTERIAL INFECTION; COMMUNICABLE DISEASE; CROSS-SECTIONAL STUDY; ISOLATION AND PURIFICATION; POISSON DISTRIBUTION; POLYMERASE CHAIN REACTION; QUESTIONNAIRE; SENSITIVITY AND SPECIFICITY;

ADULT; COMMUNICABLE DISEASES, EMERGING; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MYCOPLASMA GENITALIUM; MYCOPLASMA INFECTIONS; POISSON DISTRIBUTION; POLYMERASE CHAIN REACTION; PREVALENCE; QUESTIONNAIRES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SEXUAL BEHAVIOR; SEXUALLY TRANSMITTED DISEASES, BACTERIAL; UNITED STATES;

EID: 34250842522     PISSN: 00900036     EISSN: 15410048     Source Type: Journal    
DOI: 10.2105/AJPH.2005.074062     Document Type: Article

References (65)

1. Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance, 2003. Atlanta, Ga: US Dept of Health and Human Services; 2004.
2. Martin DH, Bowie WR. Urethritis in males. In: Holmes KK, Sparling PF, Mardh P-A, et al., eds. Sexually Transmitted Diseases. New York, NY: McGraw Hill; 1999: 833-845.
3. Holmes KK, Stamm WE. Lower genital tract infection in women. In: Holmes KK, Sparling PF, Mardh P-A, et al., eds. Sexually Transmitted Diseases. New York, NY: McGraw Hill; 1999:761-782.
4. Wasserheit JN. The significance and scope of reproductive tract infections among Third World women. Suppl Int J Gynecol Obstet. 1989;3:145-168.
5. Laga M, Manoka A, Kivuvu M, et al. Nonulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS. 1993;7:95-102.
6. Ghys PD, Fransen K, Diallo MO, et al. The associations between cervicovaginal HIV shedding, sexually transmitted diseases and immunosuppression in female sex workers in Abidjan, Cote d'Ivoire. AIDS. 1997; 11:F85-F93.
7. Cohen CR, Plummer FA, Mugo N, et al. Increased interleukin-10 in the the endocervical secretions of women with non-ulcerative sexually transmitted diseases: a mechanism for enhanced HIV-1 transmission? AIDS. 1999;13:327-332.
8. Ryan CA, Courtois BN, Hawes SE, Stevens CE, Eschenbach DA, Holmes KK. Risk assessment, symptoms, and signs as predictors of vulvovaginal and cervical infections in an urban US STD clinic: implications for use of STD algorithms. Sex Transm Infect. 1998;74(suppl 1):S59-S76.
9. Kiviat NB, Paavonen JA, Wolner-Hanssen P, et al. Histopathology of endocervical infection caused by Chlamydia trachomatis, herpes simplex virus, Trichomonas vaginalis, and Neisseria gonorrhoeae. Hum Pathol. 1990; 21:831-837.
10. Lavreys L, Chohan V, Overbaugh J, et al. Hormonal contraception and risk of cervical infections among HIV-1-seropositive Kenyan women. AIDS. 2004;18:2179-2184.
11. Tully JG, Taylor-Robinson D, Cole RM, Rose DL. A newly discovered mycoplasma in the human urogenital tract. Lancet. 1981;1:1288-1291.
12. Jensen JS, Uldum SA, Sondergard-Andersen J, Vuust J, Lind K. Polymerase chain reaction for detection of Mycoplasma genitalium in clinical samples. J Clin Microbiol. 1991;29:46-50.
13. Palmer HM, Gilroy CB, Furr PM, Taylor-Robinson D. Development and evaluation of the polymerase chain reaction to detect Mycoplasma genitalium. FEMS Microbiol Lett. 1991;61:199-203.
14. Ballard RC, Fehler HG, Htun Y, Radebe F, Jensen JS, Taylor-Robinson D. Coexistence of urethritis with genital ulcer disease in South Africa: influence on provision of syndromic management. Sex Transm Infect. 2002;78:274-277.
15. Bjornelius E, Lidbrink P, Jensen JS. Mycoplasma genitalium in nongonococcal urethritis-a study in Swedish male STD patients. Int J STD AIDS. 2000;11:292-296.
16. Keane FE, Thomas BJ, Gilroy CB, Renton A, Taylor-Robinson D. The association of Chlamydia trachomatis and Mycoplasma genitalium with non-gonococcal urethritis: observations on heterosexual men and their female partners. Int J STD AIDS. 2000;11:435-439.
17. Jensen JS. Mycoplasma genitalium: a cause of nongonococcal urethritis? Genitourin Med. 1994;70:363.
18. Mena L, Wang X, Mroczkowski TF, Martin DH. Mycoplasma genitalium infections in asymptomatic men and men with urethritis attending a sexually transmitted diseases clinic in New Orleans. Clin Infect Dis. 2002;35:1167-1173.
19. Janier M, Lassau F, Casin I, et al. Male urethritis with and without discharge: a clinical and microbiological study. Sex Transm Dis. 1995;22:244-252.
20. Horner PJ, Gilroy CB, Thomas BJ, Naidoo RO, Taylor-Robinson D. Association of Mycoplasma genitalium with acute non-gonococcal urethritis. Lancet. 1993;342:582-585.
21. Totten PA, Schwartz MA, Sjostrom KE, et al. Association of Mycoplasma genitalium with nongonococcal urethritis in heterosexual men. J Infect Dis. 2001;183:269-276.
22. Pépin J, Sobéla F, Deslandes S, et al. Etiology of urethral discharge in West Africa: the role of Mycoplasma genitalium and Trichomonas vaginalis. Bull World Health Organ. 2001;79:118-126.
23. Taylor-Robinson D, Furr PM, Hanna NF. Microbiological and serological study of non-gonococcal urethritis with special reference to Mycoplasma genitalium. Genitourin Med. 1985;61:319-324.
24. Maeda S, Tamaki M, Nakano M, Uno M, Deguchi T, Kawada Y. Detection of Mycoplasma genitalium in patients with urethritis. J Urol. 1998;159:405-407.
25. Uno M, Deguchi T, Komeda H, et al. Mycoplasma genitalium in the cervices of Japanese women. Sex Transm Dis. 1997;24:284-286.
26. Manhart LE, Critchlow CW, Holmes KK, et al. Mucopurulent cervicitis and Mycoplasma genitalium. J Infect Dis. 2003;187:650-657.
27. Falk L, Fredlund H, Jensen JS. Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection. Sex Transm Infect. 2005;81:73-78.
28. Anagrius C, Loré B. Association of Mycoplasma genitalium with cervicitis and female urethritis. ISSTDR Congress 2003; July 27-30, 2003. Ottawa Canada: Abstract #0732.
29. Pepin J, Labbe AC, Khonde N, et al. Mycoplasma genitalium: an organism commonly associated with cervicitis among west African sex workers. Sex Transm Infect. 2005;81:67-72.
30. Cohen CR, Manhart LE, Bukusi EA, et al. Association between Mycoplasma genitalium and acute endometritis. Lancet. 2002;359:765-766.
31. Simms I, Eastick K, Mallinson H, et al. Associations between Mycoplasma genitalium, Chlamydia trachomatis, and pelvic inflammatory disease. Sex Transm Infect. 2003;79:154-156.
32. Clausen HF, Fedder J, Drasbek M, et al. Serological investigation of Mycoplasma genitalium in infertile women. Hum Reprod. 2001;16:1866-1874.
33. Manhart LE, Aral SO, Holmes KK, et al. Influence of study population on the identification of risk factors for sexually transmitted diseases using a case-control design: the example of gonorrhea. Am J Epidemiol. 2004; 160:393-402.
34. Bearman PS, Jones J, Udry JR. The National Longitudinal Study of Adolescent Health: study design. Available at http://www.cpc.unc.edu/projects/ addhealth/design.html. Accessed February 13, 2007.
35. Brookmeyer R, Gail M. AIDS Epidemiology: A Quantitative Approach. New York, NY: Oxford University Press; 1994.
36. Wroblewski JK, Manhart LE, Dickey KA, Hudspeth M, Totten PA. Comparison of transcription-mediated amplification and PCR assay results for various genital specimen types for detection of Mycoplasma genitalium. J Clin Microbiol. 2006;44:3306-3312.
37. Dutro SM, Hebb JK, Garin CA, Hughes JP, Kenny GE, Totten PA. Development and performance of a microwell-plate-based polymerase chain reaction assay for Mycoplasma genitalium. Sex Transm Dis. 2003;30:756-763.
38. The Add Health Biomarker Team. Biomarkers in Wave III of the Add Health Study. Available at: http://www.cpc.unc.edu/projects/addhealth/files/biomark. pdf. Accessed February 13, 2007..
39. Miller WC, Ford CA, Morris M, et al. Prevalence of chlamydial and gonococcal infections among young adults in the United States. JAMA. 2004;291:2229-2236.
40. Kaydos-Daniels SC, Miller WC, Hoffman I, et al. Validation of a urine-based PCR-enzyme-linked immunosorbent assay for use in clinical research settings to detect Trichomonas vaginalis in men. J Clin Microbiol. 2003;41:318-323.
41. Kaydos-Daniels SC, Miller WC, Hoffman I, et al. The use of specimens from various genitourinary sites in men to detect Trichomonas vaginalis infection. J Infect Dis. 2004;189:1926-1931.
42. Weaver BA, Feng Q, Holmes KK, et al. Evaluation of genital sites and sampling techniques for detection of human papillomavirus DNA in men. J Infect Dis. 2004;189:677-685.
43. Carolina Population Center. Add Health Study Code Books. Available at: http://www.cpc.unc.edu/addhealth/codebooks.html. Accessed February 11, 2007.
44. Miller WC, Swygard H, Hobbs MM, et al. The prevalence of trichomoniasis in young adults in the United States. Sex Transm Dis. 2005;32:593-598.
45. Taylor-Robinson D, Gilroy CB, Jensen JS. The biology of Mycoplasma genitalium. Venereology. 2000;13:119-126.
46. Keane FE, Thomas BJ, Gilroy CB, Renton A, Taylor-Robinson D. The association of Mycoplasma hominis, Ureaplasma urealyticum and Mycoplasma genitalium with bacterial vaginosis: observations on heterosexual women and their male partners. Int J STD AIDS. 2000;11:356-360.
47. Horner P, Thomas B, Gilroy CB, Egger M, Taylor-Robinson D. Role of Mycoplasma genitalium and Ureaplasma urealyticum in acute and chronic nongonococcal urethritis. Clin Infect Dis. 2001;32:995-1003.
48. Grosskurth H, Mosha F, Todd J, et al. Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial. Lancet. 1995;346:530-536.
49. Uno M, Deguchi T, Saito A, Yasuda M, Komeda H, Kawada Y. Prevalence of Mycoplasma genitalium in asymptomatic men in Japan. Int J STD AIDS. 1997;8:259-260.
50. Chandeying V, Skov S, Duramad P, Makepeace B, Ward M, Khunigij P. The prevalence of urethral infections amongst asymptomatic young men in Hat Yai, southern Thailand. Int J STD AIDS. 2000;11:402-405.
51. Cohen CR, Mugo NR, Astete SG, et al. Detection of Mycoplasma genitalium in women with laparascopically diagnosed acute salplingitis. Sex Transm Infect. 2005;81:463-466.
52. Gambini D, Decleva I, Lupica L, Ghislanzoni M, Cusini M, Alessi E. Mycoplasma genitalium in males with nongonococcal urethritis: prevalence and clinical efficacy of eradication. Sex Transm Dis. 2000;27:226-229.
53. Falk L, Fredlund H, Jensen JS. Tetracycline treatment does not eradicate Mycoplasma genitalium. Sex Transm Infect. 2003;79:318-319.
54. Johannisson G, Enstrom Y, Lowhagen GB, et al. Occurrence and treatment of Mycoplasma genitalium in patients visiting STD clinics in Sweden. Int J STD AIDS. 2000;11:324-326.
55. Maeda SI, Tamaki M, Kojima K, et al. Association of Mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis. Sex Transm Dis. 2001;28:472-476.
56. Bjornelius E, Anagrius C, Bojs G, et al. Mycoplasma genitalium: when to test and treat. Present status in Scandinavia. ISSTDR Congress; July 27-30, 2003; Ottawa, Canada. Abstract 0388.
57. Mroczkowski TF, Mena LA, Nsuami M, Martin DH. A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium (MG) positive urethritis in men. Paper presented at: 16th Biennial Meeting of the International Society for Sexually Transmitted Diseases Research (ISSTDR); July 10-13, 2005; Amsterdam, the Netherlands. Abstract WP-107.
58. Laumann EO, Youm Y. Racial/ethnic group differences in the prevalence of sexually transmitted diseases in the United States: a network explanation. Sex Transm Dis. 1999;26:250-261.
59. Adimora AA, Schoenbach VJ, Bonas DM, Martinson FE, Donaldson KH, Stancil TR. Concurrent sexual partnerships among women in the United States. Epidemiology. 2002;13:320-327.
60. Adimora AA, Schoenbach VJ, Martinson FE, Donaldson KH, Fullilove RE, Aral SO. Social context of sexual relationships among rural African Americans. Sex Transm Dis. 2001;28:69-76.
61. Zenilman JM, Weisman CS, Rompalo AM, et al. Condom use to prevent incident STDs: the validity of self-reported condom use. Sex Transm Dis. 1995;22:15-21.
62. Van Der Pol B, Ferrero DV, Buck-Barrington L, et al. Multicenter evaluation of the BDProbeTec ET System for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine specimens, female endocervical swabs, and male urethral swabs. J Clin Microbiol. 2001;39:1008-1016.
63. Martin DH, Cammarata C, Van Der Pol B, et al. Multicenter evaluation of AMPLICOR and automated COBAS AMPLICOR CT/NG tests for Neisseria gonorrhoeae. J Clin Microbiol. 2000;38:3544-3549.
64. Smith K, Harrington K, Wingood G, Oh MK, Hook EW III, DiClemente RJ. Self-obtained vaginal swabs for diagnosis of treatable sexually transmitted diseases in adolescent girls. Arch Pediatr Adolesc Med. 2001;155:676-679.
65. Hsieh YH, Howell MR, Gaydos JC, McKee KT Jr, Quinn TC, Gaydos CA. Preference among female Army recruits for use of self-administrated vaginal swabs or urine to screen for Chlamydia trachomatis genital infections. Sex Transm Dis. 2003;30:769-773.