Hepatoprotective effects of vitamin e/selenium against malathion-induced injuries on the antioxidant status and apoptosis-related gene expression in rats

Journal of Toxicological Sciences

Volumn 36, Issue 3, 2011, Pages 285-296

  Aboul Soud, Mourad A M ^a,b   Al Othman, Abdulaziz M ^c   El Desoky, Gaber E ^a,b   Al Othman, Zeid A ^a   Yusuf, Kareem ^a   Ahmad, Javed ^a   Al Khedhairy, Abdulaziz A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b CAIRO UNIVERSITY   (Egypt)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Antioxidant enzymes; Apoptosis related genes; Malathion; Oxidative damage; Real time PCR; Selenium; tocopherol

Indexed keywords

ACETYLCHOLINESTERASE; ALPHA TOCOPHEROL; CASPASE 3; CASPASE 9; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALATHION; PROTEIN P53; SELENIUM; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEGENERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; LD 50; LIPID PEROXIDATION; LIVER LEVEL; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; LONG TERM EXPOSURE; MALE; MORNING DOSAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RAT; UPREGULATION;

RATTUS;

EID: 79958062794     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.36.285     Document Type: Article

References (70)

1. Aebi, H. (1983): Catalase. In Methods of Enzymatic Analysis. (Bergmeyer, H.U. ed.), pp.227-282, Weinheim and Academic Press.
2. Agar, E., Demir, S., Amanvermez, R., Boşnak, M., Ayyildiz, M. and Celik, C. (2003): The effects of ethanol consumption on the lipid peroxidation and glutathione levels in the right and left brains of rats. Int. J. Neurosci., 113, 1643-1652.
3. Akhtar, M.S., Farooq, A.A. and Mushtaq, M. (2009): Serum concentrations of copper, iron, zinc and selenium in cyclic and anoestrus Nili-Ravi buffaloes kept under farm conditions. Pak. Vet. J., 29, 47-48.
4. Al-Roba, A.A., Aboul-Soud, M.A.M., Ahmed, A.M. and Al- Khedhairy, A.A. (2011): The gene expression of caspasses is upregulated during the signaling response of Aedes caspius against larvicidal bacteria. Afr. J. Biotechnol., 10, 225-233.
5. Ashakumari, L. and Vijayammal, P.L. (1996): Additive effect of alcohol and nicotine on lipid peroxidation and antioxidant defence mechanism in rats. J. Appl. Toxicol., 16, 305-308.
6. Aslam, F., Khan, A., Khan, M.Z., Sharaf, S., Gul, S.T. and Saleemi, M.K. (2010): Toxico- pathological changes induced by cypermethrin in broiler chicks: their attenuation with Vitamin E and selenium. Exp. Toxicol. Pathol., 62, 441-450.
7. Banerjee, B.D., Seth, V., Bhattacharya, A., Pasha, S.T. and Chakraborty, A.K. (1999): Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers. Toxicol. Lett., 107, 33-47.
8. Bebe, F.N. and Panemangalore, M. (2003): Exposure to low doses of endosulfan and chlorpyrifos modifies endogenous antioxidants in tissues of rats. J. Environ. Sci. Health B, 38, 349-363.
9. Bradford, M.M. (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
10. Buyukokuroglu, M.E., Cemek, M., Yurumez, Y., Yavuz, Y. and Aslan, A. (2008): Antioxidative role of melatonin in organophosphate toxicity in rats. Cell Biol. Toxicol., 24, 151-158.
11. Calaf, G.M. and Roy, D. (2008): Cancer genes induced by malathion and parathionin the presence of estrogen in breast cells. Int. J. Mol. Med., 21, 261-268.
12. Chowdhury, B.A., Friel, J.K. and Chandra R.K. (1987): Cadmiuminduced immunopathology is prevented by zinc administration in mice. J. Nutr., 117, 1788-1794.
13. Costa L.G. (2006): Current issues in organophosphate toxicology. Clin. Chim. Acta, 366, 1-13.
14. El-Demerdash, F.M., Yousef, M.I., Kedwany, F.S. and Baghdadi, H.H. (2004): Role of alpha-tocopherol and beta-carotene in ameliorating the fenvalerate-induced changes in oxidative stress, hemato-biochemical parameters, and semen quality of male rats. J. Environ. Sci. Health B, 39, 443-459.
15. El-Gharieb, M.A., El-Masry, T.A., Emara, A.M. and Hashem, M.A. (2010): Potential hepatoprotective effects of vitamin E and Nig- ella sativa oil on hepatotoxicity induced by chronic exposure to malathion in human and male albino rats. Toxicol. Environ. Chem., 92, 391-407.
16. Ellman, G.L., Courney, K.D., Andres, V.Jr. and Featherstone, R.M. (1961): A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol., 7, 88-95.
17. El-Shenawy, N.S., El-Salmy, F., Al-Eisa, R.A. and El-Ahmary, B. (2010): Amelioratory effect of vitamin E on organophosphorus insecticide diazinon-induced oxidative stress in mice liver. Pestic. Biochem. Phys., 96, 101-107.
18. Evstigneeva, R.P., Volkov, I.M. and Chudinova, V.V. (1998): Vitamin E as a universal antioxidant and stabilizer of biological membranes. Membr. Cell Biol., 12, 151-172.
19. Falck, F., Ricci, A., Wolff, M.S., Godbold, J. and Deckers, P. (1992): Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch. Environ. Health, 47, 143-146.
20. Folch, J., Alvira, D., Lopez-Querol, M., Tajes, M., Sureda F.X., Forsby, A., Rimbau, V., Camins, A. and Pallas, M. (2010): Evaluation of transcriptional activity of caspase-3 gene as a marker of acute neurotoxicity in rat cerebellar granular cells. Toxicol. In Vitro, 24, 465-471.
21. Gaines, T.B. (1960): The acute toxicity of pesticides to rats. Toxicol. Appl. Pharmacol., 2, 88-99.
22. Gokcimen, A., Gulle, K., Demirin, H., Bayram, D., Kocak, A. and Altuntas, I. (2007): Effects of diazinon at different doses on rat liver and pancreas tissues. Pestic. Biochem. Phys., 87, 103-108.
23. Gultekin, F., Ozturk, M. and Akdogan, M. (2000): The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro). Arch. Toxicology, 74, 533-538.
24. Halliwell, B. and Gutteridge, J.M.C. (1999): Free radicals in biology and medicine, Oxford University Press, London, p. 936.
25. Hazarika, A., Sarkar, S.N., Hajare, S., Kataria, M. and Malik, J.K. (2003): Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study. Toxicology, 185, 1-8.
26. Jalili, Sh., Ilkhanipour, M., Heydari, R. and Farshid, A.A. (2007): The effects of vitamin E on endosulfan induced oxidative stress in rat heart. Pak. J. Nutr., 6, 375-380.
27. Kakkar, P., Das, B. and Viswanathan, P.N. (1984): A modified spectrophotometric assay of superoxide dismutase. Indian J. Biochem. Biophys., 21, 130-132.
28. Kalender, S., Uzun, F.G., Durak, D., Demir, F. and Kalender, Y. (2010): Malathion-induced hepatotoxicity in rats: The effects of vitamins C and E. Food Chem. Toxicol., 48, 633-638.
29. Kehrer, J.P., Jones, D.P., Lemasters, J.J., Farber, J.L. and Jaeschke, H. (1990): Contemporary issue in toxicology: mechanisms of hypoxic cell injury. Toxicol. Appl. Pharmacol., 106, 165-178.
30. Khan, S.M. and Kour, G. (2007): Subacute oral toxicity of chlorpyrifos and protective effect of green tea extract. Pest. Biochem. Physiol., 89, 118-123.
31. Klaasen, C.D. (1990): Nonmetallic environmental toxicants: air pollutants, solvents and vapors, and pesticides. In The Pharmacological Basis of Therapeutics (Goodman Gilman, A., Rall, T.W., Nies, A.S. and Taylor, P. eds.), pp.1615-1635, New York: Pergamon Press Inc.
32. Kramer, J.A. and Kolaja, K.L. (2002): Toxicogenomics: an opportunity to optimise drug development and safety evaluation. Expert Opin. Drug Saf., 1, 275-286.
33. Kruman, I.I., Wersto, R.P., Cardozo-Pelaez, F., Smilenov, L., Chan, S.L., Chrest, F.J., Emokpae, R.Jr., Gorospe, M. and Mattson, M.P. (2004): Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron, 41, 549-561.
34. Livak, K.J. and Schmittgen, T.D. (2001): Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods, 25, 402-408.
35. Machlin, L.J. (1991): Vitamin E. In Handbook of Vitamins (L.J. Machlin ed.), pp.99-145, Marcel Dekker, New York.
36. Monteiro, D.A., de Almeida, J.A., Rantin, F.T. and Kalinin A.L. (2006): Oxidative stress biomarkers in the freshwater characid fish, Brycon cephalus, exposed to organophosphorus insecticideFolisuper 600 (methyl parathion). Comp. Biochem. Physiol. C Toxicol. Pharmacol., 143, 141-149.
37. Morowati, M. (1997): Inhalation toxicity studies of thimet (phorate) in male swiss albino mouse, mus musculus: I. Hepatotoxicity. Environ. Pollut., 96, 283-288.
38. National Cancer Institute (1978): Bioassay of malathion for possible carcinogenicity. Technical report series no. 24. DHEW Publication no. NIH, 780-824.
39. Ohkawa, H., Ohishi, N. and Yagi, K. (1979): Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95, 351-358.
40. Packer, L. (1991): Protective role of vitamin E in biological systems. Am. J. Clin. Nutr., 53, 1050S-1055S.
41. Paglia, D.E. and Valentine, W.N. (1967): Studies on the qualitative and quantitative characterization of erythrocyte glutathione peroxidase. Lab. Clin. Med., 70, 158-169.
42. Patra, R.C., Swarup, D. and Divedi, S.K. (2001): Antioxidant effects of alpha tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicol., 162, 81-88.
43. Peixoto, F., Vicente, J. and Madeira, V.M. (2004): A comparative study of plant and animal mitochondria exposed to paraquat reveals that hydrogen peroxide is not related to the observed toxicity. Toxicol. In Vitro, 18, 733-739.
44. Pham-Huy, L.I., He, H. and Pham-Huy, C. (2008): Free radicals, antioxidants in disease and health. Int. J. Biomed. Sci., 4, 89-96.
45. Pierrefiche, G. and Laborit, H. (1995): Oxygen free radicals, melatonin, and aging. Exp. Gerontol., 30, 213-227.
46. Ramiro-Puig, E., Urpi-Sarda, M., Perez-Cano, F.J., Franch, A., Castellote, C., Andres-Lacueva, C., Izquierdo-Pulido, M. and Castell, M. (2007): Cocoa-enriched diet enhances antioxidant enzyme activity and modulates lymphocyte composition in thymus from young rats. J. Agric. Food Chem., 55, 6431-6438.
47. Ramos, S. (2008): Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol. Nutr. Food Res., 52, 507-526.
48. Rezg, R., Mornagui, B., El-Fazaa, S. and Gharbi, N. (2008): Caffeic acid attenuates malathion induced metabolic disruption in rat liver, involvement of acetylcholinesterase activity. Toxicology, 250, 27-31.
49. Sakhi, S., Sun, N., Wing, L.L., Mehta, P. and Schreiber, S.S. (1996): Nuclear accumulation of p53 protein following kainic acidinduced seizures. Neuroreport, 7, 493-496.
50. Savolainen, K. (2001).Understanding the toxic actions of organophosphates. In Handbook of Pesticide Toxicology vol. 2 (Krieger, R.I. ed.), pp.1013-1041, Academic Press, New York.
51. Sayim, F. (2007): Dimethoate-induced biochemical and histopathological changes in the liver of rats. Exp. Toxicol. Pathol., 59, 237-243.
52. Schwenke, D.C. and Behr, S.R. (1998): Vitamin E combined with selenium inhibits atherosclerosis in hypercholesterolemic rabbits independently of effects on plasma cholesterol concentrations. Circ. Res., 83, 366-377.
53. Sedlak, J. and Lindsay, R.H. (1968): Estimation of total, proteinbound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem., 25, 192-205.
54. Sies, H. and Murphy, M.E. (1991): Role of tocopherols in the protection of biological systems against oxidative damage. J. Photochem. Photobiol. B, 8, 211-218.
55. Smith, W.W., Gorospe, M. and Kusiak J.W. (2006): Signaling mechanisms underlying Abeta toxicity: potential therapeutic targets for Alzheimer's disease. CNS Neurol. Disord. Drug Targets, 5, 355-361.
56. Stajn, A., Zikić, R.V., Ognjanović, B., Saicić, Z.S., Pavlović, S.Z., Kostić, M.M. and Petrović, V.M. (1997): Effect of cadmium and selenium on the antioxidant defense system in rat kidneys. Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol., 117, 167-172.
57. Taylor, P. (1990): Anticholinesterase agents. In The Pharmacological Basis of Therapeutics (Goodman Gilman, A., Rall, T.W., Nies, A.S. and Taylor, P. eds.), pp.131-147, New York: Pergamon Press Inc.
58. Thomson, C.D. (2004): Assessment of requirements for selenium and adequacy of selenium status: a review. Eur. J. Clin. Nutr., 58, 391-402.
59. Uberti, D., Belloni, M., Grilli, M., Spano, P. and Memo, M. (1998): Induction of tumour suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids. Eur. J. Neurosci., 10, 246-254.
60. Ulrich, R. and Friend, S.H. (2002): Toxicogenomics and drug discovery: will new technologies help us produce better drugs? Nat. Rev. Drug Discov., 1, 84-88.
61. Verma, R.S., Mehta, A. and Srivastava, N. (2007): In vivo chlorpyrifos induced oxidative stress: attenuation by antioxidant vitamins. Pestic. Biochem. Phys., 88, 191-196.
62. Verma, R.S. and Srivastava, N. (2001): Chlorpyrifos induced alterations in levels of thiobarbituric acid reactive substances and glutathione in rat brain. Indian J. Exp. Biol., 39, 174-177.
63. Waters, M.D., Jackson, M. and Lea, I. (2010): Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods. Mutat. Res., 705, 184-200.
64. Yang, M.C., McLean, A.J., Rivory, L.P. and Le Couteur, D.G. (2000): Hepatic disposition of neurotoxins and pesticides, Pharmacol. Toxicol., 87, 286-291.
65. Yee, J.K. and Ima-Nirwana, S. (1998): Palm vitamin E protects against ferric nitrilotriacetate-induced impairment of bone calcification. Asia Pac. J. Pharmacol., 13, 1-7.
66. Yehia, M.A., El-Banna, S.G. and Okab, A.B. (2007): Diazinon toxicity affects histophysiological and biochemical parameters in rabbits. Exp. Toxicol. Pathol., 59, 215-225.
67. Yousef, M.I., Awad, T.I. and Mohamed, E.H. (2006): Deltamethrininduced oxidative damage and biochemical alterations in rat and its attenuation by vitamin E. Toxicology, 227, 240-247.
68. Xiang, H., Hochman, D.W., Saya, H., Fujiwara, T., Schwartzkroin, P.A. and Morrison, R.S. (1996): Evidence for p53-mediated modulation of neuronal viability. J. Neurosci., 16, 6753-6765.
69. Xu, H., Watkins, B.A. and Seifert, M.F. (1995). Vitamin E stimulates trabecular bone formation and alters epiphyseal cartilage morphometry. Calcified Tissue Int., 57, 293-300.
70. Zhou, J.F., Xu, G.B. and Fang, W.J. (2002): Relationship between acute organophosphorus pesticide poisoning and damages induced by free radicals, Biomed. Environ. Sci., 15, 177-186.