Anti-ulcerogenic and proton pump (H+, K+ ATPase) inhibitory activity of Kolaviron from Garcinia kola Heckel in rodents

Indian Journal of Experimental Biology

Volumn 49, Issue 6, 2011, Pages 461-468

  Onasanwo, Samuel A ^a,b   Singh, Neetu ^b   Olaleye, Samuel B ^a   Palit, Gautam ^b  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Anti secretory; Cyto protection; Garcinia kola; H+,K+ ATPase; Kolaviron; Omeprazole; Peptic ulcer

Indexed keywords

ANTIULCER AGENT; FLAVONOID; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; KOLAVIRON; PLANT EXTRACT;

ANIMAL; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GARCINIA KOLA; ISOLATION AND PURIFICATION; MEDICINAL PLANT; RAT; SECRETION; SPRAGUE DAWLEY RAT; STOMACH JUICE; STOMACH ULCER;

ANIMALS; ANTI-ULCER AGENTS; FLAVONOIDS; GARCINIA KOLA; GASTRIC JUICE; H(+)-K(+)-EXCHANGING ATPASE; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

GARCINIA KOLA; RATTUS; RODENTIA;

EID: 79958061572     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Peskar B M & Maricic N, Role of prostaglandins in gastroprotection, Dig Dis Sci, 43 (1998) 23S.
2. Toma W, Hiruma-Lima C A, Guerrero R O & Souza Brito A R M, Preliminary studies of Mammea americana L. (Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer models in mice, Phytomedicine, 12 (2005) 345.
3. Belaiche J, Burette A, De-Vos M, Louis E, Huybrechts M & Deltenre M, Study Group of NSAID-GI complications, Observational survey of NSAID-related upper gastrointestinal adverse events in Belgium, Acta Gastroenterologic Belgiam, 65 (2002) 65.
4. Soll A H, Pathogenesis of peptic ulcer and implications for therapy, N Engl J Med, 322(13) (1990) 909.
5. Bighetti A E, Antônio M A, Kohn L K, Rehder V L G, Foglio M A, Possenti A, Vilela L & Carvalho J E, Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip, Phytomedicine, 12 (2005) 72.
6. Lee C K, Park K K, Lim S S, Park J H & Chung W Y, Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer, Biol Pharm Bull, 30 (2007) 2191.
7. Gordana S C, Sonja M D, Jasna M C & Vesna T T, Antioxidant properties of marigold extracts, Food Res Int, 37 (2004) 643.
8. Iwu M M, Igboko O A, Elekwa O K & Tempesta M S, Prevention of thioacetamide-induced hepatotoxicity by biflavanones of Garcinia kola, Phytother Res, 4 (1990a) 157.
9. Adaramoye O A & Medeiros I A, Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds in rat superior mesenteric arteries, J Smooth Muscle Res, 45 (2009) 39.
10. Iwu M M, Traditional Igbo medicine, Nsukka: Institute of African studies (University of Nigeria) 1982, 104.
11. Iwu M M, Igboko O A, Okunji C O & Tempesta M S, Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola, J Pharm Pharmacol, 42 (1990b) 290.
12. Iwu M M, Antihepatotoxicity of Garcinia kola seeds, Experientia, 41 (1985) 699.
13. Akintonwa A & Essien A R, Protective effects of Garcinia kola seed extract against paracetamol-induced hepatotoxicity in rats, J Ethnopharmacol, 29 (1990) 207.
14. Olaleye S B, Farombi E O, Adewoye E O, Onasanwo S A, Owoyele B V & Elegbe R A, Analgesic and antiinflammatory effects of kolaviron (a Garcinia kola seed extract), Afr J Biomed Res, 3 (2000) 163.
15. Farombi E O, Tahnteng J G, Agboola O, Nwankwo J O & Emerole G O, Chemoprevention of 2-acetyl aminofluoreneinduced hepatotoxicity and lipid peroxidation in rats by kolaviron-a Garcinia kola seed extract, Food Chem Toxicol, 38 (2000) 535.
16. Farombi E O, Adepoju B F, Ola-Davies O E & Emerole G O, Inhibition of aflatoxin B1-induced clastogenicity and hepatocarcinogenicity by kolaviron (Garcinia biflavanones) in rats, Mutat Res, 483 (2001) S106.
17. Farombi E O, Akanni O O & Emerole G O, Antioxidative and scavenging activities of kolaviron in vitro, Pharm Biol, 40 (2002a) 107.
18. Farombi E O, Akuru T O & Alabi M C, Kolaviron modulates cellular redox status and impairment of membrane protein activities by potassium bromate (KBrO3) in rats, Pharmacol Res, 45 (2002b) 63.
19. Adaramoye O A & Adeyemi E O, Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocininduced diabetes mellitus rats, J Pharm Pharmacol, 18 (2006b) 121.
20. Braide V B & Grill V, The histological alterations by a diet containing seeds of Garcinia kola: Effect on liver, kidney and intestine in the rat, Gegenbaurs Morphol Jahrb, 136 (1990) 95.
21. Ibironke G F, Olaleye S B, Balogun O & Aremu D A, Effect of diets containing seeds of Garcinia kola (Heckel) on gastric acidity and experimental ulceration in rats, Phytother Res, 11 (1997) 312.
22. Olaleye S B & Farombi E O, Attenuation of Indomethacinand HCl/Ethanol-Induced Oxidative Gastric Mucosa Damage in Rats by Kolaviron, A Natural Biflavonoid of Garcinia kola Seed, Phytother Res, 20 (2006) 14.
23. Cotterhill P J, Scheinmann F & Stenhouse T A, Extractives from Guttiferae: Kolaflavanone, a new biflavanone from the nuts of Garcinia kola Heckel, J Chem Soc Perkin Trans, 1 (1978) 246.
24. Farombi E O, Mechanisms for the hepatoprotective action of kolaviron: Studies on hepatic enzymes, microsomal lipids and lipid peroxidation in carbon tetrachloride-treated rats, Pharmacol Res, 42 (2000) 75.
25. Okoko T, Chromatographic characterisation, in vitro antioxidant and free radical scavenging activities of Garcinia kola seeds, Afr J Biotechnol, 8(24) (2009) 7133.
26. Süleyman H, Demirezer L Ö, Büyükokuroglu M E, Akcay M F, Gepdiremen A, Banoglu Z N & Göcer F, Antiulcerogenic effect of Hippophae rhamnoides L, Phytother Res, 15 (2001) 625.
27. Suleyman H, Akcay F & Altinkaynak K, The effect of nimesulide on the indomethacin and ethanol induced gastric ulcer in rats, Pharm Res, 45 (2002) 155.
28. Goel R K, Das D G & Sanyal A K, Effect of vegetable banana powder on changes induced by ulcerogenic agents in dissolved mucosubstances of gastric juice, Indian J Gastroenterol, 4 (1985) 49.
29. Shay M, Kamarov S A, Fels D, Meraaze D, Grueinstein H & Siplet H, A simple method for the uniform production of gastric ulceration in the rat, Gastroenterology, 5 (1945) 43.
30. Srivastava S K, Nath C, Gupta M B, Vrat S, Sinha J N, Dhawan K N & Gupta G P, Protection against gastric ulcer by verapamil, Pharmacological Research, 23 (1991) 81.
31. Anoop A & Jegadeesan M, Biochemical studies on the antiulcerogenic potential of Hemidesmus indicus R. Br. var. indicus, J Ethnopharmacol, 84 (2003) 149.
32. Debnath P K, Gode K D, Das D G & Sanyal A K, Effects of propanolol on gastric secretion in albino rats, Br J Pharmacol, 51(2) (1974) 213.
33. Crowther R S & Wetmore R F, Fluorometric assay of 0-linked glycoprotein by reaction with 2 cyanoacetamide, Anal Biochem, 163 (1987) 170.
34. Berglindh T, Gastric glands and cells: Preparation and in vitro methods, Methods in enzymology, 192 (1990) 93.
35. Bradford M, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal Biochem, 72 (1976) 248.
36. Sanui H, Measurement of inorganic orthophosphate in biological materials: Extraction properties of Butyl Acetate, Analytical Biochemistry, 60 (1974) 489.
37. Lakshmi V, Singh N, Shrivastva S, Mishra S K, Dharmani P, Mishra V & Palit G, Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats, Phytomedicine, 7(8-9) (2010) 569.
38. Singh N, Shukla N, Singh P, Sharma R, Rajendran S M, Maurya R & Palit G, Verbascoside isolated from Tectona grandis mediates gastric protection in rats via inhibiting proton pump activity, Fitoterapia, 81(7) (2010) 755.
39. Dharmani P, Mishra P K, Maurya R, Chauhan V S & Palit G, Desmodium gangeticum: A potent anti-ulcer agent, Indian J Exp Biol, 43 (2005) 517.
40. Dharmani P, Kuchibhotla V K, Maurya R, Srivastava S, Sharma S & Palit G, Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn, J Ethnopharmacol, 93 (2004) 197.
41. Sairam K, Priyambada S, Aryya N C & Goel R K, Gastroduodenal ulcer protective activity of Asparagus racemosus: An experimental, biochemical and histological study, J Ethnopharmacol, 86 (2003) 1.
42. Borrelli F & Izzo A A, The Plant Kingdom as a Source of Anti-ulcer Remedies, Phytother Res, 14 (2000) 581.
43. Zayachkivska O S, Konturek S J, Drozdowicz D, Konturek P C, Brzozowski T & Ghegotsky M R, Gastroprotective effects of flavonoids in plant extracts, J Physiol Pharmacol, 56(1) (2005) 219.
44. Pfeiffer C J, Mucosal surface convolutions. Cellular aggregates observed on the enteric surface of various species, Biol Gastroenterol, 3(3) (1971) 225.
45. Jainu M, Srinivasulu C & Devi S, Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: Possible mechanism for the inhibition of acid formation, J Ethnopharmacol, 104 (2006) 156.
46. Goel R K & Bhattacharya S K, Gastroduodenal mucosal defense and mucosal protective agents, Indian J Exp Biol, 29 (1991) 701.
47. Baggio C H, Freitas C S, Rieck L & Marques M C A, Gastroprotective effects of a crude extract of Baccharis illinita DC in rats, Pharm Res, 47(1) (2003) 93.
48. Davenport H W, Warner H A & Code C F, Functional significance of gastric mucosal barrier to sodium, Gastroenterology, 54(4) (1968) S709.
49. Terano A, Hiraishi H, Ota S, Shiga J & Sugimoto T, Role of superoxide and hydroxyl radicals in rat gastric mucosal injury induced by ethanol, Gastroenterol, 24(5) (1989) 488.
50. Olaleye S B & Farombi E O, Attenuation of Indomethacinand HCl/Ethanol-Induced Oxidative Gastric Mucosa Damage in Rats by Kolaviron, A Natural Biflavonoid of Garcinia kola Seed, Phytother Res, 20 (2006) 14.
51. Robert A, Nezamis J E, Lancester C & Hanchar A J, Cytoprotection by prostaglandins in rats, Gastroenterol, 77 (1979) 433.
52. Bhargava K P, Gupta M B & Tangri K K, Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone, Eur J Pharmacol, 22(2) (1973) 191.
53. Scheiman J M, In: Dubais R N, Giardiello F M (Eds.), NSAIDs, Eicosonoids and the Gastroenteric Tract (Saunders, Philadelphia) 25 (1996) 279.
54. Adaramoye O A, Farombi E O, Adeyemi E O & Emerole G O, Inhibition of human low density lipoprotein oxidation by flavonoids of Garcinia kola seeds, Pak J Med Sci, 21 (2005a) 331.
55. Kyogoku K, Hatayama K, Yokomori S, Saziki R, Nakane S, Sasajima M, Sawada J, Ohzeki M & Tanaka I, Anti-ulcer effect of isoprenyl flavonoids. II. Synthesis and anti-ulcer activity of new chalcones related to sophoradin, Chem Pharm Bull, 27(12) (1979) 2943.
56. Chiu P J, Barnett A, Gerhart C, Policelli M & Kaminski J, Gastric cytoprotective properties of SCH 32651, a novel antiulcer agent, Arch Int Pharmacodyn Ther, 270(1) (1984) 128.