Effect of age on homeostasis of lymphocytes in an interleukin-7-deficient mouse model

European Cytokine Network

Volumn 22, Issue 1, 2011, Pages 63-72

  Stienen, Astrid ^a,b   Feyen, Oliver ^a   Niehues, Tim ^a,c  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c Helios Hospital Krefeld   (Germany)

Author keywords

Homeostasis; Il 7; Immunodeficiency; Memory T cells

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 7;

AGE; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BONE MARROW; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CONTROLLED STUDY; FLOW CYTOMETRY; HOMEOSTASIS; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; INTERLEUKIN 7 DEFICIENCY; LIVER; LUNG; LYMPHOCYTE; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MEMORY T LYMPHOCYTE; MOUSE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; SMALL INTESTINE; SPLEEN;

AGING; ANIMALS; BODY WEIGHT; BONE MARROW; HOMEOSTASIS; INTERLEUKIN-7; INTESTINE, SMALL; LIVER; LYMPHOCYTE SUBSETS; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; ORGAN SPECIFICITY; SPLEEN;

MUS;

EID: 79958028573     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: 10.1684/ecn.2011.0273     Document Type: Article

References (38)

1. Namen AE, Lupton S, Hjerrild K, et al. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 1988; 333: 571-573.
2. Welch PA, Namen AE, Goodwin RG, Armitage R, Cooper MD. Human IL-7: a novel T cell growth factor. J Immunol 1989; 143: 3562-3567.
3. Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood 2002; 99: 3892-3904.
4. Sakata T, Iwagami S, Tsuruta Y, et al. Constitutive expression of interleukin-7 mRNA and production of IL-7 by a cloned murine thymic stromal cell line. J Leukoc Biol 1990; 48: 205-212.
5. Bolotin E, Annett G, Parkman R, Weinberg K. Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant 1999; 23: 783-788.
6. Madrigal-Estebas L, McManus R, Byrne B, et al. Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymicT-cell differentiation.HumImmunol 1997; 58: 83-90.
7. Gutierrez-Ramos JC, Olsson C, Palacios R. Interleukin (IL1 to IL7) gene expression in fetal liver and bone marrow stromal clones: cytokine-mediated positive and negative regulation. Exp Hematol 1992; 20: 986-990.
8. Golden-Mason L, Kelly AM, Traynor O, et al. Expression of interleukin 7 (IL-7) mRNA and protein in the normal adult human liver: implications for extrathymic T cell development. Cytokine 2001; 14: 143-151.
9. Heufler C, Topar G, Grasseger A, et al. Interleukin 7 is produced by murine and human keratinocytes. J Exp Med 1993; 178: 1109-1114.
10. Sorg RV, McLellan AD, Hock BD, Fearnley DB, Hart DN. Human dendritic cells express functional interleukin-7. Immunobiology 1998; 198: 514-526.
11. Kroncke R, Loppnow H, Flad HD, Gerdes J. Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur J Immunol 1996; 26: 2541-2544.
12. Fry TJ, Mackall CL. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol 2005; 174: 6571-6576.
13. Ziegler SE, Morella KK, Anderson D, et al. Reconstitution of a functional interleukin (IL)-7 receptor demonstrates that the IL-2 receptor gamma chain is required for IL-7 signal transduction. Eur J Immunol 1995; 25: 399-404.
14. Kondo M, Takeshita T, Higuchi M, et al. Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Science 1994; 263: 1453-1454.
15. Milne CD, Fleming HE, Paige CJ. IL-7 does not prevent pro-B/pre-B cell maturation to the immature/sIgM(+) stage. Eur J Immunol 2004; 34: 2647-26455.
16. Leonard WJ. Interleukin-7 deficiency in rheumatoid arthritis. Arthritis Res Ther 2005; 7: 42-3.
17. Rochman Y, Leonard WJ. The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis. J Immunol 2008; 181: 7699-7705.
18. Candeias S, Peschon JJ, Muegge K, Durum SK. Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice. Immunol Lett 1997; 57: 9-14.
19. Capitini CM, Chisti AA, Mackall CL. Modulating T-cell homeostasis with IL-7: preclinical and clinical studies. J Intern Med 2009; 266: 141-153.
20. Mazzucchelli R, Durum SK. Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol 2007; 7: 144-154.
21. Buckley RH, Schiff RI, Schiff SE, et al. Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants. J Pediatr 1997; 130: 378-387.
22. Puel A, Ziegler SF, Buckley RH, Leonard WJ. Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat Genet 1998; 20: 394-397.
23. von Freeden-Jeffry U, Vieira P, et al. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 1995; 181: 1519-1526.
24. Sportes C, Hakim FT, Memon SA, et al. Administration of rhIL- 7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J Exp Med 2008; 205: 1701-1714.
25. Dias S, Silva Jr. H, Cumano A, Vieira P. Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors. J Exp Med 2005; 201: 971-979.
26. Carvalho TL, Mota-Santos T, Cumano A, Demengeot J, Vieira P. Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/-) mice. J Exp Med 2001; 194: 1141-50.
27. Moore TA, von Freeden-Jeffry U, Murray R, Zlotnik A. Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice. J Immunol 1996; 157: 2366-2373.
28. Feyen O, Gobel U, Schneider DT, Burdach SE, Niehues T. Long-term haematopoietic reconstitution and survival without interleukin-7 in a murine syngeneic bone marrow transplantation model. Scand J Immunol 2006; 64: 601-608.
29. Polak JM, Van Noorden S. An Introduction to Immunocytochemistry: Current Techniques and Problems. 3rd ed. Oxford: BIOS Scientific Publishers, 2003.
30. Schwartzkopff J. Die Rolle von Interferon gamma bei der Tumorabwehr. [PhD thesis], 2001.
31. Boenisch T. Immunohistochemical Staining Methods. 3rd edition. DAKO Corporation, 2001.
32. Peschon JJ, Morrissey PJ, Grabstein KH, et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 1994; 180: 1955-1960.
33. Macia L, Viltart O, Delacre M, et al. Interleukin-7, a new cytokine targeting the mouse hypothalamic arcuate nucleus: role in body weight and food intake regulation. PLoS One 2010; 5: e9953.
34. Guimond M, Fry TJ, Mackall CL. Cytokine signals in T-cell homeostasis. J Immunother 2005; 28: 289-294.
35. Tan JT, Ernst B, Kieper WC, LeRoy E, Sprent J, Surh CD. Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med 2002; 195: 1523-1532.
36. Al-Shami A, Spolski R, Kelly J, et al. A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med 2004; 200: 159-168.
37. French JD, Roark CL, Born WK, O'Brien RL. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci USA 2005; 102: 14741-14746.
38. Ikawa T, Hirose S, Masuda K, et al. An essential developmental checkpoint for production of the T cell lineage. Science 2010; 329: 93-96.