Treatment of pressure ulcers with autologous bone marrow nuclear cells in patients with spinal cord injury

Journal of Spinal Cord Medicine

Volumn 34, Issue 3, 2011, Pages 301-307

  Gonzalez Sarasua J ^a   Pérez López, Silvia ^a   Alvarez Viejo M ^a   Perez Basterrechea M ^a   Fernandez Rodriguez A ^a   Ferrero Gutierrez A ^a   Garcia Gala J ^a   Menendez Menendez Y ^a   Escudero Augusto, D ^a   Perez Arias A ^a   Otero Hernandez J ^a  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

Author keywords

Mononuclear cells; Pressure ulcers; Spinal cord injury; Stem cell therapy

Indexed keywords

FICOLL;

ADULT; AGED; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE MARROW BIOPSY; BONE MARROW CELL; CELL COUNT; CELL ISOLATION; CLINICAL ARTICLE; DEBRIDEMENT; DECUBITUS; DISEASE DURATION; FEMALE; FOLLOW UP; HUMAN; ILIAC CREST; LENGTH OF STAY; MALE; MINIMALLY INVASIVE SURGERY; MONONUCLEAR CELL; OUTCOME ASSESSMENT; SPINAL CORD INJURY; TREATMENT DURATION; WOUND CARE; WOUND HEALING;

ADULT; AGED; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; DIAGNOSTIC IMAGING; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PRESSURE ULCER; SPINAL CORD INJURIES; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME;

EID: 79958005202     PISSN: 10790268     EISSN: None     Source Type: Journal    
DOI: 10.1179/2045772311Y.0000000010     Document Type: Article

References (38)

1. Kierney PC, Engrav LH, Isik FF, Esselman PC, Cardenas DD, Rand RP. Results of 268 pressure sores in 158 patients managed jointly by plastic surgery and rehabilitation medicine. Plast Reconstr Surg 1998;102(3):765-72. (Pubitemid 28402620)
2. Chen Y, DeVivo MJ, Jackson AB. Pressure ulcer prevalence in people with spinal cord injury: age-period-duration effects. Arch Phys Med Rehabil 2005;86(6):1208-13. (Pubitemid 40797776)
3. Byrne DW, Salzberg CA. Major risk factors for pressure ulcers in spinal cord disabled: a literature review. Spinal Cord 1996;34(5): 255-63. (Pubitemid 26188557)
4. Bergstrom N, Allman RM, Bennett MA. 'Treatment of pressure ulcers: clinical practice guideline', 'Treatment of pressure ulcers', US Dept of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, Rockville, MD, 1994. 'Clinical practice guideline'. Technical Report No 15. AHCPR Publication 96-N014-96-N015.
5. Agren M, Strömberg HE. Topical treatment of pressure ulcers: a randomized comparative trial of Varidase and zinc oxide. Scand J Plast Reconstr Surg 1985;19(1):97-100.
6. Galpin JE, Chow AW, Bayer AS, Guze LB. Sepsis associated with decubitus ulcers. Am J Med 1976;61(3):346-50.
7. Thompson D. A critical review of the literature on pressure ulcer aetiology. J Wound Care 2005;14(2):87-90.
8. Cannon BC, Cannon JP. Management of pressure ulcers. Am J Health-Syst Pharm 2004;61(18):1895-905.
9. Mortenson WB, Miller WC. A review of scales for assessing the risk of developing a pressure ulcer in individuals with SCI. Spinal Cord 2008;46(3):168-75. (Pubitemid 351347934)
10. Maslauskas K, Samsanavicius D, Rimdeika R, Kaikaris V. Surgical treatment of pressure ulcers: an 11-year experience at the department of plastic and reconstructive surgery of Hospital of Kaunas University of Medicine. Medicina Kaunas 2009;45(4): 269-75.
11. Reddy M, Gill SS, Kalkar SR, Wu W, Anderson PJ, Rochon PA. Treatment of pressure ulcers: a systematic review. JAMA 2008; 300(22):2647-62.
12. Leri A, Kajstura J, Anversa P. Cardiac stem cells and mechanisms of myocardial regeneration. Physiol Rev 2005;85(4):1373-416. (Pubitemid 41362274)
13. Nakano-Doi A, Nakagomi T, Fujikawa M, Nakagomi N, Kubo S, Lu S, et al. Bone marrow mononuclear cells promote proliferation of endogenous neural stem cells through vascular niches after cerebral infarction. Stem Cells 2010;28(7):1292-302.
14. Wu Y, Wang J, Scott PG, Tredget EE. Bone marrow-derived stem cells in wound healing: a review. Wound Repair Regen 2007; 15(Suppl. 1):S18-26.
15. Taylor DA, Zenovich AG. Cardiovascular cell therapy and endogenous repair. Diabetes Obes Metab 2008;10(Suppl. 4):5-15.
16. Uitterdijk A, Groenendijk BC, van Der Giessen WJ. Stem cell therapy for chronic heart failure. Hellenic J Cardiol 2009;50(2): 127-32.
17. Zhang H, Zhang N, Li M, Feng H, Jin W, Zhao H, et al. Therapeutic angiogenesis of bone marrow mononuclear cells (MNCs) and peripheral blood MNCs: transplantation for ischemic hindlimb. Ann Vasc Surg 2008;22(2):238-47.
18. Saito Y, Sasaki K, Katsuda Y, Murohara T, Takeshita Y, Okazaki T, et al. Effect of autologous bone-marrow cell transplantation on ischemic ulcer in patients with Buerger's disease. Circ J 2007;71(8): 1187-92. (Pubitemid 47195332)
19. Chen L, Tredget EE, Wu PY, Wu Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 2008;3(4):e1886.
20. Tang YL, Zhao Q, Zhang YC, Cheng L, Liu M, Shi J, et al. Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept 2004;117(1):3-10. (Pubitemid 37548393)
21. Ono I, Yamashita T, Hida T, Jin HY, Ito Y, Hamada H, et al. Local administration of hepatocyte growth factor gene enhances the regeneration of dermis in acute incisional wounds. J Surg Res 2004;120(1):47-55. (Pubitemid 38686529)
22. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006;98(5):1076-84. (Pubitemid 44128350)
23. Urbán VS, Kiss J, Kovács J, Gócza E, Vas V, Monostori E, et al. Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes. Stem Cells 2008;26(1):244-53.
24. Bansal C, Scott R, Stewart D, Cockerell CJ. Decubitus ulcers: a review of the literature. Int J Dermatol 2005;44(10):805-10. (Pubitemid 41535694)
25. Srivastava A, Gupta A, Taly AB, Murali T. Surgical management of pressure ulcers during impatient neurologic rehabilitation: outcomes for patients with spinal cord disease. J Spinal Cord Med 2009;32(2):125-31.
26. Sørensen JL, Jørgensen B, Gottrup F. Surgical treatment of pressure ulcers. Am J Surg 2004;188(Suppl. 1A):42-51.
27. Disa JJ, Carlton JM, Goldberg NH. Efficacy of operative cure in pressure sore patients. Plast Reconstr Surg 1992;89(2):272-8.
28. González Sarasua J, Pérez Arias A, Fueyo Lorente A, Arranz JL, Alzaga FB, Campano JG. Selección de técnicas quirúrgicas y prevención de las complicaciones en el tratamiento de las úlceras por presión. Cirugía Plástica Ibero-Latinoamericana 1992; XVIII(4):411-8.
29. Casas LA, Lewis Jr, VL. A reliable approach to the closure of large acquired midline defects of the back. Plast Reconstr Surg 1989; 84(4):632-41. (Pubitemid 19249826)
30. Anthony JP, Huntsman WT, Mathes SJ. Changing trends in the management of pelvic pressure ulcers: a 12-year review. Decubitus 1992;5(3):44-7, 50-1.
31. Conway H, Griffith BH. Plastic surgery for closure of decubitus ulcers in patients with paraplegia; based on experience with 1,000 cases. Am J Surg 1956;91(6):946-75.
32. Minnerup J, Seeger FH, Kuhnert K, Diederich K, Schilling M, Dimmeler S, et al. Intracarotid administration of human bone marrow mononuclear cells in rat photothrombotic ischemia. Exp Transl Stroke Med 2010;2(1):3.
33. Mathieu M, Bartunek J, El Oumeiri B, Touihri K, Hadad I, Thoma P, et al. Cell therapy with autologous bone marrow mononuclear stem cells is associated with superior cardiac recovery compared with use of nonmodified mesenchymal stem cells in a canine model of chronic myocardial infarction. J Thorac Cardiovasc Surg 2009;138(3):646-53.
34. Samdani AF, Paul C, Betz RR, Fischer I, Neuhuber B. Transplantation of human marrow stromal cells and mononuclear bone marrow cells into the injured spinal cord: a comparative study. Spine (Phila Pa 1976) 2009;34(24):2605-12.
35. Kamata Y, Takahashi Y, Iwamoto M, Matsui K, Murakami Y, Muroi K, et al. Local implantation of autologous mononuclear cells from bone marrow and peripheral blood for treatment of ischaemic digits in patients with connective tissue diseases. Rheumatol Oxford 2007;46(5):882-4. (Pubitemid 47061726)
36. Fathke C, Wilson L, Hutter J, Kapoor V, Smith A, Hocking A, et al. Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair. Stem Cells 2004;22(5):812-22. (Pubitemid 39166938)
37. Deng W, Han Q, Liao L, Li C, Ge W, Zhao Z, et al. Engrafted bone marrow-derived flk-1+. mesenchymal stem cells regenerate skin tissue. Tissue Eng 2005;11(1-2):110-9. (Pubitemid 40515179)
38. Yang M, Sheng L, Li H, Weng R, Li QF. Improvement of the skin flap survival with the bone marrow-derived mononuclear cells transplantation in a rat model. Microsurgery 2010;30(4):275-81.