Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes

Diabetes Research and Clinical Practice

Volumn 92, Issue 3, 2011, Pages

  Katakami, N ^a   Kaneto, H ^a   Takahara, M ^a   Matsuoka, T A ^a   Imamura, K ^b   Ishibashi, F ^c   Kanda, T ^d   Kawai, K ^e   Osonoi, T ^f   Matsuhisa, M ^g   Kashiwagi, A ^h   Kawamori, R ⁱ   Shimomura, I ^a   Yamasaki, Y ^j  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Imamura Clinic   (Japan)

^c Ishibashi Clinic   (Japan)

^d Kanda Naika Clinic   (Japan)

^e Kawai Clinic   (Japan)

^f Naka Memorial Clinic   (Japan)

^g UNIVERSITY OF TOKUSHIMA   (Japan)

^h SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

ⁱ JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^j OSAKA UNIVERSITY   (Japan)

more..

Author keywords

Aldose reductase; Diabetes; Polymorphism; Retinopathy

Indexed keywords

ALDEHYDE REDUCTASE; HEMOGLOBIN A1C; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; 2,4 THIAZOLIDINEDIONE DERIVATIVE; AMINO ACID; BIGUANIDE; DNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; SULFONYLUREA; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ALLELE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROMOTER REGION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; AMINO ACID SUBSTITUTION; ANAMNESIS; BRAIN INFARCTION; COLORIMETRY; COMPUTER ASSISTED TOMOGRAPHY; DISEASE ASSOCIATION; DYSLIPIDEMIA; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL EXAMINATION;

AGED; ALDEHYDE REDUCTASE; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; CEREBRAL INFARCTION; COHORT STUDIES; DIABETES COMPLICATIONS; GENOTYPE; PROGNOSIS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79958004192     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2011.02.017     Document Type: Article

References (13)

1. Hohman T.C., Nishimura C., Robison W.G. Aldose reductase and polyol in cultured pericytes of human retinal capillaries. Exp Eye Res 1989, 48:55-60.
2. Nishimura C., Saito T., Ito O., Omori Y., Tanimoto T. High levels of erythrocyte aldose reductase and diabetic retinopathy in NIDDM patients. Diabetologia 1994, 37:2294-2298.
3. Stevens M.J., Killen P., Wang P., Larkin D.D., Greene D.A. Over-expression of aldose reductase (AR) in human retinal pigment epithelial (RPE) cell lines is associated with a polymorphism in the AR basal promoter region. Diabetes 2000, 49(Suppl. 1):A167-A168.
4. Yang B., Millward A., Demaine A. Functional differences between the susceptibility Z-2/C-106 and protective Z+2/T-106 promoter region polymorphism of the aldose reductase gene may account for the association with diabetic microvascular complications. Biochem Biophys Acta 2003, 1639:1-7.
5. Kao Y.L., Donaghue K., Chan A., Knight J., Silink M. A novel polymorphism in the aldose reductase gene promoter region is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes. Diabetes 1999, 48:1338-1340.
6. Richeti F., Noronha R.M., Waetge R.T., de Vasconcellos J.P., de Souza O.F., Kneipp B., et al. Evaluation of AC(n) and C(-106)T polymorphisms of the aldose reductase gene in Brazilian patients with DM1 and susceptibility to diabetic retinopathy. Mol Vis 2007, 13:740-745.
7. Olmos P., Bastias M.J., Vollrath V., Toro L., Trincado A., Salinas P., et al. C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy. Diabetes Res Clin Pract 2006, 74:175-182.
8. Santos K.G., Tschiedel B., Schneider J., Souto K., Roisenberg I. Diabetic retinopathy in Euro-Brazilian type 2 diabetic patients: relationship with polymorphisms in the aldose reductase, the plasminogen activator inhibitor-1 and the methylenetetrahydrofolate reductase genes. Diabetes Res Clin Pract 2003, 61:133-136.
9. Sivenius K., Niskanen L., Voutilainen-Kaunisto R., Laakso M., Uusitupa M. Aldose reducatase gene polymorphism and susceptibility to microvascular complications in type 2 diabetes. Diabet Med 2004, 21:1325-1333.
10. Wang Y., Ng M.C., Lee S.C., So W.Y., Tong P.C., Cockram C.S., et al. Phenotypic heterogeneity and association of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes. Diabetes Care 2003, 26:2410-2415.
11. Yamada Y., Izawa H., Ichihara S., Takatsu F., Ishihara H., Hirayama H., et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 2002, 347:1916-1923.
12. Weedon M.N., McCarthy M.I., Hitman G., Walker M., Groves C.J., Zeggini E., et al. Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 2006, 3:e374.
13. Martinelli N., Trabetti E., Pinotti M., Olivieri O., Sandri M., Friso S., et al. Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis. PLoS One 2008, 3(2):e1523.