Implementation of the three Rs in the human hazard assessment of Brazilian medicinal plants: An evaluation of the cytotoxic and genotoxic potentials of Dipteryx alata vogel

Alternatives to Laboratory Animals

Volumn 39, Issue 2, 2011, Pages 189-196

  Esteves Pedro, Natália M ^a   Rodas, Andrea C D ^b   Dal Belo, Cháriston A ^c   Oshima Franco, Yoko ^a   Dos Santos, Márcio G ^d   Lopes, Patricia S ^e  

^a UNIVERSITY OF SOROCABA   (Brazil)

^b INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES   (Brazil)

^c UNIVERSIDADE FEDERAL DO PAMPA   (Brazil)

^d UNIVERSIDADE FEDERAL DO TOCANTINS   (Brazil)

^e FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

CHO; Cytotoxicity; Dipteryx alata; Medicinal plant; Micronucleus test; Three Rs

Indexed keywords

CYTOCHALASIN B; DIPTERYX ALATA VOGEL EXTRACT; MITOMYCIN C; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TESTING REDUCTION; ANIMAL TESTING REFINEMENT; ANIMAL TESTING REPLACEMENT; ARTICLE; BARK; BRAZIL; CELL PROLIFERATION; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; DIPTERYX ALATA VOGEL; FEMALE; GENOTOXICITY; HEALTH HAZARD; IC 50; IN VITRO STUDY; IN VIVO STUDY; LD 50; MEDICINAL PLANT; METABOLIC ACTIVATION; MICRONUCLEUS; MITOSIS; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT;

ANIMALIA; CRICETULUS GRISEUS; DIPTERYX ALATA;

EID: 79958000908     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119291103900207     Document Type: Article

References (31)

1. Chamberlain, M. & Parish, W.E. (1990). Hazard and risk based on in vitro test data. Toxicology in Vitro 4, 694-697. (Pubitemid 20364982)
2. Balls, M. (2009). The Three Rs and the Humanity Criterion. An abridged version of The Principles of Humane Experimental Technique by W.M.S. Russell and R.L. Burch, 131pp. Nottingham, UK: Fund for the Replacement of Animals in Medical Experiments.
3. ANVISA (2004). Agência Nacional de Vigilância Sanitária Directive 90: Guia para a realização de estudos de toxicidade pré-clínica de fitoterápicos, 4pp. [In Portuguese] Available at: http://portal.saude.gov.br/portal/arquivos/pdf/re-90- guia-tox.pdf (Accessed 17.03.11).
4. ANVISA (2003). V.5.1.3.Toxicidade. In Farmacopeia Brasileira, 4th edition, vol. 5, 286pp. São Paulo, SP, Brazil: Atheneu. [In Portuguese]
5. Presgrave, O.A.F. (2008). The need for the establishment of a Brazilian Centre for the Validation of Alternative Methods (BraCVAM). ATLA 36, 705-708.
6. Pio Corrêa, M. (1984). Dicionário das plantas úteis do Brasil e das plantas exóticas cultivadas, vol. 2, 707pp. Rio de Janeiro, RJ, Brazil: Imprensa Nacional. [In Portuguese]
7. Lorenzi, H. (1992). Árvores brasileiras: Manual de identificação e cultivo de plantas arbóreas nativas do Brasil, 202pp. Nova Odessa, SP, Brazil: Plantarum. [In Portuguese]
8. Rizzini, C.T. & Wors, W.B. (1976). Botânica econômica brasileira, 207pp. São Paulo, SP, Brazil: EPUSP. [In Portuguese]
9. Santos, M.G., Lolis, S.F. & Dal Belo, C.A. (2006). Levantamentos etnobotânicos realizados em duas comunidades remanescentes de negros da região do Jalapão, Estado do Tocantins. In Sociabilidades Negras, Comunidades Remanescentes, Escravidão e Cultura, pp. 29-49. Belo Horizonte, MG, Brazil: Pires ALCS. [In Portuguese]
10. Rodas, A.C.D., Maizato, M.J.S., Leirner, A.A., Pitombo, R.N.M., Polakiewicz, B., Beppu, M.M. & Higa, O.Z. (2008). Cytotoxicity and genotoxicity of bovine pericardium preserved in glycerol. Artificial Organs 32, 272-276. (Pubitemid 351442638)
11. Nazato, V.S., Mauro, L.R., Vieira, N.A.G., Rocha-Junior, D.S.R., Silva, M.G., Lopes, P.S., Dal Belo, C.A., Cogo, J.C., Santos, M.G., Cruz-Hölling, M.A. & Oshima-Franco, Y. (2010). In vitro antiophidian properties of Dipteryx alata Vogel bark extracts. Molecules 15, 5956-5970.
12. Barltrop, J.A. & Owen, T.C. (1991). 5-(3-Carboxy-methoxyphenyl)-2-(4, 5-dimethylthiazolyl)-3-(4-sulfophenyl) tetrazolium, inner salt (MTS) and related analogs of 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) reducing to purple water-soluble formazans as cell-viability indicators. Bioorganic & Medicinal Chemistry Letters 1, 611-614.
13. OECD (2010). Guideline for the Testing of Chemicals, No. 487, In Vitro Mammalian Cell Micronucleus Test, 23pp. Paris, France: Organisation for Economic Co-operation and Development. Available at: http://iccvam.niehs.nih.gov/ SuppDocs/FedDocs/OECD/OECD-TG487.pdf (Accessed 21.02.11).
14. Margolin, B.H., Resnick, M.A., Rimpo, J.Y., Archer, P., Galloway, S.M., Bloom, A.D. & Zeiger, E. (1986). Statistical analyses for in vitro cytogenetic assays using Chinese hamster ovary cells. Mutation Research 8, 183-204. (Pubitemid 16093362)
15. Festing, M.F.W. (2001). Guidelines for the design and statistical analysis of experiments in papers submitted to ATLA. ATLA 29, 427-446.
16. NIH (2001). Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity, No. 01-4500, 102pp. Bethesda, MA, USA: National Institutes of Health. Available at: http://www.epa.gov/hpv/pubs/ general/nih2001b.pdf (Accessed 17.03.11).
17. OECD (2010). Phototox Version 2.0. In Chemical Testing - Guidelines, Section 4: Software. Paris, France: Organisation for Economic Co-operation and Development. Available at: http://www.oecd.org/document/62/0,3343,en-2649-34377- 44706494-1-1-1-1,00.html (Accessed 25.02.11).
18. NIH (2006). Peer Review Panel Report: The Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing, 62pp. Bethesda, MA, USA: National Institutes of Health. Available at: http://iccvam.niehs.nih.gov/docs/acutetox-docs/ATpanelrpt06/ ATpanelrpt.pdf (Accessed 17.03.11).
19. Mesquita, M.L., Paula, J.E., Pessoa, C., Moraes, M.O., Costa-Latufo, V., Grougnet, R., Michel, S., Tille quin, F. & Espindola, S. (2009). Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines. Journal of Ethnopharmacology 123, 439-445.
20. Rodrigues, E. (2007). Plants of restricted use indicated by three cultures in Brazil (Caboclo-river dweller Indian and Quilombola). Journal of Ethnopharmacology 111, 295-302.
21. Barcelos, G.R.M., Shimabukuro, F., Mori, M.P., Maciel, M.A.M. & Cólus, M.S. (2007). Evaluation of mutagenicity and antimutagenicity of cashew stem bark methanolic extract in vitro. Journal of Ethnopharmacology 114, 268-273. (Pubitemid 47539831)
22. Machado, M.P., Rodrigues Filho, E., Terezan, A.P., Ribeiro, L.R. & Mantovani, M.S. (2005). Cytotoxicity, genotoxicity and antimutagenicity of hexane extracts of Agaricus blazei determined in vitro by the comet assay and CHO/HGPRT gene mutation assay. Toxicology in Vitro 19, 533-539.
23. Demma, J., Engidawork, E. & Hellman, B. (2009). Potential genotoxicity of plant extracts used in Ethiopian traditional medicine. Journal of Ethnopharmacology 122, 136-142.
24. Sánchez-Lamar, A., Fonseca, G., Fuentes, J.L., Cozzi, R., Cundari, E., Fiore, M., Ricordy, R., Perticone, P., Degrassi, F. & Salvia, R. (2008). Assessment of the genotoxic risk of Punica granatum L. (Punicaceae) whole fruit extracts. Journal of Ethnopharmacology 115, 416-422.
25. Costa, R.J., Diniz, A., Mantovani, M.S. & Jordão, B.Q. (2008). In vitro study of mutagenic potential of Bidens pilosa Linné and Mikania glomerata Sprengel using the comet and micronucleus assays. Journal of Ethnopharmacology 118, 86-93.
26. Fenech, M. (2007). Cytokinesis-block micronucleus cytome assay. Nature Protocols 2, 1084-1104.
27. Kalweit, S., Utesch, U., Von Der Hude, W. & Madle, S. (1999). Chemically induced micronucleus formation in V79 cells - comparison of three different test approaches. Mutation Research 439, 183-190. (Pubitemid 29094809)
28. Lorge, E., Hayashi, M., Albertini, S. & Kirkland, D. (2008). Comparison of different methods for the evaluation of cytotoxicity in the in vitro micronucleus test. Mutation Research 655, 1-3.
29. Kirsch-Volders, M., Sofuni, T., Aardema, M., Albertini, S., Fenech, M., Jr, Ishidate, M., Kirchner, S., Lorge, E., Morita, T., Norppa, H., Surralles, J., Vanhauwaert, A. & Wakata, A. (2003). Report from the in vitro micronucleus assay working group. Mutation Research 540, 153-163. (Pubitemid 37209943)
30. Fenech, M. & Morley, A.A. (1986). Cytokinesis-block micronucleus method in human lymphocytes: Effect of in vivo ageing and low dose X-irradiation. Mutation Research 161, 193-198. (Pubitemid 16099496)
31. Phillips, B.J. & Jenkinson, P. (2001). Is ethanol genotoxic? A review of the published data. Mutagenesis 16, 91-101. (Pubitemid 32184470)