Association of serum BDNF levels with hippocampal volumes in first psychotic episode drug-naive schizophrenic patients

Schizophrenia Research

Volumn 129, Issue 2-3, 2011, Pages 201-204

  Rizos, E N ^a   Papathanasiou, M ^a   Michalopoulou, P G ^a,b   Mazioti, A ^a   Douzenis, A ^a   Kastania, A ^c   Nikolaidou, P ^a   Laskos, E ^d   Vasilopoulou, K ^a   Lykouras, L ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^d Athens Psychiatric Hospital Dromokaition   (Greece)

Author keywords

FEP; Hippocampus; MRI volume; Schizophrenia; Serum BDNF

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; AGE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; FEMALE; GENDER; HIPPOCAMPAL VOLUME; HIPPOCAMPUS; HUMAN; MALE; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHIZOPHRENIA;

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; FUNCTIONAL LATERALITY; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; STATISTICS AS TOPIC; YOUNG ADULT;

EID: 79957996065     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2011.03.011     Document Type: Article

References (34)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders. DSM IV 1994, American Psychiatric Association, Washington, DC.
2. Berger G.E., Wood S., McGorry P.D. Incipient neurovulnerability and neuroprotection in early psychosis. Psychopharmacol. Bull. 2003, 37:79-101.
3. Buckley P., Mahadick S., Pillai A., Terry A. Neurotrophins and schizophrenia. Schizophr. Res. 2007, 94:1-11.
4. Buehlmann E., Berger G., Aston J., Gschwandtner U., Pflueger M., Borgwardt S., Radue E.W., Riecher-Rossler Hippocampus abnormalities in at risk mental states for psychosis? A cross-sectional high resolution region of interest magnetic resonance imaging study. J. Psychiatry Res. 2010, 44:447-453.
5. Cook M.J., Fish D.R., Shorvon S.D., Straughan K., Stevens J.M. Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy. Brain 1992, 115:1001-1015.
6. Duman R.S., Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry 2006, 59:1116-1127.
7. Durany N., Michel T., Zöchling R., Boissl K., Cruz-Sánchez F., Riederer P., Thome J. Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr. Res. 2001, 52:79-86.
8. Ebdrup B., Glenthoj B., Rasmussen H., Aggernaes B., Langkilde A., Paulson O., Lublin H., Skimminge A., Baaré W. Hippocampal and caudate volume reductions in antipsychotic-naïve first-episode schizophrenia. J. Psychiatry Neurosci. 2010, 35:95-104.
9. Eker C., Kitis O., Taneli F., Eker O., Ozan E., Yucel K., Coburn K., Gonul A.S. Correlation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patients. Eur. Arch. Psychiatry Clin. Neurosci 2010, 260:527-533.
10. Elfving B., Plougmann P.H., Muller H.K., Mathe A.A., Rosenberg R., Wegener G. Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. Int. J. Neuropsychopharmacol. 2009, 2:1-10.
11. Erickson K., Prakash R.S., Voss M.W., Chaddock L., Heo S., McLaren M., Pence B.D., Martin S.A., Vieira V.J., Woods J.A., McAuley E., Kramer A.F. Brain derived neurotrophic factor is associated with age-related decline in hippocampal volume. J. Neurosci. 2010, 14:5368-5375.
12. Erickson K.I., Prakash R.S., Voss M.W., Chaddock L., Hu L., Morris K.S., White S.M., Wojcicki T.R., McAuley E., Kramer A.F. Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 2009, 19:1030-1039.
13. Feinberg I. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence?. J. Psychiatry Res. 1983, 17:319-334.
14. Free S.L., Bergin P.S., Fish D.R., Cook M.J., Shorvon S.D., Stevens J.M. Methods for normalization of hippocampal volumes measured with MR. Am. J. Neuroradiol. 1995, 16:637-643.
15. Green M.J., Matheson S.L., Shepherd A., Weickert C.S., Car V.J. Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis. Mol. Psychiatry 2010, 24:1-13.
16. Hurlemann R., Jessen F., Wagner M., Frommann I., Ruhrmann S., Brockhaus A., Picker H., Scheef L., Block W., Schild H.H., Moller-Hartmann W., Krug B., Falkai P., Klosterkotter J., Maier W. Interrelated neuropsychological and anatomical evidence of hippocampal pathology in the at-risk mental state. Psychol. Med. 2008, 38:843-851.
17. Hohn A., Leibrock J., Bailey K., Barde Y.A. Identification of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 1990, 344:339-341.
18. Honea R., Crow T.J., Passingham D., Mackey C.E. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am. J. Psychiatry 2005, 162:2233-2245.
19. Jindal R.D., Pilai A.K., Mahadik S.P., Eklund K., Montrose D.M., Keshavan M.S. Decreased BDNF in patients with antipsychotic-naïve first episode schizophrenia. Schizophr. Res. 2010, 119:47-51.
20. Karege F., Schwald M., Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci. Lett. 2002, 328:261-264.
21. Knable M.B., Barci B.M., Webster M.J., Meador-Woodruff J., Torrey E., Stanley E. Molecular abnormalities of the hippocampus in severe psychiatric illness: post mortem findings from the Stanley Neuropathology Consortium. Mol. Psychiatry 2004, 9:609-620.
22. Lieberman J.A., Perkins D.O., Jarskog L.F. Neuroprotection: a therapeutic strategy to prevent deterioration associated with schizophrenia. CNS Spectr. 2007, 12:1-13.
23. Yutaka M., Mitsue N., Etsuro M., Shigeru I., Yoshiharu K., Yosuke U. Left hippocampal volume inversely correlates with enhanced emotional memory in healthy middle-aged women. J. Neuropsychiatry Clin. Neurosci. 2007, 19:335-338.
24. Pan W., Banks W.A., Fasold M.B., Bluth J., Kastin A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998, 37:1553-1561.
25. Razi K., Greene K., Sakuma M., Ge S., Kushner M., DeLisi L. Reduction of the parahippocampal gyrus and the hippocampus in patients with chronic schizophrenia. Br. J. Psychiatry 1999, 174:512-519.
26. Rizos E.N., Rontos I., Laskos E., Arsenis G., Michalopoulou P.G., Vasilopoulos D., Gournellis R., Lykouras L. Investigation of serum BDNF levels in drug-naïve patients with schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008, 32:1308-1311.
27. Rizos E.N., Papadopoulou A., Laskos E., Michalopoulou P.G., Kastania A., Vasilopoulos D., Katsafouros K., Lykouras L. Reduced serum BDNF levels in patients with chronic schizophrenic disorder in relapse, who were treated with atypical antipsychotics. World J. Biol. Psychiatry 2010, 11:251-255.
28. Sartorius A., Hellweg R., Litzke J., Vogt M., Dormann C., Vollmayr B., Danker-Hopfe H., Gass P. Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats. Pharmacopsychiatry 2009, 42:270-276.
29. Shenton M.E., Dickey C.C., Frumin M., McCarley R.W. A review of MRI findings in schizophrenia. Schizophr. Res. 2001, 49:1-52.
30. Shoval G., Weizman A. The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia. Eur. Neuropsychopharmacol. 2005, 15:19-329.
31. Suzuki F., Junier M.P., Guilhem D., Sorensen J.C., Onteniente B. Morphogenetic effect of kainite on adult hippocampal neurons associated with a prolonged expression of brain-derived neurotrophic factor. Neurosciences 1995, 64:665-674.
32. Vita A., De Peri L., Silenzi C., Cieci M. Brain morphology in first-episode schizophrenia: a meta-analysis of quantitative magnetic resonance imaging studies. Schizophr. Res. 2006, 82:75-88.
33. Webster M.J., Herman M.M., Kleinman J.E., Shannon W.C. BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan. Gene Expr. Patterns 2006, 6:941-951.
34. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry 1987, 44:660-669.