How helpful is age at colorectal cancer onset in finding HNPCC?

Diseases of the Colon and Rectum

Volumn 54, Issue 5, 2011, Pages 515-517

  Lynch, Patrick M ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER SCREENING; COLORECTAL CANCER; EDITORIAL; FAMILY HISTORY; GENE MUTATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; ONSET AGE; COLORECTAL TUMOR; DIFFERENTIAL DIAGNOSIS; GENETIC PREDISPOSITION; GENETICS; INCIDENCE; MIDDLE AGED; NEW ZEALAND; NOTE; RISK FACTOR;

COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DIAGNOSIS, DIFFERENTIAL; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INCIDENCE; MIDDLE AGED; NEW ZEALAND; RISK FACTORS;

EID: 79957981050     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/DCR.0b013e31820e2f83     Document Type: Editorial

References (15)

1. Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology. 1999;116:1453-1456. (Pubitemid 29258894)
2. Wright DM, Arnold JL, Parry B, et al. Immunohistochemistry to detect hereditary nonpolyposis colorectal cancer in young patients: the 7-year Auckland experience. Dis Colon Rectum. 2011;54:552-558.
3. Hampel H, Frankel WL, Martin E, et al. Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med. 2005;352:1851-1860.
4. Aaltonen LA, Salovaara R, Kristo P, et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med. 1998;338:1481-1487. (Pubitemid 28226275)
5. Piñol V, Castells A, Andreu M, et al. Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. JAMA. 2005;293:1986-1994. (Pubitemid 40570892)
6. Hyde A, Fontaine D, Stuckless S, et al. A histology-based model for predicting microsatellite instability in colorectal cancers. Am J Surg Pathol. 2010;34:1820-1829.
7. Lindor NM, Burgart LJ, Leontovich O, et al. Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol. 2002;20:1043-1048. (Pubitemid 34141849)
8. Deng G, Chen A, Hong J, Chae HS, Kim YS. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res. 1999;59:2029-2033. (Pubitemid 29217657)
9. Deng G, Bell I, Crawley S, et al. BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin Cancer Res. 2004;10(1 pt 1):191-195. (Pubitemid 38114179)
10. Schofield L, Watson N, Grieu F, et al. Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test. Int J Camcer. 2009;124:1097-1102.
11. Limburg P, Harmsen WS, Chen HH, et al. DNA mismatch repair gene alterations in a population-based sample of youngonset colorectal cancer patients. Clin Gastroenterol Hepatol. In press.
12. Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatelliteinstability status as a predictor of benefit from fluorouracilbased adjuvant chemotherapy for colon cancer. N Engl J Med. 2003;349:247-257. (Pubitemid 36859476)
13. Rex DK, Johnson DA, Anderson JC, et al. American College of Gastroenterology Guidelines for colorectal cancer screening 2008. Am J Gastroenterol. 2009;104:739-750.
14. Pino MS, Mino-Kenudson M, Wildemore BM, et al. Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas. J Mol Diagn. 2009;11:238-247.
15. Schmeler KM, Lynch HT, Chen LM, et al. Prophylactic surgery to reduce the risk of gynecologic cancers in the Lynch syndrome. N Engl J Med. 2006;354:261-269. (Pubitemid 43113031)