Ginsenoside Rb1 inhibits proliferation and inflammatory responses in rat aortic smooth muscle cells

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 11, 2011, Pages 6312-6318

  Li, Qun Yi ^a   Chen, Li ^b,c   Fu, Wen Huan ^a   Li, Zhong Dong ^a   Wang, Bin ^a   Shi, Xiao Jin ^a   Zhong, Ming Kang ^a  

^a FUDAN UNIVERSITY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Xuhui District Central Hospital   (China)

Author keywords

estrogen receptor; ginsenoside Rb1; inflammation; phytoestrogen; proliferation; vascular smooth muscle cells

Indexed keywords

ESTROGEN RECEPTOR; GINSENOSIDE RB1; INFLAMMATION; PHYTOESTROGEN; PROLIFERATION; VASCULAR SMOOTH MUSCLE CELLS;

BLOOD VESSELS; CELLS; GENES; GROWTH KINETICS; PHOSPHORYLATION;

MUSCLE;

GINSENOSIDE; GINSENOSIDE RB 1; PLANT EXTRACT;

ANIMAL; AORTA; ARTICLE; CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CYTOLOGY; DOWN REGULATION; DRUG EFFECT; FEMALE; IMMUNOLOGY; RAT; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT;

ANIMALS; AORTA; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; DOWN-REGULATION; FEMALE; GINSENOSIDES; MYOCYTES, SMOOTH MUSCLE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

BOVINAE; PANAX GINSENG; RATTUS;

EID: 79957972684     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf200424k     Document Type: Article

References (38)

1. Ling, S.; Komesaroff, P.; Sudhir, K. Cellular mechanisms underlying the cardiovascular actions of oestrogens Clin. Sci. (London) 2006, 111, 107-118 (Pubitemid 44220524)
2. Isles, C. G.; Hole, D. J.; Hawthorne, V. M.; Lever, A. F. Relation between coronary risk and coronary mortality in women of the Renfrew and Paisley survey: comparison with men Lancet 1992, 339, 702-706
3. Kuller, L. H. Cardiovascular disease is preventable among women Expert Rev. Cardiovasc. Ther. 2010, 8, 175-187
4. Rossouw, J. E.; Anderson, G. L.; Prentice, R. L.; LaCroix, A. Z.; Kooperberg, C.; Stefanick, M. L.; Jackson, R. D.; Beresford, S. A.; Howard, B. V.; Johnson, K. C.; Kotchen, J. M.; Ockene, J. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial JAMA, J. Am. Med. Assoc. 2002, 288, 321-333 (Pubitemid 34761611)
5. Anderson, G. L.; Limacher, M.; Assaf, A. R.; Bassford, T.; Beresford, S. A.; Black, H.; Bonds, D.; Brunner, R.; Brzyski, R.; Caan, B.; Chlebowski, R.; Curb, D.; Gass, M.; Hays, J.; Heiss, G.; Hendrix, S.; Howard, B. V.; Hsia, J.; Hubbell, A.; Jackson, R.; Johnson, K. C.; Judd, H.; Kotchen, J. M.; Kuller, L.; LaCroix, A. Z.; Lane, D.; Langer, R. D.; Lasser, N.; Lewis, C. E.; Manson, J.; Margolis, K.; Ockene, J.; O'Sullivan, M. J.; Phillips, L.; Prentice, R. L.; Ritenbaugh, C.; Robbins, J.; Rossouw, J. E.; Sarto, G.; Stefanick, M. L.; Van Horn, L.; Wactawski-Wende, J.; Wallace, R.; Wassertheil-Smoller, S. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial JAMA, J. Am. Med. Assoc. 2004, 291, 1701-1712 (Pubitemid 38489892)
6. Hsia, J.; Langer, R. D.; Manson, J. E.; Kuller, L.; Johnson, K. C.; Hendrix, S. L.; Pettinger, M.; Heckbert, S. R.; Greep, N.; Crawford, S.; Eaton, C. B.; Kostis, J. B.; Caralis, P.; Prentice, R. Conjugated equine estrogens and coronary heart disease: the Women's Health Initiative Arch. Intern. Med. 2006, 166, 357-365 (Pubitemid 43244325)
7. Simpkins, J. W.; Yang, S. H.; Liu, R.; Perez, E.; Cai, Z. Y.; Covey, D. F.; Green, P. S. Estrogen-like compounds for ischemic neuroprotection Stroke 2004, 35, 2648-2651 (Pubitemid 39458359)
8. Rivard, A.; Andres, V. Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases Histol. Histopathol. 2000, 15, 557-571 (Pubitemid 30218852)
9. Andres, V.; Castro, C. Antiproliferative strategies for the treatment of vascular proliferative disease Curr. Vasc. Pharmacol. 2003, 1, 85-98
10. Dubey, R. K.; Gillespie, D. G.; Mi, Z.; Rosselli, M.; Keller, P. J.; Jackson, E. K. Estradiol inhibits smooth muscle cell growth in part by activating the cAMP-adenosine pathway Hypertension 2000, 35, 262-266 (Pubitemid 30054183)
11. Akishita, M.; Ouchi, Y.; Miyoshi, H.; Kozaki, K.; Inoue, S.; Ishikawa, M.; Eto, M.; Toba, K.; Orimo, H. Estrogen inhibits cuff-induced intimal thickening of rat femoral artery: effects on migration and proliferation of vascular smooth muscle cells Atherosclerosis 1997, 130, 1-10 (Pubitemid 27158023)
12. Jia, L.; Zhao, Y.; Liang, X. J. Current evaluation of the millennium phytomedicine - ginseng (II): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine Curr. Med. Chem. 2009, 16, 2924-2942
13. He, F.; Guo, R.; Wu, S. L.; Sun, M.; Li, M. Protective effects of ginsenoside Rb1 on human umbilical vein endothelial cells in vitro J. Cardiovasc. Pharmacol. 2007, 50, 314-320 (Pubitemid 47428981)
14. Ohashi, R.; Yan, S.; Mu, H.; Chai, H.; Yao, Q.; Lin, P. H.; Chen, C. Effects of homocysteine and ginsenoside Rb1 on endothelial proliferation and superoxide anion production J. Surg. Res. 2006, 133, 89-94
15. Chai, H.; Wang, Q.; Huang, L.; Xie, T.; Fu, Y. Ginsenoside Rb1 inhibits tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in human endothelial cells Biol. Pharm. Bull. 2008, 31, 2050-2056
16. Chai, H.; Dong, Y.; Wang, X.; Zhou, W. Ginsenoside Rb1 attenuates homocysteine-augmented guidewire injury-induced intimal hyperplasia in mice J. Surg. Res. 2009, 157, 193-198
17. Chai, H.; Schultz, G.; Aghaie, K.; Zhou, W. In vivo assessment of the effects of ginsenoside Rb1 on intimal hyperplasia in ApoE knockout mice J. Surg. Res. 2010, 162, 26-32
18. Rodriguez, A.; Fortuno, A.; Gomez-Ambrosi, J.; Zalba, G.; Diez, J.; Fruhbeck, G. The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism Endocrinology 2007, 148, 324-331 (Pubitemid 46021465)
19. Sasu, S.; LaVerda, D.; Qureshi, N.; Golenbock, D. T.; Beasley, D. Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation Circ. Res. 2001, 89, 244-250 (Pubitemid 34132682)
20. Ekshyyan, V. P.; Hebert, V. Y.; Khandelwal, A.; Dugas, T. R. Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production J. Cardiovasc. Pharmacol. 2007, 50, 83-93 (Pubitemid 47220451)
21. Pizarro, J. G.; Yeste-Velasco, M.; Esparza, J. L.; Verdaguer, E.; Pallas, M.; Camins, A.; Folch, J. The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes J. Pineal Res. 2008, 45, 8-16 (Pubitemid 351986256)
22. Miller, A. P.; Feng, W.; Xing, D.; Weathington, N. M.; Blalock, J. E.; Chen, Y. F.; Oparil, S. Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries Circulation 2004, 110, 1664-1669 (Pubitemid 39297991)
23. Livak, K. J.; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method Methods 2001, 25, 402-408 (Pubitemid 34164012)
24. Nelson, P. R.; Yamamura, S.; Mureebe, L.; Itoh, H.; Kent, K. C. Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase J. Vasc. Surg. 1998, 27, 117-125 (Pubitemid 28081167)
25. Welt, F. G.; Rogers, C. Inflammation and restenosis in the stent era Arterioscler. Thromb. Vasc. Biol. 2002, 22, 1769-1776 (Pubitemid 35315761)
26. Leung, K. W.; Cheung, L. W.; Pon, Y. L.; Wong, R. N.; Mak, N. K.; Fan, T. P.; Au, S. C.; Tombran-Tink, J.; Wong, A. S. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen β receptor Br. J. Pharmacol. 2007, 152, 207-215 (Pubitemid 47517604)
27. Geraldes, P.; Sirois, M. G.; Tanguay, J. F. Specific contribution of estrogen receptors on mitogen-activated protein kinase pathways and vascular cell activation Circ. Res. 2003, 93, 399-405 (Pubitemid 37100004)
28. Xing, D.; Feng, W.; Miller, A. P.; Weathington, N. M.; Chen, Y. F.; Novak, L.; Blalock, J. E.; Oparil, S. Estrogen modulates TNF-α-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-β activation Am. J. Physiol. Heart Circ. Physiol. 2007, 292, H2607-H2612
29. Zhu, D.; Wu, L.; Li, C. R.; Wang, X. W.; Ma, Y. J.; Zhong, Z. Y.; Zhao, H. B.; Cui, J.; Xun, S. F.; Huang, X. L.; Zhou, Z.; Wang, S. Q. Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis J. Cell Biochem. 2009, 108, 117-124
30. Lu, J. M.; Yao, Q.; Chen, C. Ginseng compounds: an update on their molecular mechanisms and medical applications Curr. Vasc. Pharmacol. 2009, 7, 293-302
31. Peng, C. Y.; Pan, S. L.; Huang, Y. W.; Guh, J. H.; Chang, Y. L.; Teng, C. M. Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-κB activity in vascular smooth-muscle cells Naunyn-Schmiedeberg's Arch. Pharmacol. 2008, 6, 579-588
32. Adam, R. M.; Borer, J. G.; Williams, J.; Eastham, J. A.; Loughlin, K. R.; Freeman, M. R. Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate Endocrinology 1999, 140, 5866-5875 (Pubitemid 30645375)
33. Wei, G. L.; Krasinski, K.; Kearney, M.; Isner, J. M.; Walsh, K.; Andres, V. Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty Circ. Res. 1997, 80, 418-426 (Pubitemid 27093357)
34. Sites, C. K.; Toth, M. J.; Cushman, M.; L'Hommedieu, G. D.; Tchernof, A.; Tracy, R. P.; Poehlman, E. T. Menopause-related differences in inflammation markers and their relationship to body fat distribution and insulin-stimulated glucose disposal Fertil. Steril. 2002, 77, 128-135 (Pubitemid 34093904)
35. Clausell, N.; de Lima, V. C.; Molossi, S.; Liu, P.; Turley, E.; Gotlieb, A. I.; Adelman, A. G.; Rabinovitch, M. Expression of tumour necrosis factor α and accumulation of fibronectin in coronary artery restenotic lesions retrieved by atherectomy Br. Heart J. 1995, 73, 534-539
36. Ferreri, N. R. Estrogen-TNF interactions and vascular inflammation Am. J. Physiol. Heart Circ. Physiol. 2007, 292, H2566-H2569
37. Watanabe, T.; Akishita, M.; Nakaoka, T.; Kozaki, K.; Miyahara, Y.; He, H.; Ohike, Y.; Ogita, T.; Inoue, S.; Muramatsu, M.; Yamashita, N.; Ouchi, Y. Estrogen receptor β mediates the inhibitory effect of estradiol on vascular smooth muscle cell proliferation Cardiovasc. Res. 2003, 59, 734-744 (Pubitemid 38368690)
38. Lindner, V.; Kim, S. K.; Karas, R. H.; Kuiper, G. G.; Gustafsson, J. A.; Mendelsohn, M. E. Increased expression of estrogen receptor-β mRNA in male blood vessels after vascular injury Circ. Res. 1998, 83, 224-229 (Pubitemid 28354468)