Mythology of antioxidant vitamins?

Journal of Evidence-Based Complementary and Alternative Medicine

Volumn 16, Issue 1, 2011, Pages 149-159

  Howes, Randolph M ^a,b,c  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b UNIVERSITY OF SANTO TOMAS   (Philippines)

^c SOUTHEASTERN LOUISIANA UNIVERSITY   (United States)

Author keywords

Antioxidants; Free radical theory; Oxidation; Reactive oxygen species; Vitamins

Indexed keywords

EID: 79957940129     PISSN: 21565872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Millen AE, Dodd KW, Subar AF. Use of vitamin, mineral, nonvi-tamin, and nonmineral supplements in the United States: The 1987, 1992, and 2000 National Health Interview Survey results. J Am Diet Assoc. 2004;104:942-950.
2. Food and Drug Administration. http://www.fda.gov/food/dietarysupplements/default.htm. Accessed August 28, 2010.
3. Howes RM. Book 1: Death In Small Doses? Book 2: Vitamins Are Making a Killing. Victoria, Canada: Trafford; 2010.
4. Blendon RJ, DesRoches CM, Benson JM, Brodie M, Altman DE. Americanś views on the use and regulation of dietary supplements. Arch Intern Med. 2001;161:805-810.
5. Rogovik AL, Vohra S, Goldman RD. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann Pharmacother. 2010;44:311-324.
6. Orient A, Donkó A, SzabóA, Leto TL, Geiszt M. Novel sources of reactive oxygen species in the human body. Nephrol Dial Transplant. 2007;22:1281-1288.
7. Nathan C. Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. J Clin Invest. 2003;111: 769-778.
8. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. Oxford, UK: Oxford University Press; 1999.
9. Winterbourn CC, Metodiewa D. Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide. Free Radic Biol Med. 1999;27:322-328.
10. Le Moan N, Clement G, Le Maout S, Tacnet F, Toledano MB. The Saccharomyces cerevisiae proteome of oxidized protein thiols: contrasted functions for the thioredoxin and glutathione pathways. J Biol Chem. 2006;281:10420-10430.
11. Waris G, Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog. 2006; 5:14.
12. Ratner MA, Schatz GC. Introduction to Quantum Mechanics in Chemistry. 1st ed. Upper Saddle River, NJ: Prentice Hall; 2000.
13. Nohl H, Kozlov AV, Gille L, Staniek K. Cell respiration and formation of reactive oxygen species: facts and artifacts. Biochem Soc Trans. 2003;31:1308-1311.
14. Carper J. Stop Aging Now! New York, NY: HarperCollins; 1995.
15. Greenberg ER. Vitamin E supplements: good in theory, but is the theory good? Ann Intern Med. 2005;142:75-76.
16. Adelman R, Saul RL, Ames B. Oxidative damage to DNA: relation to species metabolic rate and life span. Proc Natl Acad Sci U S A. 1988;85:2706-2708.
17. Howes RM. Reactive Oxygen Species vs. Antioxidants: The Oxy-pocalypse or The War That Never Was. Kentwood, LA: Free Radical Publishing; 2010.
18. Howes RM. U.T.O.P.I.A.-Unified Theory of Oxygen Participation in Aerobiosis. Kentwood, LA: Free Radical Publishing; 2004.
19. Howes RM. The Medical and Scientific Significance of Oxygen Free Radical Metabolism. Kentwood, LA: Free Radical Publishing; 2005.
20. Howes RM. Hydrogen Peroxide Monograph 1: Scientific, Medical and Biochemical Overview & Antioxidant Vitamins A, C, & E. Monograph 2: Equivocal Scientific Studies. Kentwood, LA: Free Radical Publishing; 2006.
21. Howes RM. Cardiovascular Disease and Oxygen Free Radical Mythology. Kentwood, LA: Free Radical Publishing; 2006.
22. Howes RM. Diabetes and Oxygen Free Radical Sophistry. Kentwood, LA: Free Radical Publishing; 2006.
23. Gerschman R, Gilbert DL, Nye SW, Dwyer P, Fenn WO. Oxygen poisoning and X-irradiation: a mechanism in common. Science. 1954;119:623-626.
24. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298-300.
25. Harman D. Prolongation of the normal life span by radiation protection chemicals. J Gerontol. 1957;12:257-263.
26. Harman D. The aging process. Proc Natl Acad Sci USA. 1981; 78:7124-7128.
27. Harman D. Aging: overview. Ann N Y Acad Sci. 2000;928:1-21.
28. Cross CE, Halliwell B, Borish ET, et al. Oxygen radicals and human disease. Ann Intern Med. 1987;107:526-545.
29. Howes R. Hydrogen peroxide: a review of a scientifically verifiable omnipresent ubiquitous essentiality of obligate, aerobic, carbon-based life forms. Internet J Plast Surg. 2010;7(1).
30. Maiorino M. Ursini F. Metal ion induced lipid peroxidation: anti-oxidant and prooxidant role of vitamin E. In: Davies KJA, UrsineF, eds. The Oxygen Paradox. Padua, Italy: CLEUP University Press; 1995:665.
31. Halliwell B, Gutteridge JMC, eds. Free Radicals in Biology and Medicine. Oxford, UK: Clarendon Press; 1989.
32. Suzuki YJ, Tritschler H, Packer L. Can alpha-lipoic acid be used as a therapeutic antioxidant? In: Davies KJA, Ursine F, eds. The Oxygen Paradox. Padua, Italy: CLEUP University Press; 1995:674.
33. Howes RM. The free radical fantasy: a panoply of paradoxes. Ann N Y Acad Sci. 2006;1067:22-26.
34. Ristow M, Zarse K, Oberbach A, et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A. 2009;106:8665-8670.
35. Gupta YK, Gupta M, Kohli K. Neuroprotective role of melatonin in oxidative stress vulnerable brain. Indian J Physiol Pharmacol. 2003;47:373-386.
36. Passwater RA. The Antioxidants. New Canaan, CT; Keats Publishing; 1997.
37. Madamanchi NR, Vendrov A, Runge MS. Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol. 2005;25:29-38.
38. Mayo Clinic. http://www.mayoclinic.com/health/antioxidant-supplements/MY00527. Accessed August 28, 2010.
39. Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet. 2003;361: 2017-2023.
40. Zhang X, Min X, Li C, et al. Involvement of reductive stress in the cardiomyopathy in transgenic mice with cardiac-specific overex-pression of heat shock protein 27. Hypertension. 2010;55: 1412-1417.
41. Howes RM. Aging and anti-aging claims: a review on antioxidant vitamins A, C & E. Philica.com Article no. 116. 2008. http://philica.com/display_article.php?article_id1/4116. Accessed August 29, 2010.
42. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998;78:547-581.
43. Fox News. http://www.foxnews.com/story/0,2933,255920,00.html. Accessed August 28, 2010.
44. Heart Protection Study Collaborative Group. MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high risk individuals: a randomized placebo-controlled trial. Lancet. 2002;360:23-33.
45. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297:842-857.
46. Koubova J, Guarente L. How does calorie restriction work? Genes Dev. 2003;17:313-321.
47. Barja G. Aging in vertebrates and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism. Biol Rev Camb Philos Soc. 2004;79:235-251.
48. Leaf D, Glassman P. The Oxidative Balance: How to Lead the Antioxidant Lifestyle. Durant, OK: Emis; 2000.
49. Meagher EA, Barry OP, Lawson JA, Rokach J, FitzGerald GA. Effects of vitamin E on lipid peroxidation in healthy persons. JAMA. 2001;285:1178-1182.
50. Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342:154-160.
51. Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37-46.
52. Lee D-H, Folsom AR, Harnack L, Halliwell B, Jacobs DR Jr. Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? Am J Clin Nutr. 2004;80:1194-1200.
53. Waters DD, Alderman EL, Hsia J, et al. Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial. JAMA. 2002;288:2432-2440.
54. Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334:1150-1155.
55. Moss RW. Antioxidants Against Cancer. State College, PA: Equinox Press; 2002.
56. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxi-dant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet. 2004;364: 1219-1228.
57. Howes RM. Antioxidant vitamins: a review of policy statements and recommendations. Am J Cosmet Surg. 2009;26:63-78.
58. Heinonen OP, Huttunen JK, Albanes D; ATBC Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;330:1029-1035.
59. Omenn GS, Goodman GE, Thornquist MD, et al. Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst. 1996; 88:1550-1559.
60. Lippman SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009;301:39-51.