Serotonin transporter gene (5HTT) polymorphisms and temporal lobe epilepsy

Epilepsy Research

Volumn 95, Issue 1-2, 2011, Pages 152-157

  Schenkel, Laila Cigana ^a,b   Bragatti, José Augusto ^a,b   Torres, Carolina Machado ^a,b   Martin, Kelin Cristine ^a   Manfro, Gisele Gus ^a   Leistner Segal, Sandra ^a   Bianchin, Marino Muxfeldt ^a,b  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

5 HTTVNTR; 5HTTLPR; Epileptogenesis; Serotoninergic system

Indexed keywords

SEROTONIN TRANSPORTER;

5 HTT GENE; ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE CLASSIFICATION; EPILEPTOGENESIS; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; PRIORITY JOURNAL; TEMPORAL LOBE EPILEPSY;

5' FLANKING REGION; ADULT; ALLELES; BRAZIL; CASE-CONTROL STUDIES; EPILEPSY, TEMPORAL LOBE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MALE; MINISATELLITE REPEATS; MUTAGENESIS, INSERTIONAL; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE DELETION; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 79957933701     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2011.03.013     Document Type: Article

References (30)

1. Ahmad S., Fowler L.J., Whitton P.S. Lamotrigine, carbamazepine and phenytoin differentially alter extracellular levels of 5-hydroxytryptamine, dopamine and amino acids. Epilepsy Res. 2005, 63:141-149.
2. Anguelova M., Benkelfat C., Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol. Psychiatry 2003, 646-653.
3. Bagdy G., Kecskemeti V., Riba P., Jakus R. Serotonin and epilepsy. J. Neurochem. 2007, 100:857-873.
4. Bateman L.M., Li C.S., Lin T.C., Seyal M. Serotonin reuptake inhibitors are associated with reduced severity of ictal hypoxemia in medically refractory partial epilepsy. Epilepsia 2010, epub ahead of print.
5. Bragatti J.A., Torres C.M., Assmann J.B., Fontana V., Rigotti C.P., Hidalgo M.P., Chaves M.L., Bianchin M.M. Left-sided EEG focus and positive psychiatric family history are independent risk factors for affective disorders in temporal lobe epilepsy. Epilepsy Res. 2009, 87:169-176.
6. Catalano M. Functionally gene-linked polymorphic region and genetically controlled neurotransmitters metabolism. Eur. Neuropsycopharmacol. 2001, 11:431-439.
7. Cavalheiro E.A., Fernandes M.J., Turski L., Naffah-Mazzacoratti M.G. Spontaneous recurrent seizures in rats: amino acid and monoamine determination in the hippocampus. Epilepsia 2004, 35:1-11.
8. Cordeiro Q., Rezende Souza B., Correa H., Guindalini C., Hutz M.H., Vallada H., Romano-Silva M. A review of psychiatric genetics research in the Brazilian population. Rev. Bras. Psiquiatr. 2008, 415:1-9.
9. Garcia L.F., Aluja A., Fibla J., Cuevas L., García O. Incremental effect for antisocial personality disorder genetic risk combinning 5-HTTLPR and 5-HTTVNTR polymorphisms. Psychiatry Res. 2010, 177:161-166.
10. Hecimovic H., Jasminka S., Lipa C.-S., Vida D., Branimir J. Association of serotonin transporter promoter (5-HTTLPR) and intron 2 (VNTR-2) polymorphisms with treatment response in temporal lobe epilepsy. Epilepsy Res. 2010, 91(1):35-38.
11. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., Lesch P. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 1996, 66:2621-2624.
12. Holmes A.J., Bogdan R., Pizzagalli D.A. Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression. Neuropsychopharmacology 2010, 35(5):1186-1197.
13. Hranilovic D., Stefulj J., Schwab S., Borrmann-Hassenbach M., Albus M., Jernej B., Wildenauer D. Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol. Psychiatry 2004, 55:1090-1094.
14. Kanner A.M. Depression and epilepsy: a review of multiple facets of their close relation. Neurol. Clin. 2009, 27:865-880.
15. Kauffman M.A., Consalvo D., Gonzalez-Morón D., Aguirre F., D'Alessio L., Kochen S. Serotonin transporter gene variation and refractory mesial temporal epilepsy with hippocampal sclerosis. Epilepsy Res. 2009, 85:231-234.
16. Kent L., Doerry U., Hardy E., Parmar R., Gingell K., Hawi Z., Kirley A., Lowe N., Fitzgerald M., Gill M., Craddock N. Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis. Mol. Psychiatry 2002, 7:908-912.
17. Lazarova M., Bendotti C., Samanin R. Studies on the role of serotonin in different regions of the rat central nervous system on pentylenetetrazole-induced seizures and the effect of di-n-propylacetate. Arch Pharmacol. 1983, 322:147-152.
18. Lesch K.P. Variation of serotoninergic gene expression: neurodevelopment and the complexity of response to psychopharmacologic drugs. Eur. Neuropsycopharmacol. 2001, 11:457-474.
19. Lesch K.P., Balling U., Gross J., Strauss K., Wolozin B.L., Murphy D.L., Riederer P. Organization of the human serotonin transporter gene. J. Neural Transm. Gen. 1994, 157-162.
20. Lesh K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274:1527-1531.
21. Lovejoy E.A., Scott A.C., Fiskerstrand C.E., Bubb V.J., Quinn J.P. The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unit. Eur. J. Neurosci. 2003, 17:417-420.
22. Manna I., Labate A., Gambardella A., Forabosco P., La Russa A., Le Piane E., Aguglia U., Quattrone A. Serotonin transporter gene (5-HTT): association analysis with temporal lobe epilepsy. Neurosci. Lett. 2007, 421:52-56.
23. Miller A.S., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988, 16(3):1215.
24. Nakamu M., Ueno S., Sano A., Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol. Psychiatry 2000, 5(1):32-38.
25. Nordquist N., Oreland L. Serotonin, genetic variability, behavior, and psychiatric disorders-a rewiew. Ups. J. Med. Sci. 2010, 115:2-10.
26. Olgivie A.D., Battersby S., Bubb V.J., Harmar A.J., Goodwin G.M., Dale Smith C.A. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996, 347:731-733.
27. Sander J.W. The epidemiology of epilepsy revisited. Curr. Opin. Neurol. 2003, 16(2):165-170.
28. Savic I., Lindstrom P., Gulyas B., Halldin C., Andree B., Farde L. Limbic reductions of 5-HT1A receptor binding in human temporal lobe epilepsy. Neurology 2004, 62:1343-1351.
29. Stefulj J., Bordukalo-Niksic T., Hecimovic H., Demarin V., Jernej B. Epilepsy and serotonin (5HT): variation of 5HT-related genes in temporal lobe epilepsy. Neurosci. Lett. 2010, 478:29-31.
30. Weese-Mayer D.E., Zhou L., Berry-Kravis E.M., Maher B.S., Silvestri J.M., Marazita M.L. Association of the serotonin transporter gene with sudden infant death syndrome: a haplotype analysis. Am. J. Med. Genet. A 2003, 122A:238-245.