Effect of frusemide on transvascular fluid fluxes across the lung in exercising horses

Equine Veterinary Journal

Volumn 43, Issue 4, 2011, Pages 451-459

  Vengust, M ^a,b   Kerr, C ^b   Staempfli, H R ^b   Pringle, J ^c   Heigenhauser, G J ^d   Viel, L ^b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY OF GUELPH   (Canada)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^d MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

Exercise induced pulmonary haemorrhage; Furosemide; Horse; Pulmonary circulation; Water transport

Indexed keywords

DIURETIC AGENT; FUROSEMIDE; HEMOGLOBIN; PLASMA PROTEIN;

ANIMAL; ANIMAL DISEASE; ANIMAL EXPERIMENT; ARTICLE; CROSSOVER PROCEDURE; DRUG EFFECT; FEMALE; HEART OUTPUT; HEMATOCRIT; HORSE; LUNG; LUNG CIRCULATION; LUNG GAS EXCHANGE; MALE; METABOLISM; PHYSIOLOGY; VASCULARIZATION;

ANIMALS; BLOOD PROTEINS; CARDIAC OUTPUT; CROSS-OVER STUDIES; DIURETICS; FEMALE; FUROSEMIDE; HEMATOCRIT; HEMOGLOBINS; HORSES; LUNG; MALE; PHYSICAL CONDITIONING, ANIMAL; PULMONARY CIRCULATION; PULMONARY GAS EXCHANGE;

CONGIOPODIDAE; EQUIDAE;

EID: 79957931890     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2010.00301.x     Document Type: Article

References (55)

1. Almirall, J.J., Dolman, C.S. and Eidelman, D.H. (1997) Furosemide-induced bronchodilation in the rat bronchus: Evidence of a role for prostaglandins. Lung 175, 155-163.
2. Arthur, R.M. (1991) Furosemide: Practice and politics. Proc. Am. Ass. equine Practnrs. 37, 173-188.
3. 133xenon technique. Scand. J. Clin. Lab. Invest. 22, 99-106.
4. Bianco, S., Vaghi, A., Robuschi, M. and Pasargiklian, M. (1988) Prevention of exercise-induced bronchoconstriction by inhaled frusemide. Lancet 2, 252-255.
5. Bretcher, M.S. (1971) A major protein which spans the human erythrocyte membrane. J. Mol. Biol. 59, 351-357.
6. Chay, S., Woods, W.E., Rowse, K., Nugent, T.E., Blake, J.W. and Tobin, T. (1983) The pharmacology of furosemide in the horse. V. Pharmacokinetics and blood levels of furosemide after intravenous administration. Drug Metab. Dispos. 11, 226-231.
7. Costill, D.L., Branam, L., Eddy, D. and Fink, W. (1974) Alterations in red cell volume following exercise and dehydration. J. appl. Physiol. 37, 912-916.
8. Dexter, L., Whittenberger, J.L., Haynes, F.W., Goodale, W.T., Gorlin, R. and Sawyer, C.G. (1951) Effect of exercise on circulatory dynamics of normal individuals. J. appl. Physiol. 3, 439-453.
9. Dill, D.B. and Costill, D.L. (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J. appl. Physiol. 37, 247-248.
10. Erickson, B.K., Erickson, H.H. and Coffman, J.R. (1990) Pulmonary artery, aortic and oesophageal pressure changes during high intensity treadmill exercise in the horse: A possible relation to exercise-induced pulmonary haemorrhage. Equine vet. J., Suppl. 9, 47-52.
11. Erickson, H.H., Bernard, S.L., Glenny, R.W., Fedde, M.R., Polissar, N.L., Basaraba, R.J., Walther, S.M., Gaughan, E.M., McMurphy, R. and Hlastala, M.P. (1999) Effect of furosemide on pulmonary blood flow distribution in resting and exercising horses. J. appl. Physiol. 86, 2034-2043.
12. Forro, M. and Lindinger, M.I. (2006) Frusemide results in an extracellular to intracellular fluid shift in horses. Equine vet. J., Suppl. 36, 245-253.
13. Greenberg, S., McGowan, C., Xie, J. and Summer, W.R. (1994) Selective pulmonary and venous smooth muscle relaxation by furosemide: A comparison with morphine. J. Pharmacol. Exp. Ther. 270, 1077-1085.
14. Greger, R. and Wangemann, P. (1987) Loop diuretics. Renal Physiol. 10, 174-183.
15. Groves, B.M., Reeves, J.T., Sutton, J.R., Wagner, P.D., Cymerman, A., Malconian, M.K., Rock, P.B., Young, P.M. and Houston, C.S. (1987) Operation Everest II: Elevated high-altitude pulmonary resistance unresponsive to oxygen. J. appl. Physiol. 63, 521-530.
16. Guizouarn, H., Gabillat, N., Motais, R. and Borgese, F. (2001) Multiple transport functions of a red blood cell anion exchanger, tAE1: Its role in cell volume regulation. J. Physiol. 535, 497-506.
17. Hinchcliff, K.W. and McKeever, K.H. (1998) Fluid administration attenuates the haemodynamic effect of frusemide in running horses. Equine vet. J. 30, 246-250.
18. Hinchcliff, K.W., McKeever, K.H. and Muir, W.W. III (1991) Furosemide induced changes in plasma and blood volume of horses. J. vet. Pharmacol. Ther. 14, 411-417.
19. Hinchcliff, K.W., Morley, P.S. and Guthrie, A.J. (2009) Efficacy of furosemide for prevention of exercise-induced pulmonary haemorrhage in Thoroughbred racehorses. J. Am. vet. med. Ass. 235, 76-82.
20. Hinchcliff, K.W., Hubbell, J.A.E., Grosenbough, D., Mitten, L.A. and Beard, W.L. (1996) Hemodynamic effects of furosemide are dependent on diuresis. Proc. Am. Ass. equine Practnrs. 42, 229-230.
21. Hlastala, M.P., Bernard, S.L., Erickson, H.H., Fedde, M.R., Gaughan, E.M., McMurphy, R., Emery, M.J., Polissar, N. and Glenny, R. (1996) Pulmonary blood flow distribution in standing horses is not dominated by gravity. J. appl. Physiol. 81, 1051-1061.
22. Hopper, M.K., Pieschl, R.L., Pelletier, N.G. and Erickson, H.H. (1991) Cardiopulmonary effects of acute blood volume alteration prior to exercise. Equine Exerc. Physiol. 3, 9-16.
23. Johnson, R.L. Jr, Spicer, W.S., Bishop, J.M. and Foster, R.E. (1960) Pulmonary capillary blood volume, flow and diffusing capacity during exercise. J. appl. Physiol. 15, 893-902.
24. Kindig, C.A., McDonough, P., Fenton, G., Poole, D.C. and Erickson, H.H. (2001) Efficacy of nasal strip and furosemide in mitigating EIPH in Thoroughbred horses. J. appl. Physiol. 91, 1396-1400.
25. Kracke, G.R. and Dunham, P.B. (1987) Effect of membrane potential on furosemide-inhibitable sodium influxes in human red blood cells. J. Membr. Biol. 98, 117-124.
26. Lai-Fook, S.J. (1986) Mechanics of lung fluid balance. Crit. Rev. Biomed. Eng. 13, 171-200.
27. Lambert, A. and Lowe, A.G. (1980) Chloride-bicarbonate exchange in human red cells measured using a stopped flow apparatus. J. Physiol. 306, 431-443.
28. Lester, G., Clark, C., Rice, B., Steible-Hartless, C. and Vetro-Widenhouse, T. (1999) Effect of timing and route of administration of furosemide on pulmonary hemorrhage and pulmonary arterial pressure in exercising thoroughbred racehorses. Am. J. vet. Res. 60, 22-28.
29. Lucas, C.L. (1984) Fluid mechanics of the pulmonary circulation. Crit. Rev. Biomed. Eng. 10, 317-393.
30. Lundergan, C.F., Fitzpatrick, T.M., Rose, J.C., Ramwell, P.W. and Kot, P.A. (1988) Effect of cyclooxygenase inhibition on the pulmonary vasodilator response to furosemide. J. Pharmacol. Exp. Ther. 246, 102-106.
31. McDonough, P., Kindig, C.A., Hildreth, T.S., Padilla, D.J., Behnke, B.J., Erickson, H.H. and Poole, D.C. (2004) Effect of furosemide and the equine nasal strip on exercise-induced pulmonary haemorrhage and time-to-fatigue in maximally exercising horses. Equine Comp. Exerc. Physiol. 1, 177-184.
32. Mairbaurl, H., Mayer, K., Kim, K.J., Borok, Z., Bfsch, P. and Crandall, E.D. (2002) Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers. Am. J. Physiol. Lung Cell. Mol. Physiol. 282, L659-L665.
33. Manohar, M. (1993) Furosemide attenuates the exercise-induced increase in pulmonary artery wedge pressure in horses. Am. J. vet. Res. 54, 952-958.
34. Manohar, M. (1994) Pulmonary vascular pressures of strenuously exercising Thoroughbreds after administration of flunixin meglumine and furosemide. Am. J. vet. Res. 55, 1308-1312.
35. Manohar, M. and Goetz, T.E. (1996) Pulmonary vascular pressures of exercising Thoroughbred horses with and without endoscopic evidence of EIPH. J. appl. Physiol. 81, 1589-1593.
36. Manohar, M., Hutchens, E. and Coney, E. (1994) Furosemide attenuates the exercise-induced rise in pulmonary capillary blood pressure in horses. Equine vet. J. 26, 51-54.
37. Newman, J.H., Cochran, C.P., Roselli, R.J., Parker, R.E. and King, L.S. (1993) Pressure and flow changes in the pulmonary circulation in exercising sheep: Evidence for elevated microvascular pressure. Am. Rev. Respir. Dis. 147, 921-926.
38. Odlind, B. (1979) Relation between renal tubular sretion and effects of five loop diuretics. J. Pharmacol. exp. Ther. 211, 238-244.
39. Olsen, S.C., Coyne, C.P., Lowe, B.S., Pelletier, N., Raub, E.M. and Erickson, H.H. (1992a) Influence of furosemide on hemodynamic responses during exercise in horses. Am. J. vet. Res. 53, 742-747.
40. Olsen, S.C., Coyne, C.P., Lowe, B.S., Pelletier, N., Raub, E.M. and Erickson, H.H. (1992b) Influence of cyclooxygenase inhibitors on furosemide-induced hemodynamic effects during exercise in horses. Am. J. vet. Res. 53, 1562-1567.
41. Parker, J.C., Ardell, J.L., Hamm, C.R., Barman, S.A. and Coker, P.J. (1995) Regional pulmonary blood flow during rest, tilt, and exercise in unanesthetized dogs. J. appl. Physiol. 78, 838-846.
42. Parker, J.C., Stevens, T., Randall, J., Weber, D.S. and King, J.A. (2006) Hydraulic conductance of pulmonary microvascular and macrovascular endothelial cell monolayers. Am. J. Physiol. Lung Cell. Mol. Physiol. 291, 30-37.
43. Rubie, S., Robinson, N.E., Stoll, M., Broadstone, R.V. and Derksen, F.J. (1993) Flunixin meglumine blocks frusemide-induced bronchodilation in horses with chronic obstructive pulmonary disease. Equine vet. J. 25, 138-142.
44. Schaffartzik, W., Arcos, J., Tsukimoto, K., Mathieu-Costello, O. and Wagner, P.D. (1993) Pulmonary interstitial edema in the pig after heavy exercise. J. appl. Physiol. 75, 2535-2540.
45. Silke, B. (1993) Central hemodynamic effects of diuretic therapy in chronic heart failure. Cardiovasc. Drugs Ther. 7 (Suppl. 1), 45-53.
46. Sinha, A.K., Gleed, R.D., Hakim, T.S., Dobson, A. and Shannon, K.J. (1996) Pulmonary capillary pressure during exercise in horses. J. appl. Physiol. 80, 1792-1798.
47. Starling, E.H. (1896) On the absorbtion of fluid from connective tissue spaces. J. Physiol. 19, 312-326.
48. Staub, N.C. (1974) Pulmonary edema. Physiol. Rev. 54, 678-811.
49. Vengust, M., Staempfli, H.R., Viel, L. and Heigenhauser, G.J. (2006a) Transvascular fluid flux from the pulmonary vasculature at rest and during exercise in horses. J. Physiol. 570, 397-405.
50. Vengust, M., Staempfli, H.R., Viel, L. and Heigenhauser, G.J. (2006b) Effects of chronic acetazolamide administration on fluid flux from the pulmonary vasculature at rest and during exercise in horses. Equine vet. J., Suppl. 36, 508-515.
51. Wagner, P.D., Gale, G.E., Moon, R.E., Torre-Bueno, J.R., Stolp, B.W. and Saltzman, H.A. (1986) Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J. appl. Physiol. 61, 260-270.
52. Wagner, P.D., Gillespie, J.R., Landgren, G.L., Fedde, M.R., Jones, B.W., DeBowes, R.M., Pieschl, R.L. and Erickson, H.H. (1989) Mechanism of exercise-induced hypoxemia in horses. J. appl. Physiol. 66, 1227-1233.
53. West, J.B., Mathieu-Costello, O., Jones, J.H., Birks, E.K., Logemann, R.B., Pascoe, J.R. and Tyler, W.S. (1993) Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage. J. appl. Physiol. 75, 1097-1109.
54. Widdicombe, J.H., Nathanson, I.T. and Highland, E. (1983) Effects of loop diuretics on ion transport by dog tracheal epithelium. Am. J. Physiol. 245, C388-C396.
55. Wilkins, P.A., Gleed, R.D., Krivitski, N.M. and Dobson, A. (2001) Extravascular lung water in the exercising horse. J. appl. Physiol. 91, 2442-2450.