Role of peripheral serotonin in glucose and lipid metabolism

Current Opinion in Lipidology

Volumn 22, Issue 3, 2011, Pages 186-191

  Watanabe, Hitoshi ^a   Rose, Michael T ^b   Aso, Hisashi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b ABERYSTWYTH UNIVERSITY   (United Kingdom)

Author keywords

Bile acids; glucose metabolism; lipid metabolism; peripheral serotonin; serotonin receptor

Indexed keywords

BILE ACID; GLUCOSE; LIPID; SEROTONIN;

ARTICLE; GLUCOSE METABOLISM; HYPERGLYCEMIA; HYPERINSULINEMIA; LIPID METABOLISM; LIPID STORAGE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BILE ACIDS AND SALTS; BLOOD GLUCOSE; GLUCOSE; HUMANS; LIPID METABOLISM; LIPIDS; LIVER; SEROTONIN;

MUS;

EID: 79957923563     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0b013e3283462273     Document Type: Article

References (60)

1. Ramamoorthy S, Bauman AL, Moore KR, et al. Antidepressant-and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 1993; 90:2542-2546. (Pubitemid 23078664)
2. Cases O, Sefi I, Grimsby J, et al. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 1995; 268:1763-1766.
3. Tecott LH, Sun LM, Akana SF, et al. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 1995; 374:542-546.
4. Rocha BA, Scearce Levie K, Lucas JJ, et al. Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature 1998; 393:175-178. (Pubitemid 28242258)
5. Parks CL, Robinson PS, Sibille E, et al. Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci USA 1998; 95:10734-10739.
6. Gainetdinov RR, Wetsel WC, Jones SR, et al. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 1999; 283:397-401.
7. Rapport MM, Green AA, Page IH. Crystalline serotonin. Science 1948; 108:329-330.
8. Chester AH, Martin GR, Bodelsson M, et al. 5-Hydroxytryptamine receptor profilein healthy and diseased human epicardial coronaryarteries.Cardiovasc Res 1990; 24:932-937. (Pubitemid 20384704)
9. Hixson EJ, Lehrmann GV, Maickel RP. Contractile responses to tryptamine analogues in isolated smooth muscle. Arch Int Phamacodyn Ther 1977; 229:4-14. (Pubitemid 8210901)
10. Holland JM. Serotonin deficiency and prolonged bleeding in beige mice. Proc Soc Exp Biol Med 1976; 151:32-39.
11. Lesurtel M, Graf R, Aleil B, et al. Platelet-derived serotonin mediates liver regeneration. Science 2006; 312:104-107.
12. Geba GP, Ptak W, Anderson GM, et al. Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensi-tivity. J Immunol 1996; 157:557-565. (Pubitemid 26231356)
13. Walther DJ, Peter JU, Bashamakh S, et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003; 299:76. (Pubitemid 36042402)
14. Walther DJ, Bader M. A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 2003; 66:1673-1680. (Pubitemid 37249312)
15. Woolley DW, Shaw E. A biological and pharmacological suggestion about certain mental disorders. Proc Natl Acad Sci USA 1954; 40:228-231.
16. Merritt JH, Chamness AF, Allen SJ. Studies on blood-brain barrier perme-ability after microwave-radiation. Radiat Environ Biophys 1978; 15:367-377. (Pubitemid 9076635)
17. Hoyer D, Hannon JP, Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 2002; 71:533-554. (Pubitemid 34219205)
18. Watanabe H, Akasaka D, Ogasawara H, et al. Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover. Endocrinology 2010; 151:4776-4786.
19. Moore MC, Geho WB, Lautz M, et al. Portal infusion and glucose disposal in conscious dogs. Diabetes 2004; 53:14-20. (Pubitemid 38044692)
20. Hajduch E, Rencurel F, Balendran A, et al. Serotonin (5- hydroxytryptamine), a novel regulator of glucose transport in rat skelet al muscle. J Biol Chem 1999; 274:13563-13568.
21. Kinoshita M, Ono K, Horie T, et al. Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. Mol Endocrinol 2010; 24:1978-1987.
22. Srinivasan S, Sadegh L, Elle IC, et al. Serotonin regulates C elegans fat and feeding through independent molecular mechanisms. Cell Metab 2008; 7:533-544. (Pubitemid 351729208)
23. Yamada J, Sugimoto Y, Kimura I, et al. Serotonin-induced hypoglycemia and increased serum insulin levels in mice. Life Sci 1989; 45:1931-1936. (Pubitemid 19284683)
24. Sugimoto Y, Kimura I, Yamada J, et al. Effects of serotonin on blood glucose and insulin levels of glucose-and streptozotocin-treated mice. Jpn J Pharma-col 1990; 54:93-96. (Pubitemid 20259982)
25. Zawalich WS, Tesz GJ, Zawalich KC. Effects of prior 5-hydroxytryptamine exposure on rat islet insulin secretory and phospholipase C responses. Endocrine 2004; 23:11-16. (Pubitemid 38621634)
26. Paulmann N, Grohmann M, Voigt JP, et al. Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation. PLoS Biol 2009; 7:e1000229.
27. Matsuda M, Imaoka T, Vomachka AJ, et al. Serotonin regulates mammary gland development via an autocrine-paracrine loop. Dev Cell 2004; 6:1 93-203. (Pubitemid 38195217)
28. Kim H, Toyofuku Y, Lynn FC, et al. Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med 2010; 16:804-808.
29. Chaouloff F, Laude D, Baudrie V. Ganglionictransmission is a prerequisitefor the adrenaline-releasing and hyperglycemic effects of 8-OH-DPAT. Eur J Pharmacol 1990; 185:11-18. (Pubitemid 20254892)
30. Sugimoto Y, Yamada J, Kimura I, et al.The effects of theserotonin1 A receptor agonist buspirone on the blood glucose and pancreatic hormones in rats. Jpn J Pharmacol 1992; 60:145-148.
31. Yamada J, Sugimoto Y, Yoshikawa T, et al. The involvement of the peripheral 5-HT2A receptor in peripherally administered serotonin-induced hyperglyce-mia in rats. Life Sci 1995; 57:819-825.
32. Hampson LJ, Mackin P, Agius L Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 2007; 50:1743-1751. (Pubitemid 47036645)
33. Moore MC, Kimura K, Shibata H, et al. Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs. Am J Physiol Endocrinol Metab 2005; 289:E225-E231. (Pubitemid 41076622)
34. Blundell JE. Serotonin manipulations and the structure of feeding behavior. Appetite 1986; 7:39-56. (Pubitemid 16030863)
35. Curzon G. Serotonin and appetite. Ann N Y Acad Sci 1990; 600:521-530.
36. Leibowitz SF, Weiss GF, Shor-Posner G. Hypothalamic serotonin: pharma-cological, biochemical, and behavioral analyses of its feeding-suppressive action.Clin Neuropharmacol 1988; 11 (Suppl. 1):S51-S71.
37. Simansky KJ. Serotonergic control of the organization of feeding and satiety. Behav Brain Res 1996; 73:37-42. (Pubitemid 26008760)
38. Leibowitz SF, Alexander JT. Hypothalamic serotonin in control of eating behavior, meal size, and body weight Biol Psychiatry 1998; 44:851-864. (Pubitemid 28520223)
39. Waku T, Shiraki T, Oyama T, et al. The nuclear receptor PPAR7 individually responds to serotonin-and fatty acid-metabolites. EMBO J 2010; 29:3395-3407
40. Kim HJ, Kim JH, Noh S, et al. Metabolomic analysis of livers and serum from high-fat diet induced obese mice. J Proteome Res 2011; 10:722-731.
41. Kidd M, Modlin IM, Gustafsson BI, et al. Luminal regulation of normal and neoplastic human ECcell serotonin release is mediated by bile salts, amines tastants, and olfactants. Am J Physiol Gastrointest Liver Physiol 2008; 295:G260-G272.
42. Gershon MD. Reviewarticle: serotonin roles played by 5-hydroxytryptamine in the physiologyof the bowel. Aliment Pharmacol Ther 1999; 13 (Suppl 2):15-30. (Pubitemid 29219277)
43. Peregrin A, Ahlman H, Jodal M, Lundgren O. Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin. Br J Pharmacol 1999; 127:887-894. (Pubitemid 29295347)
44. Racke K, Reimann A, Schworer H, Kilbinger H. Regulation of 5-HT release from enterochromaffin cells Behav. Brain Res 1996; 73:83-87. (Pubitemid 26008766)
45. Zhu J, Wu X, Owyang C, Li Y. Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat J Physiol 2001; 530:431-442. (Pubitemid 32162331)
46. Duran-Sandoval D, Cariou B, Percevault F, et al. The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition. J Biol Chem 2005; 280:29971-29979. (Pubitemid 41177076)
47. Zhang Y, Lee FY, Barrera G, et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci USA 2006; 103:1006-1011. (Pubitemid 43212212)
48. Watanabe M, Houten SM, Wang L, et al. Bileacids lowertriglyceride levelsvia a pathway involving FXR, SHP, and SREBP-1c J Clin Invest 2004; 113:1408-1418.
49. Watanabe M, Houten SM, Mataki C, et al. Bile acids induce energy expen-diture by promoting intracellular thyroid hormone activation. Nature 2006; 439:484-489. (Pubitemid 43152840)
50. Bogach PG, Liashchenko PS. The effect of serotonin on bile secretion in dugs. Fiziol Zh SSSR Im I M Sechenova 1976; 62:283-288.
51. Ivy AC, Oldberg E. A hormone mechanism of gallbladder contraction and evacuation. Am J Physiol 1928; 86:599-613.
52. Briejer MR, Mathis C, Schuurkes JA. 5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction. Neuro-gastroenterol Motil 1997; 9:231-237. (Pubitemid 27499526)
53. Choi M, Moschetta A, Bookout AL, et al. Identification of a hormonal basis for gallbladder filling. Nat Med 2006; 12:1253-1255. (Pubitemid 44706926)
54. Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 2003; 72:137-174. (Pubitemid 36930444)
55. InagakiT, Choi M, MoschettaA, et al. Fibroblastgrowthfactor 15functionsas an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005; 2:217-225.
56. Oelkers P, Kirby LC, Heubi JE, Dawson PA. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J Clin Invest 1997; 99:1880-1887. (Pubitemid 27175935)
57. Dawson PA, Haywood J, Craddock AL, et al. Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. J Biol Chem 2003; 278:33920-33927. (Pubitemid 37553226)
58. Sinha J, Chen F, Miloh T, et al. Beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholan-giocytes. Am J Physiol Gastrointest Liver Physiol 2008; 295:G996-G1003.
59. Neimark E, Chen F, Li X, Shneider BL Bile acid-induced negative feedback regulation of the human ileal bile acid transporter. Hepatology 2004; 40:149-156. (Pubitemid 38877576)
60. Jung D, InagakiT, Gerard RD, et al. FXRagonistsand FGF15 reducefecal bile acid excretion in a mouse model of bile acid malabsorption. J Lipid Res 2007; 48:2693-2700. (Pubitemid 350272854)