Structural basis for the role of LYS220 as proton donor for nucleotidyl transfer in HIV-1 reverse transcriptase

Biophysical Chemistry

Volumn 157, Issue 1-3, 2011, Pages 1-6

  Michielssens, Servaas ^a   Moors, Samuel L C ^a   Froeyen, Mathy ^b   Herdewijn, Piet ^b   Ceulemans, Arnout ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Enzymatic catalysis; HIV reverse transcriptase; Molecular dynamics; Protein dynamics; QM MM

Indexed keywords

LYS220 PROTEIN; NUCLEOTIDYLTRANSFERASE; PYROPHOSPHATE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; PROTEIN STRUCTURE; QUANTUM MECHANICS;

CRYSTALLOGRAPHY, X-RAY; HIV REVERSE TRANSCRIPTASE; LYSINE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; NUCLEIC ACIDS; PROTONS; QUANTUM THEORY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79957916557     PISSN: 03014622     EISSN: 18734200     Source Type: Journal    
DOI: 10.1016/j.bpc.2011.03.009     Document Type: Article

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