Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2′-5′-ADP and FMN binding traits

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Lian, Lu Yun ^a   Widdowson, Philip ^a   McLaughlin, Lesley A ^b   Paine, Mark J I ^c  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' ADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE; CYTOCHROME C; DIPHENYLIODONIUM SALT; FLAVINE MONONUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG; ADENOSINE 2',5' DIPHOSPHATE; ADENOSINE 2',5'-DIPHOSPHATE; INSECT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ANOPHELES GAMBIAE; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOCHEMICAL COMPOSITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME PURIFICATION; HUMAN; IC 50; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PROTEIN EXPRESSION; REDUCTION; SEQUENCE ALIGNMENT; STEADY STATE; AMINO ACID SEQUENCE; ANIMAL; CALORIMETRY; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; SEQUENCE HOMOLOGY;

ANOPHELES GAMBIAE; ESCHERICHIA COLI;

ADENOSINE DIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; ANOPHELES GAMBIAE; BINDING SITES; CALORIMETRY; CYTOCHROMES C; FLAVIN MONONUCLEOTIDE; HUMANS; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79957870064     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020574     Document Type: Article

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