CovR-controlled global regulation of gene expression in streptococcus mutans

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Dmitriev, Alexander ^a,b   Mohapatra, Saswat S ^a   Chong, Patrick ^a,d   Neely, Melody ^c   Biswas, Saswati ^a   Biswas, Indranil ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Russian Federation)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; PROTEIN COVR; UNCLASSIFIED DRUG; REPRESSOR PROTEIN;

ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CONTROLLED STUDY; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REGULON; SIGNAL TRANSDUCTION; STREPTOCOCCUS MUTANS; TRANSCRIPTION REGULATION; UPREGULATION; WILD TYPE; DNA MICROARRAY; GENETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TWO DIMENSIONAL GEL ELECTROPHORESIS;

STREPTOCOCCUS; STREPTOCOCCUS MUTANS;

BACTERIAL PROTEINS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, BACTERIAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REGULON; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOCOCCUS MUTANS;

EID: 79957868056     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020127     Document Type: Article

References (62)

1. Loesche WJ, (1986) Role of Streptococcus mutans in human dental decay. Microbiol Rev 50: 353-380.
2. Hamada S, Slade HD, (1980) Biology, immunology, and cariogenicity of Streptococcus mutans. Microbiol Rev 44: 331-384.
3. Banas JA, (2004) Virulence properties of Streptococcus mutans. Front Biosci 9: 1267-1277.
4. Carlsson J, Hamilton IR, (1994) Metabolic activity of oral bacteria Copenhagen, Denmark Munksgaard.
5. Edgar WM, Higham SM, (1996) Saliva and the control of plaque pH. In: O'Mullane WMEaDM, editors. Saliva and oral health. 2nd ed London, United Kingdom British Dental Association pp. 81-94.
6. Kuramitsu H, (1993) Virulence factors of mutans streptococci: role of molecular genetics. Crit Rev Oral Biol Med 4: 159-176.
7. Ullman RF, Miller SJ, Strampfer MJ, Cunha BA, (1988) Streptococcus mutans endocarditis: report of three cases and review of the literature. Heart Lung 17: 209-212.
8. Stock AM, Robinson VL, Goudreau PN, (2000) Two-component signal transduction. Annu Rev Biochem 69: 183-215.
9. Mitrophanov AY, Groisman EA, (2008) Signal integration in bacterial two-component regulatory systems. Genes Dev 22: 2601-2611.
10. Laub MT, Goulian M, (2007) Specificity in two-component signal transduction pathways. Annu Rev Genet 41: 121-145.
11. Mascher T, Helmann JD, Unden G, (2006) Stimulus perception in bacterial signal-transducing histidine kinases. Microbiol Mol Biol Rev 70: 910-938.
12. Jordan S, Hutchings MI, Mascher T, (2008) Cell envelope stress response in Gram-positive bacteria. FEMS Microbiol Rev 32: 107-146.
13. Groisman EA, Mouslim C, (2006) Sensing by bacterial regulatory systems in host and non-host environments. Nat Rev Microbiol 4: 705-709.
14. Novick RP, Geisinger E, (2008) Quorum sensing in staphylococci. Annu Rev Genet 42: 541-564.
15. Ajdic D, McShan WM, McLaughlin RE, Savic G, Chang J, et al. (2002) Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc Natl Acad Sci U S A 99: 14434-14439.
16. Biswas I, Drake L, Erkina D, Biswas S, (2008) Involvement of sensor kinases in the stress tolerance response of Streptococcus mutans. J Bacteriol 190: 68-77.
17. Chong P, Drake L, Biswas I, (2008) Modulation of covR expression in Streptococcus mutans UA159. J Bacteriol 190: 4478-4488.
18. Biswas S, Biswas I, (2006) Regulation of the glucosyltransferase (gtfBC) operon by CovR in Streptococcus mutans. J Bacteriol 188: 988-998.
19. Federle MJ, McIver KS, Scott JR, (1999) A response regulator that represses transcription of several virulence operons in the group A streptococcus. Journal of Bacteriology 181: 3649-3657.
20. Graham MR, Smoot LM, Lei B, Musser JM, (2001) Toward a genome-scale understanding of group A Streptococcus pathogenesis. Curr Opin Microbiol 4: 65-70.
21. Graham MR, Smoot LM, Migliaccio CA, Virtaneva K, Sturdevant DE, et al. (2002) Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling. Proc Natl Acad Sci U S A 99: 13855-13860.
22. Heath A, DiRita VJ, Barg NL, Engleberg NC, (1999) A two-component regulatory system, CsrR-CsrS, represses expression of three Streptococcus pyogenes virulence factors, hyaluronic acid capsule, streptolysin S, and pyrogenic exotoxin B. Infection and Immunity 67: 5298-5305.
23. Levin JC, Wessels MR, (1998) Identification of csrR/csrS, a genetic locus that regulates hyaluronic acid capsule synthesis in group A Streptococcus. Molecular Microbiology 30: 209-219.
24. Lamy MC, Zouine M, Fert J, Vergassola M, Couve E, et al. (2004) CovS/CovR of group B streptococcus: a two-component global regulatory system involved in virulence. Mol Microbiol 54: 1250-1268.
25. Steiner K, Malke H, (2002) Dual control of streptokinase and streptolysin S production by the covRS and fasCAX two-component regulators in Streptococcus dysgalactiae subsp. equisimilis. Infect Immun 70: 3627-3636.
26. Sumby P, Whitney AR, Graviss EA, DeLeo FR, Musser JM, (2006) Genome-wide analysis of group a streptococci reveals a mutation that modulates global phenotype and disease specificity. PLoS Pathog 2: e5.
27. Jiang SM, Ishmael N, Hotopp JD, Puliti M, Tissi L, et al. (2008) Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity. J Bacteriol 190: 1956-1965.
28. Miller AA, Engleberg NC, DiRita VJ, (2001) Repression of virulence genes by phosphorylation-dependent oligomerization of CsrR at target promoters in S. pyogenes. Molecular Microbiology 40: 976-990.
29. Federle MJ, Scott JR, (2002) Identification of binding sites for the group A streptococcal global regulator CovR. Molecular Microbiology 43: 1161-1172.
30. Gusa AA, Scott JR, (2005) The CovR response regulator of group A streptococcus (GAS) acts directly to repress its own promoter. Mol Microbiol 56: 1195-1207.
31. Gao J, Gusa AA, Scott JR, Churchward G, (2005) Binding of the global response regulator protein CovR to the sag promoter of Streptococcus pyogenes reveals a new mode of CovR-DNA interaction. J Biol Chem pp. 38948-38956.
32. Gusa AA, Froehlich BJ, Desai D, Stringer V, Scott JR, (2007) CovR activation of the dipeptide permease promoter (PdppA) in Group A Streptococcus. J Bacteriol 189: 1407-1416.
33. Biswas I, Drake L, Biswas S, (2007) Regulation of gbpC expression in Streptococcus mutans. J Bacteriol 189: 6521-6531.
34. Chong P, Chattoraj P, Biswas I, (2010) Activation of the SMU.1882 transcription by CovR in Streptococcus mutans. PLoS One 5: e15528.
35. Churchward G, (2007) The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci. Mol Microbiol 64: 34-41.
36. Dalton TL, Scott JR, (2004) CovS inactivates CovR and is required for growth under conditions of general stress in Streptococcus pyogenes. J Bacteriol 186: 3928-3937.
37. Biswas I, Scott JR, (2003) Identification of rocA, a Positive Regulator of covR Expression in the Group A Streptococcus. J Bacteriol 185: 3081-3090.
38. Perez-Casal J, Caparon MG, Scott JR, (1991) Mry, a trans-acting positive regulator of the M protein gene of Streptococcus pyogenes with similarity to the receptor proteins of two-component regulatory systems. Journal of Bacteriology 173: 2617-2624.
39. Burne RA, Wen ZT, Chen YY, Penders JE, (1999) Regulation of expression of the fructan hydrolase gene of Streptococcus mutans GS-5 by induction and carbon catabolite repression. J Bacteriol 181: 2863-2871.
40. Biswas I, Drake L, Johnson S, Thielen D, (2007) Unmarked gene modification in Streptococcus mutans by a cotransformation strategy with a thermosensitive plasmid. Biotechniques 42: 487-490.
41. Shemesh M, Tam A, Steinberg D, (2007) Differential gene expression profiling of Streptococcus mutans cultured under biofilm and planktonic conditions. Microbiology 153: 1307-1317.
42. Biswas I, Germon P, McDade K, Scott JR, (2001) Generation and surface localization of intact M protein in Streptococcus pyogenes are dependent on sagA. Infect Immun 69: 7029-7038.
43. Chaussee MA, Callegari EA, Chaussee MS, (2004) Rgg regulates growth phase-dependent expression of proteins associated with secondary metabolism and stress in Streptococcus pyogenes. J Bacteriol 186: 7091-7099.
44. Crowley PJ, Brady LJ, Michalek SM, Bleiweis AS, (1999) Virulence of a spaP mutant of Streptococcus mutans in a gnotobiotic rat model. Infect Immun 67: 1201-1206.
45. Waterhouse JC, Russell RR, (2006) Dispensable genes and foreign DNA in Streptococcus mutans. Microbiology 152: 1777-1788.
46. Waterhouse JC, Swan DC, Russell RR, (2007) Comparative genome hybridization of Streptococcus mutans strains. Oral Microbiol Immunol 22: 103-110.
47. Chattoraj P, Banerjee A, Biswas S, Biswas I, (2010) ClpP of Streptococcus mutans differentially regulates expression of genomic islands, mutacin production, and antibiotic tolerance. J Bacteriol 192: 1312-1323.
48. Biswas S, Biswas I, (2005) Role of HtrA in Surface Protein Expression and Biofilm Formation by Streptococcus mutans. Infect Immun 73: 6923-6934.
49. Gryllos I, Grifantini R, Colaprico A, Jiang S, Deforce E, et al. (2007) Mg(2+) signalling defines the group A streptococcal CsrRS (CovRS) regulon. Mol Microbiol 65: 671-683.
50. Jungblut PR, Bumann D, Haas G, Zimny-Arndt U, Holland P, et al. (2000) Comparative proteome analysis of Helicobacter pylori. Mol Microbiol 36: 710-725.
51. Guillot A, Gitton C, Anglade P, Mistou MY, (2003) Proteomic analysis of Lactococcus lactis, a lactic acid bacterium. Proteomics 3: 337-354.
52. Folio P, Chavant P, Chafsey I, Belkorchia A, Chambon C, et al. (2004) Two-dimensional electrophoresis database of Listeria monocytogenes EGDe proteome and proteomic analysis of mid-log and stationary growth phase cells. Proteomics 4: 3187-3201.
53. Chaussee MA, McDowell EJ, Rieck LD, Callegari EA, Chaussee MS, (2006) Proteomic analysis of a penicillin-tolerant rgg mutant strain of Streptococcus pyogenes. J Antimicrob Chemother 58: 752-759.
54. Tadesse S, Graumann PL, (2007) DprA/Smf protein localizes at the DNA uptake machinery in competent Bacillus subtilis cells. BMC Microbiol 7: 105.
55. Ulijasz AT, Falk SP, Weisblum B, (2009) Phosphorylation of the RitR DNA-binding domain by a Ser-Thr phosphokinase: implications for global gene regulation in the streptococci. Mol Microbiol 71: 382-390.
56. Santi I, Grifantini R, Jiang SM, Brettoni C, Grandi G, et al. (2009) CsrRS regulates group B Streptococcus virulence gene expression in response to environmental pH: a new perspective on vaccine development. J Bacteriol 191: 5387-5397.
57. Engleberg NC, Heath A, Vardaman K, DiRita VJ, (2004) Contribution of CsrR-regulated virulence factors to the progress and outcome of murine skin infections by Streptococcus pyogenes. Infect Immun 72: 623-628.
58. Miyoshi-Akiyama T, Ikebe T, Watanabe H, Uchiyama T, Kirikae T, et al. (2006) Use of DNA arrays to identify a mutation in the negative regulator, csrR, responsible for the high virulence of a naturally occurring type M3 group A streptococcus clinical isolate. J Infect Dis 193: 1677-1684.
59. Neely MN, Pfeifer JD, Caparon M, (2002) Streptococcus-zebrafish model of bacterial pathogenesis. Infect Immun 70: 3904-3914.
60. Gryllos I, Levin JC, Wessels MR, (2003) The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+. Proc Natl Acad Sci U S A 100: 4227-4232.
61. Froehlich BJ, Bates C, Scott JR, (2009) Streptococcus pyogenes CovRS mediates growth in iron starvation and in the presence of the human cationic antimicrobial peptide LL-37. J Bacteriol 191: 673-677.
62. Rajagopal L, Vo A, Silvestroni A, Rubens CE, (2006) Regulation of cytotoxin expression by converging eukaryotic-type and two-component signaling mechanisms in Streptococcus agalactiae. Mol Microbiol 62: 941-957.