Induced pluripotent stem cells and primary immunodeficiencies: A new frontier reached, a new world beyond?

Journal of Allergy and Clinical Immunology

Volumn 127, Issue 6, 2011, Pages 1408-1409

  Gaspar, H Bobby ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

disease pathogenesis; gene therapy; Induced pluripotent stem cells; primary immunodeficiencies

Indexed keywords

FANCONI ANEMIA GROUP A PROTEIN; FANCONI ANEMIA GROUP D2 PROTEIN; LENTIVIRUS VECTOR; LEVO IDURONIDASE; SMALL INTERFERING RNA;

CELL DIFFERENTIATION; EDITORIAL; FANCONI ANEMIA; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HURLER SYNDROME; IMMUNE DEFICIENCY; NONHUMAN; PLURIPOTENT STEM CELL; PRIMARY IMMUNODEFICIENCY; PRIORITY JOURNAL; SEVERE COMBINED IMMUNODEFICIENCY; SKIN FIBROBLAST; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; CELL TRANSDIFFERENTIATION; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INDUCED PLURIPOTENT STEM CELLS; MICE;

EID: 79957861474     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.02.038     Document Type: Editorial

References (11)

1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76. (Pubitemid 44233629)
2. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20.
3. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008;451:141-6.
4. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature 1997;385:810-3. (Pubitemid 27106068)
5. Pessach IM, Ordovas-Montanes J, Zhang SY, Casanova JL, Giliani S, Gennery AR, et al. Induced pluripotent stem cells: A novel frontier in the study of human primary immunodeficiencies. J Allergy Clin Immunol 2011;127:1400-7.
6. Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, et al. Disease-specific induced pluripotent stem cells. Cell 2008;134:877-86.
7. Sakamoto H, Tsuji-Tamura K, Ogawa M. Hematopoiesis from pluripotent stem cell lines. Int J Hematol 2010;91:384-91.
8. Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, et al. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 2007;318:1920-3.
9. Raya A, Rodriguez-Piza I, Guenechea G, Vassena R, Navarro S, Barrero MJ, et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 2009;460:53-9.
10. Tolar J, Park IH, Xia L, Lees CJ, Peacock B, Webber B, et al. Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome). Blood 2011;117:839-47.
11. Hacein-Bey-Abina S, Garrigue A, Wang GP, Soulier J, Lim A, Morillon E, et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest 2008;118:3132-42.