11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis

Neuropharmacology

Volumn 61, Issue 1-2, 2011, Pages 133-137

  Kaminski, Rafal M ^a,c   Rogawski, Michael A ^a,b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UCB PHARMA   (Belgium)

Author keywords

Allotetrahydrodeoxycorticosterone; Etomidate; Finasteride; Metyrapone; Neurosteroid; Steroid 11 hydroxylase (CYP11B1) inhibitor

Indexed keywords

11BETA HYDROXYLASE INHIBITOR; ENZYME INHIBITOR; ETOMIDATE; FINASTERIDE; METYRAPONE; STEROID 11BETA MONOOXYGENASE; TETRAHYDRODEOXYCORTICOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT THERAPY; ARTICLE; CHEMOPROPHYLAXIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG TARGETING; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SEIZURE; STEROID BLOOD LEVEL; STEROIDOGENESIS;

ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MALE; METYRAPONE; MICE; NEUROPROTECTIVE AGENTS; NEUROTRANSMITTER AGENTS; SEIZURES; STEROID 11-BETA-HYDROXYLASE;

EID: 79957861451     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.03.019     Document Type: Article

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