Measuring Permeability in Acute Ischemic Stroke

Neuroimaging Clinics of North America

Volumn 21, Issue 2, 2011, Pages 315-325

  Kassner, Andrea ^a   Mandell, Daniel M ^a   Mikulis, David J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

CT; Dynamic contrast enhanced imaging; Hemorrhagic transformation; MRI; Permeability; Stroke

Indexed keywords

ALTEPLASE; GADOLINIUM PENTETATE;

BLOOD BRAIN BARRIER; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CAPILLARY PERMEABILITY; COMPARTMENT MODEL; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CONTRAST MEDIUM EXTRAVASATION; FIBRINOLYTIC THERAPY; GLOMERULUS FILTRATION; HUMAN; IMAGE QUALITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PERMEABILITY BARRIER; PRIORITY JOURNAL; REVIEW; SIGNAL NOISE RATIO;

CAPILLARY PERMEABILITY; CEREBRAL ANGIOGRAPHY; CEREBRAL HEMORRHAGE; HUMANS; ISCHEMIC ATTACK, TRANSIENT; PERFUSION IMAGING;

EID: 79957857308     PISSN: 10525149     EISSN: 15579867     Source Type: Journal    
DOI: 10.1016/j.nic.2011.01.004     Document Type: Review

References (44)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995, 333:1581-1587.
2. Hacke W., Kaste M., Bluhmki E., et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008, 359:1317-1329.
3. Hamann G.F., Okada Y., del Zoppo G.J. Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion. J Cereb Blood Flow Metab 1996, 16:1373-1378.
4. Dijkhuizen R.M., Asahi M., Wu O., et al. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke 2002, 33:2100-2104.
5. Busch E., Kruger K., Fritze K., et al. Blood-brain barrier disturbances after rt-PA treatment of thromboembolic stroke in the rat. Acta Neurochir 1997, 70:206-208.
6. Kelly M.A., Shuaib A., Todd K.G. Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis. Exp Neurol 2006, 200:38-49.
7. Montaner J., Molina C.A., Monasterio J., et al. Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation 2003, 107:598-603.
8. Yepes M., Sandkvist M., Moore E.G., et al. Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest 2003, 112:1533-1540.
9. Weinmann H.J., Laniado M., Mutzel W. Pharmacokinetics of Gd-DTPA/dimeglumine after intravenous injection into healthy volunteers. Physiol Chem Phys Med NMR 1984, 16:167-172.
10. Vo K.D., Santiago F., Lin W., et al. MR imaging enhancement patterns as predictors of hemorrhagic transformation in acute ischemic stroke. AJNR Am J Neuroradiol 2003, 24:674-679.
11. Kim E.Y., Na D.G., Kim S.S., et al. Prediction of hemorrhagic transformation in acute ischemic stroke: role of diffusion-weighted imaging and early parenchymal enhancement. AJNR Am J Neuroradiol 2005, 26:1050-1055.
12. Kastrup A., Groschel K., Ringer T.M., et al. Early disruption of the blood-brain barrier after thrombolytic therapy predicts hemorrhage in patients with acute stroke. Stroke 2008, 39:2385-2387.
13. Merten C.L., Knitelius H.O., Assheuer J., et al. MRI of acute cerebral infarcts, increased contrast enhancement with continuous infusion of gadolinium. Neuroradiology 1999, 41:242-248.
14. Virapongse C., Mancuso A., Quisling R. Human brain infarcts: Gd-DTPA-enhanced MR imaging. Radiology 1986, 161:785-794.
15. Mikulis DJ, Guo G, Wu R, et al. Gadolinium Enhancement Predicts Hemorrhagic Transformation in Acute Ischemic Stroke [abstract: 43]. In: 44th Annual Meeting of the American Society for Neuroradiology. San Diego (CA), May 2006.
16. Latour L.L., Kang D.W., Ezzeddine M.A., et al. Early blood-brain barrier disruption in human focal brain ischemia. Ann Neurol 2004, 56:468-477.
17. Wang X., Tsuji K., Lee S.R., et al. Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke. Stroke 2004, 35:2726-2730.
18. Kassner A., Roberts T.P. Beyond perfusion: cerebral vascular reactivity and assessment of microvascular permeability. Top Magn Reson Imaging 2004, 15:58-65.
19. Cheng H.L. Investigation and optimization of parameter accuracy in dynamic contrast-enhanced MRI. J Magn Reson Imaging 2008, 28:736-743.
20. Kassner A., Roberts T., Taylor K., et al. Prediction of hemorrhage in acute ischemic stroke using permeability MR imaging. AJNR Am J Neuroradiol 2005, 26:2213-2217.
21. Roberts T.P. Physiologic measurements by contrast-enhanced MR imaging: expectations and limitations. J Magn Reson Imaging 1997, 7:82-90.
22. Pruessmann K.P., Weiger M., Scheidegger M.B., et al. SENSE: sensitivity encoding for fast MRI. Magn Reson Med 1999, 42:952-962.
23. Donahue K.M., Weisskoff R.M., Burstein D. Water diffusion and exchange as they influence contrast enhancement. J Magn Reson Imaging 1997, 7:102-110.
24. Larsson H.B., Stubgaard M., Frederiksen J.L., et al. Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors. Magn Reson Med 1990, 16:117-131.
25. Brix G., Semmler W., Port R., et al. Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr 1991, 15:621-628.
26. Tofts P.S., Kermode A.G. Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging: 1. Fundamental concepts. Magn Reson Med 1991, 17:357-367.
27. Patlak C.S., Blasberg R.G., Fenstermacher J.D. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983, 3:1-7.
28. Patlak C.S., Blasberg R.G. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 1985, 5:584-590.
29. Tofts P.S., Brix G., Buckley D.L., et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 1999, 10:223-232.
30. Roberts H.C., Roberts T.P., Brasch R.C., et al. Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade. AJNR Am J Neuroradiol 2000, 21:891-899.
31. Ewing J.R., Knight R.A., Nagaraja T.N., et al. Patlak plots of Gd-DTPA MRI data yield blood-brain transfer constants concordant with those of 14C-sucrose in areas of blood-brain opening. Magn Reson Med 2003, 50:283-292.
32. Knight R.A., Barker P.B., Fagan S.C., et al. Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats. Stroke 1998, 29:144-151.
33. Kassner A, Liu F, Matta S, et al. Quantitative dynamic contrast-enhanced MRI: a potential tool for guiding treatment decisions in acute ischemic stroke. In: Joint Annual Meeting ISMRM-ESMRMB. Berlin (Germany), May 2007. p. 499.
34. Ding G., Jiang Q., Li L., et al. Detection of BBB disruption and hemorrhage by Gd-DTPA enhanced MRI after embolic stroke in rat. Brain Res 2006, 1114:195-203.
35. Vidarsson L., Thornhill R.E., Liu F., et al. Quantitative permeability MRI in acute ischemic stroke: how long do we need to scan?. Magn Reson Imaging 2009, 27(9):1216-1222.
36. Dankbaar J.W., Hom J., Schneider T., et al. Dynamic perfusion CT assessment of the blood-brain barrier permeability: first pass versus delayed acquisition. AJNR Am J Neuroradiol 2008, 29:1671-1676.
37. Lin K., Kazmi K.S., Law M., et al. Measuring elevated microvascular permeability and predicting hemorrhagic transformation in acute ischemic stroke using first-pass dynamic perfusion CT imaging. AJNR Am J Neuroradiol 2007, 28:1292-1298.
38. Hom J., Dankbaar J.W., Schneider T., et al. Optimal duration of acquisition for dynamic perfusion CT assessment of blood-brain barrier permeability using the Patlak model. AJNR Am J Neuroradiol 2009, 30:1366-1370.
39. Aviv R.I., d'Esterre C.D., Murphy B.D., et al. Hemorrhagic transformation of ischemic stroke: prediction with CT perfusion. Radiology 2009, 250:867-877.
40. Kassner A., Annesley D.J., Zhu X.P., et al. Abnormalities of the contrast re-circulation phase in cerebral tumors demonstrated using dynamic susceptibility contrast-enhanced imaging: a possible marker of vascular tortuosity. J Magn Reson Imaging 2000, 11:103-113.
41. Lupo J.M., Cha S., Chang S.M., et al. Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity. AJNR Am J Neuroradiol 2005, 26:1446-1454.
42. Bang O.Y., Buck B.H., Saver J.L., et al. Prediction of hemorrhagic transformation after recanalization therapy using T2*-permeability magnetic resonance imaging. Ann Neurol 2007, 62:170-176.
43. Wu SP, Vidarsson L, Winter J, et al. Estimates of relative contrast recirculation obtained from perfusion MRI: a potential tool for guiding treatment decision in acute ischemic stroke. In: 16th Scientific Meeting and Exhibition of the ISMRM. Toronto (ON), May 2008. p. 307.
44. Jackson A., Kassner A., Annesley-Williams D., et al. Abnormalities in the recirculation phase of contrast agent bolus passage in cerebral gliomas: comparison with relative blood volume and tumor grade. AJNR Am J Neuroradiol 2002, 23:7-14.