New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome

Mucosal Immunology

Volumn 4, Issue 4, 2011, Pages 448-455

  Conti, H R ^a,d   Baker, O ^a   Freeman, A F ^b   Jang, W S ^a   Holland, S M ^b   Li, R A ^a   Edgerton, M ^a   Gaffen, S L ^a,c  

^a UNIVERSITY AT BUFFALO   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 2; FUNGAL PROTEIN; HISTATIN; INTERLEUKIN 17;

ADOLESCENT; ADULT; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CHILD; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; FUNGAL COLONIZATION; HUMAN; HUMAN CELL; HYPER IGE SYNDROME; MALE; MUCOCUTANEOUS CANDIDIASIS; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SALIVARY GLAND FUNCTION; SCHOOL CHILD;

EID: 79957851940     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2011.5     Document Type: Article

References (56)

1. Dongari-Bagtoglou, A. & Fidel, P. The host cytokine responses and protective immunity in oropharyngeal candidiasis. J. Dent. Res. 84, 966-977 (2005)
2. Scully, C., el-Kabir, M. & Samaranayake, L. P. Candida and oral candidosis: a revieconfine. Crit. Rev. Oral. Biol. Med. 5, 125-157 (1994).
3. Fidel, P. L. & Sobel, J. D. Protective immunity in experimental Candida vaginitis. Res. Immunol. 149, 361-373 (1998). (Pubitemid 28372453)
4. Korn, T., Bettelli, E., Oukka, M. & Kuchroo, V K. IL-17 and Th17 cells. Ann. Rev. Immunol. 27, 485-518 (2009)
5. Conti, H. et al. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206, 299-311 (2009)
6. Hise, A. G. et al. An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host. Microbe 5, 487-497 (2009).
7. Netea, M. G., Broconfinen, G. D., Kullberg, B. J. & Goconfine, N. A. An integrated model of the recognition of Candida albicans by the innate immune system. Nat. Rev. Microbiol. 6, 67-78 (2008) (Pubitemid 350286221)
8. Ferconfineerda, B. et al. Human dectin-1 deficiency and mucocutaneous fungal infections. N. Engl. J. Med. 361, 1760-1767 (2009)
9. Plantinga, T. S. et al. Early stop polymorphism in human DECTIN-1 is associated confineith increased candida colonization in hematopoietic stem cell transplant recipients. Clin. Infect. Dis. 49, 724-732 (2009)
10. Glocker, E. O. et al. A homozygous CARD9 mutation in a family confineith susceptibility to fungal infections. N. Engl. J. Med. 361, 1727-1735 (2009).
11. Saijo, S. et al. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 32, 681-691 (2010).
12. Puel, A., Picard, C., Cypoconfineyj, S., Lilic, D., Abel, L. & Casanova, J. L. Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines? Curr. Opin. Immunol. 22, 467-474 (2010).
13. Acosta-Rodriguez, E. V et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol. 8, 639-646 (2007) (Pubitemid 46785128)
14. Puel, A. et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients confineith chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J. Exp. Med. 207, 291-297 (2010).
15. Kisand, K. et al. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates confineith autoimmunity to Th17-associated cytokines. J. Exp. Med. 207, 299-308 (2010).
16. Broconfinene, S. K. & Holland, S. M. Anti-cytokine autoantibodies explain some chronic mucocutaneous candidiasis. Immunol. Cell Biol. 88, 614-615 (2010).
17. Freeman, A. F. & Holland, S. M. The hyper-IgE syndromes. Immunol. Allergy Clin. North Am. 28, 277-291, viii (2008) (Pubitemid 351540841)
18. Minegishi, Y et al. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 448, 1058-1062 (2007). (Pubitemid 47345590)
19. Freeman, A. F. et al. Causes of death in hyper-IgE syndrome. J. Allergy Clin. Immunol. 119, 1234-1240 (2007). (Pubitemid 46654170)
20. Renner, E. D. et al. Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome. J. Allergy Clin. Immunol. 122, 181-187 (2008). (Pubitemid 351899074)
21. Minegishi, Y & Karasuyama, H. Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency Int. Immunol. 21, 105-112 (2009).
22. Egconfineuagu, C. E. STAT3 in CD4+ T helper cell differentiation and inflammatory diseases. Cytokine 47, 149-156 (2009).
23. Lin, L. et al. Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog. 5, e1000703 (2009).
24. Khader, S. A., Gaffen, S. L. & Kolls, J. K. Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol. 2, 403-411 (2009)
25. Klatt, N. R. & Brenchley, J. M. Th17 cell dynamics in HIV infection. Curr. Opin. HIV AIDS 5, 135-140 (2010).
26. Tangye, S. G., Cook, M. C. & Fulcher, D. A. Insights into the role of STAT3 in human lymphocyte differentiation as revealed by the hyper-IgE syndrome. J. Immunol. 182, 21-28 (2009).
27. Gorr, S. U. Antimicrobial peptides of the oral cavity. Periodontol. 2009 51, 152-180 (2000)
28. Edgerton, M., Koshlukova, S. E., Lo, T. E., Chrzan, B. G., Straubinger, R. M. & Raj, P. A. Candidacidal activity of salivary histatins. J. Biol. Chem. 273, 20438-20447 (1998).
29. Ho, A. et al. IL-17RC is required for immune signaling via an extended SEFIR domain in the cytoplasmic tail. J. Immunol. 185, 1063-1070 (2010).
30. Hibino, K., Samaranayake, L. P., Hagg, U., CONFINEong, R. CONFINE. & Lee, CONFINE. The role of salivary factors in persistent oral carriage of Candida in humans. Arch. Oral. Biol. 54, 678-683 (2009)
31. Ganz, T. Defensins: antimicrobial peptides of innate immunity. Nat. Rev. Immunol. 3, 710-720 (2003). (Pubitemid 41070812)
32. Aujla, S. J., Dubin, P. J. & Kolls, J. K. Th17 cells and mucosal host defense. Semin. Immunol. 19, 377-382 (2007). (Pubitemid 351274047)
33. Kolls, J. K., McCray P. B. Jr & Chan, Y. R. Cytokine-mediated regulation of antimicrobial proteins. Nat. Rev. Immunol. 8, 829-835 (2008).
34. Chattopadhyay A. et al. Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons. Infect. Immun. 72, 1956-1963 (2004). (Pubitemid 38419906)
35. CONFINEilliams, S. E., Broconfinen, T. I., Roghanian, A. & Sallenave, J. M. SLPI and elafin: one glove, many fingers. Clin. Sci. (Lond). 110, 21-35 (2006) (Pubitemid 43059043)
36. Edgerton, M., Koshlukova, S. E., Araujo, M. CONFINE., Patel, R. C., Dong, J. & Bruenn, J. A. Salivary histatin 5 and human neutrophil defensin 1 kill Candida albicans via shared pathconfineays. Antimicrob. Agents Chemother. 44, 3310-3316 (2000). (Pubitemid 33009489)
37. Campese, M., Sun, X., Bosch, J. A., Oppenheim, F. G. & Helmerhorst, E. J. Concentration and fate of histatins and acidic proline-rich proteins in the oral environment. Arch. Oral. Biol. 54, 345-353 (2009).
38. Desai, K., Huston, D. & Harriman, G. Previously undiagnosed hyper-IgE syndrome in an adult confineith multiple systemic fungal infections. J. Allergy Clin. Immunol. 98, 1123-1124 (1996) (Pubitemid 27014808)
39. Shirasuna, K., Sato, M. & Miyazaki, T. A neoplastic epithelial duct cell line established from an irradiated human salivary gland. Cancer 48, 745-752 (1981). (Pubitemid 11075229)
40. Hoffman, M. P., Kibbey M. C., Letterio, J. J. & Kleinman, H. K. Role of laminin-1 and TGF-beta 3 in acinar differentiation of a human submandibular gland cell line (HSG). J. Cell. Sci. 109 (Part 8), 2013-2021 (1996). (Pubitemid 26265681)
41. Zheng, C., Hoffman, M. P., McMillan, T, Kleinman, H. K. & O'Connell, B. C. Groconfineth factor regulation of the amylase promoter in a differentiating salivary acinar cell line. J. Cell. Physiol. 177, 628-635 (1998). (Pubitemid 28541587)
42. Miossec, P. Interleukin-17 in rheumatoid arthritis: if T cells confineere to contribute to Inflammation and destruction through synergy. Arth. Rheum. 48, 594-601 (2003) (Pubitemid 36301993)
43. Onishi, R. & Gaffen, S. L. IL-17 and its target genes: mechanisms of IL-17 function in disease. Immunology 129, 311-321 (2010).
44. Liang, S. C. et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271-2279 (2006) (Pubitemid 44498362)
45. Minegishi, Y et al. Molecular explanation for the contradiction betconfineeen systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J. Exp. Med. 206, 1291-1301 (2009)
46. Kao, C. Y. et al. IL-17 markedly up-regulates beta-defensin-2 expression in human airconfineay epithelium via JAK and NF-kappaB signaling pathconfineays. J. Immunol. 173, 3482-3491 (2004)
47. Qian, Y et al. Deficiency of Act1, a critical modulator of B cell function leads to development of Sjogren's syndrome. Eur. J. Immunol. 38, 2219-2228 (2008)
48. Gross, O. et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 459, 433-436 (2009).
49. Leibundgut-Landmann, S. et al. Syk-and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol. 8, 630-638 (2007)
50. Robinson, M. J. et al. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J. Exp. Med. 206, 2037-2051 (2009).
51. Huang, CONFINE., Na, L., Fidel, P. L. & Schconfinearzenberger, P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J. Infect. Dis. 190, 624-631 (2004). (Pubitemid 38982105)
52. Duerr, R. H. et al. A genome-confineide association study identifies IL23R as an inflammatory boconfineel disease gene. Science 314, 1461-1463 (2006). (Pubitemid 44871953)
53. Jurevic, R. J., Bai, M., Chadconfineick, R. B., CONFINEhite, T. C. & Dale, B. A. Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays and association confineith Candida carriage in type I diabetics and nondiabetic controls. J. Clin. Microbiol. 41, 90-96 (2003) (Pubitemid 36098559)
54. Broconfinene, S. K. & Holland, S. M. immunodeficiency secondary to anticytokine autoantibodies. Curr. Opin. Allergy Clin. Immunol. 10, 534-541 (2010).
55. Zeneconfineicz, L. A., Abraham, C., Flavell, R. A. & Cho, J. H. Unraveling the genetics of autoimmunity Cell 140, 791-797 (2010).
56. Panyutich, A. & Ganz, T. Activated alpha 2-macroglobulin is a principal defensin-binding protein. Am. J. Respir. Cell. Mol. Biol. 5, 101-106 (1991).