The effects of vitamin D on skeletal muscle function and cellular signaling

Journal of Steroid Biochemistry and Molecular Biology

Volumn 125, Issue 3-5, 2011, Pages 159-168

  Dirks Naylor, Amie J ^a   Lennon Edwards, Shannon ^b  

^a WINGATE UNIVERSITY   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

Author keywords

1,25 (OH)2D3; Atrophy; Calcitriol; Myoblasts; Myotubes; VDR

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE; ARACHIDONIC ACID; CALCITRIOL; CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; COLECALCIFEROL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ERGOCALCIFEROL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATE; PHOSPHORUS; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN KINASE C; SYNAPTOPHYSIN; VITAMIN D; VITAMIN D RECEPTOR;

ADOLESCENT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARACHIDONIC ACID METABOLISM; BODY EQUILIBRIUM; BODY MASS; CALCIUM BLOOD LEVEL; CALCIUM HOMEOSTASIS; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; FALLING; GRIP STRENGTH; HAIR LOSS; HAND GRIP; HUMAN; HYPERPARATHYROIDISM; INSULIN RESISTANCE; INTRACELLULAR SIGNALING; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE DEVELOPMENT; MUSCLE FUNCTION; MUSCLE STRENGTH; MUSCLE WEAKNESS; MYOBLAST; MYOTUBE; NONHUMAN; PHOSPHATE BLOOD LEVEL; PHOSPHATE DEFICIENCY; PHYSICAL PERFORMANCE; RECEPTOR BINDING; REVIEW; RICKETS; ROTATOR CUFF; SKELETAL MUSCLE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN METABOLISM; VITAMIN SUPPLEMENTATION; WEIGHT REDUCTION;

ANIMALS; CALCITRIOL; HUMANS; MUSCLE, SKELETAL; RECEPTORS, CALCITRIOL; SIGNAL TRANSDUCTION; VITAMIN D; VITAMINS;

ANIMALIA;

EID: 79957850644     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2011.03.003     Document Type: Review

References (91)

1. M.F. Holick, Vitamin D deficiency, N. Engl. J. Med. 357 (2007) 266-281.
2. J. Kumar, P. Muntner, F.J. Kaskel, S.M. Hailpern, M.L. Melamed, Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001-2004, Pediatrics 124 (2009) 362-370.
3. A. Mithal, D.A. Wahl, J.P. Bonjour, P. Burckhardt, B. Dawson-Hughes, J.A. Eisman, G. El-Hajj Fuleihan, R.G. Josse, P. Lips, J. Morales-Torres, Global vitamin D status and determinants of hypovitaminosis D, Osteoporos. Int. 20 (2009) 1807-1820.
4. A.A. Ginde, M.C. Liu, C.A. Camargo Jr., Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004, Arch. Intern. Med. 169 (2009) 626-632.
5. T.L. Clemens, J.S. Adams, S.L. Henderson, M.F. Holick, Increased skin pigment reduces the capacity of skin to synthesise vitamin D3, Lancet 1 (1982) 74-76. (Pubitemid 12248649)
6. J. Wortsman, L.Y. Matsuoka, T.C. Chen, Z. Lu, M.F. Holick, Decreased bioavailability of vitamin D in obesity, Am. J. Clin. Nutr. 72 (2000) 690-693. (Pubitemid 30667088)
7. T.J. Wang, F. Zhang, J.B. Richards, B. Kestenbaum, J.B. van Meurs, D. Berry, D.P. Kiel, E.A. Streeten, C. Ohlsson, D.L. Koller, L. Peltonen, J.D. Cooper, P.F. O'Reilly, D.K. Houston, N.L. Glazer, L. Vandenput, M. Peacock, J. Shi, F. Rivadeneira, M.I. McCarthy, P. Anneli, I.H. de Boer, M. Mangino, B. Kato, D.J. Smyth, S.L. Booth, P.F. Jacques, G.L. Burke, M. Goodarzi, C.L. Cheung, M. Wolf, K. Rice, D. Goltzman, N. Hidiroglou, M. Ladouceur, N.J. Wareham, L.J. Hocking, D. Hart, N.K. Arden, C. Cooper, S. Malik, W.D. Fraser, A.L. Hartikainen, G. Zhai, H.M. Macdonald, N.G. Forouhi, R.J. Loos, D.M. Reid, A. Hakim, E. Dennison, Y. Liu, C. Power, H.E. Stevens, L. Jaana, R.S. Vasan, N. Soranzo, J. Bojunga, B.M. Psaty, M. Lorentzon, T. Foroud, T.B. Harris, A. Hofman, J.O. Jansson, J.A. Cauley, A.G. Uitterlinden, Q. Gibson, M.R. Jarvelin, D. Karasik, D.S. Siscovick, M.J. Econs, S.B. Kritchevsky, J.C. Florez, J.A. Todd, J. Dupuis, E. Hypponen, T.D. Spector, Common genetic determinants of vitamin D insufficiency: a genome-wide association study, Lancet 376 (2010) 180-188.
8. M.F. Holick, The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action, Mol. Aspects Med. 29 (2008) 361-368.
9. K.L. Munger, S.M. Zhang, E. O'Reilly, M.A. Hernan, M.J. Olek, W.C. Willett, A. Ascherio, Vitamin D intake and incidence of multiple sclerosis, Neurology 62 (2004) 60-65.
10. L.A. Merlino, J. Curtis, T.R. Mikuls, J.R. Cerhan, L.A. Criswell, K.G. Saag, Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study, Arthritis Rheum. 50 (2004) 72-77. (Pubitemid 38084289)
11. S.G. Rostand, Ultraviolet light may contribute to geographic and racial blood pressure differences, Hypertension 30 (1997) 150-156. (Pubitemid 27328990)
12. Y.C. Li, J. Kong, M. Wei, Z.F. Chen, S.Q. Liu, L.P. Cao, 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system, J. Clin. Invest. 110 (2002) 229-238.
13. J.M. Lappe, D. Travers-Gustafson, K.M. Davies, R.R. Recker, R.P. Heaney, Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial, Am. J. Clin. Nutr. 85 (2007) 1586-1591. (Pubitemid 46890428)
14. D. Teegarden, S.S. Donkin, Vitamin D: emerging new roles in insulin sensitivity, Nutr. Res. Rev. 22 (2009) 82-92.
15. R. Kremer, P.P. Campbell, T. Reinhardt, V. Gilsanz, Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women, J. Clin. Endocrinol. Metab. 94 (2009) 67-73.
16. T. Keisala, A. Minasyan, Y.R. Lou, J. Zou, A.V. Kalueff, I. Pyykko, P. Tuohimaa, Premature aging in vitamin D receptor mutant mice, J. Steroid Biochem. Mol. Biol. 115 (2009) 91-97.
17. J.B. Richards, A.M. Valdes, J.P. Gardner, D. Paximadas, M. Kimura, A. Nessa, X. Lu, G.L. Surdulescu, R. Swaminathan, T.D. Spector, A. Aviv, Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women, Am. J. Clin. Nutr. 86 (2007) 1420-1425. (Pubitemid 350126247)
18. M.F. Holick, T.C. Chen, Vitamin D deficiency: a worldwide problem with health consequences, Am. J. Clin. Nutr. 87 (2008) 1080S-1086S.
19. I. Endo, D. Inoue, T. Mitsui, Y. Umaki, M. Akaike, T. Yoshizawa, S. Kato, T. Matsumoto, Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors, Endocrinology 144 (2003) 5138-5144. (Pubitemid 37476038)
20. C. Buitrago, R. Boland, Caveolae and caveolin-1 are implicated in 1alpha 25(OH)(2)-vitamin D(3)-dependent modulation of Src,MAPKcascades andVDR localization in skeletal muscle cells, J. Steroid Biochem. Mol. Biol. 121 (2010) 169-175.
21. C.G. Buitrago, A.C. Ronda, A.R. de Boland, R. Boland, MAP kinases p38 and JNK are activated by the steroid hormone 1alpha,25(OH)2-vitamin D3 in the C2C12 muscle cell line, J. Cell. Biochem. 97 (2006) 698-708.
22. C. Buitrago, V. Gonzalez Pardo, A.R. de Boland, Nongenomic action of 1alpha,25(OH)(2)-vitamin D3. Activation of muscle cell PLC gamma through the tyrosine kinase c-Src and PtdIns 3-kinase, Eur. J. Biochem. 269 (2002) 2506-2515.
23. H.A. Bischoff, M. Borchers, F. Gudat, U. Duermueller, R. Theiler, H.B. Stahelin, W. Dick, In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue, Histochem. J. 33 (2001) 19-24.
24. H.A. Bischoff-Ferrari, M. Borchers, F. Gudat, U. Durmuller, H.B. Stahelin, W. Dick, Vitamin D receptor expression in human muscle tissue decreases with age, J. Bone Miner. Res. 19 (2004) 265-269.
25. M. Pfeifer, B. Begerow, H.W. Minne, Vitamin D and muscle function, Osteoporos. Int. 13 (2002) 187-194.
26. H.A. Bischoff-Ferrari, M. Conzelmann, H.B. Stahelin, W. Dick, M.G. Carpenter, A.L. Adkin, R. Theiler, M. Pfeifer, J.H. Allum, Is fall prevention by vitaminDmediated by a change in postural or dynamic balance? Osteoporos. Int. 17 (2006) 656-663.
27. P. Lips, F.C. van Ginkel, M.J. Jongen, F. Rubertus, W.J. van der Vijgh, J.C. Netelenbos, Determinants of vitamin D status in patients with hip fracture and in elderly control subjects, Am. J. Clin. Nutr. 46 (1987) 1005-1010. (Pubitemid 18032753)
28. P. Lips, Vitamin D deficiency and osteoporosis: the role of vitamin D deficiency and treatment with vitamin D and analogues in the prevention of osteoporosis-related fractures, Eur. J. Clin. Invest. 26 (1996) 436-442. (Pubitemid 26226405)
29. M.S. LeBoff, W.G. Hawkes, J. Glowacki, J. Yu-Yahiro, S. Hurwitz, J. Magaziner, Vitamin D-deficiency and post-fracture changes in lower extremity function and falls in women with hip fractures, Osteoporos. Int. 19 (2008) 1283-1290.
30. M.F. Holick, L.Y. Matsuoka, J. Wortsman, Age, vitamin D, and solar ultraviolet, Lancet 2 (1989) 1104-1105.
31. M.F. Holick, Resurrection of vitamin D deficiency and rickets, J. Clin. Invest. 116 (2006) 2062-2072.
32. M.S. Hutchinson, G. Grimnes, R.M. Joakimsen, Y. Figenschau, R. Jorde, Low serum 25-hydroxyvitamin D levels are associated with increased all-cause mortality risk in a general population: the Tromso study, Eur. J. Endocrinol. 162 (2010) 935-942.
33. J.J. Cannell, B.W. Hollis, M.B. Sorenson, T.N. Taft, J.J. Anderson, Athletic performance and vitamin D, Med. Sci. Sports Exerc. 41 (2009) 1102-1110.
34. K.A. Ward, G. Das, J.L. Berry, S.A. Roberts, R. Rawer, J.E. Adams, Z. Mughal, Vitamin D status and muscle function in post-menarchal adolescent girls, J. Clin. Endocrinol. Metab. 94 (2009) 559-563.
35. L.H. Foo, Q. Zhang, K. Zhu, G. Ma, X. Hu, H. Greenfield, D.R. Fraser, Low vitamin D status has an adverse influence on bone mass, bone turnover, and muscle strength in Chinese adolescent girls, J. Nutr. 139 (2009) 1002-1007.
36. Y. Dong, N. Pollock, I.S. Stallmann-Jorgensen, B. Gutin, L. Lan, T.C. Chen, D. Keeton, K. Petty, M.F. Holick, H. Zhu, Low 25-hydroxyvitamin D levels in adolescents: race, season, adiposity, physical activity, and fitness, Pediatrics 125 (2010) 1104-1111.
37. F. Alagol, Y. Shihadeh, H. Boztepe, R. Tanakol, S. Yarman, H. Azizlerli, O. Sandalci, Sunlight exposure and vitamin D deficiency in Turkish women, J. Endocrinol. Invest. 23 (2000) 173-177.
38. T. Atli, S. Gullu, A.R. Uysal, G. Erdogan, The prevalence of Vitamin D deficiency and effects of ultraviolet light on VitaminDlevels in elderly Turkish population, Arch. Gerontol. Geriatr. 40 (2005) 53-60. (Pubitemid 39505212)
39. A.A. Mishal, Effects of different dress styles on vitamin D levels in healthy young Jordanian women, Osteoporos. Int. 12 (2001) 931-935.
40. R.P. van der Wielen, M.R. Lowik, H. van den Berg, L.C. de Groot, J. Haller, O. Moreiras, W.A. van Staveren, Serum vitamin D concentrations among elderly people in Europe, Lancet 346 (1995) 207-210.
41. D.K. Houston, M. Cesari, L. Ferrucci, A. Cherubini, D. Maggio, B. Bartali, M.A. Johnson, G.G. Schwartz, S.B. Kritchevsky, Association between vitamin D status and physical performance: the InCHIANTI study, J. Gerontol. A: Biol. Sci. Med. Sci. 62 (2007) 440-446. (Pubitemid 47065713)
42. P. Gerdhem, K.A. Ringsberg, K.J. Obrant, K. Akesson, Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women, Osteoporos. Int. 16 (2005) 1425-1431. (Pubitemid 41534648)
43. M. Visser, D.J. Deeg, P. Lips, Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam, J. Clin. Endocrinol. Metab. 88 (2003) 5766-5772. (Pubitemid 38033048)
44. H.A. Bischoff-Ferrari, T. Dietrich, E.J. Orav, F.B. Hu, Y. Zhang, E.W. Karlson, B Dawson-Hughes, Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged ≥60 y, Am. J. Clin. Nutr. 80 (2004) 752-758. (Pubitemid 41115542)
45. J.M. Guralnik, L. Ferrucci, E.M. Simonsick, M.E. Salive, R.B. Wallace, Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability, N. Engl. J. Med. 332 (1995) 556-561.
46. C. Annweiler, A.M. Schott, G. Berrut, B. Fantino, O. Beauchet, Vitamin D-related changes in physical performance: a systematic review, J. Nutr. Health Aging 13 (2009) 893-898.
47. H.A. Bischoff-Ferrari, B. Dawson-Hughes, H.B. Staehelin, J.E. Orav, A.E. Stuck, R. Theiler, J.B. Wong, A. Egli, D.P. Kiel, J. Henschkowski, Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials, BMJ 339 (2009) b3692.
48. M. Pfeifer, B. Begerow, H.W. Minne, C. Abrams, D. Nachtigall, C. Hansen, Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderlywomen,J. Bone Miner. Res. 15 (2000) 1113-1118.
49. H.A. Bischoff, H.B. Stahelin, W. Dick, R. Akos, M. Knecht, C. Salis, M. Nebiker, R. Theiler, M. Pfeifer, B. Begerow, R.A. Lew, M. Conzelmann, Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial, J. Bone Miner. Res. 18 (2003) 343-351.
50. R.L. Prince, N. Austin, A. Devine, I.M. Dick, D. Bruce, K. Zhu, Effects of ergocalciferol added to calcium on the risk of falls in elderly high-risk women, Arch. Intern. Med. 168 (2008) 103-108.
51. M. Pfeifer, B. Begerow, H.W. Minne, K. Suppan, A. Fahrleitner-Pammer, H. Dobnig, Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals, Osteoporos. Int. 20 (2009) 315-322.
52. L. Flicker, R.J. MacInnis, M.S. Stein, S.C. Scherer, K.E. Mead, C.A. Nowson, J. Thomas, C. Lowndes, J.L. Hopper, J.D. Wark, Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial, J. Am. Geriatr. Soc. 53 (2005) 1881-1888. (Pubitemid 41826064)
53. H.A. Bischoff-Ferrari, E.J. Orav, B. Dawson-Hughes, Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial, Arch. Intern. Med. 166 (2006) 424-430.
54. Y. Sato, J. Iwamoto, T. Kanoko, K. Satoh, Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial, Cerebrovasc. Dis. 20 (2005) 187-192.
55. K.E. Broe, T.C. Chen, J. Weinberg, H.A. Bischoff-Ferrari, M.F. Holick, D.P. Kiel, A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, multiple-dose study, J. Am. Geriatr. Soc. 55 (2007) 234-239.
56. N.K. Latham, C.S. Anderson, A. Lee, D.A. Bennett, A. Moseley, I.D. Cameron, A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the Frailty Interventions Trial in Elderly Subjects (FITNESS), J. Am. Geriatr. Soc. 51 (2003) 291-299.
57. A.M. Kenny, B. Biskup, B. Robbins, G. Marcella, J.A. Burleson, Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men, J. Am. Geriatr. Soc. 51 (2003) 1762-1767.
58. R. Boland, Role of vitamin D in skeletal muscle function, Endocr. Rev. 7 (1986) 434-448.
59. L. Ceglia, Vitamin D and its role in skeletal muscle, Curr. Opin. Clin. Nutr. Metab. Care 12 (2009) 628-633.
60. R. Gupta, U. Sharma, N. Gupta, M. Kalaivani, U. Singh, R. Guleria, N.R. Jagannathan, R. Goswami, Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D deficient Asian Indians: a randomized controlled trial, Clin. Endocrinol. (Oxf.) 73 (4) (2010) 445-451.
61. G. El-Hajj Fuleihan, M. Nabulsi, H. Tamim, J.Maalouf, M. Salamoun, H. Khalife, M. Choucair, A. Arabi, R. Vieth, Effect of vitamin D replacement on musculoskeletal parameters in school children: a randomized controlled trial, J. Clin. Endocrinol. Metab. 91 (2006) 405-412. (Pubitemid 43236902)
62. J.H. Oh, S.H. Kim, J.H. Kim, Y.H. Shin, J.P. Yoon, C.H. Oh, The level of vitamin D in the serum correlates with fatty degeneration of the muscles of the rotator cuff, J. Bone Joint Surg. Br. 91 (2009) 1587-1593.
63. A.S. Tagliafico, P. Ameri, M. Bovio, M. Puntoni, E. Capaccio, G. Murialdo, C. Martinoli, Relationship between fatty degeneration of thigh muscles and vitamin D status in the elderly: a preliminary MRI study, Am. J. Roentgenol. 194 (2010) 728-734.
64. T.H. Burne, J.J. McGrath, D.W. Eyles, A. Mackay-Sim, Behavioural characterization of vitamin D receptor knockout mice, Behav. Brain Res. 157 (2005) 299-308.
65. T.H. Burne, A.N. Johnston, J.J. McGrath, A. Mackay-Sim, Swimming behaviour and post-swimming activity in Vitamin D receptor knockout mice, Brain Res. Bull. 69 (2006) 74-78.
66. A. Minasyan, T. Keisala, J. Zou, Y. Zhang, E. Toppila, H. Syvala, Y.R. Lou, A.V. Kalueff, I. Pyykko, P. Tuohimaa, Vestibular dysfunction in vitamin D receptor mutant mice, J. Steroid Biochem. Mol. Biol. 114 (2009) 161-166.
67. T. Yoshizawa, Y. Handa, Y. Uematsu, S. Takeda, K. Sekine, Y. Yoshihara, T. Kawakami, K. Arioka, H. Sato, Y. Uchiyama, S. Masushige, A. Fukamizu, T. Matsumoto, S. Kato, Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning, Nat. Genet. 16 (1997) 391-396. (Pubitemid 27323308)
68. S. Kato, K. Takeyama, S. Kitanaka, A. Murayama, K. Sekine, T. Yoshizawa, In vivo function of VDR in gene expression-VDR knock-out mice, J. Steroid Biochem. Mol. Biol. 69 (1999) 247-251.
69. Y.C. Li, A.E. Pirro, M. Amling, G. Delling, R. Baron, R. Bronson, M.B. Demay, Targeted ablation of the vitamin D receptor: an animal model of vitamin Ddependent rickets type II with alopecia, Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 9831-9835.
70. L. Schubert, H.F. Deluca, Hypophosphatemia is responsible for skeletal muscle weakness of vitamin D deficiency, Arch. Biochem. Biophys. 500 (2010) 157-161.
71. E.M. Costa, H.M. Blau, D Feldman, 1,25-Dihydroxyvitamin D3 receptors and hormonal responses in cloned human skeletal muscle cells, Endocrinology 119 (1986) 2214-2220.
72. B. Hamilton, Vitamin D and human skeletal muscle, Scand. J. Med. Sci. Sports 20 (2010) 182-190.
73. D. Capiati, S. Benassati, R.L. Boland, 1,25(OH)2-vitamin D3 induces translocation of the vitaminDreceptor (VDR) to the plasmamembranein skeletal muscle cells, J. Cell. Biochem. 86 (2002) 128-135.
74. 2+ influx in skeletal muscle cells, J. Biol. Chem. 275 (2000) 16134-16138.
75. D.A. Capiati, G. Vazquez, M.T. Tellez Inon, R.L. Boland, Role of protein kinase C in 1,25(OH)(2)-vitamin D(3) modulation of intracellular calcium during development of skeletal muscle cells in culture, J. Cell. Biochem. 77 (2000) 200-212.
76. 2+ influx in skeletal muscle cells. Modulation by phospholipase c, protein kinase c, and tyrosine kinases, J. Biol. Chem. 273 (1998) 33954-33960.
77. G. Santillan, S. Katz, G. Vazquez, R.L. Boland, TRPC3-like protein and vitamin D receptor mediate 1alpha,25(OH)2D3-induced SOC influx in muscle cells, Int. J. Biochem. Cell Biol. 36 (2004) 1910-1918.
78. G. Vazquez, A.R. de Boland, R.L. Boland, 1alpha,25-(OH)2-vitamin D3 stimulates the adenylyl cyclase pathway in muscle cells by a GTP-dependent mechanism which presumably involves phosphorylation of G alpha i, Biochem. Biophys. Res. Commun. 234 (1997) 125-128. (Pubitemid 27267545)
79. S. Morelli, A.R. de Boland, R.L. Boland, Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3, Biochem. J. 289 (Pt 3) (1993) 675-679.
80. 2+ uptake in rat and chick cultured myoblasts, Biochim. Biophys. Acta 1310 (1996) 157-162.
81. L. Drittanti, A.R. de Boland, R. Boland, Involvement of the 3′,5′-cyclic AMP pathway in the induction of calmodulin synthesis in myoblasts by 1,25(OH)2-vitamin D3, Biochem. Biophys. Res. Commun. 192 (1993) 886-892.
82. D.A. Capiati, M.T. Tellez-Inon, R.L. Boland, Participation of protein kinase C alpha in 1,25-dihydroxy-vitamin D3 regulation of chick myoblast proliferation and differentiation, Mol. Cell. Endocrinol. 153 (1999) 39-45.
83. C.G. Buitrago, V.G. Pardo, A.R. de Boland, R. Boland, Activation of RAF-1 through Ras and protein kinase Calpha mediates 1alpha,25(OH)2-vitamin D3 regulation of the mitogen-activated protein kinase pathway in muscle cells, J. Biol. Chem. 278 (2003) 2199-2205.
84. A.C. Ronda, C. Buitrago, A. Colicheo, A.R. de Boland, E. Roldan, R. Boland, Activation of MAPKs by 1alpha,25(OH)2-Vitamin D3 and 17beta-estradiol in skeletal muscle cells leads to phosphorylation of Elk-1 and CREB transcription factors, J. Steroid Biochem. Mol. Biol. 103 (2007) 462-466. (Pubitemid 46401284)
85. R. Boland, A.R. De Boland, C. Buitrago, S. Morelli, G. Santillan, G. Vazquez, D. Capiati, C. Baldi, Non-genomic stimulation of tyrosine phosphorylation cascades by 1,25(OH)(2)D(3) by VDR-dependent and -independent mechanisms in muscle cells, Steroids 67 (2002) 477-482.
86. Q.G. Zhou, F.F. Hou, Z.J. Guo, M. Liang, G.B. Wang, X. Zhang, 1,25-Dihydroxyvitamin D improved the free fatty-acid-induced insulin resistance in cultured C2C12 cells, Diabetes Metab. Res. Rev. 24 (2008) 459-464.
87. C. Mathieu, C. Gysemans, A. Giulietti, R. Bouillon, Vitamin D and diabetes, Diabetologia 48 (2005) 1247-1257.
88. L.A. Martini, R.J. Wood, Vitamin D status and the metabolic syndrome, Nutr. Rev. 64 (2006) 479-486.
89. A.R. de Boland, R.L. Boland, 1,25-Dihydroxyvitamin D-3 induces arachidonate mobilization in embryonic chick myoblasts, Biochim. Biophys. Acta 1179 (1993) 98-104.
90. M. Borkman, L.H. Storlien, D.A. Pan, A.B. Jenkins, D.J. Chisholm, L.V. Campbell, The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids, N. Engl. J. Med. 328 (1993) 238-244. (Pubitemid 23035309)
91. M.J. Stables, D.W. Gilroy, Old and new generation lipid mediators in acute inflammation and resolution, Prog. Lipid Res. 50 (2011) 35-51.