Adenosine A2A receptor induces protein kinase A-dependent functional modulation of human α3β4 nicotinic receptor

Journal of Physiology

Volumn 589, Issue 11, 2011, Pages 2755-2766

  Di Angelantonio, Silvia ^a   Piccioni, Alessio ^a   Moriconi, Claudia ^a   Trettel, Flavia ^a   Cristalli, Gloria ^b   Grassi, Francesca ^a   Limatola, Cristina ^a,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

^c IRCCS NEUROMED   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A2A RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN FUNCTION; CELL STIMULATION; CELL STRAIN HEK293; CERVICAL GANGLION; CONSENSUS SEQUENCE; CONTROLLED STUDY; CYTOPLASM; EMBRYO; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN STRUCTURE; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

2-CHLOROADENOSINE; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ACETYLCHOLINE; ADENOSINE A2 RECEPTOR AGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ADENOSINE DEAMINASE; AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANIMALS, NEWBORN; CARBAZOLES; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNITS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGICAL PHENOMENA; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; NEURONS; NICOTINE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; PYRROLES; RECEPTOR, ADENOSINE A2A; RECEPTORS, NICOTINIC; SIGNAL TRANSDUCTION; SUPERIOR CERVICAL GANGLION; TRANSFECTION; TRIAZOLES;

EID: 79957825777     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.207282     Document Type: Article

References (36)

1. Caratsch CG, Grassi F & Eusebi F (1992). Functional regulation of nicotinic acetylcholine receptor channels in muscle. Ion Channels 3, 177-206.
2. Correia-de-Sá P & Ribeiro JA (1994). Tonic adenosine A2A receptor activation modulates nicotinic autoreceptor function at the rat neuromuscular junction. Eur J Pharmacol 271, 349-355.
3. Dani JA (2001). Overview of nicotinic receptors and their roles in the central nervous system. Biol Psychiatry 49, 166-174.
4. Di Angelantonio S, De Stefano ME, Piccioni A, Lombardi L, Gotti C & Paggi P (2011). Lack of dystrophin functionally affects α3β2/β4-nicotinic acethylcholine receptors in sympathetic neurons of dystrophic mdx mice. Neurobiol Dis 41, 528-537.
5. Downing JE & Role LW (1987). Activators of protein kinase C enhance acetylcholine receptor desensitization in sympathetic ganglion neurons. Proc Natl Acad Sci U S A 84, 7739-7743.
6. 2A-receptors coupled to adenylate cyclase/cyclic AMP pathway downregulates nicotinic autoreceptor function at the rat myenteric nerve terminals. Neurochem Int 45, 641-651.
7. Fenster CP, Beckman ML, Parker JC, Sheffield EB, Whitworth TL, Quick MW & Lester RA (1999). Regulation of α4β2 nicotinic receptor desensitization by calcium and protein kinase C. Mol Pharmacol 55, 432-443.
8. Fitzgerald RS, Shirahata M & Chang I (2009). The impact of adenosine and an A2A adenosine receptor agonist on the ACh-induced increase in intracellular calcium of the glomus cells of the cat carotid body. Brain Res 1301, 20-33.
9. Giniatullin R, Nistri A & Yakel J (2005). Desensitization of nicotinic ACh receptors: shaping cholinergic signaling. Trends Neurosci 28, 371-378.
10. Grady SR, Moretti M, Zoli M, Marks MJ, Zanardi A, Pucci L, Clementi F & Gotti C (2009). Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the α3β4* and α3β3β4* subtypes mediate acetylcholine release. J Neurosci 29, 2272-2282.
11. 2+. J Neurophysiol 97, 93-101.
12. Jacobson KA & Gao Z-G (2006). Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 5, 247-264.
13. Katz B & Thesleff S (1957). A study of the desensitization produced by acetylcholine at the motor end-plate. J Physiol 138, 63-80.
14. Khiroug L, Sokolova E, Giniatullin R, Afzalov R & Nistri A (1998). Recovery from desensitization of neuronal nicotinic acetylcholine receptors of rat chromaffin cells is modulated by intracellular calcium through distinct second messengers. J Neurosci 18, 2458-2466.
15. Lendvai B & Vizi ES (2008). Nonsynaptic chemical transmission through nicotinic acetylcholine receptors. Physiol Rev 88, 333-349.
16. Moriconi C, Di Angelantonio S, Piccioni A, Trettel F, Sabatelli M & Grassi F (2011). Mutant human β4 subunit identified in amyotrophic lateral sclerosis patients impairs nicotinic receptor function. Pflugers Arch 461, 225-233.
17. Oldfield S, Hancock J, Mason A, Hobson SA, Wynick D, Kelly E, Randall AD & Marrion NV (2009). Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts. Mol Pharmacol 76, 1279-1289.
18. Paradiso K & Brehm P (1998). Long-term desensitization of nicotinic acetylcholine receptors is regulated via protein kinase A-mediated phosphorylation. J Neurosci 18, 9227-9237.
19. Picciotto MR, Addy NA, Mineur YS & Brunzell DH (2008). It is not 'either/or': activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Prog Neurobiol 84, 329-342.
20. Picciotto MR & Zoli M (2008). Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Front Biosci 13, 492-504.
21. Pitchford S, Day JW, Gordon A & Mochly-Rosen D (1992). Nicotinic acetylcholine receptor desensitization is regulated by activation-induced extracellular adenosine accumulation. J Neurosci 12, 4540-4544.
22. Pollock VV, Pastoor TE & Wecker L (2007). Cyclic AMP-dependent protein kinase (PKA) phosphorylates Ser362 and 467 and protein kinase C phosphorylates Ser550 within the M3/M4 cytoplasmic domain of human nicotinic receptor α4 subunits. J Neurochem 103, 456-466.
23. Ramirez SH, Fan S, Maguire CA, Perry S, Hardiek K, Ramkumar V, Gelbard HA, Dewhurst S & Maggirwar SB (2004). Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal. J Neurosci Res 77, 258-269.
24. Ren J, Qin C, Hu F, Tan J, Qiu L, Zhao S, Feng G & Luo M (2011). Habenula 'cholinergic' neurons corelease glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron 69, 445-452.
25. Quitadamo C, Fabbretti E, Lamanauskas N & Nistri A (2005). Activation and desensitization of neuronal nicotinic receptors modulate glutamatergic transmission on neonatal rat hypoglossal motoneurons. Eur J Neurosci 22, 2723-2734.
26. Sabatelli M, Eusebi F, Al-Chalabi A, Conte A, Madia F, Luigetti M, Mancuso I, Limatola C, Trettel F, Sobrero F, Di Angelantonio S, Grassi F, Di Castro A, Moriconi C, Fucile S, Lattante S, Marangi G, Murdolo M, Orteschi D, Del Grande A, Tonali P, Neri G & Zollino M (2009). Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis. Hum Mol Genet 18, 397-400.
27. Sala F, Nistri A & Criado M (2008). Nicotinic acetylcholine receptors of adrenal chromaffin cells. Acta Physiol (Oxf) 192, 203-212.
28. Sarter M, Parikh V & Howe WM (2009). Phasic acetylcholine release and the volume transmission hypothesis: time to move on. Nat Rev Neurosci 10, 383-390.
29. Sebastião AM & Ribeiro JA (2009). Tuning and fine-tuning of synapses with adenosine. Curr Neuropharmacol 7, 180-194.
30. Shirahata M, Balbir A, Otsubo T & Fitzgerald RS (2007). Role of acetylcholine in neurotransmission of the carotid body. Respir Physiol Neurobiol 157, 93-105.
31. Swope SL, Moss SJ, Blackstone CD & Huganir RL (1992). Phosphorylation of ligand-gated ion channels: a possible mode of synaptic plasticity. FASEB J 6, 2514-2523.
32. Timóteo MA, Faria M & Correia-de-Sá P (2003). Endogenous adenosine prevents post-tetanic release facilitation mediated by α3β2 nicotinic autoreceptors. Eur J Pharmacol 464, 115-125.
33. Ubersax JA & Ferrell JE Jr (2007). Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol 8, 530-541.
34. Vijayaraghavan S, Schmid HA, Halvorsen SW & Berg DK (1990). Cyclic AMP-dependent phosphorylation of a neuronal acetylcholine receptor α-type subunit. J Neurosci 10, 3255-3262.
35. Volpini R, Costanzi S, Lambertucci C, Portino FR, Taffi S, Vittori S, Zablocki JA, Klotz K-N & Cristalli G (2004). Adenosine receptor agonists: synthesis and binding affinity of 2-(aryl)alkylthioadenosine derivatives. ARKIVOC 301-311.
36. 2+ permeation of stably transfected α3/β4 neuronal nicotinic acetylcholine receptor. Mol Pharmacol 55, 970-981.