Severe QTc prolongation under mild hypothermia treatment and incidence of arrhythmias after cardiac arrest-A prospective study in 34 survivors with continuous Holter ECG

Resuscitation

Volumn 82, Issue 7, 2011, Pages 859-862

  Storm, Christian ^a   Hasper, Dietrich ^a   Nee, Jens ^a   Joerres, Achim ^a   Schefold, Joerg C ^a   Kaufmann, Jan ^b   Roser, Mattias ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Arrhythmia; Cardiac arrest; Hypothermia; Torsade de pointes

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; HEART ARREST; HEART ARRHYTHMIA; HEART RHYTHM; HEART VENTRICLE TACHYCARDIA; HOLTER MONITORING; HOSPITAL ADMISSION; HUMAN; INCIDENCE; INDUCED HYPOTHERMIA; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QT PROLONGATION; SURVIVOR; TORSADE DES POINTES;

AGED; ARRHYTHMIAS, CARDIAC; ELECTROCARDIOGRAPHY, AMBULATORY; FEMALE; FOLLOW-UP STUDIES; GERMANY; HEART ARREST; HUMANS; HYPOTHERMIA, INDUCED; INCIDENCE; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RESUSCITATION; RISK FACTORS; SURVIVAL RATE;

EID: 79957810529     PISSN: 03009572     EISSN: 18731570     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2011.02.043     Document Type: Article

References (14)

1. Nolan J.P., Morley P.T., Hoek T.L., Hickey R.W. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation. Resuscitation 2003, 57:231-235.
2. Lasky R.E., Parikh N.A., Williams A.L., Padhye N.S., Shankaran S. Changes in the PQRST intervals and heart rate variability associated with rewarming in two newborns undergoing hypothermia therapy. Neonatology 2009, 96:93-95.
3. Tiainen M., Parikka H.J., Makijarvi M.A., et al. Arrhythmias and heart rate variability during and after therapeutic hypothermia for cardiac arrest. Crit Care Med 2009, 37:403-409.
4. Khan J.N., Prasad N., Glancy J.M. QTc prolongation during therapeutic hypothermia: are we giving it the attention it deserves?. Europace 2010, 12:266-270.
5. Johnson J.N., Ackerman M.J. QTc: how long is too long?. Br J Sports Med 2009, 43:657-662.
6. Jennett B., Bond M. Assessment of outcome after severe brain damage. Lancet 1975, 1:480-484.
7. Aslam A.F., Aslam A.K., Vasavada B.C., Khan I.A. Hypothermia: evaluation, electrocardiographic manifestations, and management. Am J Med 2006, 119:297-301.
8. Polderman K.H., Herold I. Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical considerations, side effects, and cooling methods. Crit Care Med 2009, 37:1101-1120.
9. Boddicker K.A., Zhang Y., Zimmerman M.B., Davies L.R., Kerber R.E. Hypothermia improves defibrillation success and resuscitation outcomes from ventricular fibrillation. Circulation 2005, 111:3195-3201.
10. Rhee B.J., Zhang Y., Boddicker K.A., Davies L.R., Kerber R.E. Effect of hypothermia on transthoracic defibrillation in a swine model. Resuscitation 2005, 65:79-85.
11. Redfern W.S., Carlsson L., Davis A.S., et al. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and Torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res 2003, 58:32-45.
12. Haverkamp W., Breithardt G., Camm A.J., et al. The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications, Report on a policy conference of the European Society of Cardiology. Eur Heart J 2000, 21:1216-1231.
13. Khan J.N., Prasad N., Glancy J. Amiodarone use in therapeutic hypothermia following cardiac arrest due to ventricular tachycardia and ventricular fibrillation. Europace 2009, 11:1566-1567.
14. Seftchick M.W., Adler P.H., Hsieh M., et al. The prevalence and factors associated with QTc prolongation among emergency department patients. Ann Emerg Med 2009, 54:763-768.