Impact of inflammation on male fertility

Frontiers in Bioscience - Elite

Volumn 3 E, Issue 1, 2011, Pages 89-95

  Sarkar, Oli ^a,c   Bahrainwala, Jamila ^b   Chandrasekaran, Sambamurthy ^b   Kothari, Shiva ^b   Mathur, Premendu P ^c   Agarwal, Ashok ^b  

^a PONDICHERRY UNIVERSITY   (India)

^b LERNER RESEARCH INSTITUTE   (United States)

^c MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

Cytokine; Infertility; Inflammation; Oxidative Stress; Review; Sperm

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PROTEIN; REACTIVE OXYGEN METABOLITE; STEROID ACUTE REGULATORY PROTEIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY REACTION; APOPTOSIS; ARTICLE; ASTHENOSPERMIA; CELL INFILTRATION; DISEASE MARKER; DNA DAMAGE; EPIDIDYMITIS; FERTILIZATION IN VITRO; GERM CELL; GRAM NEGATIVE INFECTION; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; LEUKOCYTE; LEUKOCYTOSPERMIA; LEYDIG CELL; MALE; MALE FERTILITY; MALE GENITAL TRACT INFECTION; MALE INFERTILITY; ORCHITIS; OXIDATIVE STRESS; SEMEN ABNORMALITY; SERTOLI CELL; SPERM; SPERMATOGENESIS; SPERMATOZOON; SPERMATOZOON MOTILITY; STEROIDOGENESIS; EPIDIDYMIS; FERTILITY; INFLAMMATION; METABOLISM; MICROBIOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TESTIS; UROGENITAL TRACT DISEASE;

BACTERIA (MICROORGANISMS);

EPIDIDYMIS; FERTILITY; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; INFLAMMATION; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; MALE; MALE UROGENITAL DISEASES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SPERMATOGENESIS; SPERMATOZOA; TESTIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79957806057     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article

References (78)

1. L. D. Russell: Movement of spermatocytes from the basal to the adluminal compartment of the rat testis. Am J Anat, 148, 313-328 (1977)
2. M. Dym: Spermatogonial stem cells of the testis. Proc Natl Acad Sci U S A, 91(24), 11287-9 (1994) (Pubitemid 24356329)
3. R. Goldman, E. Ferber and U. Zort: Reactive oxygen species are involved in the activation of cellular phospholipase A2. FEBS Lett, 309(2), 190-2 (1992)
4. E. de Lamirande and C. Gagnon: Human sperm hyperactivation and capacitation as parts of an oxidative process. Free Radic Biol Med, 14(2), 157-66 (1993) (Pubitemid 23037071)
5. P. Leclerc, E. de Lamirande and C. Gagnon: Regulation of protein-tyrosine phosphorylation and human sperm capacitation by reactive oxygen derivatives. Free Radic Biol Med, 22(4), 643-56 (1997) (Pubitemid 27043401)
6. K. Toshimori: Dynamics of the Mammalian Sperm Head. In: Advances in Anatomy, Embryology and Cell Biology. Ed K. Toshimori. Springer Berlin Heidelberg, Berlin (2009)
7. R. J. Aitken and J. S. Clarkson: Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil, 81(2), 459-69 (1987) (Pubitemid 17160425)
8. S. C. Sikka: Relative impact of oxidative stress on male reproductive function. Curr Med Chem, 8(7), 851-62 (2001) (Pubitemid 32427913)
9. R. J. Aitken: The Amoroso Lecture. The human spermatozoon - a cell in crisis? J Reprod Fertil, 115(1), 1-7 (1999)
10. J. S. Armstrong, M. Rajasekaran, W. Chamulitrat, P. Gatti, W. J. Hellstrom and S. C. Sikka: Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism. Free Radic Biol Med, 26(7-8), 869-80 (1999) (Pubitemid 29198359)
11. A. Agarwal and R. A. Saleh: Role of oxidants in male infertility: rationale, significance, and treatment. Urol Clin North Am, 29(4), 817-27 (2002) (Pubitemid 36015326)
12. B. Saradha and P. P. Mathur: Oxidative stress and male reproduction. In: Hormone Biotechnology. Ed S. K. Maitra. Daya Publishing House, Delhi (2007)
13. M. M. Reddy, S. V. Mahipal, J. Subhashini, M. C. Reddy, K. R. Roy, G. V. Reddy, P. R. Reddy and P. Reddanna: Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats. Reprod Toxicol, in press (2006)
14. M. Cutolo, E. Balleari, M. Giusti, M. Monachesi and S. Accardo: Sex hormone status of male patients with rheumatoid arthritis: evidence of low serum concentrations of testosterone at baseline and after human chorionic gonadotropin stimulation. Arthritis Rheum, 31(10), 1314-7 (1988)
15. M. Cutolo, E. Balleari, M. Giusti, E. Intra and S. Accardo: Androgen replacement therapy in male patients with rheumatoid arthritis. Arthritis Rheum, 34(1), 1-5 (1991)
16. M. Wallgren, H. Kindahl and H. Rodriguez-Martinez: Alterations in testicular function after endotoxin injection in the boar. Int J Androl, 16(3), 235-43 (1993) (Pubitemid 23241021)
17. M. K. O'Bryan, S. Schlatt, O. Gerdprasert, D. J. Phillips, D. M. de Kretser and M. P. Hedger: Inducible nitric oxide synthase in the rat testis: evidence for potential roles in both normal function and inflammation-mediated infertility. Biology of Reproduction, 63(5), 1285-93 (2000)
18. D. B. Hales: Interleukin-1 inhibits Leydig cell steroidogenesis primarily by decreasing 17 alphahydroxylase/ C17-20 lyase cytochrome P450 expression. Endocrinology, 131(5), 2165-72 (1992)
19. T. Lin, T. L. Wang, M. L. Nagpal, J. H. Calkins, W. W. Chang and R. Chi: Interleukin-1 inhibits cholesterol side-chain cleavage cytochrome P450 expression in primary cultures of Leydig cells. Endocrinology, 129(3), 1305-11 (1991)
20. T. Lin, D. Wang and D. M. Stocco: Interleukin-1 inhibits Leydig cell steroidogenesis without affecting steroidogenic acute regulatory protein messenger ribonucleic acid or protein levels. J Endocrinol, 156(3), 461-7 (1998) (Pubitemid 28131463)
21. S. H. Liew, S. J. Meachem and M. P. Hedger: A stereological analysis of the response of spermatogenesis to an acute inflammatory episode in adult rats. J Androl, 28(1), 176-85 (2007) (Pubitemid 46048092)
22. K. Tremellen: Oxidative stress and male infertility - a clinical perspective. Hum Reprod Update, 14(3), 243-58 (2008) (Pubitemid 351566975)
23. D. Sanocka, P. Jedrzejczak, A. Szumala-Kaekol, M. Fraczek and M. Kurpisz: Male genital tract inflammation: The role of selected interleukins in regulation of pro-oxidant and antioxidant enzymatic substances in seminal plasma. J Androl, 24(3), 448-55 (2003) (Pubitemid 39571801)
24. F. H. Comhaire, A. M. Mahmoud, C. E. Depuydt, A. A. Zalata and A. B. Christophe: Mechanisms and effects of male genital tract infection on sperm quality and fertilizing potential: the andrologist's viewpoint. Hum Reprod Update, 5(5), 393-8 (1999) (Pubitemid 29512128)
25. S. Vaithinathan, B. Saradha and P. P. Mathur: Methoxychlor induces apoptosis via mitochondria- and FasL-mediated pathways in adult rat testis. Chem Biol Int, In press, DOI: 10.1016/j.cbi.2010.03.014 (2010)
26. E. de Lamirande, H. Jiang, A. Zini, H. Kodama and C. Gagnon: Reactive oxygen species and sperm physiology. Rev Reprod, 2(1), 48-54 (1997) (Pubitemid 27165966)
27. R. J. Aitken: Free radicals, lipid peroxidation and sperm function. Reprod Fertil Dev, 7(4), 659-68 (1995)
28. J. P. Twigg, D. S. Irvine and R. J. Aitken: Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Hum Reprod, 13(7), 1864-71 (1998)
29. E. de Lamirande and C. Gagnon: Reactive oxygen species and human spermatozoa. I. Effects on the motility of intact spermatozoa and on sperm axonemes. J Androl, 13(5), 368-78 (1992)
30. E. de Lamirande and C. Gagnon: Reactive oxygen species and human spermatozoa. II. Depletion of adenosine triphosphate plays an important role in the inhibition of sperm motility. J Androl, 13(5), 379-86 (1992)
31. S. Walrand, S. Valeix, C. Rodriguez, P. Ligot, J. Chassagne and M. P. Vasson: Flow cytometry study of polymorphonuclear neutrophil oxidative burst: a comparison of three fluorescent probes. Clin Chim Acta, 331(1-2), 103-10 (2003) (Pubitemid 36412031)
32. S. C. Sikka: Oxidative stress and role of antioxidants in normal and abnormal sperm function. Front Biosci, 1, e78-86 (1996)
33. J. F. Griveau and D. Le Lannou: Reactive oxygen species and human spermatozoa: physiology and pathology. Int J Androl, 20(2), 61-9 (1997) (Pubitemid 27390290)
34. J. C. Kefer, A. Agarwal and E. Sabanegh: Role of antioxidants in the treatment of male infertility. Int J Urol, 16(5), 449-57 (2009) doi:IJU2280 [pii]
35. L. O. Drevius: Bull spermatozoa as osmometers. J Reprod Fertil, 28(1), 29-39 (1972)
36. A. Agarwal, K. Makker and R. Sharma: Clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol, 59(1), 2-11 (2008) doi:AJI559 [pii] (Pubitemid 350285578)
37. R. D'Agata, E. Vicari, M. L. Moncada, G. Sidoti, A. E. Calogero, M. C. Fornito, G. Minacapilli, A. Mongioi and P. Polosa: Generation of reactive oxygen species in subgroups of infertile men. Int J Androl, 13(5), 344-51 (1990) (Pubitemid 20331771)
38. J. E. Hong, L. A. Santucci, X. Tian and D. J. Silverman: Superoxide dismutase-dependent, catalase-sensitive peroxides in human endothelial cells infected by Rickettsia rickettsii. Infect Immun, 66(4), 1293-8 (1998) (Pubitemid 128471482)
39. J. M. Potts and F. F. Pasqualotto: Seminal oxidative stress in patients with chronic prostatitis. Andrologia, 35(5), 304-8 (2003) (Pubitemid 37363522)
40. K. Whittington and W. C. Ford: Relative contribution of leukocytes and of spermatozoa to reactive oxygen species production in human sperm suspensions. Int J Androl, 22(4), 229-35 (1999) (Pubitemid 29361236)
41. H. Wolff: The biologic significance of white blood cells in semen. Fertil Steril, 63(6), 1143-57 (1995)
42. D. R. Blake, R. E. Allen and J. Lunec: Free radicals in biological systems - a review orientated to inflammatory processes. Br Med Bull, 43(2), 371-85 (1987) (Pubitemid 17077721)
43. M. Fraczek and M. Kurpisz: Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa. J Androl, 28(2), 325-33 (2007) (Pubitemid 46423916)
44. M. Rajasekaran, W. J. Hellstrom, R. K. Naz and S. C. Sikka: Oxidative stress and interleukins in seminal plasma during leukocytospermia. Fertil Steril, 64(1), 166-71 (1995)
45. D. Sanocka, M. Fraczek, P. Jedrzejczak, A. Szumala-Kakol and M. Kurpisz: Male genital tract infection: an influence of leukocytes and bacteria on semen. J Reprod Immunol, 62(1-2), 111-24 (2004) (Pubitemid 38993276)
46. F. R. Ochsendorf: Infections in the male genital tract and reactive oxygen species. Hum Reprod Update, 5(5), 399-420 (1999) (Pubitemid 29512129)
47. M. Feldmann and J. Saklatvala: Proinflammatory cytokines. In: Cytokine Reference. Ed J. Oppenheim&F. M. Academic Press, New York (2001)
48. W. Xia, D. D. Mruk, W. M. Lee and C. Y. Cheng: Cytokines and junction restructuring during spermatogenesis - a lesson to learn from the testis. Cytokine Growth Factor Rev, 16(4-5), 469-93 (2005) (Pubitemid 41022014)
49. M. K. Y. Siu, D. D. Mruk, W. M. Lee and C. Y. Cheng: Adhering junction dynamics in the testis are regulated by an interplay of β1-integrin and the focal adhesion complex-associated proteins. Endocrinology, 144, 2141-2163 (2003) (Pubitemid 36543354)
50. C. Y. Hong, J. H. Park, R. S. Ahn, S. Y. Im, H. S. Choi, J. Soh, S. H. Mellon and K. Lee: Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha. Mol Cell Biol, 24(7), 2593-604 (2004) (Pubitemid 38381254)
51. V. Pentikainen, K. Erkkila, L. Suomalainen, M. Otala, M. O. Pentikainen, M. Parvinen and L. Dunkel: TNFalpha down-regulates the Fas ligand and inhibits germ cell apoptosis in the human testis. J Clin Endocrinol Metab, 86(9), 4480-8 (2001) (Pubitemid 32848578)
52. K. Mealy, B. Robinson, C. F. Millette, J. Majzoub and D. W. Wilmore: The testicular effects of tumor necrosis factor. Ann Surg, 211(4), 470-5 (1990) (Pubitemid 20138189)
53. E. Martinez-Prado and M. I. Camejo Bermudez: Expression of IL-6, IL-8, TNF-alpha, IL-10, HSP-60, anti- HSP-60 antibodies, and anti-sperm antibodies, in semen of men with leukocytes and/or bacteria. Am J Reprod Immunol, 63(3), 233-43
54. S. Seshadri, M. Bates, G. Vince and D. I. Jones: The role of cytokine expression in different subgroups of subfertile men. Am J Reprod Immunol, 62(5), 275-82 (2009)
55. C. Cudicini, H. Lejeune, E. Gomez, E. Bosmans, F. Ballet, J. Saez and B. Jégou: Human Leydig cells and Sertoli cells are producers of Interleukins-1 and -6. J Clin Endocrinol Metab, 82(5), 1426-33 (1997) (Pubitemid 27200413)
56. M. Huleihel, E. Lunenfeld, S. Horowitz, A. Levy, G. Potashnik and M. Glezerman: Production of interleukin-1- like molecules by human sperm cells. Fertility and Sterility, 73(6), 1132-1137 (2000) (Pubitemid 30336756)
57. C. A. Dinarello: Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol, 27, 519-50 (2009)
58. J. P. Stephan, V. Syed and B. Jegou: Regulation of Sertoli cell IL-1 and IL-6 production in vitro. Mol Cell Endocrinol, 134(2), 109-18 (1997) (Pubitemid 27510877)
59. N. Gerard, V. Syed and B. Jegou: Lipopolysaccharide, latex beads and residual bodies are potent activators of Sertoli cell interleukin-1 alpha production. Biochem Biophys Res Commun, 185(1), 154-61 (1992)
60. K. Svechnikov, C. Petersen, T. Sultana, A. Wahlgren, C. Zetterstrom, E. Colon, C. Bornestaf and O. Soder: The paracrine role played by interleukin-1 alpha in the testis. Current Drug Targets - Immune Endocrine & Metabolic Disorders, 4(1), 67-74 (2004) (Pubitemid 38854883)
61. J. H. Calkins, H. Guo, M. M. Sigel and T. Lin: Tumor necrosis factor-alpha enhances inhibitory effects of interleukin-1 beta on Leydig cell steroidogenesis. Biochem Biophys Res Commun, 166(3), 1313-8 (1990) (Pubitemid 20068983)
62. M. Huleihel, D. Zeyse, E. Lunenfeld, M. Zeyse and M. Mazor: Induction of transferrin secretion in murine Sertoli cells by FSH and IL-1: the possibility of different mechanism(s) of regulation. Am J Reprod Immunol, 47(2), 112-7 (2002) (Pubitemid 34552383)
63. V. Syed, J. P. Stephan, N. Gérard, A. Legrand, M. Parvinen, C. W. Bardin and B. Jégou: Residual bodies activate Sertoli cell interleukin-1 alpha (IL-1 alpha) release, which triggers IL-6 production by an autocrine mechanism, through the lipoxygenase pathway. Endocrinology, 136(7), 3070-8 (1995)
64. O. Sarkar, P. P. Mathur, C. Y. Cheng and D. D. Mruk: Interleukin 1 alpha (IL1A) is a novel regulator of the bloodtestis barrier in the rat. Biol Reprod, 78(3), 445-54 (2008) (Pubitemid 351416480)
65. W. Eggert-Kruse, I. Kiefer, C. Beck, T. Demirakca and T. Strowitzki: Role for tumor necrosis factor alpha (TNFalpha) and interleukin 1-beta (IL-1beta) determination in seminal plasma during infertility investigation. Fertil Steril, 87(4), 810-23 (2007) (Pubitemid 46550410)
66. C. Petersen, B. C, F. B and S. O: Interleukin-1 is a potent growth factor for immature rat sertoli cells. Mol Cell Endocrinol, 186(1), 37-47 (2002) (Pubitemid 34189777)
67. M. S. Gruschwitz, R. Brezinschek and H. P. Brezinschek: Cytokine levels in the seminal plasma of infertile males. J Androl, 17(2), 158-63 (1996) (Pubitemid 26131760)
68. J. Jiwakanon, M. Berg, E. Persson, C. Fossum and A. M. Dalin: Cytokine expression in the gilt oviduct: Effects of seminal plasma, spermatozoa and extender after insemination. Anim Reprod Sci
69. R. J. Aitken, D. Buckingham, K. West, F. C. Wu, K. Zikopoulos and D. W. Richardson: Differential contribution of leucocytes and spermatozoa to the generation of reactive oxygen species in the ejaculates of oligozoospermic patients and fertile donors. J Reprod Fertil, 94(2), 451-62 (1992)
70. W. Krause, C. Bohring, A. Gueth, S. Horster, A. Krisp and J. Skrzypek: Cellular and biochemical markers in semen indicating male accessory gland inflammation. Andrologia, 35(5), 279-82 (2003) (Pubitemid 37363517)
71. D. J. Anderson: Cell-mediated immunity and inflammatory processes in male infertility. Arch Immunol Ther Exp (Warsz), 38(1-2), 79-86 (1990)
72. J. A. Hill, J. Cohen and D. J. Anderson: The effects of lymphokines and monokines on human sperm fertilizing ability in the zona-free hamster egg penetration test. Am J Obstet Gynecol, 160(5 Pt 1), 1154-9 (1989) (Pubitemid 19144477)
73. H. Wolff, J. A. Politch, A. Martinez, F. Haimovici, J. A. Hill and D. J. Anderson: Leukocytospermia is associated with poor semen quality. Fertil Steril, 53(3), 528-36 (1990) (Pubitemid 20093619)
74. M. I. el-Demiry, T. B. Hargreave, A. Busuttil, K. James, A. W. Ritchie and G. D. Chisholm: Lymphocyte sub-populations in the male genital tract. Br J Urol, 57(6), 769-74 (1985) (Pubitemid 16211569)
75. H. W. Baker: Management of male infertility. Baillieres Best Pract Res Clin Endocrinol Metab, 14(3), 409-22 (2000) (Pubitemid 32000307)
76. D. Sakkas, E. Mariethoz, G. Manicardi, D. Bizzaro, P. G. Bianchi and U. Bianchi: Origin of DNA damage in ejaculated human spermatozoa. Rev Reprod, 4(1), 31-7 (1999) (Pubitemid 29078542)
77. R. Henkel, G. Maass, M. Hajimohammad, R. Menkveld, T. Stalf, J. Villegas, R. Sanchez, T. F. Kruger and W. B. Schill: Urogenital inflammation: changes of leucocytes and ROS. Andrologia, 35(5), 309-13 (2003) (Pubitemid 37363523)
78. H. M. Shen, J. Dai, S. E. Chia, A. Lim and C. N. Ong: Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality. Hum Reprod, 17(5), 1266-73 (2002) (Pubitemid 34537361)