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Volumn 13, Issue 11, 2011, Pages 2948-2951

Diamine-catalyzed conjugate addition to acrylate derivatives

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EID: 79957801476     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol201013x     Document Type: Article
Times cited : (25)

References (60)
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    • Optimization of the reaction conditions by varying diamine catalysts has been done for each nucleophile in combination with 2a; see Supporting Information.
    • Optimization of the reaction conditions by varying diamine catalysts has been done for each nucleophile in combination with 2a; see Supporting Information.
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    • The reactions of malononitrile were complicated by the formation of di- and monoalkylated products as well as polymelization of acyrylate derivatives so that 2-substituted malononitriles and their derivatives were utilized for this study. Nucleophiles derived from 1,3-diketones and malonate esters resulted in no reaction under the present reaction conditions.
    • The reactions of malononitrile were complicated by the formation of di- and monoalkylated products as well as polymelization of acyrylate derivatives so that 2-substituted malononitriles and their derivatives were utilized for this study. Nucleophiles derived from 1,3-diketones and malonate esters resulted in no reaction under the present reaction conditions.
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    • Optimization of the reaction conditions by varying diamine catalysts has been done for each acrylate in combination with 1a; see Supporting Information.
    • Optimization of the reaction conditions by varying diamine catalysts has been done for each acrylate in combination with 1a; see Supporting Information.
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    • 2 atmosphere at 0 °C. Upon completion indicated by TLC, toluene was removed under reduced pressure and the crude mixture was subjected to column chromatography to yield conjugate addition products.
    • 2 atmosphere at 0 °C. Upon completion indicated by TLC, toluene was removed under reduced pressure and the crude mixture was subjected to column chromatography to yield conjugate addition products.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.