DNA threading bis(9-aminoacridine-4-carboxamides): Effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 8, 2008, Pages 4390-4400

  He, Zhicong ^a   Bu, Xianyong ^a   Eleftheriou, Alexandra ^a   Zihlif, Malik ^a   Qing, Zhang ^a   Stewart, Bernard W ^a,b   Wakelin, Laurence P G ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b Public Health Unit   (Australia)

Author keywords

Bisintercalator; Diacridine; Threading agent; Transcriptional inhibitor

Indexed keywords

1,10 BIS[4 [N(2 PIPERIDINYLETHYL)CARBAMOYL]ACRIDIN 9 YL] 1,4,7,10 TRIAZADECANE; 1,10 BIS[4 [N(2 PIPERIDINYLETHYL)CARBAMOYL]ACRIDIN 9 YL] 1,5,10 TRIAZADECANE; 1,10 BIS[4 [N(N METHYLPIPERIDIN 4 YL)CARBAMOYL]ACRIDIN 9 YL] 1,4,7,10 TETRA AZADECANE; 1,10 BIS[4 [N(N METHYLPIPERIDIN 4 YL)CARBAMOYL]ACRIDIN 9 YL] 1,5,10 TRIAZA HEPTANE; 1,6 BIS[4 [N(2 PIPERIDINYLETHYL)CARBAMOYL]ACRIDIN 9 YL]DIAMINOHEXANE; 1,6 BIS[4 [N(N METHYLPIPERIDIN 4 YL)CARBAMOYL]ACRIDIN 9 YL]DIAMINOHEXANE; 1,7 BIS[4 [N(2 PIPERIDINYLETHYL)CARBAMOYL]ACRIDIN 9 YL] 1,4,7 TRIAZA HEPTANE; 1,7 BIS[4 [N(N METHYLPIPERIDIN 4 YL)CARBAMOYL]ACRIDIN 9 YL] 1,4,7 TRIAZA HEPTANE; 1,8 BIS[4 [N(2 PIPERIDINYLETHYL)CARBAMOLY]ACRIDIN 9 YL]DIAMINOOCTANE; 9 AMINO N (2 DIMETHYLAMINOETHYL) 4 ACRIDINECARBOXAMIDE; ACRIDINE DERIVATIVE; ALKYL GROUP; AMSACRINE; DACTINOMYCIN; N (2 DIMETHYLAMINOETHYL) 4 ACRIDINECARBOXAMIDE; N (N METHYLPIPERIDIN 4 YL) 9 AMINOACRIDINE 4 CARBOXAMIDE; N (N METHYLPIPERIDIN 4 YL) 9 CHLOROACRIDINE 4 CARBOXAMIDE; N [2 (N PIPERIDINYL)ETHYL] 9 AMINOACRIDINE 4 CARBOXAMIDE; N [2 (N PIPERIDINYL)ETHYL] 9 CHLOROACRIDINE 4 CARBOXAMIDE; N,N BIS[4 [N (N METHYLPIPERIDIN 4 YL)CARBAMOLY]ACRIDIN 9 YL] [1,4 BIS(2 AMINOETHYL)PIPERAZINE; N,N BIS[4 [N (N PIPERIDINYLETHYL)CARBAMOLY]ACRIDIN 9 YL] [1,4 BIS(2 AMINOETHYL)PIPERAZINE; PIPERAZINE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL;

AMINOACRIDINES; CELL CYCLE; CELL LINE, TUMOR; DIMERIZATION; DNA; HUMANS; MOLECULAR STRUCTURE; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 42249088722     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.063     Document Type: Article

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