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In preparative organic syntheses, the oxidation of thioethers into sulfoxides can be accomplished with many oxidizing agents, including peracids or hydrogen peroxide in the presence of various catalysts. Organic peroxides, such as tert-butyl hydroperoxide have also been widely used as stoichiometric oxidants in such transition-metal-catalyzed reactions. However, in the absence of catalysts, the reaction of hydrogen peroxides or alkyl hydroperoxides is sluggish in aqueous solutions at room temperature and physiological pH. By contrast, HOCl shows sufficient oxidizing power under these conditions for the oxidation to proceed, which helps rationalize the observed selectivity of probe 2. See
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2 already causes significant cytotoxicity. Consequently, longer reaction times and/or higher concentrations of the analyte were required to compensate for the slow kinetics of internalization of hypochlorite into the cells
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