Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia

Journal of Medicinal Chemistry

Volumn 54, Issue 10, 2011, Pages 3661-3668

  Dahl, Russell ^a   Bravo, Yalda ^a   Sharma, Vandana ^a   Ichikawa, Mie ^a   Dhanya, Raveendra Panickar ^a   Hedrick, Michael ^a   Brown, Brock ^a   Rascon, Justin ^a   Vicchiarelli, Michael ^a   Mangravita Novo, Arianna ^a   Yang, Li ^a   Stonich, Derek ^a   Su, Ying ^a   Smith, Layton H ^a   Sergienko, Eduard ^a   Freeze, Hudson H ^a   Cosford, Nicholas D P ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUORO 2 PHENYLBENZO[D]ISOTHIAZOL 3(2H) ONE; ENZYME INHIBITOR; MANNOSE PHOSPHATE ISOMERASE INHIBITOR; ML 089; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONGENITAL DISORDER OF GLYCOSYLATION TYPE 1A; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN;

ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; COMBINATORIAL CHEMISTRY TECHNIQUES; CONGENITAL DISORDERS OF GLYCOSYLATION; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MANNOSE-6-PHOSPHATE ISOMERASE; MODELS, CHEMICAL; PERMEABILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 79957703837     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101401a     Document Type: Article

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