Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 20, 2011, Pages 8473-8478

  Drew, Patrick J ^a,b,c   Shih, Andy Y ^a   Kleinfeld, David ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b The Pennsylvania State University   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d University of California San Diego   (United States)

Author keywords

Blood oxygen level dependent functional MRI; Neurovascular coupling; Two photon imaging; Vasomotion; Vibrissa somatosensation

Indexed keywords

ANIMAL EXPERIMENT; ARTERIOLE; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN CORTEX; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSORY STIMULATION; STIMULUS RESPONSE; VENOUS BLOOD; VENULE; VIBRISSA;

ANIMALS; ARTERIOLES; HEMODYNAMICS; MAGNETIC RESONANCE IMAGING; MICE; RODENTIA; SOMATOSENSORY CORTEX; VASODILATION; VIBRISSAE;

MUS; RODENTIA;

EID: 79957698081     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100428108     Document Type: Article

References (49)

1. Ogawa S, Lee TM, Nayak AS, Glynn P (1990) Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14:68-78. (Pubitemid 20243866)
2. Grinvald A, Lieke EE, Frostig RD, Gilbert CD, Wiesel TN (1986) Functional architecture of cortex revealed by optical imaging of intrinsic signals. Nature 324:361-364. (Pubitemid 17180109)
3. Logothetis NK, Wandell BA (2004) Interpreting the BOLD signal. Annu Rev Physiol 66: 735-769. (Pubitemid 40614461)
4. Buxton RB, Wong EC, Frank LR (1998) Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 39:855-864. (Pubitemid 28237743)
5. Mandeville JB, et al. (1999) Evidence of a cerebrovascular postarteriole windkessel with delayed compliance. J Cereb Blood Flow Metab 19:679-689. (Pubitemid 30161221)
6. Lee SP, Duong TQ, Yang G, Iadecola C, Kim SG (2001) Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI. Magn Reson Med 45:791-800. (Pubitemid 32402021)
7. Drew PJ, et al. (2010) Chronic optical access through a polished and reinforced thinned skull. Nat Methods 7:981-984.
8. Sohler TP, Lothrop GN, Forbes HS (1941) The pial circulation of normal, nonanesthetized animals. Part 1. Description of a method of observation. J Pharmacol Exp Ther 71:325-330.
9. O'Connor DH, et al. (2010) Vibrissa-based object localization in head-fixed mice. J Neurosci 30:1947-1967.
10. Devor A, et al. (2007) Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. J Neurosci 27:4452-4459. (Pubitemid 46640720)
11. Peppiatt CM, Howarth C, Mobbs P, Attwell D (2006) Bidirectional control of CNS capillary diameter by pericytes. Nature 443:700-704. (Pubitemid 44564713)
12. Fernández-Klett F, Offenhauser N, Dirnagl U, Priller J, Lindauer U (2010) Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain. Proc Natl Acad Sci USA 107:22290-22295.
13. Ogawa S, et al. (1992) Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 89:5951-5955.
14. Kim T, Kim SG (2010) Temporal dynamics and spatial specificity of aterial and venous blood volume changes during visual stimulation: Implication for BOLD quantification. J Cereb Blood Flow Metab, 10.1038/jcbfm.2010.226.
15. Kim T, Hendrich KS, Masamoto K, Kim SG (2007) Arterial versus total blood volume changes during neural activity-induced cerebral blood flow change: Implication for BOLD fMRI. J Cereb Blood Flow Metab 27:1235-1247. (Pubitemid 46808710)
16. Silva AC, Koretsky AP, Duyn JH (2007) Functional MRI impulse response for BOLD and CBV contrast in rat somatosensory cortex. Magn Reson Med 57:1110-1118. (Pubitemid 46911295)
17. Hirano Y, Stefanovic B, Silva AC (2011) Spatiotemporal evolution of the functional magnetic resonance imaging response to ultrashort stimuli. J Neurosci 31:1440-1447.
18. Stefanovic B, et al. (2008) Functional reactivity of cerebral capillaries. J Cereb Blood Flow Metab 28:961-972. (Pubitemid 351589632)
19. Kobat D, et al. (2009) Deep tissue multiphoton microscopy using longer wavelength excitation. Opt Express 17:13354-13364.
20. Ji N, Milkie DE, Betzig E (2010) Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues. Nat Methods 7:141-147.
21. Rueckel M, Mack-Bucher JA, Denk W (2006) Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing. Proc Natl Acad Sci USA 103:17137-17142. (Pubitemid 44788935)
22. Tsai PS, et al. (2007) Spherical aberration correction in nonlinear microscopy and optical ablation using a transparent deformable membrane. Appl Phys Lett 91: 191102.
23. Débarre D, et al. (2009) Image-based adaptive optics for two-photon microscopy. Opt Lett 34:2495-2497.
24. Mayhew JEW, et al. (1996) Cerebral vasomotion: A 0.1-Hz oscillation in reflected light imaging of neural activity. Neuroimage 4:183-193.
25. Vincent JL, et al. (2007) Intrinsic functional architecture in the anaesthetized monkey brain. Nature 447:83-86. (Pubitemid 46685840)
26. Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34: 537-541.
27. Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700-711. (Pubitemid 47283145)
28. Komiyama T, et al. (2010) Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice. Nature 464:1182-1186.
29. Dombeck DA, Khabbaz AN, Collman F, Adelman TL, Tank DW (2007) Imaging largescale neural activity with cellular resolution in awake, mobile mice. Neuron 56:43-57. (Pubitemid 47484173)
30. Kalatsky VA, Stryker MP (2003) New paradigm for optical imaging: Temporally encoded maps of intrinsic signal. Neuron 38:529-545. (Pubitemid 36645029)
31. Lee EJ, Woodske ME, Zou B, O'Donnell CP (2009) Dynamic arterial blood gas analysis in conscious, unrestrained C57BL/6J mice during exposure to intermittent hypoxia. J Appl Physiol 107:290-294.
32. Helmchen F, Kleinfeld D (2008) Chapter 10. In vivo measurements of blood flow and glial cell function with two-photon laser-scanning microscopy. Methods Enzymol 444: 231-254.
33. Tsai PS, Kleinfeld D (2009) In vivo two-photon laser scanning microscopy with concurrent plasma-mediated ablation: Principles and hardware realization. Methods for Vivo Optical Imaging, ed Frostig RD (CRC Press, Boca Raton, FL), 2nd Ed, pp 59-115.
34. Driscoll JD, et al. (2011) Photon counting, censor corrections, and lifetime imaging for improved detection in two-photon microscopy. J Neurophysiol, in press.
35. Nguyen QT, Tsai PS, Kleinfeld D (2006) MPScope: A versatile software suite for multiphoton microscopy. J Neurosci Methods 156:351-359. (Pubitemid 44233677)
36. Kleinfeld D, Mitra PP, Helmchen F, Denk W (1998) Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc Natl Acad Sci USA 95:15741-15746. (Pubitemid 29018770)
37. Drew PJ, Feldman DE (2007) Representation of moving wavefronts of whisker deflection in rat somatosensory cortex. J Neurophysiol 98:1566-1580. (Pubitemid 47435902)
38. Guizar-Sicairos M, Thurman ST, Fienup JR (2008) Efficient subpixel image registration algorithms. Opt Lett 33:156-158. (Pubitemid 351328267)
39. Shih AY, et al. (2009) Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke. J Cereb Blood Flow Metab 29: 738-751.
40. Mitra PP, Ogawa S, Hu X, Uǧurbil K (1997) The nature of spatiotemporal changes in cerebral hemodynamics as manifested in functional magnetic resonance imaging. Magn Reson Med 37:511-518. (Pubitemid 27146829)
41. Thomson DJ (1982) Spectral estimation and harmonic analysis. Proc IEEE 70: 1055-1096.
42. Kleinfeld D, Mitra PP (2011) Applications of spectral methods in functional brain imaging. Imaging: A Laboratory Manual, ed Yuste R (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY), Vol 1, pp 12.11-12.17.
43. Fisher NI (1993) Statistical Analysis of Circular Data (Cambridge Press, Cambridge, MA).
44. Mitra PP, Bokil HS (2008) Observed Brain Dynamics (Oxford Univ Press, New York).
45. Valmianski I, et al. (2010) Automatic identification of fluorescently labeled brain cells for rapid functional imaging. J Neurophysiol 104:1803-1811.
46. Drew PJ, Blinder P, Cauwenberghs G, Shih AY, Kleinfeld D (2010) Rapid determination of particle velocity from space-time images using the Radon transform. J Comput Neurosci 29:5-11.
47. Tsai PS, et al. (2009) Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of cell nuclei and microvessels. J Neurosci 18:14553-14570.
48. Drew PJ, Feldman DE (2009) Intrinsic signal imaging of deprivation-induced contraction of whisker representations in rat somatosensory cortex. Cereb Cortex 19: 331-348.
49. White BR, et al. (2011) Imaging of functional connectivity in the mouse brain. PLoS One 6:e16322.