Chemokine receptor CXCR4-mediated transformation of mammary epithelial cells by enhancing multiple RTKs expression and deregulation of the p53/MDM2 axis

Cancer Letters

Volumn 307, Issue 2, 2011, Pages 132-140

  Su, Hua ^a   Sobrino Najul, Elias J ^a   Toth, Theodore A ^a   Ng, Crystal Mei ^b   Lelievre, Sophie A ^c   Fred, Matthew ^a   Tang, Careen K ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c PURDUE UNIVERSITY   (United States)

Author keywords

CXCR4; P53 MDM2 axis; RTKs; Signaling network; Transformation

Indexed keywords

CELL CYCLE PROTEIN; CHEMOKINE RECEPTOR CXCR4; MYC PROTEIN; PROTEIN MDM2; PROTEIN P53; PROTEIN TYROSINE KINASE; UVOMORULIN;

ARTICLE; BREAST EPITHELIUM; CANCER INVASION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRADUCTAL CARCINOMA; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 79957666443     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.03.025     Document Type: Article

References (27)

1. Vandercappellen J., Van Damme J., Struyf S. The role of CXC chemokines and their receptors in cancer. Cancer Lett. 2008, 267:226-244.
2. Kang H., Watkins G., Douglas-Jones A., Mansel R.E., Jiang W.G. The elevated level of CXCR4 is correlated with nodal metastasis of human breast cancer. The Breast 2005, 14:360-367.
3. Müller A., Homey B., Soto H., Ge N., Catron D., Buchanan M., McClanahan T., Murphy E., Yuan W., Wagner S., Barrera J., Mohar A., et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001, 410:50-56.
4. Akekawatchai C., Holland J., Kochetkova M., Wallace J., McColl S. Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells. J. Biol. Chem. 2005, 280:39701-39708.
5. Chen Y., Stamatoyannopoulos G., Song C. Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res. 2003, 63:4801-4804.
6. Liang Z., Yoon Y., Votaw J., Goodman M., Williams L., Shim H. Silencing of CXCR4 blocks breast cancer metastasis. Cancer Res. 2005, 65:967-971.
7. Li Y., Pan Y., Wei Y., Cheng X., Zhou B., Tan M., Zhou X., Xia W., Hortobagyi G., Yu D., Hung M. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 2004, 6:459-469.
8. Schmid B., Rudas M., Rezniczek G., Leodolter S., Zeillinger R. CXCR4 is expressed in ductal carcinoma in situ of the breast and in atypical ductal hyperplasia. Breast Cancer Res. Treat. 2004, 84:247-250.
9. Salvucci O., Bouchard A., Baccarelli A., Deschênes J., Sauter G., Simon R., Bianchi R., Basik M. The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study. Breast Cancer Res. Treat. 2006, 97:275-283.
10. Chaudary N., Hill R. Increased expression of metastasis-related genes in hypoxic cells sorted from cervical and lymph nodal xenograft tumors. Lab. Invest. 2009, 89:587-596.
11. Basolo F., Elliott J., Tait L., Chen X.Q., Maloney T., Russo I.H., Pauley R., Momiki S., Caamano J., Klein-Szanto A.J.P., Koszalka M., Russo J. Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol. Carcinog. 1991, 4:25-35.
12. Worsham M., Pals G., Schouten J., Miller F., Tiwari N., van Spaendonk R., Wolman S. High-resolution mapping of molecular events associated with immortalization, transformation, and progression to breast cancer in the MCF10 model. Breast Cancer Res. Treat. 2006, 96:177-186.
13. Bissell M.J., Radisky D. Putting tumours in context. Nat. Rev. Cancer 2001, 1:46-54.
14. Debnath J., Brugge J.S. Modelling glandular epithelial cancers in three-dimensional cultures. Nat. Rev. Cancer 2005, 5:675-688.
15. Momand J., Zambetti G.P., Olson D.C., George D., Levine A.J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992, 69:1237-1245.
16. Haupt Y., Maya R., Kazaz A., Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997, 387:296-299.
17. Chen J., Imanaka N., Griffin J.D. Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br. J. Cancer 2009, 102:351-360.
18. Meng Q., Qi M., Chen D.-Z., Yuan R., Goldberg I.D., Rosen E., Auborn K., Fan S. Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J. Mol. Med. 2000, 78:155-165.
19. Prenzel N., Zwick E., Daub H., Leserer M., Abraham R., Wallasch C. Ullrich A.EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999, 402:884-888.
20. Gschwind A., Hart S., Fischer O.M., Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J. 2003, 22:2411-2421.
21. Aulmann S., Bentz M., Sinn H.P. C-myc oncogene amplification in ductal carcinoma in situ of the breast. Breast Cancer Res. Treat. 2002, 74:25-31.
22. Lin H.M., Chatterjee A., Lin Y.H., Anjomshoaa A., Fukuzawa R., McCall J.L., Reeve A.E. Genome wide expression profiling identifies genes associated with colorectal liver metastasis. Oncol. Rep. 2007, 17:1541-1549.
23. Blanchot-Jossic F., Jarry A., Masson D., Bach-Ngohou K., Paineau J., Denis M.G., Laboisse C.L., Mosnier J.F. Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells. J. Pathol. 2005, 207:156-163.
24. Merchant N.B., Voskresensky I., Rogers C.M., Lafleur B., Dempsey P.J., Graves-Deal R., Revetta F., Foutch A.C., Rothenberg M.L., Washington M.K., Coffey R.J. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin. Cancer Res. 2008, 14:1182-1191.
25. Camp R.L., Rimm E.B., Rimm D.L. Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma. Cancer 1999, 86:2259-2265.
26. Pelengaris S., Khan M., Evan G. C-MYC: more than just a matter of life and death. Nat. Rev. Cancer 2002, 2:764-776.
27. Jeschke U., Mylonas I., Kuhn C., Shabani N., Kunert-Keil C., Schindlbeck C., Gerber B., Friese K. Expression of E-cadherin in human ductal breast cancer carcinoma in situ, invasive carcinomas, their lymph node metastases, their distant metastases, carcinomas with recurrence and in recurrence. Anticancer Res. 2007, 27(4A):1969-1974.