Spontaneous and training-induced visual learning in cortical blindness: Characteristics and neural substrates

Topics in Cognitive Science

Volumn 2, Issue 2, 2010, Pages 306-319

  Martin, Tim ^a   Huxlin, Krystel R ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Blindsight; Extrastriate cortex; Plasticity; V1 damage; Visual learning; Visual motion

Indexed keywords

ADAPTATION; ADULT; ANIMAL; BLINDNESS; HUMAN; INJURIES; LEARNING; NERVE CELL; NERVE CELL PLASTICITY; PATHOPHYSIOLOGY; PHYSIOLOGY; VISION; VISUAL CORTEX; VISUAL FIELD;

ADAPTATION, PHYSIOLOGICAL; ADULT; ANIMALS; BLINDNESS; HUMANS; LEARNING; NEURONAL PLASTICITY; NEURONS; VISUAL CORTEX; VISUAL FIELDS; VISUAL PERCEPTION;

EID: 79957665746     PISSN: 17568757     EISSN: 17568765     Source Type: Journal    
DOI: 10.1111/j.1756-8765.2009.01052.x     Document Type: Article

References (105)

1. Barbur, J. L., Harlow, A. J., & Weiskrantz, L. (1994). Spatial and temporal response properties of residual vision in a case of hemianopia. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 343, 157-166.
2. Barmashenko, G., Eysel, U. T., & Mittmann, T. (2003). Changes in intracellular calcium transients and LTP in the surround of visual cortex lesions in rats. Brain Research, 990, 120-128.
3. Benevento, L. A., & Rezak, M. (1976). The cortical projections of the inferior pulvinar and adjacent lateral pulvinar in the rhesus monkey (Macaca mulatta): An autoradiographic study. Brain Research, 108, 1-24.
4. Benzel, E. C., & Mirfarkhraee, M. (1987). Complete homonymous hemianopia: Reversal with arterial bypass. Southern Medical Journal, 80, 249-251.
5. Blythe, I. M., Kennard, C., & Ruddock, K. H. (1987). Residual vision in patients with retro-geniculate lesions of the visual pathways. Brain, 110, 887-905.
6. Chedru, F., Leblanc, M., & Lhermitte, F. (1973). Visual searching in normal and brain-damaged subjects (contribution to the study of unilateral inattention). Cortex, 9, 94-111.
7. Chowdhury, S. A., & DeAngelis, G. C. (2008). Fine discrimination training alters the causal contribution of macaque area MT to depth perception. Neuron, 60, 1-11.
8. Cowey, A., & Stoerig, P. (1989). Projection patterns of surviving neurons in the dorsal lateral geniculate nucleus following discrete lesions of striate cortex: Implications for residual vision. Experimental Brain Research, 75(3), 631-638.
9. Cowey, A., & Stoerig, P. (1991). The neurobiology of blindsight. Trends in Neurosciences, 14(4), 140-145.
10. Cowey, A., & Stoerig, P. (1995). Blindsight in monkeys. Nature, 373, 247-249.
11. Cowey, A., Stoerig, P., & Perry, V. H. (1989). Transneuronal retrograde degeneration of retinal ganglion cells after damage to striate cortex in macaque monkeys: Selective loss of Pβ cells. Neuroscience, 29(1), 65-80.
12. Cowey, A., & Weiskrantz, L. (1963). A perimetric study of visual field defects in monkey. The Quarterly Journal of Experimental Psychology, 15, 91-115.
13. Cragg, B. G. (1969). The topography of the afferent projections in the circumstriate visual cortex of the monkey studied by the Nauta method. Vision Research, 9(7), 733-747.
14. Darian-Smith, C., & Gilbert, C. D. (1994). Axonal sprouting accompanies functional reorganization in adult cat striate cortex. Nature, 368(6473), 737-740.
15. Darian-Smith, C., & Gilbert, C. D. (1995). Topographic reorganisation in the striate cortex of the adult cat and monkey is cortically mediated. Journal of Neuroscience, 15(3), 1631-1647.
16. Das, A., & Gilbert, C. D. (1995). Receptive field expansion in adult visual cortex is linked to dynamic changes in strength of cortical connections. Journal of Neurophysiology, 74(2), 779-792.
17. De Weerd, P., Gattass, R., Desimone, R., & Ungerleider, L. G. (1995). Responses of cells in monkey visual cortex during perceptual filling-in of an artificial scotoma. Nature, 377(6551), 731-734.
18. Dilks, D. D., Serences, J. T., Rosenau, B., Yantis, S., & McCloskey, M. (2007). Human adult cortical reorganization and consequent visual distortion. Journal of Neuroscience, 27(36), 9585-9594.
19. Dosher, B. A., & Lu, Z. I. (1998). Perceptual learning reflects external noise filtering and internal noise reduction through channel reweighting. Proceedings of the National Academy of Science of the United States of America, 95, 13988-13993.
20. Dosher, B., & Lu, Z. (1999). Mechanisms of perceptual learning. Vision Research, 39, 3197-3221.
21. Dosher, B. A., & Lu, Z. (2006). Level and mechanisms of perceptual learning: Learning first-order luminance and second-order texture objects. Vision Research, 46, 1996-2007.
22. Eysel, U. T. (1997). Perilesional cortical dysfunction and reorganization. Advances in Neurology, 73, 195-206.
23. Eysel, U. T., & Schmidt-Kastner, R. (1991). Neuronal dysfunction at the border of focal lesions in cat visual cortex. Neuroscience Letters, 131(1), 45-48.
24. Eysel, U. T., & Schweigart, G. (1999). Increased receptive field size in the surround of chronic lesions in the adult cat visual cortex. Cerebral Cortex, 9(2), 101-109.
25. Eysel, U. T., Schweigart, G., Mittmann, T., Eyding, D., Qu, Y., Vandesande, F., Orban, G. A., & Arckens, L. (1999). Reorganization in the visual cortex after retinal and cortical damage. Restorative Neurology and Neuroscience, 15, 153-164.
26. Feeney, D. M., & Baron, J. C. (1986). Diaschisis. Stroke, 17, 817-830.
27. Felleman, D. J., & Van Essen, D. C. (1991). Distributed hierarchical processing in the primate cerebral cortex. Cerebral Cortex, 1, 1-47.
28. Fendrich, R., Wessinger, C. M., & Gazzaniga, M. S. (1992). Residual vision in a scotoma: Implications for blindsight. Science, 258, 1489-1491.
29. Ghose, G. M., Yang, T., & Maunsell, J. H. (2002). Physiological correlates of perceptual learning in monkey V1 and V2. Journal of Neurophysiology, 87(4), 1867-1888.
30. Girard, P., Salin, P. A., & Bullier, J. (1992). Response selectivity of neurons in area MT of the macaque monkey during reversible inactivation of area V1. Journal of Neurophysiology, 67, 1437-1446.
31. Goldstone, R. L. (1998). Perceptual learning. Annual Review of Psychology, 49, 585-612.
32. Hallett, M. (2001). Plasticity of the human motor cortex and recovery from stroke. Brain Research Reviews, 36, 169-174.
33. Hayhoe, M. M., & Ballard, D. (2005). Eye movements in natural behavior. Trends in Cognitive Sciences, 9(4), 188-194.
34. Hendry, S. H., & Reid, R. C. (2000). The koniocellular pathway in primate vision. Annual Reviews in Neuroscience, 23, 127-153.
35. Henriksson, L., Raninen, A., Näsänen, R., Hyvärinen, L., & Vanni, S. (2007). Training-induced cortical representation of a hemianopic hemifield. Journal of Neurology, Neurosurgery, and Psychiatry, 78, 74-81.
36. Holbach, K. H., Wassman, H., Hoheluchter, K. L., & Jain, K. K. (1977). Differentiation between reversible and irreversible stroke changes in brain tissue: Its relevance for cerebral vascular surgery. Surgical Neurology, 7, 325-333.
37. Holmes, G. (1918). Disturbances of vision by cerebral lesions. British Journal of Ophthalmology, 2, 353-384.
38. Horton, J. C. (2005). Disappointing results from Nova Vision's visual restoration therapy. British Journal of Ophthalmology, 89(1), 1-2.
39. Hubel, D. H. (1982). Evolution of ideas on the primary visual cortex, 1955-1978: A biased historical account. Bioscience Reports, 2(7), 435-469.
40. Hubel, D. H., & Wiesel, T. N. (1959). Receptive fields of single neurones in the cat's striate cortex. Journal of Physiology, 148, 574-591.
41. Huxlin, K. R. (2008). Perceptual plasticity in damaged adult visual systems. Vision Research, 48, 2154-2166.
42. Huxlin, K. R., Riley, M. E., Martin, T., Kelly, K. N., Friedman, D. I., Burgin, W. S., & Hayhoe, M. (2009). Perceptual re-learning of complex visual motion after V1 damage in humans. Journal of Neuroscience, 29(13), 3981-3991.
43. Huxlin, K. R., Williams, J. M., & Price, T. (2008). A neurochemical signature of visual recovery after extrastriate cortical damage in the adult cat. Journal of Comparative Neurology, 508, 45-61.
44. Ishiai, S., Furukawa, T., & Tsukagoshi, H. (1987). Eye-fixation patterns in homonymous hemianopia and unilateral spatial neglect. Neuropsychologia, 25, 675-679.
45. Jakobs, K. M., & Donoghue, J. P. (1991). Reshaping the cortical motor map by unmasking latent intracortical connections. Science, 251, 944-947.
46. Kasten, E., Poggel, D. A., & Sabel, B. A. (2000). Computer-based training of stimulus dection improves color and simple pattern recognition in the defective field of hemianopic subjects. Journal of Cognitive Neuroscience, 12(6), 1001-1012.
47. Kasten, E., & Sabel, B. A. (1995). Visual field enlargment after computer-training in brain-damaged patients with homonymous deficits-an open pilot trial. Restorative Neurology and Neuroscience, 8, 113-127.
48. Kasten, E., Wüst, S., Behrens-Baumann, W., & Sabel, B. A. (1998). Computer-based training for the treatment of partial blindness. Nature Medicine, 4(9), 1083-1087.
49. Keck, T., Mrsic-Flogel, T. D., Afonso, M. V., Eysel, U. T., Bonhoeffer, T., & Hübnener, M. (2008). Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex. Nature Neuroscience, 11, 1162-1167.
50. Kononen, M., Kuikka, J. T., Husso-Saastamoinen, M., Vanninen, E., Vanninen, R., Soimakallio, S., Mervaala, E., Sivenius, J., Pitkanen, K., & Tarkka, I. M. (2005). Increased perfusion in motor areas after constraint-induced movement therapy in chronic stroke: A single-photon emission computerized tomography study. Journal of Cerebral Blood Flow and Metabolism, 25(12), 1668-1674.
51. Law, C.-T., & Gold, J. (2008). Neural correlates of perceptual learning in a sensory-motor, but not a sensory, cortical area. Nature Neuroscience, 11(4), 505-513.
52. Lee, T. S., Mumford, D., Romero, R., & Lamme, V. A. (1998). The role of the primary visual cortex in higher level vision. Vision Research, 38(15-16), 2429-2454.
53. Lee, T. S., Yang, C. F., Romero, R. D., & Mumford, D. (2002). Neural activity in early visual cortex reflects behavioral experience and higher-order perceptual saliency. Nature Neuroscience, 5(6), 589-597.
54. Leff, A., Scott, S., Crewes, H., Hodgson, T., Cowey, A., Howard, D., & Wise, R. (2000). Impaired reading in patients with right hemianopia. Annals of Neurology, 47, 171-178.
55. Marigold, D. S., Weedersteyn, V., Patla, A. E., & Duysens, J. (2007). Keep looking ahead? Re-direction of visual fixation does not always occur during an unpredictable obstacle avoidance task Experimental Brain Research, 176(1), 32-42.
56. Martin, T., Riley, M. E., Kelly, K. N., Hayhoe, M., & Huxlin, K. R. (2007). Visually-guided behavior of homonymous hemianopes in a naturalistic task. Vision Research, 47, 3434-3446.
57. McDonald, S. A., Spitsyna, G., Shillcock, R. C., Wise, R. J., & Leff, A. P. (2006). Patients with hemianopic alexia adopt an inefficient eye movement strategy when reading text. Brain, 129, 158-167.
58. Meienberg, O., Zangemeister, E. H., Rosenberg, M., Hoyt, W. F., & Stark, L. (1981). Saccadic eye movement strategies in patients with homonymous hemianopia. Annals of Neurology, 9, 537-544.
59. Mendola, J. D., Conner, I. P., Sharma, S., Bahekar, A., & Lemieux, S. (2006). fMRI measures of perceptual filling-in in the human visual cortex. Journal of Cognitive Neuroscience, 18, 363-375.
60. Mendola, J. D., Dale, A. M., Fischl, B., Liu, A. K., & Tootell, R. B. (1999). The representation of illusory and real contours in human cortical visual areas revealed by functional magnetic resonance imaging. Journal of Neuroscience, 19(19), 8560-8572.
61. Mohler, C. W., & Wurtz, R. H. (1977). The role of striate cortex and superior colliculus in visual guidance of saccadic eye movements. Journal of Neurophysiology, 40, 74-94.
62. Morland, A. B., Jones, S. R., Finlay, A. L., Deyzac, E., Le, S., & Kemp, S. (1999). Visual perception of motion, luminance and color in a human hemianope. Brain, 122, 1183-1198.
63. Morland, A. B., Le, S., Carrol, E., Hoffmann, M. B., & Pambakian, A. (2004). The role of spared calcarine cortex and lateral occipital cortex in the responses of human hemianopes to visual motion. Journal of Cognitive Neuroscience, 16, 204-218.
64. Mueller, I., Poggel, D. A., Kenkel, S., Kasten, E., & Sabel, B. A. (2003). Vision restoration therapy after brain damage: Subjective improvements of activities of daily life and their relationship to visual field enlargements. Vision Impairment Research, 5, 157-178.
65. Nelles, G., Widman, G., De Greiff, A., Meistrowitz, A., Dimitrova, A., Weber, J., Forsting, M., Esser, J., & Diener, H. C. (2002). Brain representation of hemifield stimulation in poststroke visual field defects. Stroke, 33(5), 1286-1293.
66. Pambakian, A. L. M., & Kennard, C. (1997). Can visual function be restored in patients with homonymous hemianopia. British Journal of Ophthalmology, 81, 324-328.
67. Pambakian, A. L. M., Mannan, S. K., Hodgson, T. L., & Kennard, C. (2004). Saccadic visual search training: A treatment for patients with homonymous hemianopia. Journal of Neurology, Neurosurgery and Psychiatry, 75, 1443-1448.
68. Pambakian, A. L. M., Wooding, D. S., Patel, N., Morland, A. B., Kennard, C., & Mannan, S. K. (2000). Scanning the visual world: A study of patients with homonymous hemianopia. Journal of Neurology, Neurosurgery and Psychiatry, 69, 751-759.
69. Pasik, P., & Pasik, T. (1982). Visual functions in monkeys after total removal of visual cerebral cortex. Contributions to Sensory Physiology, 7, 147-200.
70. Peli, E. (2000). Field expansion for homonymous hemianopia by optically induced peripheral exotropia. Optometry and Vision Science, 77(9), 453-464.
71. Poggel, D. A., Kasten, E., Müller-Oehring, E. M., Sabel, B. A., & Brandt, S. A. (2001). Unusual spontaneous and training induced visual field recovery in a patient with a gunshot lesion. Journal of Neurology, Neurosurgery and Psychiatry, 70, 236-239.
72. Pöppel, E., Held, R., & Frost, D. (1973). Residual visual function after brain wounds involving the central visual pathways in man. Nature, 243, 295-296.
73. Raninen, A., Vanni, S., Hyvärinen, L., & Näsänen, R. (2006). Temporal sensitivity in a hemianopic visual field can be improved by long-term training using flicker stimulation. Journal of Neurology, Neurosurgery, and Psychiatry, 78, 66-73.
74. Reinhard, J., Schreiber, A., Schiefer, U., Sabel, B. A., Kenkel, S., Vontheim, R., & Trauzettel-Klosinski, S. (2005). Does visual restitution training change absolute homonymous visual field defects? A fundus controlled study. British Journal of Ophthalmology, 89, 30-35.
75. Riddoch, G. (1917). Dissociations of visual perceptions due to occipital injuries with especial reference to appreciation of movement. Brain, 40, 15-57.
76. Riley, M., Kelly, K., Martin, T., Hayhoe, M. M., & Huxlin, K. R. (2007). Homonymous hemianopia alters distribution of visual fixations in 3-dimensional virtual environments. Sarasota, FL: Vision Sciences Society.
77. Roski, R., Spetzler, R. F., & Owen, M. (1979). Reversal of seven-year-old visual field defect with extracranial-intracranial arterial anastomosis. Surgical Neurology, 10, 267-268.
78. Rossi, A. F., Rittenhouse, C. D., & Paradiso, M. A. (1996). The representation of brightness in primary visual cortex. Science, 273(5278), 1104-1107.
79. Rumpel, S., Hoffmann, H., Hatt, H., Gottmann, K., Mittmann, T., & Eysel, U. T. (2000). Lesion-induced changes in NMDA receptor subunit mRNA expression in rat visual cortex. NeuroReport, 11(18), 4021-4025.
80. Sabel, B. A. (1997). Unrecognized potential for surviving neurons: Within-systems plasticity, recovery of function, and the hypothesis of minimal residual structure. The Neuroscientist, 3, 366-370.
81. Sabel, B. A., & Kasten, E. (2000). Restoration of vision by training of residual functions. Current Opinion in Ophthalmology, 11, 430-436.
82. Sabel, B. A., Kenkel, S., & Kasten, E. (2004). Vision restoration therapy (VRT) efficacy as assessed by comparative parametric analysis and subjective questionnaires. Restorative Neurology and Neuroscience, 22, 399-420.
83. Sagi, D., & Tanne, D. (1994). Perceptual learning: Learning to see. Current Opinion in Neurobiology, 4, 195-199.
84. Sahraie, A., Trevethan, C. T., MacLeod, M. J., Murray, A. D., Olson, J. A., & Weiskrantz, L. (2006). Increased sensitivity after repeated stimulation of residual spatial channels in blindsight. Proceedings of the National Academy of Sciences of the United States of America, 103(40), 14971-14976.
85. Sahraie, A., Trevethan, C. T., Weiskrantz, L., Olson, J. A., MacLeod, M. J., Murray, A. D., Dijkhuizen, R. S., Counsell, C., & Coleman, R. (2003). Spatial channels of visual processing in cortical blindness. European Journal of Neuroscience, 18, 1189-1194.
86. Schoups, A., Vogels, R., Qian, N., & Orban, G. A. (2001). Practising orientation identification improves orientation coding in V1 neurons. Nature, 412, 549-553.
87. Sincich, L. C., Park, K. F., Wohlgemuth, M. J., & Horton, J. C. (2004). Bypassing V1: A direct genicular input to area MT. Nature Neuroscience, 7(10), 1123-1128.
88. Tant, M. L. M., Cornelissen, F. W., Kooijman, A. C., & Brouwer, W. H. (2002). Hemianopic visual field defects elicit hemianopic scanning. Vision Research, 42, 1339-1348.
89. Taub, E., Uswatte, G., & Elbert, T. (2002). New treatments in neurorehabilitation founded on basic research. Nature Reviews Neuroscience, 3, 228-236.
90. Teuber, H.-L., Battersby, W. S., & Bender, M. B. (1960). Visual field defects after penetrating missile wounds of the brain. Cambridge, MA: Harvard University Press.
91. Tiel, K., & Kolmel, H. W. (1991). Patterns of recovery from homonymous hemianopia subsequent to infarction in the distribution of the posterior cerebral artery. Neuro-ophthalmology, 11, 33-39.
92. Triesch, J., Ballard, D. H., Hayhoe, M., & Sullivan, B. T. (2003). What you see is what you need. Journal of Vision, 3, 86-94.
93. Turano, K. A., Broman, A. T., Bandeen-Roche, K., Munoz, B., Rubin, G. S., West, S. K., & Team, S. P. (2004). Association of visual field loss and mobility performance in older adults: Salisbury Eye Evaluation Study. Optometry and Vision Science, 81(5), 298-307.
94. Van Essen, D. C., Anderson, C. H., & Felleman, D. J. (1992). Information processing in the primate visual system: An integrated systems perspective. Science, 255, 419-423.
95. Weiskrantz, L. (1986). Blindsight: A case study and implications. Oxford, England: Oxford University Press.
96. Weiskrantz, L. (1990). The Ferrier lecture, 1989 Outlooks for blindsight: Explicit methodologies for implicit processes Proceedings of the Royal Society of London, Series B: Biological Sciences, 239(1296), 247-278.
97. Weiskrantz, L. (1996). Blindsight revisited. Current Opinion in Neurobiology, 6(2), 215-220.
98. Weiskrantz, L., Harlow, A., & Barbur, J. L. (1991). Factors affecting visual sensitivity in a hemianopic subject. Brain, 114, 2269-2282.
99. Weiskrantz, L., Warrington, E. K., Sanders, M. D., & Marshall, J. (1974). Visual capacity in the hemianopic field following a restricted occipital ablation. Brain, 97, 709-728.
100. Wessinger, C. M., Fendrich, R., & Gazzaniga, M. S. (1997). Islands of residual vision in hemianopic patients. Journal of Cognitive Neuroscience, 9(2), 203-221.
101. Yang, T., & Maunsell, J. H. R. (2004). The effect of perceptual learning on neuronal responses in monkey visual area V4. Journal of Neuroscience, 24(7), 1617-1626.
102. Zangemeister, W. H., Oechsner, U., & Freksa, C. (1995). Short-term adaptation of eye movements in patients with visual hemifield defects indicates high level control of human scanpath. Optometry and Vision Science, 72(7), 467-477.
103. Zeki, S., & Ffytche, D. H. (1998). The Riddoch Syndrome: Insights into the neurobiology of conscious vision. Brain, 121, 25-45.
104. Zhang, X., Kedar, S., Lynn, M. J., Newman, N. J., & Biousse, V. (2006). Natural history of homonymous hemianopia. Neurology, 66, 901-905.
105. Zihl, J. (1995). Visual scanning behavior in patients with homonymous hemianopia. Neuropsychologia, 33(3), 287-303.