Arginine and sepsis: A question of the right balance?

Critical Care Medicine

Volumn 39, Issue 6, 2011, Pages 1569-1570

  Preiser, Jean Charles ^a   Luiking, Yvette ^b   Deutz, Nicolaas ^b  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

arginine; nitric oxide; sepsis; stable isotopes

Indexed keywords

ARGININE; CITRULLINE; DIMETHYLARGININASE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; ORNITHINE;

AMINO ACID METABOLISM; CONCENTRATION (PARAMETERS); CRITICAL ILLNESS; DIET SUPPLEMENTATION; EDITORIAL; INNATE IMMUNITY; INTENSIVE CARE UNIT; MORTALITY; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; RISK FACTOR; RISK REDUCTION; SEPSIS; SEPTIC SHOCK; SURVIVAL;

EID: 79957664728     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318215c1ea     Document Type: Editorial

References (18)

1. Gough MS, Morgan MAM, Mack CM, et al: The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis. Crit Care Med 2011; 39: 1351-1358.
2. Bakker J, Grover R, McLuckie A, et al: Administration of the nitric oxide synthase inhibitor NG-methyl-l-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: Results of a randomized, double-blind, placebocontrolled multicenter study (study no. 144-002). Crit Care Med 2004; 32:1-12. (Pubitemid 38125557)
3. Watson D, Grover R, Anzueto, A, et al: Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-l-arginine hydrochloride (546C88) in patients with septic shock: Results of a randomized, doubleblind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med 2004; 32:13-20. (Pubitemid 38125558)
4. López A; Lorente JA, Steingrub J, et al: Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock. Crit Care Med 2004; 32:21-30. (Pubitemid 38125559)
5. Critical Care Nutrition Web site. Available at: http://www. criticalcarenutrition.com. Accessed February 14, 2011.
6. McClave SA, Martindale RG, Vanek VW, et al: Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient. JPEN J Parenter Enteral Nutr 2009; 33:277-316.
7. Davis JS, Anstey NM: Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis. Crit Care Med 2011; 39:380-385.
8. Kao CC, Bandi V, Guntupalli KK, et al: Arginine, citrulline and nitric oxide metabolism in sepsis. Clin Sci (London) 2009; 117:23-30.
9. Luiking YC, Poeze M, Ramsay G, et al: Reduced citrulline production in sepsis is related to diminished De novo arginine and nitric oxide production. Am J Clin Nutr 2009; 89:142-152.
10. Morris SM Jr: Arginine: Master and commander in innate immune responses. Sci Signal 2010; 17:pe27.
11. O'Dwyer MJ, Dempsey F, Crowley V, et al: Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: A prospective observational study. Crit Care 2006; 10:R139.
12. Nakamura T, Sato E, Fujiwara N, et al: Circulating levels of advanced glycation end products (AGE) and interleukin-6 (IL-6) are independent determinants of serum asymmetrical dimethylarginine (ADMA) levels in patients with septic shock. Pharmacol Res 2009; 60:515-518.
13. Iapichino G, Umbrello M, Alpicini M, et al: Time course of endogenous nitric oxide inhibitors in severe sepsis in humans. Minerva Anestesiol 2010; 76:325-333.
14. Nijveldt RJ, Teerlink T, Van Der Hoven B, et al: Asymmetrical dimethylarginine (ADMA) in critically ill patients: High plasma ADMA concentration is an independent risk factor of ICU mortality. Clin Nutr 2003; 22:23-30. (Pubitemid 36193177)
15. Drover JW, Dhaliwal R, Weitzel L, et al: Perioperative use of arginine-supplemented diets: A systematic review of the evidence. J Am Coll Surg 2011 Jan 17 [Epub ahead of print].
16. Luiking YC, Poeze M, Dejong CH, et al: Sepsis: An arginine deficiency state? Crit Care Med 2004; 32:2135-2145. (Pubitemid 39372550)
17. Luiking YC, Engelen MP, Deutz NE: Regulation of nitric oxide production in health and disease. Curr Opin Clin Nutr Metab Care 2010; 13:97-104.
18. Bode Boger S, Scalera F, Ignarro LJ: The L-arginine paradox: Importance of the Larginine/ asymmetrical dimethylarginine ratio. Pharmacol Ther 2007; 114:295-306 (Pubitemid 46843253)