Influence of aqueous extract of Arjuna (Terminalia arjuna) on growth and antioxidant defense system of human hepatoma cell line (HepG2)

Journal of Medicinal Plants Research

Volumn 5, Issue 9, 2011, Pages 1711-1721

  Shivananjappa, Mahesh Mysore ^a   Joshi, Manoj Kumar ^a  

^a Hindustan Lever Limited   (India)

Author keywords

Antioxidant; Arjuna; Hepatoprotection; HepG2; Oxidative stress; Terminalia arjuna

Indexed keywords

CATALASE; CELL MARKER; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIPID HYDROPEROXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TERMINALIA ARJUNA EXTRACT; WATER;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL GROWTH; CELL LYSATE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL STRESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; HEPATOMA CELL; HUMAN; HUMAN CELL; NONHUMAN; OXIDATIVE STRESS; TERMINALIA; TERMINALIA ARJUNA;

TERMINALIA ARJUNA;

EID: 79957648445     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Alia M, Mateos R, Ramos S, Lecumberri E, Bravo L, Goya L (2006). Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2). Eur. J. Nutr., 45(1): 19-28.
2. Beckman JS, Koppenol WH (1996). Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol., 271: C1424-C1437.
3. Bradford MM (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254.
4. Carlberg I, Mannervik B (1985). Glutathione reductase. Methods Enzymol., 113: 484-490.
5. Colabawalla HM (1951). An evaluation of the cardiotonic and other properties of Terminalia arjuna. Indian Heart J., 3: 205-230.
6. Devi RS, Narayan S, Vani G, Shyamala Devi CS (2007). Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer. Chem. Biol. Interact., 167(1): 71-83.
7. Dwivedi S (2007). Terminalia arjuna Wight and Arn.-a useful drug for cardiovascular disorders. J. Ethnopharmacol., 114(2): 114-129.
8. Eyer P, Podhradský D (1986). Evaluation of the micromethod for determination of glutathione using enzymatic cycling and Ellman's reagent. Anal. Biochem., 153(1): 57-66.
9. Flohé L, Günzler W (1984). Assays of glutathione peroxidase. Methods Enzymol., 105: 114-121.
10. Flohé L, Otting F (1984). Superoxide dismutase assays. Methods Enzymol., 105: 93-104.
11. Francoeur AM, Assalian A (1996). Microcat: A novel cell proliferation and cytotoxicity assay based on WST-1. Biochemica., 3: 19-25.
12. Gauthaman K, Maulik M, Kumari R, Manchanda SC, Dinda AK, Maulik SK (2001). Effect of chronic treatment with bark of Terminalia arjuna: a study on the isolated ischemic-reperfused rat heart. J. Ethnopharmacol., 75(2-3): 197-201.
13. Harman D (1991). The aging process: major risk factor for disease and death. Proc. Nat. Acad. Sci., 88(12): 5360-5363.
14. Indian Pharmacopeia Commission (2007). Amalaki monograph. Indian Pharmacopoeia., 3: 2018.
15. Johansson LH, Borg LA (1988). A spectrophotometric method for determination of catalase activity in small tissue samples. Anal. Biochem., 174(1): 331-336.
16. Karthikeyan K, Bai BR, Gauthaman K, Sathish KS, Devaraj SN (2003). Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury. Life Sci., 73(21):2727-39.
17. Kotronen A, Yki-Järvinen H (2008). Fatty liver: a novel component of the metabolic syndrome. Arterioscler. Thromb. Vasc. Biol., 28(1): 27-38.
18. Lebel CP, Ischiropoulos H, Bondy SC (1992). Evaluation of the probe 2', 7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol., 5(2): 227-231.
19. Manna P, Sinha M, Sil PC (2007). Phytomedicinal activity of Terminalia arjuna against carbon tetrachloride induced cardiac oxidative stress. Pathophysiol., 14(2): 71-78.
20. Mihaljević B, Katusin-Razem B, Razem D (1996). The reevaluation of the ferric thiocyanate assay for lipid hydroperoxides with special considerations of the mechanistic aspects of the response. Free Radical Biol. Med., 21(1): 53-63.
21. Morisco F, Vitaglione P, Amoruso D, Russo B, Fogliano V, Caporaso N (2008). Foods and liver health. Mol. Aspects. Med., 29(1-2): 144-150.
22. Munasinghe TC, Seneviratne CK, Thabrew MI, Abeysekera AM (2001). Antiradical and antilipoperoxidative effects of some plant extracts used by Sri Lankan traditional medical practitioners for cardioprotection. Phytother. Res., 15(6): 519-523.
23. Nagpal A, Meena LS, Kaur S, Grover IS, Wadhwa R, Kaul SC (2000). Growth suppression of human transformed cells by treatment with bark extracts from a medicinal plant, Terminalia arjuna. In vitro Cell Dev. Biol. Anim., 36(8): 544-547.
24. Nair S, Nagar R (1997). Antioxidant flavonoids in common Indian Foods. South Asian J. Preventive Cardiol., 1: 33-35.
25. Nelson SK, Bose SK, Grunwald GK, Myhill P, McCord JM (2006). The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy. Free Radical Biol. Med., 40(2): 341-347.
26. Raghavan B, Kumari SK (2006). Effect of Terminalia arjuna stem bark on antioxidant status in liver and kidney of alloxan diabetic rats. Indian J. Physiol. Pharmacol., 50(2): 133-142.
27. Rice-Evans C, Miller N (1994). Total antioxidant status in plasma and body fluids. Methods Enzymol., 234(24): 279-293.
28. Shastri BN (1962). Terminalia Arjuna In Wealth of India: Raw Material, CSIR, Delhi, India, VI: 383-385
29. Singh G, Singh AT, Abraham A, Bhat B, Mukherjee A, Verma R, Agarwal SK, Jha S, Mukherjee R, Burman AC (2008). Protective effects of Terminalia arjuna against Doxorubicin-induced cardiotoxicity. J. Ethnopharmacol., 117(1): 123-9.
30. Sivalokanathan S, Ilayaraja M, Balasubramanian MP (2006). Antioxidant activity of Terminalia arjuna bark extract on Nnitrosodiethylamine induced hepatocellular carcinoma in rats. Mol. Cell Biochem., 281(1-2): 87-93.
31. Sivalokanathan S, Vijayababu MR, Balasubramanian MP (2006). Effects of Terminalia arjuna bark extract on apoptosis of human hepatoma cell line HepG2. World J. Gastroenterol., 12(7): 1018-24.
32. Sun FY, Chen XP, Wang JH, Qin HL, Yang SR, Du GH (2008). Arjunic acid, a strong free radical scavenger from Terminalia arjuna. Am. J. Chin. Med., 36(1): 197-207.
33. Videla LA, Rodrigo R, Araya J, Poniachik J (2006). Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease. Trends Mol. Med., 12(12): 555-558.
34. Warholm M, Guthenberg C, von Bahr C, Mannervik B (1985). Glutathione transferases from human liver. Methods Enzymol., 113: 499-504.
35. Warrier PK, Nambiar VPK Ramankutty C (1996). Terminalia arjuna. In Indian Medicinal Plants-A compendium of 500 species, 5: 253-257.
36. Wolterbeek HT, van der Meer AJ (2005). Optimization, application, and interpretation of lactate dehydrogenase measurements in microwell determination of cell number and toxicity. Assay Drug Dev. Technol., 3(6): 675-82.
37. Yen HC, Oberley TD, Vichitbandha S, Ho YS, St Clair DK (1996). The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J. Clin. Invest., 98(5): 1253-1260.